#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35346	uniprotkb:P30872	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	intact:EBI-21273948|ensembl:ENSP00000267377	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:ssr1_human(display_long)|uniprotkb:SRIF-2(gene name synonym)|uniprotkb:SSTR1(gene name)|psi-mi:SSTR1(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Grant et al. (2004)	imex:IM-29143|pubmed:15247250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054099|imex:IM-29143-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	ensembl:ENSG00000139874(gene)|ensembl:ENST00000267377(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021549"(cerebellum development)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001116(Somatostatin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_001040.1	-	-	-	figure legend:Figs. 1B, 1C, 2|agonist:"Somatostatin-14 (PRO_0000033088)"|agonist:"Somatostatin-28 (PRO_0000033087,CHEBI:80249)"|agonist:"SMS 201-995 (CHEBI:177082)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2021/07/29	2021/08/04	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rogid:FtSQPO0zdG69nJSBogdMkafkrV49606	rigid:6jAJZSReViur3PMRtRP1HVWlBBg	false	ha tag:n-n	-	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P61278-PRO_0000033088	uniprotkb:P61278-PRO_0000033088	intact:EBI-20824010	intact:EBI-20824010	psi-mi:p61278-pro_0000033088(display_long)|uniprotkb:SST(gene name)|psi-mi:SST(display_short)|uniprotkb:Growth hormone release-inhibiting factor(gene name synonym)	psi-mi:p61278-pro_0000033088(display_long)|uniprotkb:SST(gene name)|psi-mi:SST(display_short)|uniprotkb:Growth hormone release-inhibiting factor(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Grant et al. (2004)	imex:IM-29143|pubmed:15247250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054371|imex:IM-29143-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-20823968(chain-parent)	intact:EBI-20823968(chain-parent)	-	chain-seq-start:103|chain-seq-end:116	chain-seq-start:103|chain-seq-end:116	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2021/07/29	2021/08/04	rogid:wEr8YVXkvIX4GK6VDoX4HhRGPmM9606	rogid:wEr8YVXkvIX4GK6VDoX4HhRGPmM9606	rigid:ej02fMZH1jx7i07Ri9sWiH4dy2Q	false	fluorescent dye label:?-?	fluorescein label:8-8	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P61278-PRO_0000033088	uniprotkb:P35346	intact:EBI-20824010	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	psi-mi:p61278-pro_0000033088(display_long)|uniprotkb:SST(gene name)|psi-mi:SST(display_short)|uniprotkb:Growth hormone release-inhibiting factor(gene name synonym)	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Grant et al. (2004)	imex:IM-29143|pubmed:15247250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054371|imex:IM-29143-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-20823968(chain-parent)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	-	chain-seq-start:103|chain-seq-end:116	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2021/07/29	2021/08/04	rogid:wEr8YVXkvIX4GK6VDoX4HhRGPmM9606	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rigid:ej02fMZH1jx7i07Ri9sWiH4dy2Q	false	fluorescent dye label:?-?	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P61278-PRO_0000033088	uniprotkb:P35346	intact:EBI-20824010	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	psi-mi:p61278-pro_0000033088(display_long)|uniprotkb:SST(gene name)|psi-mi:SST(display_short)|uniprotkb:Growth hormone release-inhibiting factor(gene name synonym)	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Grant et al. (2004)	imex:IM-29143|pubmed:15247250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054371|imex:IM-29143-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-20823968(chain-parent)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	-	chain-seq-start:103|chain-seq-end:116	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2021/07/29	2021/08/04	rogid:wEr8YVXkvIX4GK6VDoX4HhRGPmM9606	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rigid:ej02fMZH1jx7i07Ri9sWiH4dy2Q	false	fluorescent dye label:?-?	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P35346	uniprotkb:P30872	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	intact:EBI-21273948|ensembl:ENSP00000267377	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:ssr1_human(display_long)|uniprotkb:SRIF-2(gene name synonym)|uniprotkb:SSTR1(gene name)|psi-mi:SSTR1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Grant et al. (2004)	imex:IM-29143|pubmed:15247250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054153|imex:IM-29143-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	ensembl:ENSG00000139874(gene)|ensembl:ENST00000267377(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021549"(cerebellum development)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001116(Somatostatin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_001040.1	-	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2021/07/29	2021/08/04	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rogid:FtSQPO0zdG69nJSBogdMkafkrV49606	rigid:6jAJZSReViur3PMRtRP1HVWlBBg	false	ha tag:n-n	-	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P35346	uniprotkb:P30872	intact:EBI-27053622|ensembl:ENSP00000293897|uniprotkb:P34988|uniprotkb:Q541E0|uniprotkb:Q9UJI5	intact:EBI-21273948|ensembl:ENSP00000267377	psi-mi:ssr5_human(display_long)|uniprotkb:SSTR5(gene name)|psi-mi:SSTR5(display_short)	psi-mi:ssr1_human(display_long)|uniprotkb:SRIF-2(gene name synonym)|uniprotkb:SSTR1(gene name)|psi-mi:SSTR1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Grant et al. (2004)	imex:IM-29143|pubmed:15247250	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27054209|imex:IM-29143-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162009(gene)|ensembl:ENST00000293897(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001184(Somatostatin receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001044.1|refseq:NP_001166031.1	ensembl:ENSG00000139874(gene)|ensembl:ENST00000267377(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004994"(somatostatin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0021549"(cerebellum development)|go:"GO:0030900"(forebrain development)|go:"GO:0042277"(peptide binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000586(Somatostatin receptor)|interpro:IPR001116(Somatostatin receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0005887"(integral component of plasma membrane)|refseq:NP_001040.1	-	-	-	figure legend:Fig. 3|agonist:"Somatostatin-14 (PRO_0000033088)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/07/29	2021/08/04	rogid:t5Ynz+mc7FQcdGLmFREFizkl5Ro9606	rogid:FtSQPO0zdG69nJSBogdMkafkrV49606	rigid:6jAJZSReViur3PMRtRP1HVWlBBg	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:0705"(anti tag western blot)