#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C6U8	uniprotkb:P0C6X7	intact:EBI-15810860|uniprotkb:P59641	intact:EBI-7843867|uniprotkb:Q6WGN0|uniprotkb:Q808C0|uniprotkb:P59641|uniprotkb:Q80BV8|uniprotkb:Q80BV7|intact:MINT-1487760|uniprotkb:Q80E51|uniprotkb:Q7T697	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:r1ab_sars(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Chen et al. (2011)	pubmed:22022266|imex:IM-28545	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25826073|wwpdb:3R24|imex:IM-28545-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N|genbank identifier:JN247394(identity)	rcsb pdb:5N19|rcsb pdb:5N5O|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR013016(Peptidase C30/C16)|rcsb pdb:7LCP|rcsb pdb:7LCQ|rcsb pdb:5F22|rcsb pdb:5C8S|rcsb pdb:5C8T|rcsb pdb:5C8U|rcsb pdb:5E6J|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR032505|interpro:IPR032592|rcsb pdb:4TWW|rcsb pdb:4TWY|rcsb pdb:4WY3|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:6LNQ|interpro:IPR043502|rcsb pdb:5NFY|rcsb pdb:4ZUH|rcsb pdb:5B6O|rcsb pdb:5C5N|rcsb pdb:5C5O|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|rcsb pdb:2GA6|rcsb pdb:1WOF|rcsb pdb:2QC2|rcsb pdb:1Z1J|rcsb pdb:2OZK|rcsb pdb:2Z3C|rcsb pdb:2RHB|rcsb pdb:2FAV|interpro:IPR018995|rcsb pdb:2GTB|interpro:IPR014828(Nsp7 replicase)|rcsb pdb:2GDT|interpro:IPR027352|rcsb pdb:2ALV|rcsb pdb:2JZF|rcsb pdb:2QIQ|rcsb pdb:2K87|rcsb pdb:2A5I|rcsb pdb:1UK4|interpro:IPR024375|rcsb pdb:1P9T|rcsb pdb:2D2D|rcsb pdb:3R24|rcsb pdb:2GT7|rcsb pdb:2AJ5|interpro:IPR027351|rcsb pdb:2G1F|rcsb pdb:2FE8|rcsb pdb:2GT8|rcsb pdb:1UK3|rcsb pdb:2H85|rcsb pdb:2BX3|rcsb pdb:1Q1X|rcsb pdb:2BX4|interpro:IPR021590|rcsb pdb:2Z9G|rcsb pdb:2ACF|rcsb pdb:1UK2|rcsb pdb:2GRI|rcsb pdb:2A5K|rcsb pdb:1SXF|rcsb pdb:2PWX|interpro:IPR014829(Nsp8 replicase)|interpro:IPR027417|interpro:IPR024358|rcsb pdb:3D62|rcsb pdb:2Z9J|rcsb pdb:2Z3E|rcsb pdb:2GZ8|rcsb pdb:1O5S|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|rcsb pdb:2AMD|rcsb pdb:2Z9K|rcsb pdb:1Q2W|rcsb pdb:2VJ1|rcsb pdb:2H2Z|rcsb pdb:2GX4|rcsb pdb:2AHM|rcsb pdb:1UJ1|rcsb pdb:2V6N|rcsb pdb:2HOB|rcsb pdb:1QZ8|rcsb pdb:2Z3D|rcsb pdb:1PA5|rcsb pdb:3EBN|rcsb pdb:2OP9|rcsb pdb:2DUC|rcsb pdb:2QCY|rcsb pdb:2JZD|rcsb pdb:2Q6G|rcsb pdb:1PUK|rcsb pdb:1UW7|rcsb pdb:2GZ9|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:2JZE|rcsb pdb:2C3S|rcsb pdb:2XYQ|rcsb pdb:2XYV|rcsb pdb:2AMQ|rcsb pdb:3E9S|rcsb pdb:2IDY|rcsb pdb:2Z9L|rcsb pdb:2RNK|rcsb pdb:2A5A|interpro:IPR022733|rcsb pdb:2GZ7|rcsb pdb:2Z94|rcsb pdb:1P76|interpro:IPR014822(Nsp9 replicase)|rcsb pdb:2HSX|rcsb pdb:2FYG|rcsb pdb:2XYR|rcsb pdb:2G9T|interpro:IPR042515|rcsb pdb:6NUR|rcsb pdb:6NUS|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|interpro:IPR044401|interpro:IPR029063|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037227|interpro:IPR037230|interpro:IPR042570|rcsb pdb:6JYT|interpro:IPR043503|interpro:IPR043504|rcsb pdb:6W79|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:2K7X|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|refseq:NP_828849.2|rcsb pdb:6WCO|genbank identifier:JN247397(identity)	-	-	crc64:E6504CAFDC36BC09|comment:mint|function:"The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products"|function:"The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc"|function:"The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function"|function:"The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium"|function:The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction|function:Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter|function:Nsp9 