#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35372	uniprotkb:Q5T9L3-2	intact:EBI-2624570|uniprotkb:B0FXJ1|uniprotkb:B8Q1L8|uniprotkb:B8Q1L9|uniprotkb:Q6UPP1|uniprotkb:Q86V80|uniprotkb:G8XRH8|uniprotkb:B2R9S7|uniprotkb:B8Q1L7|uniprotkb:Q12930|uniprotkb:Q4VWM1|uniprotkb:Q4VWM2|uniprotkb:Q4VWM3|uniprotkb:Q4VWM4|uniprotkb:Q4VWM6|uniprotkb:Q4VWX6|uniprotkb:Q5TDA1|uniprotkb:Q6UQ80|uniprotkb:Q7Z2D8|uniprotkb:Q8IWW3|uniprotkb:Q8IWW4|uniprotkb:Q9UCZ4|uniprotkb:Q9UN57|uniprotkb:G8XRH6|ensembl:ENSP00000328264|uniprotkb:E7EWZ3	intact:EBI-21508346|ensembl:ENSP00000346829	psi-mi:oprm_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short)|uniprotkb:MOR1(gene name synonym)|uniprotkb:Mu opioid receptor(gene name synonym)|uniprotkb:Mu opiate receptor(gene name synonym)	psi-mi:q5t9l3-2(display_long)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:"MI:0096"(pull down)	Petko et al. (2019)	pubmed:31286866|imex:IM-27806	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22118916	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272453.1|refseq:NP_001272455.1|refseq:NP_001272456.1|refseq:NP_001272457.1|refseq:NP_001138752.1|refseq:NP_001138753.1|refseq:NP_001272452.1|refseq:NP_000905.3|refseq:NP_001008503.2|refseq:NP_001008504.2|refseq:NP_001008505.2|refseq:NP_001138751.1|refseq:NP_001138754.1|refseq:NP_001138755.1|refseq:NP_001138756.1|refseq:NP_001138757.1|refseq:NP_001138758.1|refseq:NP_001138759.1|refseq:XP_016866395.1|ensembl:ENSG00000112038(gene)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007600"(sensory perception)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|ensembl:ENST00000330432(transcript)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0042755"(eating behavior)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0005768"(endosome)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35372|reactome:R-HSA-111885|reactome:R-HSA-202040|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|reactome:R-HSA-418594|reactome:R-HSA-6785807|reactome:R-HSA-9022699|reactome:R-HSA-375276	ensembl:ENSG00000116729(gene)|ensembl:ENST00000354777(transcript)|intact:EBI-2868748(isoform-parent)	intact:EBI-22118896(see-also)	-	-	figure legend:fig. 5A|negative:The interaction does not occur under these experimental conditions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/08	2020/04/02	rogid:pfkhVhvpn9gSXiBRs1OBXJBCI3s9606	rogid:suSstC7Z1iuclhX7sh47FceaErg9606	rigid:iOzFc5BSSZawFoRcWA2bFwGL1/8	true	sufficient binding region:166-187|glutathione s tranferase tag:n-n	sufficient binding region:505-543|s tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5T9L3-1	uniprotkb:Q5T9L3-2	intact:EBI-22114623|ensembl:ENSP00000262348	intact:EBI-21508346|ensembl:ENSP00000346829	psi-mi:q5t9l3-1(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:q5t9l3-2(display_long)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:"MI:0096"(pull down)	Petko et al. (2019)	pubmed:31286866|imex:IM-27806	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22118943	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|intact:EBI-2868748(isoform-parent)	ensembl:ENSG00000116729(gene)|ensembl:ENST00000354777(transcript)|intact:EBI-2868748(isoform-parent)	intact:EBI-22118931(see-also)	-	-	figure legend:fig. 5B|negative:The interaction does not occur under these experimental conditions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/08	2019/10/29	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	rogid:suSstC7Z1iuclhX7sh47FceaErg9606	rigid:DMS50QzlLZ5AEDSkiT1QM6Q8EQE	true	sufficient binding region:493-541|s tag:?-?	sufficient binding region:505-543|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)