#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62157	uniprotkb:Q13554	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-1058722|ensembl:ENSP00000379098|uniprotkb:A4D2K1|uniprotkb:A4D2K2|uniprotkb:Q9UGH9|uniprotkb:Q9UNX0|uniprotkb:Q9UNX7|uniprotkb:O95437|uniprotkb:O95438|uniprotkb:Q9UP00|uniprotkb:Q9Y5N4|uniprotkb:Q9Y6F4|uniprotkb:A4D2K0|uniprotkb:O95599|uniprotkb:Q9UGH7|uniprotkb:Q9UGH8|uniprotkb:A4D2K4|uniprotkb:A4D2K6|uniprotkb:A4D2K3|intact:EBI-1383493|uniprotkb:A4D2K5	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:kcc2b_human(display_long)|uniprotkb:CAMK2B(gene name)|psi-mi:CAMK2B(display_short)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CAMKB(gene name synonym)|uniprotkb:CAMK2(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27048803|imex:IM-29122-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000058404(gene)|ensembl:ENST00000395749(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|refseq:NP_001211.3|refseq:NP_742075.1|refseq:NP_742076.1|refseq:NP_742077.1|refseq:NP_742078.1|refseq:NP_742079.1|refseq:NP_742080.1|refseq:NP_742081.1|mint:Q13554|rcsb pdb:3BHH|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|interpro:IPR032710|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001280099.1|dip:DIP-39770N	-	-	-	figure legend:2b|agonist:"CaCl2 (CHEBI:3312)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/28	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:3RDzSxLdoGtWTECo9At60gEZfZY9606	rigid:V5iFoliK9goRa03BpKNavI091+I	false	-	sufficient binding region:291-310	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27048803|imex:IM-29122-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N	-	-	-	figure legend:2b|agonist:"CaCl2 (CHEBI:3312)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/28	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	rigid:V5iFoliK9goRa03BpKNavI091+I	false	-	sufficient binding region:101-184	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27050840|imex:IM-29122-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N|interpro:IPR009071(High mobility group box, HMG)	-	-	-	figure legend:2b|agonist:"CaCl2 (CHEBI:3312)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/28	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	rigid:rRV2Wyl1tpcaWUIFBFP6b3JLOUI	false	-	sufficient binding region:101-184(IPR009071)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:75400"	uniprotkb:P62157	intact:EBI-27051399	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	psi-mi:calmidazolium(display_short)|psi-mi:"CHEBI:75400"(display_long)|intact:R24571(synonym)|intact:"1-[bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium"(iupac name)	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27051406|imex:IM-29122-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	-	-	-	figure legend:4|agonist:"CaCl2 (CHEBI:3312)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/29	-	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	-	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27051406|imex:IM-29122-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N	-	-	-	figure legend:4|agonist:"CaCl2 (CHEBI:3312)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/29	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	-	false	-	sufficient binding region:101-184(IPR009071)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0030"(cross-linking study)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27050856|imex:IM-29122-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N	-	-	-	figure legend:2 C/D|agonist:"CaCl2 (CHEBI:3312)"|antagonist:"EGTA  (CHEBI:30740)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/28	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	rigid:rRV2Wyl1tpcaWUIFBFP6b3JLOUI	false	-	35s radiolabel:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P62157	intact:EBI-27051322	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	-	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9 dna binding region(display_short)|psi-mi:EBI-27051322(display_long)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055243|imex:IM-29122-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	-	-	-	-	figure legend:3a|comment:"The addition of mutant DNA (GGGGTTAACGTCCGCGGTAATCTGGTAGA) to the CaMSOX9 complex resulted in no changes in fluorescence emission"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/08/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055243|imex:IM-29122-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N	-	-	-	figure legend:3a|comment:"The addition of mutant DNA (GGGGTTAACGTCCGCGGTAATCTGGTAGA) to the CaMSOX9 complex resulted in