#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43516	uniprotkb:P42768	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	intact:EBI-346375|uniprotkb:Q9BU11|uniprotkb:Q9UNJ9|ensembl:ENSP00000365891	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:wasp_human(display_long)|uniprotkb:WAS(gene name)|psi-mi:WAS(display_short)|uniprotkb:IMD2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Rajmohan et al. (2009)	pubmed:19817875|imex:IM-28813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26876948|imex:IM-28813-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	refseq:NP_000368.1|dip:DIP-431N|ensembl:ENSG00000015285(gene)|ensembl:ENST00000376701(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007596"(blood coagulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008544"(epidermis development)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P42768|rcsb pdb:1CEE|rcsb pdb:1EJ5|rcsb pdb:1T84|rcsb pdb:2A3Z|rcsb pdb:2K42|rcsb pdb:2OT0|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9664422	-	-	-	figure legend:6a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/03/15	2021/03/15	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	rogid:VHtlRNZQYpIU2btQV28coDiNsO09606	rigid:bXBCynyKqn/DBI3pHqn8h6rAq2M	false	-	mutation with no effect:31-31(rs1557006239)|mutation with no effect:35-35|mutation disrupting interaction strength:73-73(rs1602176652)|mutation disrupting interaction strength:46-46|mutation with no effect:85-85|mutation disrupting interaction strength:134-134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43516	uniprotkb:P42768	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	intact:EBI-346375|uniprotkb:Q9BU11|uniprotkb:Q9UNJ9|ensembl:ENSP00000365891	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:wasp_human(display_long)|uniprotkb:WAS(gene name)|psi-mi:WAS(display_short)|uniprotkb:IMD2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rajmohan et al. (2009)	pubmed:19817875|imex:IM-28813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26877253|imex:IM-28813-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	refseq:NP_000368.1|dip:DIP-431N|ensembl:ENSG00000015285(gene)|ensembl:ENST00000376701(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007596"(blood coagulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008544"(epidermis development)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P42768|rcsb pdb:1CEE|rcsb pdb:1EJ5|rcsb pdb:1T84|rcsb pdb:2A3Z|rcsb pdb:2K42|rcsb pdb:2OT0|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9664422	-	-	-	figure legend:6b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/03/15	2021/04/11	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	rogid:VHtlRNZQYpIU2btQV28coDiNsO09606	rigid:bXBCynyKqn/DBI3pHqn8h6rAq2M	false	glutathione s tranferase tag:n-n|sufficient binding region:377-502	his tag:c-c|mutation disrupting interaction strength:31-31(rs1557006239)|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:85-85|sufficient binding region:1-320	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42768	uniprotkb:O43516	intact:EBI-346375|uniprotkb:Q9BU11|uniprotkb:Q9UNJ9|ensembl:ENSP00000365891	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:wasp_human(display_long)|uniprotkb:WAS(gene name)|psi-mi:WAS(display_short)|uniprotkb:IMD2(gene name synonym)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Rajmohan et al. (2009)	pubmed:19817875|imex:IM-28813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26877278|imex:IM-28813-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000368.1|dip:DIP-431N|ensembl:ENSG00000015285(gene)|ensembl:ENST00000376701(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007596"(blood coagulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008544"(epidermis development)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P42768|rcsb pdb:1CEE|rcsb pdb:1EJ5|rcsb pdb:1T84|rcsb pdb:2A3Z|rcsb pdb:2K42|rcsb pdb:2OT0|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9664422	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	go:"GO:0030479"(actin cortical patch)	-	-	figure legend:5|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2021/03/15	2021/03/15	rogid:VHtlRNZQYpIU2btQV28coDiNsO09606	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	rigid:bXBCynyKqn/DBI3pHqn8h6rAq2M	false	green fluorescent protein tag:c-c|mutation decreasing interaction strength:46-46|mutation disrupting interaction strength:31-31(rs1557006239)|mutation decreasing interaction strength:35-35|mutation decreasing interaction strength:73-73(rs1602176652)|mutation decreasing interaction strength:85-85|mutation decreasing interaction strength:134-134	cyan fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P42768	uniprotkb:O43516	intact:EBI-346375|uniprotkb:Q9BU11|uniprotkb:Q9UNJ9|ensembl:ENSP00000365891	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:wasp_human(display_long)|uniprotkb:WAS(gene name)|psi-mi:WAS(display_short)|uniprotkb:IMD2(gene name synonym)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Rajmohan et al. (2009)	pubmed:19817875|imex:IM-28813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26877317|imex:IM-28813-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000368.1|dip:DIP-431N|ensembl:ENSG00000015285(gene)|ensembl:ENST00000376701(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007596"(blood coagulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008544"(epidermis development)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P42768|rcsb pdb:1CEE|rcsb pdb:1EJ5|rcsb pdb:1T84|rcsb pdb:2A3Z|rcsb pdb:2K42|rcsb pdb:2OT0|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013409|reactome:R-HSA-9664422	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	go:"GO:0030479"(actin cortical patch)	-	-	figure legend:5|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2021/03/15	2021/03/15	rogid:VHtlRNZQYpIU2btQV28coDiNsO09606	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	rigid:bXBCynyKqn/DBI3pHqn8h6rAq2M	false	green fluorescent protein tag:c-c|mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:31-31(rs1557006239)|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:73-73(rs1602176652)|mutation disrupting interaction strength:85-85|mutation disrupting interaction strength:134-134	cyan fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)