#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424240|imex:IM-27705-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 9C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/10	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	-	necessary binding region:35..35-786..794|myc tag:34-35	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P04626	uniprotkb:Q96JA1	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424380|imex:IM-27705-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 10C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/11	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:C8XtNJEioAYajSx8uzBvkEg531s	false	-	myc tag:34-35|necessary binding region:35..35-786..794	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424248|imex:IM-27705-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 11C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/10	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	necessary binding region:25..25-775..775	myc tag:34-35	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04626	uniprotkb:Q6UXM1	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424266|imex:IM-27705-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	-	-	-	figure legend:Figure 4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/11	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rigid:M5+1gsCw+/Bco+95Mq0tkjje6rk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04626	uniprotkb:Q96JA1	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424266|imex:IM-27705-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/11	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:M5+1gsCw+/Bco+95Mq0tkjje6rk	false	-	myc tag:34-35	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04626	uniprotkb:Q96JA1	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424275|imex:IM-27705-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 4|antagonist:"Lrig3 (Q6UXM1)"|comment:The amount of Lrig1 precipitating with ErbB2 reproducibly decreased when Lrig3 was co-expressed.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/11	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:C8XtNJEioAYajSx8uzBvkEg531s	false	-	myc tag:34-35	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424312|imex:IM-27705-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 6B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2020/01/27	2020/02/11	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424320|imex:IM-27705-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 6C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2020/01/27	2020/02/11	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424324|imex:IM-27705-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 6D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2020/01/27	2020/02/11	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	-	myc tag:34-35	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424332|imex:IM-27705-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 6D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2020/01/27	2020/02/11	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	-	myc tag:34-35	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6UXM1	uniprotkb:Q96JA1	intact:EBI-9207843|uniprotkb:Q6UXL7|uniprotkb:Q8NC72|ensembl:ENSP00000326759	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:lrig3_human(display_long)|uniprotkb:LRIG3(gene name)|psi-mi:LRIG3(display_short)|uniprotkb:LIG3(gene name synonym)|uniprotkb:UNQ287/PRO326/PRO335(orf name)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rafidi et al. (2013)	imex:IM-27705|pubmed:23723069	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25424346|imex:IM-27705-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129523.1|refseq:NP_700356.2|ensembl:ENSG00000139263(gene)|ensembl:ENST00000320743(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:Figure 6E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/01/27	2020/02/11	rogid:ohe6qXWAkJCiiDq1Fj+RnyvD2k09606	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:wHbhbAecaV99o4iD+HeVQ3GrEC4	false	ha tag:?-?	myc tag:34-35	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)