no changes in fluorescence emission"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/08/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	-	false	-	sufficient binding region:101-184(IPR009071)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055265|imex:IM-29122-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N	-	-	-	figure legend:7a, 3a|agonist:"CaCl2 (CHEBI:3312)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/08/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	rigid:rRV2Wyl1tpcaWUIFBFP6b3JLOUI	false	-	sufficient binding region:101-184(IPR009071)|mutation with complex effect:158-158	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62157	uniprotkb:P48436	intact:EBI-397403|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q08D84|uniprotkb:Q2KJE6|uniprotkb:Q61379|uniprotkb:Q61380|ensembl:ENSBTAP00000002055|ensembl:ENSBTAP00000057928|ensembl:ENSBTAP00000058610	intact:EBI-3920028|ensembl:ENSP00000245479|uniprotkb:Q53Y80	psi-mi:calm_bovin(display_long)|uniprotkb:CALM(gene name)|psi-mi:CALM(display_short)|uniprotkb:CAM(gene name synonym)	psi-mi:sox9_human(display_long)|uniprotkb:SOX9(gene name)|psi-mi:SOX9(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Argentaro et al. (2003)	pubmed:12810722|imex:IM-29122	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27051414|imex:IM-29122-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039714.1|refseq:NP_001229501.1|refseq:NP_001229516.1|dip:DIP-36674N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P62157|rcsb pdb:1A29|rcsb pdb:1AK8|rcsb pdb:1CDM|rcsb pdb:1CM1|rcsb pdb:1CM4|rcsb pdb:1CMF|rcsb pdb:1CMG|rcsb pdb:1DEG|rcsb pdb:1FW4|rcsb pdb:1LIN|rcsb pdb:1PRW|rcsb pdb:1QIV|rcsb pdb:1QIW|rcsb pdb:1XA5|rcsb pdb:2CLN|rcsb pdb:2F2O|go:"GO:0005509"(calcium ion binding)|ensembl:ENSBTAG00000001575(gene)|ensembl:ENSBTAG00000014583(gene)|ensembl:ENSBTAG00000025644(gene)|ensembl:ENSBTAT00000002055(transcript)|ensembl:ENSBTAT00000082279(transcript)|ensembl:ENSBTAT00000083507(transcript)|go:"GO:0000922"(spindle pole)|rcsb pdb:2FOT|rcsb pdb:3IF7|rcsb pdb:6O20|rcsb pdb:2F2P	ensembl:ENSG00000125398(gene)|ensembl:ENST00000245479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002683"(negative regulation of immune system process)|go:"GO:0003170"(heart valve development)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003188"(heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0003415"(chondrocyte hypertrophy)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014036"(neural crest cell fate specification)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030850"(prostate gland development)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0030903"(notochord development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060018"(astrocyte fate commitment)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060174"(limb bud formation)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060517"(epithelial cell proliferation involved in prostatic bud elongation)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060784"(regulation of cell proliferation involved in tissue homeostasis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061046"(regulation of branching involved in lung morphogenesis)|go:"GO:0061138"(morphogenesis of a branching epithelium)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070384"(Harderian gland development)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072034"(renal vesicle induction)|go:"GO:0072190"(ureter urothelium development)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072289"(metanephric nephron tubule formation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097065"(anterior head development)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1904864"(negative regulation of beta-catenin-TCF complex assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:2000794"(regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|interpro:IPR029548|interpro:IPR036910|rcsb pdb:1S9M|rcsb pdb:1SX9|rcsb pdb:4EUW|reactome:R-HSA-3769402|reactome:R-HSA-8878166|reactome:R-HSA-9690406|refseq:NP_000337.1|dip:DIP-61319N	-	-	-	figure legend:7b-c|agonist:"CaCl2 (CHEBI:3312)"|comment:In both WT SOX9 and A158T SOX9 proteins, all of the tryptophan fluorescence was accessible to acrylamide quenching.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/28	2021/07/29	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9913	rogid:9tMOPJUNgC89D1SdrN0b4yCXRUk9606	rigid:rRV2Wyl1tpcaWUIFBFP6b3JLOUI	false	-	sufficient binding region:101-184(IPR009071)|mutation with complex effect:158-158	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)