#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35546	uniprotkb:Q96JA1	intact:EBI-2480800|ensembl:ENSMUSP00000032201|uniprotkb:Q8BQ34|uniprotkb:Q9QXH9	intact:EBI-2865191|uniprotkb:Q9BYB8|uniprotkb:Q96CF9|uniprotkb:Q6IQ51|uniprotkb:Q9UFI4|ensembl:ENSP00000273261	psi-mi:ret_mouse(display_long)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:lrig1_human(display_long)|uniprotkb:LRIG1(gene name)|psi-mi:LRIG1(display_short)|uniprotkb:LIG1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ledda et al. (2008)	pubmed:18171921|imex:IM-27714	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25425209|imex:IM-27714-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035799"(ureter maturation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000032201(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-8853659|reactome:R-MMU-5673001|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|rcsb pdb:1UEF|refseq:NP_001074249.1|refseq:NP_033076.2	refseq:NP_056356.2|ensembl:ENSG00000144749(gene)|ensembl:ENST00000273261(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|rcsb pdb:4U7L|rcsb pdb:4U7M|reactome:R-HSA-177929|reactome:R-HSA-6807004	-	-	-	figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mn1-1)|taxid:10090(mouse mn1-1)	-	2020/01/28	2020/02/13	rogid:BDIyZk6l26Iuth4Pce2alRhCG1Q10090	rogid:bnp2t5D9UqLg2EqOUJg6P6BVaE09606	rigid:ParH0xzf6Sn7MOixPQMVQW94MgY	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35546	uniprotkb:P70193	intact:EBI-2480800|ensembl:ENSMUSP00000032201|uniprotkb:Q8BQ34|uniprotkb:Q9QXH9	intact:EBI-25424165|ensembl:ENSMUSP00000032105|ensembl:ENSMUSP00000098686|ensembl:ENSMUSP00000144963|uniprotkb:E9QL89	psi-mi:ret_mouse(display_long)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:lrig1_mouse(display_long)|uniprotkb:Lrig1(gene name)|psi-mi:Lrig1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ledda et al. (2008)	pubmed:18171921|imex:IM-27714	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25425219|imex:IM-27714-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035799"(ureter maturation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000032201(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-8853659|reactome:R-MMU-5673001|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|rcsb pdb:1UEF|refseq:NP_001074249.1|refseq:NP_033076.2	ensembl:ENSMUSG00000030029(gene)|ensembl:ENSMUST00000032105(transcript)|ensembl:ENSMUST00000101126(transcript)|ensembl:ENSMUST00000204645(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|reactome:R-MMU-177929|reactome:R-MMU-6807004|refseq:NP_032403.2	-	-	-	figure legend:1F|agonist:"GDNF and GFRa1-Fc (origins not known)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mn1-1)|taxid:10090(mouse mn1-1)	-	2020/01/28	2020/02/13	rogid:BDIyZk6l26Iuth4Pce2alRhCG1Q10090	rogid:7HAE516imvVAkTFrFuWXac6rO5c10090	rigid:m/fkZpUg2CRypbMls9nK5HA+VsU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70193	uniprotkb:P35546	intact:EBI-25424165|ensembl:ENSMUSP00000032105|ensembl:ENSMUSP00000098686|ensembl:ENSMUSP00000144963|uniprotkb:E9QL89	intact:EBI-2480800|ensembl:ENSMUSP00000032201|uniprotkb:Q8BQ34|uniprotkb:Q9QXH9	psi-mi:lrig1_mouse(display_long)|uniprotkb:Lrig1(gene name)|psi-mi:Lrig1(display_short)	psi-mi:ret_mouse(display_long)|uniprotkb:Ret(gene name)|psi-mi:Ret(display_short)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ledda et al. (2008)	pubmed:18171921|imex:IM-27714	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25425234|imex:IM-27714-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030029(gene)|ensembl:ENSMUST00000032105(transcript)|ensembl:ENSMUST00000101126(transcript)|ensembl:ENSMUST00000204645(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022405"(hair cycle process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032474"(otolith morphogenesis)|go:"GO:0060384"(innervation)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|reactome:R-MMU-177929|reactome:R-MMU-6807004|refseq:NP_032403.2	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035799"(ureter maturation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0035860"(glial cell-derived neurotrophic factor receptor signaling pathway)|go:"GO:0042493"|go:"GO:0042551"(neuron maturation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060384"(innervation)|go:"GO:0061146"(Peyer's patch morphogenesis)|ensembl:ENSMUSG00000030110(gene)|ensembl:ENSMUST00000032201(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001838"(embryonic epithelial tube formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|reactome:R-MMU-8853659|reactome:R-MMU-5673001|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072300"(positive regulation of metanephric glomerulus development)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002126(Cadherin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015919(Cadherin-like)|interpro:IPR016249(Tyrosine-protein kinase, Ret receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR040667|interpro:IPR041163|interpro:IPR041317|rcsb pdb:1UEF|refseq:NP_001074249.1|refseq:NP_033076.2	-	-	-	figure legend:2|comment:"Immunofluorescence staining of tissue sections of P0 mice revealed a striking colocalization of Lrig1 and Ret expression in DRG (Dorsal root ganglion) and spinal cord motor neurons."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-spinal-cord)|taxid:10090(Mouse spinal cord)	-	2020/01/28	2020/02/13	rogid:7HAE516imvVAkTFrFuWXac6rO5c10090	rogid:BDIyZk6l26Iuth4Pce2alRhCG1Q10090	rigid:m/fkZpUg2CRypbMls9nK5HA+VsU	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)