#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C6Y4-PRO_0000037377	uniprotkb:P0C6Y4-PRO_0000037377	intact:EBI-25590411	intact:EBI-25590411	psi-mi:p0c6y4-pro_0000037377(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0c6y4-pro_0000037377(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Zeng et al. (2018)	pubmed:29925659|imex:IM-27942	taxid:229032(pedv)|taxid:229032("Porcine epidemic diarrhea virus (strain CV777)")	taxid:229032(pedv)|taxid:229032("Porcine epidemic diarrhea virus (strain CV777)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590339|wwpdb:5hiz|imex:IM-27942-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25590344(chain-parent)	intact:EBI-25590344(chain-parent)	-	chain-seq-start:3858|chain-seq-end:3965	chain-seq-start:3858|chain-seq-end:3965	figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/27	2020/04/27	rogid:vHEEesVqQVUFAdnDgmh237gQlxM229032	rogid:vHEEesVqQVUFAdnDgmh237gQlxM229032	rigid:1d2LVd30fr/EXS9PK+DobskifBM	false	his tag:c-c	his tag:c-c	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:X2G6C4	uniprotkb:X2G6C4	intact:EBI-25590436	intact:EBI-25590436	psi-mi:x2g6c4_9nido(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:x2g6c4_9nido(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zeng et al. (2018)	pubmed:29925659|imex:IM-27942	taxid:1159905(Porcine coronavirus HKU15)|taxid:1159905(Porcine coronavirus HKU15)	taxid:1159905(Porcine coronavirus HKU15)|taxid:1159905(Porcine coronavirus HKU15)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590421|wwpdb:5ym6|wwpdb:5ym8|imex:IM-27942-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0019082"(viral protein processing)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037204|interpro:IPR043178|rcsb pdb:5YM6|rcsb pdb:5YM8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR038123|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043504|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR044307|interpro:IPR044317|interpro:IPR044324|interpro:IPR044331|interpro:IPR044343|interpro:IPR044354|interpro:IPR044365|interpro:IPR044371|interpro:IPR044383|interpro:IPR044401	go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0019082"(viral protein processing)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037204|interpro:IPR043178|rcsb pdb:5YM6|rcsb pdb:5YM8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR038123|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043504|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR044307|interpro:IPR044317|interpro:IPR044324|interpro:IPR044331|interpro:IPR044343|interpro:IPR044354|interpro:IPR044365|interpro:IPR044371|interpro:IPR044383|interpro:IPR044401	-	-	-	figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/27	2020/04/27	rogid:hOTetg5GymnYzjefkB+cQepluUQ1159905	rogid:hOTetg5GymnYzjefkB+cQepluUQ1159905	rigid:i2w5E88iUO2OIfCHiipndBRjd58	false	his tag:c-c|sufficient binding region:3378-3486(IPR014822)|mutation disrupting interaction strength:3378-3384	his tag:c-c|sufficient binding region:3378-3486(IPR014822)|mutation disrupting interaction strength:3378-3384	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C6Y4-PRO_0000037377	uniprotkb:P0C6Y4-PRO_0000037377	intact:EBI-25590411	intact:EBI-25590411	psi-mi:p0c6y4-pro_0000037377(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0c6y4-pro_0000037377(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Zeng et al. (2018)	pubmed:29925659|imex:IM-27942	taxid:229032(pedv)|taxid:229032("Porcine epidemic diarrhea virus (strain CV777)")	taxid:229032(pedv)|taxid:229032("Porcine epidemic diarrhea virus (strain CV777)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590513|wwpdb:5hiy|imex:IM-27942-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25590344(chain-parent)	intact:EBI-25590344(chain-parent)	-	chain-seq-start:3858|chain-seq-end:3965	chain-seq-start:3858|chain-seq-end:3965	figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/27	2020/04/27	rogid:vHEEesVqQVUFAdnDgmh237gQlxM229032	rogid:vHEEesVqQVUFAdnDgmh237gQlxM229032	rigid:1d2LVd30fr/EXS9PK+DobskifBM	false	his tag:c-c|mutation:59-59	his tag:c-c|mutation:59-59	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:X2G6C4	uniprotkb:X2G6C4	intact:EBI-25590436	intact:EBI-25590436	psi-mi:x2g6c4_9nido(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:x2g6c4_9nido(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Zeng et al. (2018)	pubmed:29925659|imex:IM-27942	taxid:1159905(Porcine coronavirus HKU15)|taxid:1159905(Porcine coronavirus HKU15)	taxid:1159905(Porcine coronavirus HKU15)|taxid:1159905(Porcine coronavirus HKU15)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590532|imex:IM-27942-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0019082"(viral protein processing)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037204|interpro:IPR043178|rcsb pdb:5YM6|rcsb pdb:5YM8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR038123|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043504|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR044307|interpro:IPR044317|interpro:IPR044324|interpro:IPR044331|interpro:IPR044343|interpro:IPR044354|interpro:IPR044365|interpro:IPR044371|interpro:IPR044383|interpro:IPR044401	go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0019082"(viral protein processing)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037204|interpro:IPR043178|rcsb pdb:5YM6|rcsb