#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UHI7 uniprotkb:Q9UBQ7 intact:EBI-1759386|uniprotkb:O95191|uniprotkb:Q8WWB6|uniprotkb:Q9UGH4|uniprotkb:Q9UI39|ensembl:ENSP00000302701|ensembl:ENSP00000302851 intact:EBI-372445|uniprotkb:Q9H3E9|uniprotkb:Q9UKX1|ensembl:ENSP00000313432|uniprotkb:Q5T945|uniprotkb:Q9H636 psi-mi:s23a1_human(display_long)|uniprotkb:SLC23A1(gene name)|psi-mi:SLC23A1(display_short)|uniprotkb:SVCT1(gene name synonym)|uniprotkb:YSPL3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 1(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 1"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 3(gene name synonym) psi-mi:grhpr_human(display_long)|uniprotkb:MSTP035(orf name)|uniprotkb:GRHPR(gene name)|psi-mi:GRHPR(display_short)|uniprotkb:GLXR(gene name synonym) psi-mi:"MI:0018"(two hybrid) Subramanian et al. (2013) imex:IM-28773|pubmed:23599041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26687877|imex:IM-28773-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005838.3|refseq:NP_689898.2|ensembl:ENSG00000170482(gene)|ensembl:ENST00000348729(transcript)|ensembl:ENST00000353963(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0008520"("L-ascorbate:sodium symporter activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015229"(L-ascorbic acid transmembrane transporter activity)|go:"GO:0015851"(nucleobase transport)|go:"GO:0015882"(L-ascorbic acid transmembrane transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0030324"(lung development)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0043229"(intracellular organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0070904"(transepithelial L-ascorbic acid transport)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029954|reactome:R-HSA-196836 refseq:NP_036335.1|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0046487"(glyoxylate metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|mint:Q9UBQ7|rcsb pdb:2GCG|rcsb pdb:2H1S|rcsb pdb:2Q50|rcsb pdb:2WWR|reactome:R-HSA-389661|ensembl:ENSG00000137106(gene)|ensembl:ENST00000318158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007588"(excretion)|go:"GO:0008465"(glycerate dehydrogenase activity)|go:"GO:0016618"(hydroxypyruvate reductase activity)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030267"("glyoxylate reductase (NADP+) activity")|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042803"(protein homodimerization activity) - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/02/23 2021/02/26 rogid:kOlX16r4KeF61pyYqkUDhwwBqIQ9606 rogid:qPHrh5I5wHI5MWba4zncz26cUnQ9606 rigid:piEGsleNX13874jk++4Rwd9Nxyg false sufficient binding region:511-598 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UHI7 uniprotkb:Q9UBQ7 intact:EBI-1759386|uniprotkb:O95191|uniprotkb:Q8WWB6|uniprotkb:Q9UGH4|uniprotkb:Q9UI39|ensembl:ENSP00000302701|ensembl:ENSP00000302851 intact:EBI-372445|uniprotkb:Q9H3E9|uniprotkb:Q9UKX1|ensembl:ENSP00000313432|uniprotkb:Q5T945|uniprotkb:Q9H636 psi-mi:s23a1_human(display_long)|uniprotkb:SLC23A1(gene name)|psi-mi:SLC23A1(display_short)|uniprotkb:SVCT1(gene name synonym)|uniprotkb:YSPL3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 1(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 1"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 3(gene name synonym) psi-mi:grhpr_human(display_long)|uniprotkb:MSTP035(orf name)|uniprotkb:GRHPR(gene name)|psi-mi:GRHPR(display_short)|uniprotkb:GLXR(gene name synonym) psi-mi:"MI:0018"(two hybrid) Subramanian et al. (2013) imex:IM-28773|pubmed:23599041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26687922|imex:IM-28773-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005838.3|refseq:NP_689898.2|ensembl:ENSG00000170482(gene)|ensembl:ENST00000348729(transcript)|ensembl:ENST00000353963(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0008520"("L-ascorbate:sodium symporter activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015229"(L-ascorbic acid transmembrane transporter activity)|go:"GO:0015851"(nucleobase transport)|go:"GO:0015882"(L-ascorbic acid