#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43246	uniprotkb:Q9UIF7	intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146	intact:EBI-725721|uniprotkb:Q15830|uniprotkb:Q9UBP2|uniprotkb:Q9UBS7|uniprotkb:Q9UIF4|uniprotkb:Q9UIF5|uniprotkb:Q9UIF6|uniprotkb:D3DPZ4|ensembl:ENSP00000361170|ensembl:ENSP00000500891	psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym)	psi-mi:mutyh_human(display_long)|uniprotkb:MutY homolog(gene name synonym)|uniprotkb:MUTYH(gene name)|psi-mi:MUTYH(display_short)|uniprotkb:MYH(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bai et al. (2007)	pubmed:17081686|imex:IM-29293	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-27104229|imex:IM-29293-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N	refseq:NP_001041636.1|refseq:NP_001041637.1|refseq:NP_001041638.1|refseq:NP_001041639.1|refseq:NP_001121897.1|refseq:NP_036354.1|refseq:NP_001280119.1|refseq:NP_001280120.1|refseq:NP_001280121.1|refseq:NP_001280124.1|refseq:NP_001280125.1|refseq:XP_011539806.1|ensembl:ENSG00000132781(gene)|ensembl:ENST00000372098(transcript)|ensembl:ENST00000672818(transcript)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|reactome:R-HSA-9608287|reactome:R-HSA-9608290|rcsb pdb:3N5N|go:"GO:0006298"(mismatch repair)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034039"(8-oxo-7,8-dihydroguanine DNA N-glycosylase activity)|go:"GO:0035485"(adenine/guanine mispair binding)|go:"GO:0045007"(depurination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR000445(Helix-hairpin-helix motif)|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004035(Endonuclease III, iron-sulphur binding, conserved site-1)|interpro:IPR004036(Endonuclease III, conserved site-2)|interpro:IPR011257(DNA glycosylase)|interpro:IPR015797(NUDIX)|go:"GO:0006284"(base-excision repair)|interpro:IPR023170|interpro:IPR029119|interpro:IPR044298|rcsb pdb:1X51|refseq:XP_016856823.1|refseq:XP_016856824.1|dip:DIP-41972N	-	-	-	figure legend:Fig. 1|comment:"Physical interaction between hMutSα and hMYH(R231L). Purified hMutSα (hMSH2/hMSH6 complex, 460 ng) pulled down by GST-hMYH beads was fractionated by a 10% SDS-polyacrylamide gel followed by Western blot analysis using antibodies against hMSH2."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/10/11	2021/10/11	rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606	rogid:8BA0RGqpcUQP96lX/n8/GuJxVRI9606	rigid:+W9WJyt3mwVYkiODmEbWxV2d+B8	false	-	glutathione s tranferase tag:?-?|mutation with no effect:242-242	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)