pdb:5YM8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR038123|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043504|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR044307|interpro:IPR044317|interpro:IPR044324|interpro:IPR044331|interpro:IPR044343|interpro:IPR044354|interpro:IPR044365|interpro:IPR044371|interpro:IPR044383|interpro:IPR044401	-	-	-	figure legend:Fig. 2 H, 2E, 2G|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/27	2020/04/27	rogid:hOTetg5GymnYzjefkB+cQepluUQ1159905	rogid:hOTetg5GymnYzjefkB+cQepluUQ1159905	rigid:i2w5E88iUO2OIfCHiipndBRjd58	false	his tag:c-c|sufficient binding region:3378-3486(IPR014822)|mutation disrupting interaction strength:3378-3384|mutation decreasing interaction strength:3381-3381,3383-3385	his tag:c-c|sufficient binding region:3378-3486(IPR014822)|mutation disrupting interaction strength:3378-3384|mutation decreasing interaction strength:3381-3381,3383-3385	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:X2G6C4	uniprotkb:X2G6C4	intact:EBI-25590436	intact:EBI-25590436	psi-mi:x2g6c4_9nido(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:x2g6c4_9nido(display_long)|uniprotkb:orf1ab(gene name)|psi-mi:orf1ab(display_short)|uniprotkb:Growth factor-like peptide(gene name synonym)|uniprotkb:Helicase(gene name synonym)|uniprotkb:NendoU(gene name synonym)|uniprotkb:Non-structural protein 10(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4(gene name synonym)|uniprotkb:Non-structural protein 6(gene name synonym)|uniprotkb:Non-structural protein 7(gene name synonym)|uniprotkb:Non-structural protein 8(gene name synonym)|uniprotkb:Non-structural protein 9(gene name synonym)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Replicase polyprotein 1ab(gene name synonym)|uniprotkb:Uridylate-specific endoribonuclease(gene name synonym)|uniprotkb:Papain-like proteinase(gene name synonym)|uniprotkb:nsp5(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Zeng et al. (2018)	pubmed:29925659|imex:IM-27942	taxid:1159905(Porcine coronavirus HKU15)|taxid:1159905(Porcine coronavirus HKU15)	taxid:1159905(Porcine coronavirus HKU15)|taxid:1159905(Porcine coronavirus HKU15)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590554|imex:IM-27942-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0019082"(viral protein processing)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037204|interpro:IPR043178|rcsb pdb:5YM6|rcsb pdb:5YM8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR038123|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043504|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR044307|interpro:IPR044317|interpro:IPR044324|interpro:IPR044331|interpro:IPR044343|interpro:IPR044354|interpro:IPR044365|interpro:IPR044371|interpro:IPR044383|interpro:IPR044401	go:"GO:0032259"(methylation)|go:"GO:0033644"(host cell membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0019082"(viral protein processing)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR037204|interpro:IPR043178|rcsb pdb:5YM6|rcsb pdb:5YM8|interpro:IPR027351|interpro:IPR032505|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR027352|interpro:IPR037227|interpro:IPR002589(Appr-1-p processing)|interpro:IPR036333|interpro:IPR009466(NSP11)|interpro:IPR042515|interpro:IPR038123|interpro:IPR014829(Nsp8 replicase)|interpro:IPR037230|interpro:IPR014822(Nsp9 replicase)|interpro:IPR036499|interpro:IPR027417|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR018995|interpro:IPR029063|interpro:IPR043174|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043502|interpro:IPR043504|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR044307|interpro:IPR044317|interpro:IPR044324|interpro:IPR044331|interpro:IPR044343|interpro:IPR044354|interpro:IPR044365|interpro:IPR044371|interpro:IPR044383|interpro:IPR044401	-	-	-	figure legend:Fig. 2F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/27	2020/04/27	rogid:hOTetg5GymnYzjefkB+cQepluUQ1159905	rogid:hOTetg5GymnYzjefkB+cQepluUQ1159905	rigid:i2w5E88iUO2OIfCHiipndBRjd58	false	his tag:c-c|sufficient binding region:3378-3486(IPR014822)|mutation disrupting interaction strength:3378-3384|mutation with no effect:3381-3381,3383-3385|mutation with no effect:3384-3384|mutation with no effect:3473-3473|mutation with no effect:3477-3477	his tag:c-c|sufficient binding region:3378-3486(IPR014822)|mutation disrupting interaction strength:3378-3384|mutation with no effect:3381-3381,3383-3385|mutation with no effect:3384-3384|mutation with no effect:3473-3473|mutation with no effect:3477-3477	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C6Y4-PRO_0000037377	uniprotkb:P0C6Y4-PRO_0000037377	intact:EBI-25590411	intact:EBI-25590411	psi-mi:p0c6y4-pro_0000037377(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0c6y4-pro_0000037377(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0028"(cosedimentation in solution)	Zeng et al. (2018)	pubmed:29925659|imex:IM-27942	taxid:229032(pedv)|taxid:229032("Porcine epidemic diarrhea virus (strain CV777)")	taxid:229032(pedv)|taxid:229032("Porcine epidemic diarrhea virus (strain CV777)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25590575|imex:IM-27942-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25590344(chain-parent)	intact:EBI-25590344(chain-parent)	-	chain-seq-start:3858|chain-seq-end:3965	chain-seq-start:3858|chain-seq-end:3965	figure legend:Fig. 5E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/27	2020/04/27	rogid:vHEEesVqQVUFAdnDgmh237gQlxM229032	rogid:vHEEesVqQVUFAdnDgmh237gQlxM229032	rigid:1d2LVd30fr/EXS9PK+DobskifBM	false	his tag:c-c|mutation disrupting interaction strength:59-59	his tag:c-c|mutation disrupting interaction strength:59-59	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)