#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60779	uniprotkb:O60635	intact:EBI-3941998|uniprotkb:Q8WV87|uniprotkb:Q9UBL7|uniprotkb:Q9UN31|uniprotkb:Q9UN43|uniprotkb:B2R9H0|uniprotkb:Q9UKJ2|uniprotkb:B4E1X4|ensembl:ENSP00000236137	intact:EBI-3914312|uniprotkb:D3DQ14|uniprotkb:O60745|uniprotkb:Q5VST0|ensembl:ENSP00000361072	psi-mi:s19a2_human(display_long)|uniprotkb:SLC19A2(gene name)|psi-mi:SLC19A2(display_short)|uniprotkb:THT1(gene name synonym)|uniprotkb:TRMA(gene name synonym)|uniprotkb:Solute carrier family 19 member 2(gene name synonym)|uniprotkb:Thiamine carrier 1(gene name synonym)	psi-mi:tsn1_human(display_long)|uniprotkb:TSPAN1(gene name)|psi-mi:TSPAN1(display_short)|uniprotkb:Tetraspan NET-1(gene name synonym)|uniprotkb:Tetraspanin TM4-C(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nabokina et al. (2011)	pubmed:21836059|imex:IM-22638	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26686886|imex:IM-22638-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002666(Reduced folate carrier)|interpro:IPR028338|ensembl:ENSG00000117479(gene)|interpro:IPR036259|mint:O60779|ensembl:ENST00000236137(transcript)|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-196819|go:"GO:0008517"(folic acid transmembrane transporter activity)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0015888"(thiamine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071934"(thiamine transmembrane transport)|refseq:NP_008927.1|refseq:NP_001306596.1	refseq:NP_005718.2|ensembl:ENSG00000117472(gene)|ensembl:ENST00000372003(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/02/23	2021/02/24	rogid:jaxPhDzyD6VTkLBvxtw/nCixzAE9606	rogid:UTMy/pOL8pU8/RGibOskQoe9cSU9606	rigid:6gEIf0F/aRzePRmIgs8NqiXup1I	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O60779	uniprotkb:O60635	intact:EBI-3941998|uniprotkb:Q8WV87|uniprotkb:Q9UBL7|uniprotkb:Q9UN31|uniprotkb:Q9UN43|uniprotkb:B2R9H0|uniprotkb:Q9UKJ2|uniprotkb:B4E1X4|ensembl:ENSP00000236137	intact:EBI-3914312|uniprotkb:D3DQ14|uniprotkb:O60745|uniprotkb:Q5VST0|ensembl:ENSP00000361072	psi-mi:s19a2_human(display_long)|uniprotkb:SLC19A2(gene name)|psi-mi:SLC19A2(display_short)|uniprotkb:THT1(gene name synonym)|uniprotkb:TRMA(gene name synonym)|uniprotkb:Solute carrier family 19 member 2(gene name synonym)|uniprotkb:Thiamine carrier 1(gene name synonym)	psi-mi:tsn1_human(display_long)|uniprotkb:TSPAN1(gene name)|psi-mi:TSPAN1(display_short)|uniprotkb:Tetraspan NET-1(gene name synonym)|uniprotkb:Tetraspanin TM4-C(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nabokina et al. (2011)	pubmed:21836059|imex:IM-22638	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26686896|imex:IM-22638-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002666(Reduced folate carrier)|interpro:IPR028338|ensembl:ENSG00000117479(gene)|interpro:IPR036259|mint:O60779|ensembl:ENST00000236137(transcript)|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-196819|go:"GO:0008517"(folic acid transmembrane transporter activity)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0015888"(thiamine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071934"(thiamine transmembrane transport)|refseq:NP_008927.1|refseq:NP_001306596.1	refseq:NP_005718.2|ensembl:ENSG00000117472(gene)|ensembl:ENST00000372003(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2021/02/23	2021/02/24	rogid:jaxPhDzyD6VTkLBvxtw/nCixzAE9606	rogid:UTMy/pOL8pU8/RGibOskQoe9cSU9606	rigid:6gEIf0F/aRzePRmIgs8NqiXup1I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60779	uniprotkb:O60635	intact:EBI-3941998|uniprotkb:Q8WV87|uniprotkb:Q9UBL7|uniprotkb:Q9UN31|uniprotkb:Q9UN43|uniprotkb:B2R9H0|uniprotkb:Q9UKJ2|uniprotkb:B4E1X4|ensembl:ENSP00000236137	intact:EBI-3914312|uniprotkb:D3DQ14|uniprotkb:O60745|uniprotkb:Q5VST0|ensembl:ENSP00000361072	psi-mi:s19a2_human(display_long)|uniprotkb:SLC19A2(gene name)|psi-mi:SLC19A2(display_short)|uniprotkb:THT1(gene name synonym)|uniprotkb:TRMA(gene name synonym)|uniprotkb:Solute carrier family 19 member 2(gene name synonym)|uniprotkb:Thiamine carrier 1(gene name synonym)	psi-mi:tsn1_human(display_long)|uniprotkb:TSPAN1(gene name)|psi-mi:TSPAN1(display_short)|uniprotkb:Tetraspan NET-1(gene name synonym)|uniprotkb:Tetraspanin TM4-C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nabokina et al. (2011)	pubmed:21836059|imex:IM-22638	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26686911|imex:IM-22638-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002666(Reduced folate