#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A8DS70	uniprotkb:A8DS70	intact:EBI-25634990	intact:EBI-25634990	psi-mi:a8ds70_clodi(display_long)|uniprotkb:cdtB(gene name)|psi-mi:cdtB(display_short)	psi-mi:a8ds70_clodi(display_long)|uniprotkb:cdtB(gene name)|psi-mi:cdtB(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Anderson et al. (2019)	pubmed:31712627|imex:IM-28296	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25635012|imex:IM-28296-1|emdb:EMD-0610|wwpdb:6O2N|wwpdb:6O2M|wwpdb:6O2O|wwpdb:6OKS|emdb:EMD-0608|emdb:EMD-0609|emdb:EMD-20102|emdb:EMD-20104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_009890823.1|rcsb pdb:6O2M|rcsb pdb:6O2N|rcsb pdb:6O2O|rcsb pdb:6OKR|rcsb pdb:6OKS|rcsb pdb:6OKT|rcsb pdb:6OKU|interpro:IPR003896(Bacterial exotoxin B)|go:"GO:0005576"(extracellular region)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR035331|interpro:IPR011658(PA14)|interpro:IPR035088|interpro:IPR027439|interpro:IPR037149|rcsb pdb:6V1S	refseq:WP_009890823.1|rcsb pdb:6O2M|rcsb pdb:6O2N|rcsb pdb:6O2O|rcsb pdb:6OKR|rcsb pdb:6OKS|rcsb pdb:6OKT|rcsb pdb:6OKU|interpro:IPR003896(Bacterial exotoxin B)|go:"GO:0005576"(extracellular region)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR035331|interpro:IPR011658(PA14)|interpro:IPR035088|interpro:IPR027439|interpro:IPR037149|rcsb pdb:6V1S	emdb:EMD-20103(subset)	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/11/19	2020/06/01	rogid:AImIjZm3u9ukW3Su4C0549I5kUw1496	rogid:AImIjZm3u9ukW3Su4C0549I5kUw1496	rigid:KNe6HIdrPPGwYnR7iORixfnY9uo	false	binding-associated region:43-876	binding-associated region:43-876	14	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A8DS70	uniprotkb:A8DS70	intact:EBI-25634990	intact:EBI-25634990	psi-mi:a8ds70_clodi(display_long)|uniprotkb:cdtB(gene name)|psi-mi:cdtB(display_short)	psi-mi:a8ds70_clodi(display_long)|uniprotkb:cdtB(gene name)|psi-mi:cdtB(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Anderson et al. (2019)	pubmed:31712627|imex:IM-28296	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25635027|imex:IM-28296-3|wwpdb:6oku|emdb:EMD-20102|wwpdb:6OKR|emdb:EMD-20105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_009890823.1|rcsb pdb:6O2M|rcsb pdb:6O2N|rcsb pdb:6O2O|rcsb pdb:6OKR|rcsb pdb:6OKS|rcsb pdb:6OKT|rcsb pdb:6OKU|interpro:IPR003896(Bacterial exotoxin B)|go:"GO:0005576"(extracellular region)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR035331|interpro:IPR011658(PA14)|interpro:IPR035088|interpro:IPR027439|interpro:IPR037149|rcsb pdb:6V1S	refseq:WP_009890823.1|rcsb pdb:6O2M|rcsb pdb:6O2N|rcsb pdb:6O2O|rcsb pdb:6OKR|rcsb pdb:6OKS|rcsb pdb:6OKT|rcsb pdb:6OKU|interpro:IPR003896(Bacterial exotoxin B)|go:"GO:0005576"(extracellular region)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR035331|interpro:IPR011658(PA14)|interpro:IPR035088|interpro:IPR027439|interpro:IPR037149|rcsb pdb:6V1S	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/11/19	2020/06/01	rogid:AImIjZm3u9ukW3Su4C0549I5kUw1496	rogid:AImIjZm3u9ukW3Su4C0549I5kUw1496	rigid:KNe6HIdrPPGwYnR7iORixfnY9uo	false	binding-associated region:43-876	binding-associated region:43-876	7	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q86X29	uniprotkb:A8DS70	intact:EBI-1056946|uniprotkb:O00112|uniprotkb:O00426|uniprotkb:Q6ZT80|uniprotkb:Q9UQL3|uniprotkb:E9PHD4|uniprotkb:Q8NBM0|uniprotkb:Q9BT33|uniprotkb:B4DKL4|uniprotkb:A6NDW3|ensembl:ENSP00000354575|ensembl:ENSP00000480821|intact:EBI-10982122	intact:EBI-25634990	psi-mi:lsr_human(display_long)|uniprotkb:LSR(gene name)|psi-mi:LSR(display_short)|uniprotkb:LISCH(gene name synonym)	psi-mi:a8ds70_clodi(display_long)|uniprotkb:cdtB(gene name)|psi-mi:cdtB(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Anderson et al. (2019)	pubmed:31712627|imex:IM-28296	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25635051|imex:IM-28296-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_991403.1|refseq:NP_001247418.1|refseq:NP_001247419.1|refseq:NP_057009.3|refseq:NP_991404.1|ensembl:ENSG00000105699(gene)|ensembl:ENST00000361790(transcript)|ensembl:ENST00000621372(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042627"(chylomicron)|go:"GO:0060856"(establishment of blood-brain barrier)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061689"(tricellular tight junction)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904274"(tricellular tight junction assembly)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008664(LISCH7)|interpro:IPR036179|reactome:R-HSA-8964038|reactome:R-HSA-8964046	refseq:WP_009890823.1|rcsb pdb:6O2M|rcsb pdb:6O2N|rcsb pdb:6O2O|rcsb pdb:6OKR|rcsb pdb:6OKS|rcsb pdb:6OKT|rcsb pdb:6OKU|interpro:IPR003896(Bacterial exotoxin B)|go:"GO:0005576"(extracellular region)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR035331|interpro:IPR011658(PA14)|interpro:IPR035088|interpro:IPR027439|interpro:IPR037149|rcsb pdb:6V1S	-	-	-	figure legend:ExtFig6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/19	2020/06/01	rogid:jCmNdVxzNBHEpWjKNqyq5e6yEjs9606	rogid:AImIjZm3u9ukW3Su4C0549I5kUw1496	rigid:IyCa5TuKGwMw4YKPXkWEdqFVdmw	false	his tag:c-c|binding-associated region:1-259	binding-associated region:43-876	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)