#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96P20-1	uniprotkb:Q8TDX7-1	intact:EBI-14029575	intact:EBI-16193799|ensembl:ENSP00000356355|ensembl:ENSP00000444621	psi-mi:q96p20-1(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:q8tdx7-1(display_long)|uniprotkb:NEK7(gene name)|psi-mi:NEK7(display_short)|uniprotkb:Never in mitosis A-related kinase 7(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Sharif et al. (2019)	pubmed:31189953|imex:IM-27194	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21458062|imex:IM-27194-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6253230(isoform-parent)	ensembl:ENSG00000151414(gene)|ensembl:ENST00000538004(transcript)|ensembl:ENST00000367385(transcript)|intact:EBI-1055945(isoform-parent)	-	-	-	figure legend:Fig 1b, Ext Data Fig 1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/25	2019/06/25	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:2xAdwh1OOc1iBURvuTpckbOc7I09606	rigid:FjJR9RTv0Ov2sjcWKaD3DlljziU	false	alexa 488 label:?-?|binding-associated region:136-1036|maltose binding protein tag:n-n|mutation:137-137,138-138,142-142	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96P20-1	uniprotkb:Q8TDX7-1	intact:EBI-14029575	intact:EBI-16193799|ensembl:ENSP00000356355|ensembl:ENSP00000444621	psi-mi:q96p20-1(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:q8tdx7-1(display_long)|uniprotkb:NEK7(gene name)|psi-mi:NEK7(display_short)|uniprotkb:Never in mitosis A-related kinase 7(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sharif et al. (2019)	pubmed:31189953|imex:IM-27194	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21458076|imex:IM-27194-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6253230(isoform-parent)	ensembl:ENSG00000151414(gene)|ensembl:ENST00000538004(transcript)|ensembl:ENST00000367385(transcript)|intact:EBI-1055945(isoform-parent)	-	-	-	figure legend:Fig 1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/25	2019/06/25	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:2xAdwh1OOc1iBURvuTpckbOc7I09606	rigid:FjJR9RTv0Ov2sjcWKaD3DlljziU	false	binding-associated region:136-1036|maltose binding protein tag:n-n|mutation:137-137,138-138,142-142	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96P20-1	uniprotkb:Q8TDX7-1	intact:EBI-14029575	intact:EBI-16193799|ensembl:ENSP00000356355|ensembl:ENSP00000444621	psi-mi:q96p20-1(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:q8tdx7-1(display_long)|uniprotkb:NEK7(gene name)|psi-mi:NEK7(display_short)|uniprotkb:Never in mitosis A-related kinase 7(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sharif et al. (2019)	pubmed:31189953|imex:IM-27194	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21458396|imex:IM-27194-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6253230(isoform-parent)	ensembl:ENSG00000151414(gene)|ensembl:ENST00000538004(transcript)|ensembl:ENST00000367385(transcript)|intact:EBI-1055945(isoform-parent)	-	-	-	figure legend:Fig 1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/25	2019/06/25	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:2xAdwh1OOc1iBURvuTpckbOc7I09606	rigid:FjJR9RTv0Ov2sjcWKaD3DlljziU	false	maltose binding protein tag:n-n|mutation:137-137,138-138,142-142	binding-associated region:34-302|mutation:54-54,58-58,59-59,87-87,99-99,100-100,103-103,104-104	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96P20-1	uniprotkb:Q8TDX7-1	intact:EBI-14029575	intact:EBI-16193799|ensembl:ENSP00000356355|ensembl:ENSP00000444621	psi-mi:q96p20-1(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:q8tdx7-1(display_long)|uniprotkb:NEK7(gene name)|psi-mi:NEK7(display_short)|uniprotkb:Never in mitosis A-related kinase 7(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Sharif et al. (2019)	pubmed:31189953|imex:IM-27194	