#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A6NDB9	uniprotkb:Q6IA17	intact:EBI-6873185|intact:EBI-28977450|ensembl:ENSP00000344996|ensembl:ENSP00000500424	intact:EBI-719672|uniprotkb:Q3KQY2|uniprotkb:Q6UXI3|uniprotkb:Q9H733|ensembl:ENSP00000333656|ensembl:ENSP00000380756|ensembl:ENSP00000403104	psi-mi:palm3_human(display_long)|uniprotkb:PALM3(gene name)|psi-mi:PALM3(display_short)	psi-mi:sigir_human(display_long)|uniprotkb:Single Ig IL-1R-related molecule(gene name synonym)|uniprotkb:Single immunoglobulin domain-containing IL1R-related protein(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor 8(gene name synonym)|uniprotkb:SIGIRR(gene name)|psi-mi:SIGIRR(display_short)|uniprotkb:UNQ301/PRO342(orf name)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2011)	pubmed:21187075|imex:IM-29031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27021494|imex:IM-29031-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344996|ensembl:ENSP00000500424|ensembl:ENSG00000187867(gene)|ensembl:ENSG00000288318(gene)|ensembl:ENST00000340790(transcript)|ensembl:ENST00000672551(transcript)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|interpro:IPR024149|refseq:NP_001138500.1	refseq:NP_001128525.1|refseq:NP_001128526.1|refseq:NP_068577.2|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|reactome:R-HSA-166058|reactome:R-HSA-9008059|ensembl:ENSG00000185187(gene)|ensembl:ENST00000332725(transcript)|ensembl:ENST00000397632(transcript)|ensembl:ENST00000431843(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/06/22	2021/06/23	rogid:PzFwi9b2OsyYZVc5nVVWWCFiBvY9606	rogid:VNJmnqiZbOZc9UYroxKf5JJ59fY9606	rigid:BF8VsLSoFTKeG2yt+P/Fe4RR0Ps	false	sufficient binding region:413-673	sufficient binding region:161-410	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A6NDB9	uniprotkb:Q6IA17	intact:EBI-6873185|intact:EBI-28977450|ensembl:ENSP00000344996|ensembl:ENSP00000500424	intact:EBI-719672|uniprotkb:Q3KQY2|uniprotkb:Q6UXI3|uniprotkb:Q9H733|ensembl:ENSP00000333656|ensembl:ENSP00000380756|ensembl:ENSP00000403104	psi-mi:palm3_human(display_long)|uniprotkb:PALM3(gene name)|psi-mi:PALM3(display_short)	psi-mi:sigir_human(display_long)|uniprotkb:Single Ig IL-1R-related molecule(gene name synonym)|uniprotkb:Single immunoglobulin domain-containing IL1R-related protein(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor 8(gene name synonym)|uniprotkb:SIGIRR(gene name)|psi-mi:SIGIRR(display_short)|uniprotkb:UNQ301/PRO342(orf name)	psi-mi:"MI:0018"(two hybrid)	Chen et al. (2011)	pubmed:21187075|imex:IM-29031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27021504|imex:IM-29031-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344996|ensembl:ENSP00000500424|ensembl:ENSG00000187867(gene)|ensembl:ENSG00000288318(gene)|ensembl:ENST00000340790(transcript)|ensembl:ENST00000672551(transcript)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|interpro:IPR024149|refseq:NP_001138500.1	refseq:NP_001128525.1|refseq:NP_001128526.1|refseq:NP_068577.2|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|reactome:R-HSA-166058|reactome:R-HSA-9008059|ensembl:ENSG00000185187(gene)|ensembl:ENST00000332725(transcript)|ensembl:ENST00000397632(transcript)|ensembl:ENST00000431843(transcript)	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/06/22	2021/06/23	rogid:PzFwi9b2OsyYZVc5nVVWWCFiBvY9606	rogid:VNJmnqiZbOZc9UYroxKf5JJ59fY9606	rigid:BF8VsLSoFTKeG2yt+P/Fe4RR0Ps	false	sufficient binding region:413-673	sufficient binding region:161-410	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NDB9	uniprotkb:Q6IA17	