#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UHB9 uniprotkb:O76094 intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066 intact:EBI-1058850|ensembl:ENSP00000495128|intact:EBI-2654733|uniprotkb:G5E9Z8|uniprotkb:Q7Z3C0 psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym) psi-mi:srp72_human(display_long)|uniprotkb:SRP72(gene name)|psi-mi:SRP72(display_short)|uniprotkb:Signal recognition particle 72 kDa protein(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Iakhiaeva et al. (2006) pubmed:16672232|imex:IM-29382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-27814997|imex:IM-29382-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N refseq:NP_008878.3|refseq:NP_001254651.1|ensembl:ENSG00000174780(gene)|ensembl:ENST00000642900(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013699(Signal recognition particle, SRP72 subunit, RNA-binding)|interpro:IPR019734|interpro:IPR026270|interpro:IPR031545|mint:O76094|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:5WRW|rcsb pdb:7NFX|reactome:R-HSA-1799339 - - - figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/11/24 2021/11/30 rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606 rogid:NJfyOcmKiBWszQsH0EQotsdwhU09606 rigid:H+Wga2xlWmmKXb/5ip+59v/fH+8 false necessary binding region:555-627|sufficient binding region:310-620 sufficient binding region:1-163 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHB9 uniprotkb:O76094 intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066 intact:EBI-1058850|ensembl:ENSP00000495128|intact:EBI-2654733|uniprotkb:G5E9Z8|uniprotkb:Q7Z3C0 psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym) psi-mi:srp72_human(display_long)|uniprotkb:SRP72(gene name)|psi-mi:SRP72(display_short)|uniprotkb:Signal recognition particle 72 kDa protein(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Iakhiaeva et al. (2006) pubmed:16672232|imex:IM-29382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-28950266|imex:IM-29382-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N refseq:NP_008878.3|refseq:NP_001254651.1|ensembl:ENSG00000174780(gene)|ensembl:ENST00000642900(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013699(Signal recognition particle, SRP72 subunit, RNA-binding)|interpro:IPR019734|interpro:IPR026270|interpro:IPR031545|mint:O76094|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:5WRW|rcsb pdb:7NFX|reactome:R-HSA-1799339 - - - figure legend:Fig. 7|comment:Separation of a mixture of polypeptide 68c with fragments generated by mild digestion of 72b′ with chymotrypsin followed by analysis of the sucrose gradient fractions by SDS-PAGE.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/11/24 2021/12/08 rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606 rogid:NJfyOcmKiBWszQsH0EQotsdwhU09606 rigid:H+Wga2xlWmmKXb/5ip+59v/fH+8 false sufficient binding region:526-627|fusion protein:n-n sufficient binding region:1-163 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHB9 uniprotkb:O76094 intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066 intact:EBI-1058850|ensembl:ENSP00000495128|intact:EBI-2654733|uniprotkb:G5E9Z8|uniprotkb:Q7Z3C0 psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym) psi-mi:srp72_human(display_long)|uniprotkb:SRP72(gene name)|psi-mi:SRP72(display_short)|uniprotkb:Signal recognition particle 72 kDa protein(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Iakhiaeva et al. (2006) pubmed:16672232|imex:IM-29382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-27868563|imex:IM-29382-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N refseq:NP_008878.3|refseq:NP_001254651.1|ensembl:ENSG00000174780(gene)|ensembl:ENST00000642900(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013699(Signal recognition particle, SRP72 subunit, RNA-binding)|interpro:IPR019734|interpro:IPR026270|interpro:IPR031545|mint:O76094|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:5WRW|rcsb pdb:7NFX|reactome:R-HSA-1799339 - - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2021/11/24 2021/11/30 rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606 rogid:NJfyOcmKiBWszQsH0EQotsdwhU09606 rigid:H+Wga2xlWmmKXb/5ip+59v/fH+8 false sufficient binding region:526-627|fusion protein:n-n sufficient binding region:1-163 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHB9 uniprotkb:O76094 intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066 intact:EBI-1058850|ensembl:ENSP00000495128|intact:EBI-2654733|uniprotkb:G5E9Z8|uniprotkb:Q7Z3C0 psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym) psi-mi:srp72_human(display_long)|uniprotkb:SRP72(gene name)|psi-mi:SRP72(display_short)|uniprotkb:Signal recognition particle 72 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Iakhiaeva et al. (2006) pubmed:16672232|imex:IM-29382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-28950248|imex:IM-29382-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N refseq:NP_008878.3|refseq:NP_001254651.1|ensembl:ENSG00000174780(gene)|ensembl:ENST00000642900(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013699(Signal recognition particle, SRP72 subunit, RNA-binding)|interpro:IPR019734|interpro:IPR026270|interpro:IPR031545|mint:O76094|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:5WRW|rcsb pdb:7NFX|reactome:R-HSA-1799339 - - - figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/11/24 2021/12/08 rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606 rogid:NJfyOcmKiBWszQsH0EQotsdwhU09606 rigid:H+Wga2xlWmmKXb/5ip+59v/fH+8 false sufficient binding region:526-627|fusion protein:n-n sufficient binding region:1-163|glutathione s tranferase tag:?-? - - psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q9UHB9 uniprotkb:O76094 intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066 intact:EBI-1058850|ensembl:ENSP00000495128|intact:EBI-2654733|uniprotkb:G5E9Z8|uniprotkb:Q7Z3C0 psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym) psi-mi:srp72_human(display_long)|uniprotkb:SRP72(gene name)|psi-mi:SRP72(display_short)|uniprotkb:Signal recognition particle 72 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Iakhiaeva et al. (2006) pubmed:16672232|imex:IM-29382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-28950288|imex:IM-29382-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N refseq:NP_008878.3|refseq:NP_001254651.1|ensembl:ENSG00000174780(gene)|ensembl:ENST00000642900(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030911"(TPR domain binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013699(Signal recognition particle, SRP72 subunit, RNA-binding)|interpro:IPR019734|interpro:IPR026270|interpro:IPR031545|mint:O76094|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:5WRW|rcsb pdb:7NFX|reactome:R-HSA-1799339 - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.25x10^-8(molar) 2021/11/24 2021/12/08 rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606 rogid:NJfyOcmKiBWszQsH0EQotsdwhU09606 rigid:H+Wga2xlWmmKXb/5ip+59v/fH+8 false sufficient binding region:526-627|fusion protein:n-n|35s radiolabel:?-? sufficient binding region:1-163|glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)