#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48960	uniprotkb:P08174	intact:EBI-1756009|uniprotkb:O00718|uniprotkb:O76101|uniprotkb:Q8NG72|uniprotkb:Q8TBQ7|uniprotkb:A8K7Z4|uniprotkb:B2RBJ9|ensembl:ENSP00000242786	intact:EBI-1033846|uniprotkb:P09679|uniprotkb:P78361|uniprotkb:B1AP14|uniprotkb:D3DT83|uniprotkb:D3DT84|ensembl:ENSP00000356031|uniprotkb:E7ER69|uniprotkb:Q14UF2|uniprotkb:Q14UF3|uniprotkb:Q14UF4|uniprotkb:Q14UF5|uniprotkb:Q14UF6	psi-mi:agre5_human(display_long)|uniprotkb:ADGRE5(gene name)|psi-mi:ADGRE5(display_short)|uniprotkb:CD97(gene name synonym)|uniprotkb:Leukocyte antigen CD97(gene name synonym)	psi-mi:daf_human(display_long)|uniprotkb:CD55(gene name)|psi-mi:CD55(display_short)|uniprotkb:CR(gene name synonym)|uniprotkb:DAF(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lin et al. (2001)	pubmed:11297558|imex:IM-28625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26585043|imex:IM-28625-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020331.1|refseq:NP_001775.2|refseq:NP_510966.1|refseq:XP_016883036.1|dip:DIP-52292N|ensembl:ENST00000242786(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003056(GPCR, family 2, CD97 antigen)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR018097|rcsb pdb:2BOU|reactome:R-HSA-373080|reactome:R-HSA-6798695|ensembl:ENSG00000123146(gene)	refseq:NP_000565.1|refseq:NP_001108224.1|refseq:NP_001287832.1|refseq:NP_001287833.1|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0030133"(transport vesicle)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045730"(respiratory burst)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|rcsb pdb:6LA5|rcsb pdb:7C9W|reactome:R-HSA-373080|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-977606|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR035976|rcsb pdb:1H03|rcsb pdb:1H04|rcsb pdb:1H2P|rcsb pdb:1H2Q|rcsb pdb:1M11|rcsb pdb:1NWV|rcsb pdb:1OJV|rcsb pdb:1OJW|rcsb pdb:1OJY|rcsb pdb:1OK1|rcsb pdb:1OK2|rcsb pdb:1OK3|rcsb pdb:1OK9|rcsb pdb:1UOT|rcsb pdb:1UPN|rcsb pdb:2C8I|rcsb pdb:2QZD|rcsb pdb:2QZF|rcsb pdb:2QZH|rcsb pdb:3IYP|rcsb pdb:3J24|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:5FOA|rcsb pdb:6ILJ|rcsb pdb:6ILK|ensembl:ENSG00000196352(gene)|ensembl:ENST00000367064(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002456"(T cell mediated immunity)	-	-	-	figure legend:Fig. 4A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.5x10^-5(molar)	2021/01/11	2021/01/11	rogid:aWUi+Tfw2CgnBrGu/eMmHP3eoCg9606	rogid:5sa2K9j8EDzc3zJAe72+YVHTM/o9606	rigid:3A3jxUdQb13aSkmj33q1RfAtoPw	false	sufficient binding region:22..22-159..159	sufficient binding region:35..35-285..285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48960	uniprotkb:P08174	intact:EBI-1756009|uniprotkb:O00718|uniprotkb:O76101|uniprotkb:Q8NG72|uniprotkb:Q8TBQ7|uniprotkb:A8K7Z4|uniprotkb:B2RBJ9|ensembl:ENSP00000242786	intact:EBI-1033846|uniprotkb:P09679|uniprotkb:P78361|uniprotkb:B1AP14|uniprotkb:D3DT83|uniprotkb:D3DT84|ensembl:ENSP00000356031|uniprotkb:E7ER69|uniprotkb:Q14UF2|uniprotkb:Q14UF3|uniprotkb:Q14UF4|uniprotkb:Q14UF5|uniprotkb:Q14UF6	psi-mi:agre5_human(display_long)|uniprotkb:ADGRE5(gene name)|psi-mi:ADGRE5(display_short)|uniprotkb:CD97(gene name synonym)|uniprotkb:Leukocyte antigen CD97(gene name synonym)	psi-mi:daf_human(display_long)|uniprotkb:CD55(gene name)|psi-mi:CD55(display_short)|uniprotkb:CR(gene name synonym)|uniprotkb:DAF(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lin et al. (2001)	pubmed:11297558|imex:IM-28625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26585153|imex:IM-28625-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020331.1|refseq:NP_001775.2|refseq:NP_510966.1|refseq:XP_016883036.1|dip:DIP-52292N|ensembl:ENST00000242786(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003056(GPCR, family 2, CD97 antigen)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR018097|rcsb pdb:2BOU|reactome:R-HSA-373080|reactome:R-HSA-6798695|ensembl:ENSG00000123146(gene)	refseq:NP_000565.1|refseq:NP_001108224.1|refseq:NP_001287832.1|refseq:NP_001287833.1|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0030133"(transport vesicle)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045730"(respiratory burst)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|rcsb