#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15109	uniprotkb:P80511	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996803|imex:IM-29420-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 2A, 2B|comment:Interaction is Ca2+ and Zn2+-dependent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/25	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8X9w022Kqv7UmXMrI1H5D/SwzOE	false	sufficient binding region:24-344|fc-igg1:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15109	uniprotkb:P80511	intact:EBI-1646426|uniprotkb:B0V176|uniprotkb:Q15279|uniprotkb:Q9H2X7|uniprotkb:Q9Y3R3|uniprotkb:V5R6A3|uniprotkb:A2BFI7|uniprotkb:Q3L1S0|intact:EBI-3959557|uniprotkb:A6NKF0|uniprotkb:Q86SN1|uniprotkb:Q3L1R7|uniprotkb:A7Y2U9|uniprotkb:Q3L1R4|uniprotkb:Q3L1R5|uniprotkb:Q3L1R6|uniprotkb:Q3L1R8|ensembl:ENSP00000364217|ensembl:ENSP00000395812|ensembl:ENSP00000397227|ensembl:ENSP00000401068|ensembl:ENSP00000409457|ensembl:ENSP00000415144|ensembl:ENSP00000416042	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:rage_human(display_long)|uniprotkb:AGER(gene name)|psi-mi:AGER(display_short)|uniprotkb:RAGE(gene name synonym)|uniprotkb:Receptor for advanced glycosylation end products(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996812|imex:IM-29420-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127.1|refseq:NP_751947.1|refseq:NP_001193858.1|refseq:NP_001193861.1|refseq:NP_001193865.1|refseq:NP_001193883.1|refseq:NP_001193869.1|refseq:NP_001193895.1|refseq:NP_001193863.1|dip:DIP-40658N|ensembl:ENSG00000204305(gene)|ensembl:ENSG00000206320(gene)|ensembl:ENSG00000229058(gene)|ensembl:ENSG00000230514(gene)|ensembl:ENSG00000231268(gene)|ensembl:ENSG00000234729(gene)|ensembl:ENSG00000237405(gene)|ensembl:ENST00000375076(transcript)|ensembl:ENST00000426138(transcript)|ensembl:ENST00000436456(transcript)|ensembl:ENST00000447921(transcript)|ensembl:ENST00000451115(transcript)|ensembl:ENST00000456918(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010255"(glucose mediated signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031175"(neuron projection development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044548"(S100 protein binding)|ensembl:ENST00000427822(transcript)|go:"GO:0045056"(transcytosis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098794"(postsynapse)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000439"(positive regulation of monocyte extravasation)|go:"GO:2000514"(regulation of CD4-positive, alpha-beta T cell activation)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q15109|rcsb pdb:1PWI|rcsb pdb:2BJP|rcsb pdb:2E5E|rcsb pdb:2ENS|rcsb pdb:2L7U|rcsb pdb:2LE9|rcsb pdb:2LMB|rcsb pdb:2M1K|rcsb pdb:2MJW|rcsb pdb:2MOV|rcsb pdb:3CJJ|rcsb pdb:3O3U|rcsb pdb:4LP4|rcsb pdb:4LP5|rcsb pdb:4OF5|rcsb pdb:4OFV|rcsb pdb:4OI7|rcsb pdb:4OI8|rcsb pdb:4P2Y|rcsb pdb:4XYN|rcsb pdb:4YBH|rcsb pdb:5D7F|rcsb pdb:6VXG|reactome:R-HSA-445989|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 2C|comment:Interaction is Ca2+ and Zn2+-dependent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.6x10^-9(molar)	2021/11/29	2022/01/25	rogid:EdyNoJ8GUxlAzNhMlryC/ugExhY9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8X9w022Kqv7UmXMrI1H5D/SwzOE	false	sufficient binding region:24-344|fc-igg1:c-c	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996829|imex:IM-29420-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 3|comment:Interaction is Ca2+ and Zn2+-dependent|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/25	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996835|imex:IM-29420-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/25	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996835|imex:IM-29420-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/25	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80511	uniprotkb:P80511	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996852|imex:IM-29420-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 4H|comment:Dimeric in the presence of EDTA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/12	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8UIzNZs04MAyxwG979aULgSclG8	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80511	uniprotkb:P80511	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996877|imex:IM-29420-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 4H|comment:Tetrameric in the presence of zinc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/12	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8UIzNZs04MAyxwG979aULgSclG8	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80511	uniprotkb:P80511	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996881|imex:IM-29420-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 4H|comment:Hexameric in the presence of zinc and calcium|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/12	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8UIzNZs04MAyxwG979aULgSclG8	false	-	-	6	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80511	uniprotkb:P80511	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996891|imex:IM-29420-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 4H|comment:Oligomeric in the presence of increasing calcium concentrations|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/12	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:z2u++vHEoQbyAU1nrDFy1efBp0E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	