#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473418|imex:IM-27811-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:2A|comment:Collagen type 6 was also pulled down but cannot be further identified.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	-	sufficient binding region:69-653|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473440|imex:IM-27811-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:2B|comment:Collagen type 6 was also pulled down but cannot be further identified.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473817|imex:IM-27811-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:Figure 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hcf)|taxid:9606(human corneal fibroblast cell line)	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473829|imex:IM-27811-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:Figure 2D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hcf)|taxid:9606(human corneal fibroblast cell line)	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
refseq:XP_006232398.1	uniprotkb:Q15582	intact:EBI-25473213	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:periostin_rat(display_long)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473898|imex:IM-27811-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:3B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/11	2020/03/20	rogid:vf7zNSjtA2po9oGa+lHagSXgCzE10116	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:yaKtEGs+QLuiJgGYAwIRg88lpZs	false	green fluorescent protein tag:c-c	v5 tag:c-c|his tag:c-c|sufficient binding region:1-198,417-683|necessary binding region:1-139	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
refseq:XP_006232398.1	uniprotkb:Q15582	intact:EBI-25473213	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:periostin_rat(display_long)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473954|imex:IM-27811-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:3D, 5A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/11	2020/03/20	rogid:vf7zNSjtA2po9oGa+lHagSXgCzE10116	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:yaKtEGs+QLuiJgGYAwIRg88lpZs	false	necessary binding region:1-138|green fluorescent protein tag:c-c	mutation disrupting interaction strength:124-124(rs121909211)|mutation increasing interaction strength:124-124(rs121909210)|mutation decreasing interaction strength:124-124(rs121909211)|mutation decreasing interaction strength:555-555(rs121909208)|mutation decreasing interaction strength:555-555(rs121909209)|v5 tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
refseq:XP_006232398.1	uniprotkb:Q15582	intact:EBI-25473213	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:periostin_rat(display_long)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473975|imex:IM-27811-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:3F|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/11	2020/03/20	rogid:vf7zNSjtA2po9oGa+lHagSXgCzE10116	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:yaKtEGs+QLuiJgGYAwIRg88lpZs	false	sufficient binding region:1-138|green fluorescent protein tag:c-c	v5 tag:c-c|his tag:c-c|necessary binding region:1-138	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
refseq:XP_006232398.1	uniprotkb:Q15582	intact:EBI-25473213	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:periostin_rat(display_long)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25473990|imex:IM-27811-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	-	-	-	figure legend:3H|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/11	2020/03/20	rogid:vf7zNSjtA2po9oGa+lHagSXgCzE10116	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:yaKtEGs+QLuiJgGYAwIRg88lpZs	false	necessary binding region:1-132|green fluorescent protein tag:c-c	v5 tag:c-c|his tag:c-c|sufficient binding region:1-138	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
refseq:XP_006232398.1	uniprotkb:Q15582	intact:EBI-25473213	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:periostin_rat(display_long)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25474419|imex:IM-27811-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	go:"GO:0005802"(trans-Golgi network)	-	-	figure legend:4A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2020/03/11	2020/03/20	rogid:vf7zNSjtA2po9oGa+lHagSXgCzE10116	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:yaKtEGs+QLuiJgGYAwIRg88lpZs	false	green fluorescent protein tag:c-c	v5 tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25474520|imex:IM-27811-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	orphanet:"ORPHA:98963"(see-also)	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:Figure 5C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	-	mutation disrupting interaction strength:124-124(VCV000007869)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25474439|imex:IM-27811-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	go:"GO:0005802"(trans-Golgi network)	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:4B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hcf)|taxid:9606(human corneal fibroblast cell line)	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q15063	uniprotkb:Q15582	intact:EBI-7067070|uniprotkb:B1ALD8|uniprotkb:C0IMJ1|uniprotkb:C0IMJ2|uniprotkb:C0IMJ4|uniprotkb:D2KRH7|uniprotkb:F5H628|ensembl:ENSP00000369071|uniprotkb:Q29XZ0|uniprotkb:Q3KPJ5|intact:MINT-4533078|uniprotkb:Q5VSY5|uniprotkb:Q8IZF9|uniprotkb:Q15064	intact:EBI-10236573|uniprotkb:D3DQB1|uniprotkb:O43218|uniprotkb:O43217|uniprotkb:O14476|uniprotkb:O14472|uniprotkb:O43216|uniprotkb:O43219|uniprotkb:Q53XM1|uniprotkb:O14471|ensembl:ENSP00000416330	psi-mi:postn_human(display_long)|uniprotkb:POSTN(gene name)|psi-mi:POSTN(display_short)|uniprotkb:OSF2(gene name synonym)|uniprotkb:Osteoblast-specific factor 2(gene name synonym)	psi-mi:bgh3_human(display_long)|uniprotkb:TGFBI(gene name)|psi-mi:TGFBI(display_short)|uniprotkb:BIGH3(gene name synonym)|uniprotkb:Kerato-epithelin(gene name synonym)|uniprotkb:RGD-containing collagen-associated protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kim et al. (2009)	imex:IM-27811|pubmed:19478074	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25474545|imex:IM-27811-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273594.1|refseq:NP_001273595.1|refseq:NP_001273596.1|ensembl:ENSG00000133110(gene)|ensembl:ENST00000379747(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009888"(tissue development)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032355"(response to estradiol)|go:"GO:0042060"(wound healing)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071307"(cellular response to vitamin K)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990523"(bone regeneration)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)|interpro:IPR036378|rcsb pdb:5WT7|rcsb pdb:5YJG|rcsb pdb:5YJH|refseq:NP_001129407.1|refseq:NP_001129408.1|refseq:NP_001129406.1|refseq:NP_006466.2|refseq:NP_001317446.1	refseq:NP_000349.1|interpro:IPR032954|interpro:IPR036378|rcsb pdb:1X3B|rcsb pdb:2LTB|rcsb pdb:2LTC|rcsb pdb:2VXP|rcsb pdb:5NV6|rcsb pdb:7AS7|rcsb pdb:7ASC|rcsb pdb:7ASG|reactome:R-HSA-977225|ensembl:ENSG00000120708(gene)|ensembl:ENST00000442011(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000782(Beta-Ig-H3/fasciclin)|interpro:IPR011489(EMI)|interpro:IPR016666(TGF beta-induced protein bIGH3/osteoblast-specific factor 2)	orphanet:"ORPHA:98963"(see-also)	function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion|comment:mint	-	figure legend:Figure 6D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2020/03/11	2020/03/20	rogid:CLXV/YO/iii17KfzgtjspMmH9Po9606	rogid:86Kh2QpWO6GxkrQsjbtqcBrKs4M9606	rigid:oChnZhxgFNHnbuJNQ4avHFOpe0s	false	-	mutation disrupting interaction strength:124-124(VCV000007869)	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)