carrier)|interpro:IPR028338|ensembl:ENSG00000117479(gene)|interpro:IPR036259|mint:O60779|ensembl:ENST00000236137(transcript)|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-196819|go:"GO:0008517"(folic acid transmembrane transporter activity)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0015888"(thiamine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071934"(thiamine transmembrane transport)|refseq:NP_008927.1|refseq:NP_001306596.1	refseq:NP_005718.2|ensembl:ENSG00000117472(gene)|ensembl:ENST00000372003(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2021/02/23	2021/02/24	rogid:jaxPhDzyD6VTkLBvxtw/nCixzAE9606	rogid:UTMy/pOL8pU8/RGibOskQoe9cSU9606	rigid:6gEIf0F/aRzePRmIgs8NqiXup1I	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60779	uniprotkb:O60635	intact:EBI-3941998|uniprotkb:Q8WV87|uniprotkb:Q9UBL7|uniprotkb:Q9UN31|uniprotkb:Q9UN43|uniprotkb:B2R9H0|uniprotkb:Q9UKJ2|uniprotkb:B4E1X4|ensembl:ENSP00000236137	intact:EBI-3914312|uniprotkb:D3DQ14|uniprotkb:O60745|uniprotkb:Q5VST0|ensembl:ENSP00000361072	psi-mi:s19a2_human(display_long)|uniprotkb:SLC19A2(gene name)|psi-mi:SLC19A2(display_short)|uniprotkb:THT1(gene name synonym)|uniprotkb:TRMA(gene name synonym)|uniprotkb:Solute carrier family 19 member 2(gene name synonym)|uniprotkb:Thiamine carrier 1(gene name synonym)	psi-mi:tsn1_human(display_long)|uniprotkb:TSPAN1(gene name)|psi-mi:TSPAN1(display_short)|uniprotkb:Tetraspan NET-1(gene name synonym)|uniprotkb:Tetraspanin TM4-C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nabokina et al. (2011)	pubmed:21836059|imex:IM-22638	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26686924|imex:IM-22638-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002666(Reduced folate carrier)|interpro:IPR028338|ensembl:ENSG00000117479(gene)|interpro:IPR036259|mint:O60779|ensembl:ENST00000236137(transcript)|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-196819|go:"GO:0008517"(folic acid transmembrane transporter activity)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0015888"(thiamine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071934"(thiamine transmembrane transport)|refseq:NP_008927.1|refseq:NP_001306596.1	refseq:NP_005718.2|ensembl:ENSG00000117472(gene)|ensembl:ENST00000372003(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/23	2021/02/24	rogid:jaxPhDzyD6VTkLBvxtw/nCixzAE9606	rogid:UTMy/pOL8pU8/RGibOskQoe9cSU9606	rigid:6gEIf0F/aRzePRmIgs8NqiXup1I	false	-	glutathione s tranferase tag:n-n|sufficient binding region:1-215	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60779	uniprotkb:O60635	intact:EBI-3941998|uniprotkb:Q8WV87|uniprotkb:Q9UBL7|uniprotkb:Q9UN31|uniprotkb:Q9UN43|uniprotkb:B2R9H0|uniprotkb:Q9UKJ2|uniprotkb:B4E1X4|ensembl:ENSP00000236137	intact:EBI-3914312|uniprotkb:D3DQ14|uniprotkb:O60745|uniprotkb:Q5VST0|ensembl:ENSP00000361072	psi-mi:s19a2_human(display_long)|uniprotkb:SLC19A2(gene name)|psi-mi:SLC19A2(display_short)|uniprotkb:THT1(gene name synonym)|uniprotkb:TRMA(gene name synonym)|uniprotkb:Solute carrier family 19 member 2(gene name synonym)|uniprotkb:Thiamine carrier 1(gene name synonym)	psi-mi:tsn1_human(display_long)|uniprotkb:TSPAN1(gene name)|psi-mi:TSPAN1(display_short)|uniprotkb:Tetraspan NET-1(gene name synonym)|uniprotkb:Tetraspanin TM4-C(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Nabokina et al. (2011)	pubmed:21836059|imex:IM-22638	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26686941|imex:IM-22638-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002666(Reduced folate carrier)|interpro:IPR028338|ensembl:ENSG00000117479(gene)|interpro:IPR036259|mint:O60779|ensembl:ENST00000236137(transcript)|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-196819|go:"GO:0008517"(folic acid transmembrane transporter activity)|go:"GO:0015234"(thiamine transmembrane transporter activity)|go:"GO:0015888"(thiamine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042723"(thiamine-containing compound metabolic process)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071934"(thiamine transmembrane transport)|refseq:NP_008927.1|refseq:NP_001306596.1	refseq:NP_005718.2|ensembl:ENSG00000117472(gene)|ensembl:ENST00000372003(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hutu80)|taxid:9606(Human duodenum adenocarcinoma HuTu80)	-	2021/02/23	2021/02/24	rogid:jaxPhDzyD6VTkLBvxtw/nCixzAE9606	rogid:UTMy/pOL8pU8/RGibOskQoe9cSU9606	rigid:6gEIf0F/aRzePRmIgs8NqiXup1I	false	enhanced green fluorescent protein tag:?-?	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)