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21458350|wwpdb:6NPY|emdb:EMD-0476|imex:IM-27194-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6253230(isoform-parent)	ensembl:ENSG00000151414(gene)|ensembl:ENST00000538004(transcript)|ensembl:ENST00000367385(transcript)|intact:EBI-1055945(isoform-parent)	-	-	-	figure legend:Fig 1e,f, Fig 2, Ext Data Tab 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/25	2019/06/25	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:2xAdwh1OOc1iBURvuTpckbOc7I09606	rigid:FjJR9RTv0Ov2sjcWKaD3DlljziU	false	binding-associated region:136-1036|maltose binding protein tag:n-n|mutation:137-137,138-138,142-142	binding-associated region:34-302|mutation:54-54,58-58,59-59,87-87,99-99,100-100,103-103,104-104	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96P20-1	uniprotkb:Q8TDX7-1	intact:EBI-14029575	intact:EBI-16193799|ensembl:ENSP00000356355|ensembl:ENSP00000444621	psi-mi:q96p20-1(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:q8tdx7-1(display_long)|uniprotkb:NEK7(gene name)|psi-mi:NEK7(display_short)|uniprotkb:Never in mitosis A-related kinase 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sharif et al. (2019)	pubmed:31189953|imex:IM-27194	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21461379|imex:IM-27194-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6253230(isoform-parent)	ensembl:ENSG00000151414(gene)|ensembl:ENST00000538004(transcript)|ensembl:ENST00000367385(transcript)|intact:EBI-1055945(isoform-parent)	-	-	-	figure legend:FIg 3d, 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/25	2019/07/01	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:2xAdwh1OOc1iBURvuTpckbOc7I09606	rigid:FjJR9RTv0Ov2sjcWKaD3DlljziU	false	mutation:137-137,138-138,142-142|binding-associated region:136-1036|maltose binding protein tag:n-n	mutation decreasing interaction:129-129|mutation decreasing interaction:131-131|mutation decreasing interaction:121-121|mutation decreasing interaction:136-136|mutation with no effect:280-280|mutation decreasing interaction:260-261|mutation decreasing interaction:260-261,265-265|mutation decreasing interaction:294-294|mutation with no effect:128-128|mutation with no effect:280-280|mutation decreasing interaction:290-290|sumo tag:n-n|his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q96P20-1	uniprotkb:Q8TDX7-1	intact:EBI-14029575	intact:EBI-16193799|ensembl:ENSP00000356355|ensembl:ENSP00000444621	psi-mi:q96p20-1(display_long)|uniprotkb:NLRP3(gene name)|psi-mi:NLRP3(display_short)|uniprotkb:C1orf7(gene name synonym)|uniprotkb:CIAS1(gene name synonym)|uniprotkb:NALP3(gene name synonym)|uniprotkb:PYPAF1(gene name synonym)|uniprotkb:Angiotensin/vasopressin receptor AII/AVP-like(gene name synonym)|uniprotkb:Caterpiller protein 1.1(gene name synonym)|uniprotkb:Cold-induced autoinflammatory syndrome 1 protein(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:q8tdx7-1(display_long)|uniprotkb:NEK7(gene name)|psi-mi:NEK7(display_short)|uniprotkb:Never in mitosis A-related kinase 7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sharif et al. (2019)	pubmed:31189953|imex:IM-27194	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21461438|imex:IM-27194-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6253230(isoform-parent)	ensembl:ENSG00000151414(gene)|ensembl:ENST00000538004(transcript)|ensembl:ENST00000367385(transcript)|intact:EBI-1055945(isoform-parent)	-	-	-	figure legend:FIg 3d, 3e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/25	2019/07/01	rogid:OCkmgUVtTAdyHLRCQlUZ4QFKmX49606	rogid:2xAdwh1OOc1iBURvuTpckbOc7I09606	rigid:FjJR9RTv0Ov2sjcWKaD3DlljziU	false	mutation:137-137,138-138,142-142|binding-associated region:136-1036|maltose binding protein tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)