pdb:6LA5|rcsb pdb:7C9W|reactome:R-HSA-373080|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-977606|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR035976|rcsb pdb:1H03|rcsb pdb:1H04|rcsb pdb:1H2P|rcsb pdb:1H2Q|rcsb pdb:1M11|rcsb pdb:1NWV|rcsb pdb:1OJV|rcsb pdb:1OJW|rcsb pdb:1OJY|rcsb pdb:1OK1|rcsb pdb:1OK2|rcsb pdb:1OK3|rcsb pdb:1OK9|rcsb pdb:1UOT|rcsb pdb:1UPN|rcsb pdb:2C8I|rcsb pdb:2QZD|rcsb pdb:2QZF|rcsb pdb:2QZH|rcsb pdb:3IYP|rcsb pdb:3J24|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:5FOA|rcsb pdb:6ILJ|rcsb pdb:6ILK|ensembl:ENSG00000196352(gene)|ensembl:ENST00000367064(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002456"(T cell mediated immunity)	-	-	-	figure legend:Figs. 4B, 6, 7, 8 Table 1|comment:Interaction is calcium dependent|inhibition:"EGTA (CHEBI:30740)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.7x10^-5(molar)	2021/01/11	2021/01/11	rogid:aWUi+Tfw2CgnBrGu/eMmHP3eoCg9606	rogid:5sa2K9j8EDzc3zJAe72+YVHTM/o9606	rigid:3A3jxUdQb13aSkmj33q1RfAtoPw	false	sufficient binding region:22..22-159..159|mutation decreasing interaction strength:33-33|mutation decreasing interaction strength:59-59|mutation decreasing interaction strength:71-71	sufficient binding region:35..35-285..285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHX3	uniprotkb:P08174	intact:EBI-11277970|uniprotkb:B4DQ96|uniprotkb:E7ESD7|uniprotkb:E9PBR1|uniprotkb:E9PEL6|uniprotkb:E9PFQ5|uniprotkb:E9PG91|uniprotkb:Q8NG96|uniprotkb:Q9Y4B1|ensembl:ENSP00000319883	intact:EBI-1033846|uniprotkb:P09679|uniprotkb:P78361|uniprotkb:B1AP14|uniprotkb:D3DT83|uniprotkb:D3DT84|ensembl:ENSP00000356031|uniprotkb:E7ER69|uniprotkb:Q14UF2|uniprotkb:Q14UF3|uniprotkb:Q14UF4|uniprotkb:Q14UF5|uniprotkb:Q14UF6	psi-mi:agre2_human(display_long)|uniprotkb:ADGRE2(gene name)|psi-mi:ADGRE2(display_short)|uniprotkb:EGF-like module receptor 2(gene name synonym)|uniprotkb:EGF-like module-containing mucin-like hormone receptor-like 2(gene name synonym)|uniprotkb:EMR2(gene name synonym)	psi-mi:daf_human(display_long)|uniprotkb:CD55(gene name)|psi-mi:CD55(display_short)|uniprotkb:CR(gene name synonym)|uniprotkb:DAF(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Lin et al. (2001)	pubmed:11297558|imex:IM-28625	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26585164|imex:IM-28625-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001257981.1|refseq:NP_038475.2|ensembl:ENSG00000127507(gene)|ensembl:ENST00000315576(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0071621"(granulocyte chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000203(GPS)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003056(GPCR, family 2, CD97 antigen)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR018097|rcsb pdb:2BO2|rcsb pdb:2BOU|rcsb pdb:2BOX|reactome:R-HSA-373080	refseq:NP_000565.1|refseq:NP_001108224.1|refseq:NP_001287832.1|refseq:NP_001287833.1|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0030133"(transport vesicle)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045730"(respiratory burst)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|rcsb pdb:6LA5|rcsb pdb:7C9W|reactome:R-HSA-373080|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-977606|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR035976|rcsb pdb:1H03|rcsb pdb:1H04|rcsb pdb:1H2P|rcsb pdb:1H2Q|rcsb pdb:1M11|rcsb pdb:1NWV|rcsb pdb:1OJV|rcsb pdb:1OJW|rcsb pdb:1OJY|rcsb pdb:1OK1|rcsb pdb:1OK2|rcsb pdb:1OK3|rcsb pdb:1OK9|rcsb pdb:1UOT|rcsb pdb:1UPN|rcsb pdb:2C8I|rcsb pdb:2QZD|rcsb pdb:2QZF|rcsb pdb:2QZH|rcsb pdb:3IYP|rcsb pdb:3J24|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:5FOA|rcsb pdb:6ILJ|rcsb pdb:6ILK|ensembl:ENSG00000196352(gene)|ensembl:ENST00000367064(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002456"(T cell mediated immunity)	-	-	-	figure legend:Figs.7, 8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/01/11	2021/01/11	rogid:A8r/FtLZpm2oh9g3+NDylgxNC889606	rogid:5sa2K9j8EDzc3zJAe72+YVHTM/o9606	rigid:p01d3xoXolERSQ5mSV8r9iCOnwE	false	sufficient binding region:25..25-162..162|mutation causing an interaction:36-36|mutation causing an interaction:62-62|mutation causing an interaction:74-74	sufficient binding region:35..35-285..285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)