transmembrane transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0030324"(lung development)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0043229"(intracellular organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0070904"(transepithelial L-ascorbic acid transport)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029954|reactome:R-HSA-196836 refseq:NP_036335.1|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0046487"(glyoxylate metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|mint:Q9UBQ7|rcsb pdb:2GCG|rcsb pdb:2H1S|rcsb pdb:2Q50|rcsb pdb:2WWR|reactome:R-HSA-389661|ensembl:ENSG00000137106(gene)|ensembl:ENST00000318158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007588"(excretion)|go:"GO:0008465"(glycerate dehydrogenase activity)|go:"GO:0016618"(hydroxypyruvate reductase activity)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030267"("glyoxylate reductase (NADP+) activity")|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042803"(protein homodimerization activity) - - - figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/02/23 2021/02/26 rogid:kOlX16r4KeF61pyYqkUDhwwBqIQ9606 rogid:qPHrh5I5wHI5MWba4zncz26cUnQ9606 rigid:piEGsleNX13874jk++4Rwd9Nxyg false sufficient binding region:511-598 sufficient binding region:79-280 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHI7 uniprotkb:Q9UBQ7 intact:EBI-1759386|uniprotkb:O95191|uniprotkb:Q8WWB6|uniprotkb:Q9UGH4|uniprotkb:Q9UI39|ensembl:ENSP00000302701|ensembl:ENSP00000302851 intact:EBI-372445|uniprotkb:Q9H3E9|uniprotkb:Q9UKX1|ensembl:ENSP00000313432|uniprotkb:Q5T945|uniprotkb:Q9H636 psi-mi:s23a1_human(display_long)|uniprotkb:SLC23A1(gene name)|psi-mi:SLC23A1(display_short)|uniprotkb:SVCT1(gene name synonym)|uniprotkb:YSPL3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 1(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 1"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 3(gene name synonym) psi-mi:grhpr_human(display_long)|uniprotkb:MSTP035(orf name)|uniprotkb:GRHPR(gene name)|psi-mi:GRHPR(display_short)|uniprotkb:GLXR(gene name synonym) psi-mi:"MI:0096"(pull down) Subramanian et al. (2013) imex:IM-28773|pubmed:23599041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26687935|imex:IM-28773-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005838.3|refseq:NP_689898.2|ensembl:ENSG00000170482(gene)|ensembl:ENST00000348729(transcript)|ensembl:ENST00000353963(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0008520"("L-ascorbate:sodium symporter activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015229"(L-ascorbic acid transmembrane transporter activity)|go:"GO:0015851"(nucleobase transport)|go:"GO:0015882"(L-ascorbic acid transmembrane transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0030324"(lung development)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0043229"(intracellular organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0070904"(transepithelial L-ascorbic acid transport)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029954|reactome:R-HSA-196836|go:"GO:0005634"(nucleus) refseq:NP_036335.1|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0046487"(glyoxylate metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|mint:Q9UBQ7|rcsb pdb:2GCG|rcsb pdb:2H1S|rcsb pdb:2Q50|rcsb pdb:2WWR|reactome:R-HSA-389661|ensembl:ENSG00000137106(gene)|ensembl:ENST00000318158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007588"(excretion)|go:"GO:0008465"(glycerate dehydrogenase activity)|go:"GO:0016618"(hydroxypyruvate reductase activity)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030267"("glyoxylate reductase (NADP+) activity")|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042803"(protein homodimerization activity) - - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/02/23 2021/02/26 rogid:kOlX16r4KeF61pyYqkUDhwwBqIQ9606 rogid:qPHrh5I5wHI5MWba4zncz26cUnQ9606 rigid:piEGsleNX13874jk++4Rwd9Nxyg false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UHI7 uniprotkb:Q9UBQ7 