#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A0A3Q1LY00 uniprotkb:P82279 intact:EBI-26451960|ensembl:ENSBTAP00000062138 intact:EBI-1048648|uniprotkb:Q5K3A6|uniprotkb:Q5TC28|uniprotkb:Q5VUT1|uniprotkb:Q6N027|uniprotkb:Q8WWY0|uniprotkb:A2A308|uniprotkb:B9EG71|intact:EBI-1058755|uniprotkb:Q8WWY1|uniprotkb:B7Z5T2|ensembl:ENSP00000356370 psi-mi:a0a3q1ly00_bovin(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Protein PALS1(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:crum1_human(display_long)|uniprotkb:CRB1(gene name)|psi-mi:CRB1(display_short) psi-mi:"MI:0018"(two hybrid) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025698|imex:IM-29051-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0012505"(endomembrane system)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0045177"(apical part of cell)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|ensembl:ENSBTAG00000011767(gene)|ensembl:ENSBTAT00000081434(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_001192880.1|refseq:XP_015328720.1|refseq:XP_015328721.1 refseq:NP_001180569.1|refseq:NP_957705.1|refseq:NP_001244894.1|refseq:NP_001244895.1|ensembl:ENSG00000134376(gene)|ensembl:ENST00000367400(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060060"(post-embryonic retina morphogenesis in camera-type eye)|go:"GO:0061159"(establishment of bipolar cell polarity involved in cell morphogenesis)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4UU5 - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/23 2021/06/29 rogid:sROfcRNMIDIs7SQYeQ8+ZL4kTxY9913 rogid:ootDiV2LmQtjcB1YBjcBhFimWq09606 rigid:WDCkI/ZfhvFiQUGD2JGvlm+EK/4 false - sufficient binding region:1369..1369-1406 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96JB8 uniprotkb:Q8N3R9 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025711|imex:IM-29051-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/23 2021/06/29 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:8IPGA2M1pJtesPKzKYdiCQDIAdE false sufficient binding region:390-637 sufficient binding region:377-477 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96JB8 uniprotkb:Q8N3R9 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025766|imex:IM-29051-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - figure legend:Figs. 2A, 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/23 2021/06/29 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:8IPGA2M1pJtesPKzKYdiCQDIAdE false sufficient binding region:410-637 sufficient binding region:377-477 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N3R9 uniprotkb:Q8N3R9 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27090906|imex:IM-29051-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/23 2021/09/23 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:76LEqhf0uqnXLFJw50X1Lbe08Cw false sufficient binding region:408-675 sufficient binding region:377-477 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96JB8 uniprotkb:Q96JB8 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27090914|imex:IM-29051-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 - - - figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2021/06/23 2021/09/23 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rigid:7mFuYN/DfxDEd31Rj5v/nuPtDYY false sufficient binding region:410-637 sufficient binding region:345-425 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96JB8 uniprotkb:Q8N3R9 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0096"(pull down) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27027102|imex:IM-29051-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/06/23 2021/07/01 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:8IPGA2M1pJtesPKzKYdiCQDIAdE false sufficient binding region:365-637|his tag:n-n|maltose binding protein tag:n-n sufficient binding region:377-477|glutathione s tranferase tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96JB8 uniprotkb:Q8N3R9 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27027129|imex:IM-29051-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/23 2021/07/01 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:8IPGA2M1pJtesPKzKYdiCQDIAdE false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P82279 uniprotkb:Q96JB8 intact:EBI-1048648|uniprotkb:Q5K3A6|uniprotkb:Q5TC28|uniprotkb:Q5VUT1|uniprotkb:Q6N027|uniprotkb:Q8WWY0|uniprotkb:A2A308|uniprotkb:B9EG71|intact:EBI-1058755|uniprotkb:Q8WWY1|uniprotkb:B7Z5T2|ensembl:ENSP00000356370 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 psi-mi:crum1_human(display_long)|uniprotkb:CRB1(gene