#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31391	uniprotkb:P31391	intact:EBI-21274002|ensembl:ENSP00000255008|uniprotkb:Q17RM1|uniprotkb:Q17RM3|uniprotkb:Q9UIY1	intact:EBI-21274002|ensembl:ENSP00000255008|uniprotkb:Q17RM1|uniprotkb:Q17RM3|uniprotkb:Q9UIY1	psi-mi:ssr4_human(display_long)|uniprotkb:SSTR4(gene name)|psi-mi:SSTR4(display_short)	psi-mi:ssr4_human(display_long)|uniprotkb:SSTR4(gene name)|psi-mi:SSTR4(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Somvanshi et al. (2009)	imex:IM-29146|pubmed:19426801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054895|imex:IM-29146-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132671(gene)|ensembl:ENST00000255008(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001512(Somatostatin receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-418594|reactome:R-HSA-375276|refseq:NP_001043.2	ensembl:ENSG00000132671(gene)|ensembl:ENST00000255008(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001512(Somatostatin receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-418594|reactome:R-HSA-375276|refseq:NP_001043.2	-	-	-	figure legend:Fig. 1|agonist:"Somatostatin-14 (PRO_0000033088)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/08/04	2021/08/05	rogid:BVFXpopEBt4Zg1GicwjXpJDeOhs9606	rogid:BVFXpopEBt4Zg1GicwjXpJDeOhs9606	rigid:Nl9lM71DbQD8zWGnyBiHtFpDbz8	false	ha tag:n-n|necessary binding region:315-388	ha tag:n-n|necessary binding region:315-388	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P35346	uniprotkb:P31391	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	intact:EBI-21274002|ensembl:ENSP00000255008|uniprotkb:Q17RM1|uniprotkb:Q17RM3|uniprotkb:Q9UIY1	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:ssr4_human(display_long)|uniprotkb:SSTR4(gene name)|psi-mi:SSTR4(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Somvanshi et al. (2009)	imex:IM-29146|pubmed:19426801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054978|imex:IM-29146-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	ensembl:ENSG00000132671(gene)|ensembl:ENST00000255008(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001512(Somatostatin receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-418594|reactome:R-HSA-375276|refseq:NP_001043.2	-	-	-	figure legend:Figs. 5B-E, 6, Table 2|agonist:"Somatostatin-14 (PRO_0000033088)"|agonist:"L-803087 (CHEBI:177197)"|agonist:"L-817818 (CHEBI:177199)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/08/04	2021/08/05	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rogid:BVFXpopEBt4Zg1GicwjXpJDeOhs9606	rigid:GB9jtoL7dmO8eerZ7Zv7GxhEbuI	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:P35346	uniprotkb:P31391	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	intact:EBI-21274002|ensembl:ENSP00000255008|uniprotkb:Q17RM1|uniprotkb:Q17RM3|uniprotkb:Q9UIY1	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:ssr4_human(display_long)|uniprotkb:SSTR4(gene name)|psi-mi:SSTR4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Somvanshi et al. (2009)	imex:IM-29146|pubmed:19426801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27055078|imex:IM-29146-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	ensembl:ENSG00000132671(gene)|ensembl:ENST00000255008(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001512(Somatostatin receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-418594|reactome:R-HSA-375276|refseq:NP_001043.2	go:"GO:0016020"(membrane)	-	-	figure legend:Fig.7C|agonist:"Somatostatin-14 (PRO_0000033088)"|agonist:"L-803087 (CHEBI:177197)"|agonist:"L-817818 (CHEBI:177199)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/08/04	2021/08/05	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rogid:BVFXpopEBt4Zg1GicwjXpJDeOhs9606	rigid:GB9jtoL7dmO8eerZ7Zv7GxhEbuI	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35346	uniprotkb:P31391	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	intact:EBI-21274002|ensembl:ENSP00000255008|uniprotkb:Q17RM1|uniprotkb:Q17RM3|uniprotkb:Q9UIY1	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:ssr4_human(display_long)|uniprotkb:SSTR4(gene name)|psi-mi:SSTR4(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Somvanshi et al. (2009)	imex:IM-29146|pubmed:19426801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27055132|imex:IM-29146-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	ensembl:ENSG00000132671(gene)|ensembl:ENST00000255008(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016477"(cell migration)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001512(Somatostatin receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-418594|reactome:R-HSA-375276|refseq:NP_001043.2	go:"GO:0016020"(membrane)	-	-	figure legend:Fig.5A, 9|agonist:"Somatostatin-14 (PRO_0000033088)"|agonist:"L-803087 (CHEBI:177197)"|agonist:"L-817818 (CHEBI:177199)"|comment:"Colocalisation of SSTR5 and SSTR4 decreased and concomitantly increased intracellularly upon treatment with SST-14.The SSTR4/SSTR5 heterodimers internalized upon activation of hSSTR4 alone whereas upon treatment with the SSTR5 specific agonist (L-817818), a reduction in internalization of SSTR5 was observed."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/08/04	2021/08/05	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rogid:BVFXpopEBt4Zg1GicwjXpJDeOhs9606	rigid:GB9jtoL7dmO8eerZ7Zv7GxhEbuI	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)