intact:EBI-6873185|intact:EBI-28977450|ensembl:ENSP00000344996|ensembl:ENSP00000500424	intact:EBI-719672|uniprotkb:Q3KQY2|uniprotkb:Q6UXI3|uniprotkb:Q9H733|ensembl:ENSP00000333656|ensembl:ENSP00000380756|ensembl:ENSP00000403104	psi-mi:palm3_human(display_long)|uniprotkb:PALM3(gene name)|psi-mi:PALM3(display_short)	psi-mi:sigir_human(display_long)|uniprotkb:Single Ig IL-1R-related molecule(gene name synonym)|uniprotkb:Single immunoglobulin domain-containing IL1R-related protein(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor 8(gene name synonym)|uniprotkb:SIGIRR(gene name)|psi-mi:SIGIRR(display_short)|uniprotkb:UNQ301/PRO342(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:21187075|imex:IM-29031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27021518|imex:IM-29031-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344996|ensembl:ENSP00000500424|ensembl:ENSG00000187867(gene)|ensembl:ENSG00000288318(gene)|ensembl:ENST00000340790(transcript)|ensembl:ENST00000672551(transcript)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|interpro:IPR024149|refseq:NP_001138500.1	refseq:NP_001128525.1|refseq:NP_001128526.1|refseq:NP_068577.2|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|reactome:R-HSA-166058|reactome:R-HSA-9008059|ensembl:ENSG00000185187(gene)|ensembl:ENST00000332725(transcript)|ensembl:ENST00000397632(transcript)|ensembl:ENST00000431843(transcript)	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/06/22	2021/06/23	rogid:PzFwi9b2OsyYZVc5nVVWWCFiBvY9606	rogid:VNJmnqiZbOZc9UYroxKf5JJ59fY9606	rigid:BF8VsLSoFTKeG2yt+P/Fe4RR0Ps	false	sufficient binding region:413-673|ha tag:?-?	sufficient binding region:161-410|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A6NDB9	uniprotkb:Q6IA17	intact:EBI-6873185|intact:EBI-28977450|ensembl:ENSP00000344996|ensembl:ENSP00000500424	intact:EBI-719672|uniprotkb:Q3KQY2|uniprotkb:Q6UXI3|uniprotkb:Q9H733|ensembl:ENSP00000333656|ensembl:ENSP00000380756|ensembl:ENSP00000403104	psi-mi:palm3_human(display_long)|uniprotkb:PALM3(gene name)|psi-mi:PALM3(display_short)	psi-mi:sigir_human(display_long)|uniprotkb:Single Ig IL-1R-related molecule(gene name synonym)|uniprotkb:Single immunoglobulin domain-containing IL1R-related protein(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor 8(gene name synonym)|uniprotkb:SIGIRR(gene name)|psi-mi:SIGIRR(display_short)|uniprotkb:UNQ301/PRO342(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2011)	pubmed:21187075|imex:IM-29031	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27025734|imex:IM-29031-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344996|ensembl:ENSP00000500424|ensembl:ENSG00000187867(gene)|ensembl:ENSG00000288318(gene)|ensembl:ENST00000340790(transcript)|ensembl:ENST00000672551(transcript)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|interpro:IPR024149|refseq:NP_001138500.1	refseq:NP_001128525.1|refseq:NP_001128526.1|refseq:NP_068577.2|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0006953"(acute-phase response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|reactome:R-HSA-166058|reactome:R-HSA-9008059|ensembl:ENSG00000185187(gene)|ensembl:ENST00000332725(transcript)|ensembl:ENST00000397632(transcript)|ensembl:ENST00000431843(transcript)	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/06/22	2021/06/29	rogid:PzFwi9b2OsyYZVc5nVVWWCFiBvY9606	rogid:VNJmnqiZbOZc9UYroxKf5JJ59fY9606	rigid:BF8VsLSoFTKeG2yt+P/Fe4RR0Ps	false	sufficient binding region:413-673|ha tag:?-?	sufficient binding region:161-410|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)