#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05160	uniprotkb:P02747	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:J70D18e5i22Id/KdUGyA/dcTeME9606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02768	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01834	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01857	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01023	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02671	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02679	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1034422|uniprotkb:P04469|uniprotkb:P04470|uniprotkb:Q96A14|uniprotkb:Q96KJ3|uniprotkb:A8K057|uniprotkb:Q53Y18|uniprotkb:Q9UC62|uniprotkb:Q9UC63|uniprotkb:Q9UCF3|ensembl:ENSP00000336829	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:fibg_human(display_long)|uniprotkb:FGG(gene name)|psi-mi:FGG(display_short)|uniprotkb:PRO2061(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000500.2|refseq:NP_068656.2|ensembl:ENSG00000171557(gene)|ensembl:ENST00000336098(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0009306"(protein secretion)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0036345"(platelet maturation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR037581|mint:P02679|rcsb pdb:1DUG|rcsb pdb:1FIB|rcsb pdb:1FIC|rcsb pdb:1FID|rcsb pdb:1FZA|go:"GO:0070527"(platelet aggregation)|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2FIB|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2HWL|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:2VR3|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Y7L|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:2Q9I|rcsb pdb:3FIB|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4B60|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29644N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:QKWesyU4/fduceFtu5zq31oGhYI9606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02675	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1034445|uniprotkb:A0JLR9|uniprotkb:Q32Q65|uniprotkb:Q3KPF2|uniprotkb:B2R7G3|ensembl:ENSP00000306099	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:fibb_human(display_long)|uniprotkb:FGB(gene name)|psi-mi:FGB(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197484|imex:IM-27492-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_001171670.1|refseq:NP_005132.2|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037580|mint:P02675|rcsb pdb:1FZA|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:6ATZ|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|ensembl:ENSG00000171564(gene)|ensembl:ENST00000302068(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802952|reactome:R-HSA-6802948|dip:DIP-385N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 1. Bands A 1-5|comment:Resin bound recombinant FXIII-B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/11/13	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:cbcOBnZB/W/Y7eE/IxM2HfZHpK49606	rigid:hM/8qKg4uipCyNPzk8y+18hgl1c	false	his tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02787	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-714319|uniprotkb:O43890|uniprotkb:Q9NQB8|uniprotkb:Q9UHV0|uniprotkb:Q1HBA5|ensembl:ENSP00000385834	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:trfe_human(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:TF(gene name)|psi-mi:TF(display_short)|uniprotkb:PRO1400(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_001054.1|rcsb pdb:1JQF|rcsb pdb:1N7W|rcsb pdb:1N7X|rcsb pdb:1N84|rcsb pdb:1OQG|rcsb pdb:1OQH|rcsb pdb:1RYO|rcsb pdb:1SUV|rcsb pdb:2HAU|rcsb pdb:2HAV|rcsb pdb:2O7U|rcsb pdb:2O84|rcsb pdb:3FGS|rcsb pdb:3QYT|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:1FQF|rcsb pdb:3S9N|rcsb pdb:3SKP|rcsb pdb:3V83|rcsb pdb:3V89|rcsb pdb:3V8X|rcsb pdb:4H0W|rcsb pdb:4X1B|rcsb pdb:4X1D|rcsb pdb:5DYH|rcsb pdb:5H52|rcsb pdb:5WTD|rcsb pdb:5X5P|rcsb pdb:5Y6K|rcsb pdb:6CTC|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:3VE1|rcsb pdb:6JAS|rcsb pdb:6SOY|rcsb pdb:6SOZ|rcsb pdb:6UJ6|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8957275|reactome:R-HSA-917937|reactome:R-HSA-917977|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0072562"(blood microparticle)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:P02787|rcsb pdb:1A8E|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:1A8F|rcsb pdb:1B3E|rcsb pdb:1BP5|rcsb pdb:1BTJ|rcsb pdb:1D3K|rcsb pdb:1D4N|rcsb pdb:1DTG|rcsb pdb:1FQE|ensembl:ENSG00000091513(gene)|ensembl:ENST00000402696(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|refseq:XP_016862578.1|refseq:XP_016862579.1|dip:DIP-2738N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:CN9nME9TVV6/FGrhH6XHtJF9/HI9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01024	