uniprotkb:P80511	intact:EBI-968340	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996957|imex:IM-29420-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80511	uniprotkb:P80511	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996962|imex:IM-29420-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 5A, 5B, 5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/12	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8UIzNZs04MAyxwG979aULgSclG8	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996965|imex:IM-29420-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 5C, 5E, 5F|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-28996965|imex:IM-29420-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 5C, 5E, 5F|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	-	-	false	-	-	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80511	uniprotkb:P80511	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29449586|imex:IM-29420-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig.5D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/19	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	rigid:8UIzNZs04MAyxwG979aULgSclG8	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29450775|imex:IM-29420-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 5E, 5F|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29450775|imex:IM-29420-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 5E, 5F|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29450882|imex:IM-29420-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 5E, 5F|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0943"(detection by mass spectrometry)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29450882|imex:IM-29420-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig. 5E, 5F|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29454648|imex:IM-29420-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 6B, 7A,|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	uniprotkb:P80511	intact:EBI-968340	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29458337|imex:IM-29420-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig.6C, 7A|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29462517|imex:IM-29420-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig.7A,|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0051"(fluorescence technology)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29462517|imex:IM-29420-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig.7A,|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29468792|imex:IM-29420-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig 6A, 7B, 8|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29468792|imex:IM-29420-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig 6A, 7B, 8|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	uniprotkb:P80511	intact:EBI-968340	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29468787|imex:IM-29420-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 6A, 7B, 8|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29468782|imex:IM-29420-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig. 6A,  7B|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	-	-	-	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	uniprotkb:P80511	intact:EBI-1169353	intact:EBI-2823305|uniprotkb:Q7M4R1|uniprotkb:Q5SY66|uniprotkb:P83219|ensembl:ENSP00000357726	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:s10ac_human(display_long)|uniprotkb:S100A12(gene name)|psi-mi:S100A12(display_short)|uniprotkb:CGRP(gene name synonym)|uniprotkb:Calcium-binding protein in amniotic fluid 1(gene name synonym)|uniprotkb:Calgranulin-C(gene name synonym)|uniprotkb:Extracellular newly identified RAGE-binding protein(gene name synonym)|uniprotkb:Neutrophil S100 protein(gene name synonym)|uniprotkb:S100 calcium-binding protein A12(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 6(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29477336|imex:IM-29420-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005612.1|ensembl:ENSG00000163221(gene)|ensembl:ENST00000368737(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045576"(mast cell activation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:1E8A|rcsb pdb:1GQM|rcsb pdb:1ODB|rcsb pdb:2M9G|rcsb pdb:2WC8|rcsb pdb:2WCB|rcsb pdb:2WCE|rcsb pdb:2WCF|reactome:R-HSA-445989|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|go:"GO:0050729"(positive regulation of inflammatory response)	-	-	-	figure legend:Fig 9|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	rogid:+mJQPg0pOx0rsHAfchVdYqHrqyM9606	-	false	15n label:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29108"	chebi:"CHEBI:29105"	intact:EBI-1169353	intact:EBI-968340	psi-mi:"calcium(2+)"(display_short)|psi-mi:"CHEBI:29108"(display_long)	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moroz et al. (2009)	imex:IM-29420|pubmed:19386136	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-29477336|imex:IM-29420-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:Fig 9|comment:Bound Zn2+ increases the affinity of the S100A12 dimers for Ca2+.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/29	2022/01/26	-	-	-	false	15n label:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)