#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92485-2	uniprotkb:P06213-2	intact:EBI-21501656|ensembl:ENSP00000362995|intact:EBI-21950102	intact:EBI-9984921|ensembl:ENSP00000342838	psi-mi:q92485-2(display_long)|uniprotkb:SMPDL3B(gene name)|psi-mi:SMPDL3B(display_short)|uniprotkb:ASML3B(gene name synonym)|uniprotkb:ASMLPD(gene name synonym)	psi-mi:p06213-2(display_long)|uniprotkb:HIR-A(isoform synonym)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950100|imex:IM-27221-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130768(gene)|ensembl:ENST00000373888(transcript)|intact:EBI-16399091(isoform-parent)	intact:EBI-475899(isoform-parent)|uniprotkb:P06213-2(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000341500(transcript)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 3A-1|comment:SMPDL3b interacts with both IR isoforms but preferentially with IRA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/10/18	rogid:h5AmOXmGqhTah3iVFm/w5jYXlis9606	rogid:RrN+Oz91QaF2SGMLOhMIJjla2n09606	rigid:NT9ENyOMM8gP07A9xgI8bnjPERg	false	green fluorescent protein tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92485-2	uniprotkb:P06213-1	intact:EBI-21501656|ensembl:ENSP00000362995|intact:EBI-21950102	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:q92485-2(display_long)|uniprotkb:SMPDL3B(gene name)|psi-mi:SMPDL3B(display_short)|uniprotkb:ASML3B(gene name synonym)|uniprotkb:ASMLPD(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950132|imex:IM-27221-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130768(gene)|ensembl:ENST00000373888(transcript)|intact:EBI-16399091(isoform-parent)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 3A-2|comment:SMPDL3b interacts with both IR isoforms but preferentially with IRA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/10/18	rogid:h5AmOXmGqhTah3iVFm/w5jYXlis9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:eH9RoeTuy5SUIwuLJTOiv8jY0H4	false	green fluorescent protein tag:c-c	flag tag:c-c|biological feature:744-755	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92485-2	uniprotkb:P06213-2	intact:EBI-21501656|ensembl:ENSP00000362995|intact:EBI-21950102	intact:EBI-9984921|ensembl:ENSP00000342838	psi-mi:q92485-2(display_long)|uniprotkb:SMPDL3B(gene name)|psi-mi:SMPDL3B(display_short)|uniprotkb:ASML3B(gene name synonym)|uniprotkb:ASMLPD(gene name synonym)	psi-mi:p06213-2(display_long)|uniprotkb:HIR-A(isoform synonym)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950166|imex:IM-27221-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130768(gene)|ensembl:ENST00000373888(transcript)|intact:EBI-16399091(isoform-parent)	intact:EBI-475899(isoform-parent)|uniprotkb:P06213-2(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000341500(transcript)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 3B-1|comment:SMPDL3b interacts with both IR isoforms but preferentially with IRA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/10/18	rogid:h5AmOXmGqhTah3iVFm/w5jYXlis9606	rogid:RrN+Oz91QaF2SGMLOhMIJjla2n09606	rigid:NT9ENyOMM8gP07A9xgI8bnjPERg	false	ha tag:n-n|mutation with no effect:135-135	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92485-2	uniprotkb:P06213-1	intact:EBI-21501656|ensembl:ENSP00000362995|intact:EBI-21950102	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:q92485-2(display_long)|uniprotkb:SMPDL3B(gene name)|psi-mi:SMPDL3B(display_short)|uniprotkb:ASML3B(gene name synonym)|uniprotkb:ASMLPD(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950178|imex:IM-27221-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130768(gene)|ensembl:ENST00000373888(transcript)|intact:EBI-16399091(isoform-parent)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 3B-2|comment:SMPDL3b interacts with both IR isoforms but preferentially with IRA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/10/18	rogid:h5AmOXmGqhTah3iVFm/w5jYXlis9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:eH9RoeTuy5SUIwuLJTOiv8jY0H4	false	ha tag:n-n|mutation with no effect:135-135	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92485-2	uniprotkb:Q03135-1	intact:EBI-21501656|ensembl:ENSP00000362995|intact:EBI-21950102	intact:EBI-21950202|ensembl:ENSP00000339191	psi-mi:q92485-2(display_long)|uniprotkb:SMPDL3B(gene name)|psi-mi:SMPDL3B(display_short)|uniprotkb:ASML3B(gene name synonym)|uniprotkb:ASMLPD(gene name synonym)	psi-mi:q03135-1(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950190|imex:IM-27221-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130768(gene)|ensembl:ENST00000373888(transcript)|intact:EBI-16399091(isoform-parent)	ensembl:ENSG00000105974(gene)|ensembl:ENST00000341049(transcript)|intact:EBI-603614(isoform-parent)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 3B-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/10/18	rogid:h5AmOXmGqhTah3iVFm/w5jYXlis9606	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rigid:MGrsPYy0GXhAUMmwkoZJsE+g1Ng	false	ha tag:n-n|mutation with no effect:135-135	flag tag:c-c|myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03135-1	uniprotkb:P06213-2	intact:EBI-21950202|ensembl:ENSP00000339191	intact:EBI-9984921|ensembl:ENSP00000342838	psi-mi:q03135-1(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:p06213-2(display_long)|uniprotkb:HIR-A(isoform synonym)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950261|imex:IM-27221-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105974(gene)|ensembl:ENST00000341049(transcript)|intact:EBI-603614(isoform-parent)	intact:EBI-475899(isoform-parent)|uniprotkb:P06213-2(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000341500(transcript)	-	-	-	figure legend:Figure 3C-1, 3F-lane 1|comment:Overexpression of SMPDL3b facilitates the interaction of caveolin-1 and IRA  while interfering with the ability of IRB to bind caveolin-1.