name)|psi-mi:CRB1(display_short) psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27027160|imex:IM-29051-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180569.1|refseq:NP_957705.1|refseq:NP_001244894.1|refseq:NP_001244895.1|ensembl:ENSG00000134376(gene)|ensembl:ENST00000367400(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060060"(post-embryonic retina morphogenesis in camera-type eye)|go:"GO:0061159"(establishment of bipolar cell polarity involved in cell morphogenesis)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4UU5 ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 - - - figure legend:Fig. 2G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/23 2021/07/01 rogid:ootDiV2LmQtjcB1YBjcBhFimWq09606 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rigid:4nLg+PbLexdtEvYpSMB+CQERmbo false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P82279 uniprotkb:Q96JB8 intact:EBI-1048648|uniprotkb:Q5K3A6|uniprotkb:Q5TC28|uniprotkb:Q5VUT1|uniprotkb:Q6N027|uniprotkb:Q8WWY0|uniprotkb:A2A308|uniprotkb:B9EG71|intact:EBI-1058755|uniprotkb:Q8WWY1|uniprotkb:B7Z5T2|ensembl:ENSP00000356370 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 psi-mi:crum1_human(display_long)|uniprotkb:CRB1(gene name)|psi-mi:CRB1(display_short) psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27027140|imex:IM-29051-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180569.1|refseq:NP_957705.1|refseq:NP_001244894.1|refseq:NP_001244895.1|ensembl:ENSG00000134376(gene)|ensembl:ENST00000367400(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060060"(post-embryonic retina morphogenesis in camera-type eye)|go:"GO:0061159"(establishment of bipolar cell polarity involved in cell morphogenesis)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4UU5 ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 - - - figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/23 2021/07/01 rogid:ootDiV2LmQtjcB1YBjcBhFimWq09606 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rigid:4nLg+PbLexdtEvYpSMB+CQERmbo false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96JB8 uniprotkb:Q8N3R9 intact:EBI-2483346|ensembl:ENSP00000387278|uniprotkb:Q53TT3|uniprotkb:Q6ZNH6|uniprotkb:Q96Q43|uniprotkb:Q96Q44|uniprotkb:C9IZK4 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:mpp4_human(display_long)|uniprotkb:MPP4(gene name)|psi-mi:MPP4(display_short)|uniprotkb:ALS2CR5(gene name synonym)|uniprotkb:DLG6(gene name synonym)|uniprotkb:Discs large homolog 6(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27027154|imex:IM-29051-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000082126(gene)|ensembl:ENST00000409474(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035418"(protein localization to synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035600|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|refseq:NP_149055.1 go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 - - - figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/23 2021/07/01 rogid:wvsMSo8RMCImQs1xRPozCOHNQ/09606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rigid:8IPGA2M1pJtesPKzKYdiCQDIAdE false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N3R9 uniprotkb:P82279 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 intact:EBI-1048648|uniprotkb:Q5K3A6|uniprotkb:Q5TC28|uniprotkb:Q5VUT1|uniprotkb:Q6N027|uniprotkb:Q8WWY0|uniprotkb:A2A308|uniprotkb:B9EG71|intact:EBI-1058755|uniprotkb:Q8WWY1|uniprotkb:B7Z5T2|ensembl:ENSP00000356370 psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:crum1_human(display_long)|uniprotkb:CRB1(gene name)|psi-mi:CRB1(display_short) psi-mi:"MI:0663"(confocal microscopy) Kantardzhieva et al. (2005) imex:IM-29051|pubmed:15914641 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-27027253|imex:IM-29051-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 refseq:NP_001180569.1|refseq:NP_957705.1|refseq:NP_001244894.1|refseq:NP_001244895.1|ensembl:ENSG00000134376(gene)|ensembl:ENST00000367400(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060060"(post-embryonic retina morphogenesis in camera-type eye)|go:"GO:0061159"(establishment of bipolar cell polarity involved in cell morphogenesis)|go:"GO:0071482"(cellular response to light stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4UU5 - - - figure legend:Fg. 5G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-retina)|taxid:9606(Human retina cells) - 2021/06/23 2021/07/01 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 rogid:ootDiV2LmQtjcB1YBjcBhFimWq09606 rigid:C95LT0UY9cOB0m3A/xzemwETVkM false - - - - psi-mi:"MI:1198"(immunohistochemistry) psi-mi:"MI:1198"(immunohistochemistry)