#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51798	uniprotkb:Q86WC4	intact:EBI-4402346|uniprotkb:A6NEJ7|uniprotkb:A8K5T9|uniprotkb:Q9NYX5|ensembl:ENSP00000372193|uniprotkb:A8K7X1|uniprotkb:B3KPN3|uniprotkb:E9PDB9	intact:EBI-11037160|uniprotkb:E1P5E3|uniprotkb:Q8NC29|uniprotkb:Q9Y2S9|uniprotkb:Q8TC82|uniprotkb:Q6PCA7|uniprotkb:Q7RTW6|uniprotkb:Q5R391|ensembl:ENSP00000193322	psi-mi:clcn7_human(display_long)|uniprotkb:CLCN7(gene name)|psi-mi:CLCN7(display_short)|uniprotkb:Chloride channel protein 7(gene name synonym)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym)	psi-mi:ostm1_human(display_long)|uniprotkb:OSTM1(gene name)|psi-mi:OSTM1(display_short)|uniprotkb:Chloride channel 7 beta subunit(gene name synonym)|uniprotkb:GL(gene name synonym)|uniprotkb:HSPC019(orf name)|uniprotkb:UNQ6098/PRO21201(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Zhang et al. (2020)	pubmed:32851177|imex:IM-28508	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26451341|wwpdb:7bxu|emdb:EMD-30238|imex:IM-28508-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278.1|ensembl:ENST00000382745(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|mint:P51798|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351|ensembl:ENSG00000103249(gene)|refseq:NP_001107803.1	refseq:NP_054747.2|ensembl:ENSG00000081087(gene)|ensembl:ENST00000193322(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030316"(osteoclast differentiation)|interpro:IPR019172|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351	-	-	-	figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2020/11/13	2020/11/19	rogid:ze820JsKN1GtxH/lcPnPWN78k1I9606	rogid:30epOrIN64V4S7x6hVoKZcGHd949606	rigid:s5R0S70N8/Qox9RkDLXHazwMFxE	false	strep tag:c-c	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P51798	uniprotkb:Q86WC4	intact:EBI-4402346|uniprotkb:A6NEJ7|uniprotkb:A8K5T9|uniprotkb:Q9NYX5|ensembl:ENSP00000372193|uniprotkb:A8K7X1|uniprotkb:B3KPN3|uniprotkb:E9PDB9	intact:EBI-11037160|uniprotkb:E1P5E3|uniprotkb:Q8NC29|uniprotkb:Q9Y2S9|uniprotkb:Q8TC82|uniprotkb:Q6PCA7|uniprotkb:Q7RTW6|uniprotkb:Q5R391|ensembl:ENSP00000193322	psi-mi:clcn7_human(display_long)|uniprotkb:CLCN7(gene name)|psi-mi:CLCN7(display_short)|uniprotkb:Chloride channel protein 7(gene name synonym)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym)	psi-mi:ostm1_human(display_long)|uniprotkb:OSTM1(gene name)|psi-mi:OSTM1(display_short)|uniprotkb:Chloride channel 7 beta subunit(gene name synonym)|uniprotkb:GL(gene name synonym)|uniprotkb:HSPC019(orf name)|uniprotkb:UNQ6098/PRO21201(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2020)	pubmed:32851177|imex:IM-28508	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26451354|imex:IM-28508-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278.1|ensembl:ENST00000382745(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|mint:P51798|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351|ensembl:ENSG00000103249(gene)|refseq:NP_001107803.1	refseq:NP_054747.2|ensembl:ENSG00000081087(gene)|ensembl:ENST00000193322(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030316"(osteoclast differentiation)|interpro:IPR019172|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351	-	-	-	figure legend:Fig.2E|comment:"The CLC-7 E416A mutation resulted in a  remarkably reduced protein level compared with wild-type (WT)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2020/11/13	2020/11/19	rogid:ze820JsKN1GtxH/lcPnPWN78k1I9606	rogid:30epOrIN64V4S7x6hVoKZcGHd949606	rigid:s5R0S70N8/Qox9RkDLXHazwMFxE	false	strep tag:c-c	flag tag:c-c|mutation decreasing interaction strength:300-300	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51798	uniprotkb:Q86WC4	intact:EBI-4402346|uniprotkb:A6NEJ7|uniprotkb:A8K5T9|uniprotkb:Q9NYX5|ensembl:ENSP00000372193|uniprotkb:A8K7X1|uniprotkb:B3KPN3|uniprotkb:E9PDB9	intact:EBI-11037160|uniprotkb:E1P5E3|uniprotkb:Q8NC29|uniprotkb:Q9Y2S9|uniprotkb:Q8TC82|uniprotkb:Q6PCA7|uniprotkb:Q7RTW6|uniprotkb:Q5R391|ensembl:ENSP00000193322	psi-mi:clcn7_human(display_long)|uniprotkb:CLCN7(gene name)|psi-mi:CLCN7(display_short)|uniprotkb:Chloride channel protein 7(gene name synonym)|uniprotkb:Chloride channel 7 alpha subunit(gene name synonym)	psi-mi:ostm1_human(display_long)|uniprotkb:OSTM1(gene name)|psi-mi:OSTM1(display_short)|uniprotkb:Chloride channel 7 beta subunit(gene name synonym)|uniprotkb:GL(gene name synonym)|uniprotkb:HSPC019(orf name)|uniprotkb:UNQ6098/PRO21201(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2020)	pubmed:32851177|imex:IM-28508	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26451367|imex:IM-28508-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278.1|ensembl:ENST00000382745(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009268"(response to pH)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002249(Chloride channel CLC-7)|interpro:IPR014743(Chloride channel, core)|mint:P51798|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351|ensembl:ENSG00000103249(gene)|refseq:NP_001107803.1	refseq:NP_054747.2|ensembl:ENSG00000081087(gene)|ensembl:ENST00000193322(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030316"(osteoclast differentiation)|interpro:IPR019172|rcsb pdb:7BXU|rcsb pdb:7CQ5|rcsb pdb:7CQ6|rcsb pdb:7CQ7|rcsb pdb:7JM7|reactome:R-HSA-2672351	-	-	-	figure legend:Fig.2E|comment:"The CLC-7 E416A mutation resulted in a remarkably reduced protein level compared with wild-type (WT)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2020/11/13	2020/11/19	rogid:ze820JsKN1GtxH/lcPnPWN78k1I9606	rogid:30epOrIN64V4S7x6hVoKZcGHd949606	rigid:s5R0S70N8/Qox9RkDLXHazwMFxE	false	strep tag:c-c	flag tag:c-c|mutation decreasing interaction strength:300-300	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)