is a ssRNA-binding protein|function:"NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond"	figure legend:Figure 4A, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/30	2021/03/29	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	rogid:kCQUYVz2xMpwIvb+ZIpnIrNl9GI694009	-	false	his tag:n-n|binding-associated region:4240-4382	his tag:n-n|binding-associated region:6776-7073	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:15414"	uniprotkb:P0C6U8	intact:EBI-980183	intact:EBI-15810860|uniprotkb:P59641	psi-mi:s-adenosyl-l-methionine(display_short)|psi-mi:"CHEBI:15414"(display_long)	psi-mi:r1a_sars(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Chen et al. (2011)	pubmed:22022266|imex:IM-28545	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25826073|wwpdb:3R24|imex:IM-28545-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042570|interpro:IPR043177|interpro:IPR043178|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR043503|interpro:IPR043504|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|rcsb pdb:1P76|rcsb pdb:1P9T|rcsb pdb:1PA5|rcsb pdb:1PUK|go:"GO:0039604"(suppression by virus of host translation)|rcsb pdb:1Q1X|rcsb pdb:1Q2W|rcsb pdb:1QZ8|rcsb pdb:1UJ1|rcsb pdb:1UK3|rcsb pdb:1UK4|rcsb pdb:1UW7|rcsb pdb:1WOF|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:1Z1J|rcsb pdb:2A5A|rcsb pdb:2A5I|rcsb pdb:2A5K|rcsb pdb:2ACF|rcsb pdb:2AHM|rcsb pdb:2AJ5|rcsb pdb:2ALV|rcsb pdb:2AMD|rcsb pdb:2AMQ|rcsb pdb:2BX3|rcsb pdb:2BX4|rcsb pdb:2C3S|rcsb pdb:2D2D|rcsb pdb:2DUC|rcsb pdb:2FAV|rcsb pdb:2FE8|rcsb pdb:2FYG|rcsb pdb:2G9T|rcsb pdb:2GA6|rcsb pdb:2GDT|rcsb pdb:2GRI|rcsb pdb:2GT7|rcsb pdb:2GT8|rcsb pdb:2GTB|rcsb pdb:2GX4|rcsb pdb:2GZ7|rcsb pdb:2GZ8|rcsb pdb:2GZ9|rcsb pdb:2H2Z|rcsb pdb:2HOB|rcsb pdb:2HSX|rcsb pdb:2IDY|rcsb pdb:2KAF|rcsb pdb:2KQV|rcsb pdb:2KQW|rcsb pdb:2KYS|rcsb pdb:2LIZ|rcsb pdb:2OP9|rcsb pdb:2PWX|rcsb pdb:2W2G|rcsb pdb:2WCT|rcsb pdb:2Z3C|rcsb pdb:2Z3D|rcsb pdb:2Z3E|rcsb pdb:2ZU4|rcsb pdb:2ZU5|rcsb pdb:3ATW|rcsb pdb:3AVZ|rcsb pdb:3AW0|rcsb pdb:3AW1|rcsb pdb:3E91|rcsb pdb:3EA7|rcsb pdb:3EA8|rcsb pdb:3EA9|rcsb pdb:3EAJ|rcsb pdb:3EE7|rcsb pdb:3F9E|rcsb pdb:3F9F|rcsb pdb:3F9G|rcsb pdb:3F9H|rcsb pdb:3FZD|rcsb pdb:3IWM|rcsb pdb:3M3S|rcsb pdb:3M3T|rcsb pdb:3M3V|rcsb pdb:3MJ5|rcsb pdb:3R24|rcsb pdb:3SN8|rcsb pdb:3SNA|rcsb pdb:3SNB|rcsb pdb:3SNC|rcsb pdb:3SND|rcsb pdb:3SNE|rcsb pdb:1UK2|rcsb pdb:3SZN|rcsb pdb:3TIT|rcsb pdb:3TIU|rcsb pdb:3TNS|rcsb pdb:3TNT|rcsb pdb:3V3M|rcsb pdb:3VB3|rcsb pdb:3VB4|rcsb pdb:3VB5|rcsb pdb:3VB6|rcsb pdb:3VB7|rcsb pdb:4HI3|rcsb pdb:4M0W|rcsb pdb:4MDS|rcsb pdb:4MM3|rcsb pdb:4OVZ|rcsb pdb:4OW0|rcsb pdb:5F22|rcsb pdb:5Y3E|rcsb pdb:5Y3Q|rcsb pdb:6LNY|rcsb pdb:6NUR|rcsb pdb:6NUS|rcsb pdb:6W2A|rcsb pdb:6XHL|rcsb pdb:6XHN|rcsb pdb:6XHO|rcsb pdb:6Y7M|rcsb pdb:6YXJ|rcsb pdb:6LO0|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|dip:DIP-48580N|genbank identifier:JN247394(identity)	-	-	-	figure legend:Figure 4A, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/08/30	2021/03/29	-	rogid:zwPSRRjRlqC4IBqawJVQzY4HMGs694009	-	false	-	his tag:n-n|binding-associated region:4240-4382	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)