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01876	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:Mystbtg9uttxFXl//LGdoM32po09606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02747	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1220222|uniprotkb:Q7Z502|uniprotkb:Q96DL2|uniprotkb:Q96H05|ensembl:ENSP00000363768|ensembl:ENSP00000363770|ensembl:ENSP00000363771	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:c1qc_human(display_long)|uniprotkb:C1QC(gene name)|psi-mi:C1QC(display_short)|uniprotkb:C1QG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_001107573.1|refseq:NP_758957.2|refseq:NP_001334548.1|ensembl:ENSG00000159189(gene)|ensembl:ENST00000374637(transcript)|ensembl:ENST00000374639(transcript)|ensembl:ENST00000374640(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072562"(blood microparticle)|go:"GO:0098794"(postsynapse)|go:"GO:0098883"(synapse pruning)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|rcsb pdb:1PK6|rcsb pdb:2JG8|rcsb pdb:2JG9|go:"GO:0005615"(extracellular space)|rcsb pdb:2WNV|rcsb pdb:5HKJ|rcsb pdb:5HZF|rcsb pdb:6FCZ|rcsb pdb:6Z6V|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-977606|rcsb pdb:2WNU	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:J70D18e5i22Id/KdUGyA/dcTeME9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02768	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01834	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01857	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P01023	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02671	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02679	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1034422|uniprotkb:P04469|uniprotkb:P04470|uniprotkb:Q96A14|uniprotkb:Q96KJ3|uniprotkb:A8K057|uniprotkb:Q53Y18|uniprotkb:Q9UC62|uniprotkb:Q9UC63|uniprotkb:Q9UCF3|ensembl:ENSP00000336829	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:fibg_human(display_long)|uniprotkb:FGG(gene name)|psi-mi:FGG(display_short)|uniprotkb:PRO2061(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_000500.2|refseq:NP_068656.2|ensembl:ENSG00000171557(gene)|ensembl:ENST00000336098(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0009306"(protein secretion)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0036345"(platelet maturation)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR037581|mint:P02679|rcsb pdb:1DUG|rcsb pdb:1FIB|rcsb pdb:1FIC|rcsb pdb:1FID|rcsb pdb:1FZA|go:"GO:0070527"(platelet aggregation)|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2FIB|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2HWL|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:2VR3|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Y7L|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:2Q9I|rcsb pdb:3FIB|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4B60|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29644N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:QKWesyU4/fduceFtu5zq31oGhYI9606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P05160	uniprotkb:P02675	intact:EBI-22196853|ensembl:ENSP00000356382|uniprotkb:A8K3E5|uniprotkb:Q5VYL5	intact:EBI-1034445|uniprotkb:A0JLR9|uniprotkb:Q32Q65|uniprotkb:Q3KPF2|uniprotkb:B2R7G3|ensembl:ENSP00000306099	psi-mi:f13b_human(display_long)|uniprotkb:F13B(gene name)|psi-mi:F13B(display_short)|uniprotkb:Fibrin-stabilizing factor B subunit(gene name synonym)|uniprotkb:Protein-glutamine gamma-glutamyltransferase B chain(gene name synonym)|uniprotkb:Transglutaminase B chain(gene name synonym)	psi-mi:fibb_human(display_long)|uniprotkb:FGB(gene name)|psi-mi:FGB(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Singh et al. (2019)	pubmed:31159152|imex:IM-27492	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22197508|imex:IM-27492-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143278(gene)|ensembl:ENST00000367412(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007596"(blood coagulation)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|reactome:R-HSA-140875|refseq:NP_001985.2	refseq:NP_001171670.1|refseq:NP_005132.2|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037580|mint:P02675|rcsb pdb:1FZA|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:6ATZ|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|ensembl:ENSG00000171564(gene)|ensembl:ENST00000302068(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802952|reactome:R-HSA-6802948|dip:DIP-385N	-	-	-	figure legend:