intact:EBI-1759386|uniprotkb:O95191|uniprotkb:Q8WWB6|uniprotkb:Q9UGH4|uniprotkb:Q9UI39|ensembl:ENSP00000302701|ensembl:ENSP00000302851 intact:EBI-372445|uniprotkb:Q9H3E9|uniprotkb:Q9UKX1|ensembl:ENSP00000313432|uniprotkb:Q5T945|uniprotkb:Q9H636 psi-mi:s23a1_human(display_long)|uniprotkb:SLC23A1(gene name)|psi-mi:SLC23A1(display_short)|uniprotkb:SVCT1(gene name synonym)|uniprotkb:YSPL3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 1(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 1"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 3(gene name synonym) psi-mi:grhpr_human(display_long)|uniprotkb:MSTP035(orf name)|uniprotkb:GRHPR(gene name)|psi-mi:GRHPR(display_short)|uniprotkb:GLXR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Subramanian et al. (2013) imex:IM-28773|pubmed:23599041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26704048|imex:IM-28773-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005838.3|refseq:NP_689898.2|ensembl:ENSG00000170482(gene)|ensembl:ENST00000348729(transcript)|ensembl:ENST00000353963(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0008520"("L-ascorbate:sodium symporter activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015229"(L-ascorbic acid transmembrane transporter activity)|go:"GO:0015851"(nucleobase transport)|go:"GO:0015882"(L-ascorbic acid transmembrane transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0030324"(lung development)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0043229"(intracellular organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0070904"(transepithelial L-ascorbic acid transport)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029954|reactome:R-HSA-196836 refseq:NP_036335.1|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0046487"(glyoxylate metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|mint:Q9UBQ7|rcsb pdb:2GCG|rcsb pdb:2H1S|rcsb pdb:2Q50|rcsb pdb:2WWR|reactome:R-HSA-389661|ensembl:ENSG00000137106(gene)|ensembl:ENST00000318158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007588"(excretion)|go:"GO:0008465"(glycerate dehydrogenase activity)|go:"GO:0016618"(hydroxypyruvate reductase activity)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030267"("glyoxylate reductase (NADP+) activity")|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042803"(protein homodimerization activity) - - - figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2021/02/23 2021/02/26 rogid:kOlX16r4KeF61pyYqkUDhwwBqIQ9606 rogid:qPHrh5I5wHI5MWba4zncz26cUnQ9606 rigid:piEGsleNX13874jk++4Rwd9Nxyg false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UHI7 uniprotkb:Q9UBQ7 intact:EBI-1759386|uniprotkb:O95191|uniprotkb:Q8WWB6|uniprotkb:Q9UGH4|uniprotkb:Q9UI39|ensembl:ENSP00000302701|ensembl:ENSP00000302851 intact:EBI-372445|uniprotkb:Q9H3E9|uniprotkb:Q9UKX1|ensembl:ENSP00000313432|uniprotkb:Q5T945|uniprotkb:Q9H636 psi-mi:s23a1_human(display_long)|uniprotkb:SLC23A1(gene name)|psi-mi:SLC23A1(display_short)|uniprotkb:SVCT1(gene name synonym)|uniprotkb:YSPL3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 1(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 1"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 3(gene name synonym) psi-mi:grhpr_human(display_long)|uniprotkb:MSTP035(orf name)|uniprotkb:GRHPR(gene name)|psi-mi:GRHPR(display_short)|uniprotkb:GLXR(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Subramanian et al. (2013) imex:IM-28773|pubmed:23599041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-26852226|imex:IM-28773-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005838.3|refseq:NP_689898.2|ensembl:ENSG00000170482(gene)|ensembl:ENST00000348729(transcript)|ensembl:ENST00000353963(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0008520"("L-ascorbate:sodium symporter activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015229"(L-ascorbic acid transmembrane transporter activity)|go:"GO:0015851"(nucleobase transport)|go:"GO:0015882"(L-ascorbic acid transmembrane transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0030324"(lung development)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0043229"(intracellular organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0070904"(transepithelial L-ascorbic acid transport)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029954|reactome:R-HSA-196836 refseq:NP_036335.1|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0046487"(glyoxylate metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|mint:Q9UBQ7|rcsb pdb:2GCG|rcsb pdb:2H1S|rcsb pdb:2Q50|rcsb pdb:2WWR|reactome:R-HSA-389661|ensembl:ENSG00000137106(gene)|ensembl:ENST00000318158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007588"(excretion)|go:"GO:0008465"(glycerate dehydrogenase activity)|go:"GO:0016618"(hydroxypyruvate reductase activity)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030267"("glyoxylate reductase (NADP+) activity")|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042803"(protein homodimerization activity) go:"GO:0043229"(intracellular organelle) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2021/02/23 2021/02/26 rogid:kOlX16r4KeF61pyYqkUDhwwBqIQ9606 rogid:qPHrh5I5wHI5MWba4zncz26cUnQ9606 rigid:piEGsleNX13874jk++4Rwd9Nxyg false green fluorescent protein tag:n-n mcherry fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9UHI7 uniprotkb:Q9UBQ7 intact:EBI-1759386|uniprotkb:O95191|uniprotkb:Q8WWB6|uniprotkb:Q9UGH4|uniprotkb:Q9UI39|ensembl:ENSP00000302701|ensembl:ENSP00000302851 intact:EBI-372445|uniprotkb:Q9H3E9|uniprotkb:Q9UKX1|ensembl:ENSP00000313432|uniprotkb:Q5T945|uniprotkb:Q9H636 psi-mi:s23a1_human(display_long)|uniprotkb:SLC23A1(gene name)|psi-mi:SLC23A1(display_short)|uniprotkb:SVCT1(gene name synonym)|uniprotkb:YSPL3(gene name synonym)|uniprotkb:Sodium-dependent vitamin C transporter 1(gene name synonym)|uniprotkb:"Na(+)/L-ascorbic acid transporter 1"(gene name synonym)|uniprotkb:Yolk sac permease-like molecule 3(gene name synonym) psi-mi:grhpr_human(display_long)|uniprotkb:MSTP035(orf name)|uniprotkb:GRHPR(gene name)|psi-mi:GRHPR(display_short)|uniprotkb:GLXR(gene name synonym) psi-mi:"MI:0728"(gal4 vp16 complementation) Subramanian et al. (2013) imex:IM-28773|pubmed:23599041 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26852243|imex:IM-28773-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005838.3|refseq:NP_689898.2|ensembl:ENSG00000170482(gene)|ensembl:ENST00000348729(transcript)|ensembl:ENST00000353963(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0008520"("L-ascorbate:sodium symporter activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015205"(nucleobase transmembrane transporter activity)|go:"GO:0015229"(L-ascorbic acid transmembrane transporter activity)|go:"GO:0015851"(nucleobase transport)|go:"GO:0015882"(L-ascorbic acid transmembrane transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0030324"(lung development)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0043229"(intracellular organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0070904"(transepithelial L-ascorbic acid transport)|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|interpro:IPR029954|reactome:R-HSA-196836 refseq:NP_036335.1|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0046487"(glyoxylate metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070402"(NADPH binding)|go:"GO:1902494"(catalytic complex)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|mint:Q9UBQ7|rcsb pdb:2GCG|rcsb pdb:2H1S|rcsb pdb:2Q50|rcsb pdb:2WWR|reactome:R-HSA-389661|ensembl:ENSG00000137106(gene)|ensembl:ENST00000318158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007588"(excretion)|go:"GO:0008465"(glycerate dehydrogenase activity)|go:"GO:0016618"(hydroxypyruvate reductase activity)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030267"("glyoxylate reductase (NADP+) activity")|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0042803"(protein homodimerization activity) - - - figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).") - 2021/02/23 2021/02/26 rogid:kOlX16r4KeF61pyYqkUDhwwBqIQ9606 rogid:qPHrh5I5wHI5MWba4zncz26cUnQ9606 rigid:piEGsleNX13874jk++4Rwd9Nxyg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)