|antagonist:"methyl-beta-cyclodextrin:CHEBI:133151- caveolin-1 inhibitor"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/08/05	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:RrN+Oz91QaF2SGMLOhMIJjla2n09606	rigid:XP3yoDwCPvs7dhnFMqZl58XIUVE	false	green fluorescent protein tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03135-1	uniprotkb:P06213-1	intact:EBI-21950202|ensembl:ENSP00000339191	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:q03135-1(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950274|imex:IM-27221-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105974(gene)|ensembl:ENST00000341049(transcript)|intact:EBI-603614(isoform-parent)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	-	-	-	figure legend:Figure 3C-2, 3F|comment:Overexpression of SMPDL3b facilitates the interaction of caveolin-1 and IRA  while interfering with the ability of IRB to bind caveolin-1.|agonist:"methyl-beta-cyclodextrin:CHEBI:133151- caveolin-1 inhibitor"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/08/05	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:pvYPHqFGNR7aMTCy5AF58GgikzQ	false	green fluorescent protein tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15208	uniprotkb:P58242	intact:EBI-6999015|ensembl:ENSMUSP00000088837|uniprotkb:F8VPU4|intact:MINT-1516207	intact:EBI-9989230|ensembl:ENSMUSP00000030709	psi-mi:insr_mouse(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:asm3b_mouse(display_long)|uniprotkb:Smpdl3b(gene name)|psi-mi:Smpdl3b(display_short)|uniprotkb:Asml3b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950292|imex:IM-27221-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005534(gene)|ensembl:ENSMUST00000091291(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P15208|rcsb pdb:1LK2|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-74752|reactome:R-MMU-77387|refseq:NP_034698.2|dip:DIP-41452N	refseq:NP_598649.1|go:"GO:0008081"(phosphoric diester hydrolase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0050728"(negative regulation of inflammatory response)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR017064(Acid sphingomyelinase-like phosphodiesterase, predicted)|interpro:IPR029052|interpro:IPR041805|rcsb pdb:5KAR|rcsb pdb:5KAS|go:"GO:0006954"(inflammatory response)|ensembl:ENSMUSG00000028885(gene)|ensembl:ENSMUST00000030709(transcript)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006685"(sphingomyelin catabolic process)	-	comment:mint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	figure legend:Figure 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-kidney-glomerulus)|taxid:10090(mouse kidney-glomerulus)	-	2019/08/01	2019/08/05	rogid:DduFddui4LY0r8EIHI5S5EN485Y10090	rogid:V/kK5ODgngr6Z8FhRpclbH3a0FU10090	rigid:DpJ61UmQ12EEKQNh/E7b9S4AcXk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15208	uniprotkb:P49817	intact:EBI-6999015|ensembl:ENSMUSP00000088837|uniprotkb:F8VPU4|intact:MINT-1516207	intact:EBI-1161338|uniprotkb:Q8C1X7|uniprotkb:Q8CBP4|uniprotkb:Q9QYH3|uniprotkb:Q9QYH4|ensembl:ENSMUSP00000007799|ensembl:ENSMUSP00000111116	psi-mi:insr_mouse(display_long)|uniprotkb:Insr(gene name)|psi-mi:Insr(display_short)	psi-mi:cav1_mouse(display_long)|uniprotkb:Cav1(gene name)|psi-mi:Cav1(display_short)|uniprotkb:Cav(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mitrofanova et al. (2019)	pubmed:31217420|imex:IM-27221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21950292|imex:IM-27221-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005534(gene)|ensembl:ENSMUST00000091291(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0060417"(yolk)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:2000194"(regulation of female gonad development)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR000494(EGF receptor, L domain)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P15208|rcsb pdb:1LK2|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-74752|reactome:R-MMU-77387|refseq:NP_034698.2|dip:DIP-41452N	ensembl:ENSMUSG00000007655(gene)|ensembl:ENSMUST00000007799(transcript)|ensembl:ENSMUST00000115456(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042060"(wound healing)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070836"(caveola assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|interpro:IPR018361|mint:P49817|reactome:R-MMU-203615|reactome:R-MMU-203641|reactome:R-MMU-210991|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9696270|reactome:R-MMU-9696273|reactome:R-MMU-9696264|refseq:NP_001229993.1|refseq:NP_031642.1|refseq:XP_006505037.1|refseq:XP_006505038.1|refseq:XP_006505039.1|dip:DIP-35140N	-	comment:mint|function:This receptor binds insulin and has a tyrosine-protein kinase activity	-	figure legend:Figure 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-kidney-glomerulus)|taxid:10090(mouse kidney-glomerulus)	-	2019/08/01	2019/08/05	rogid:DduFddui4LY0r8EIHI5S5EN485Y10090	rogid:63vvAW/JPjuk8ZV3ZqoYdsy4umQ10090	rigid:DpJ61UmQ12EEKQNh/E7b9S4AcXk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)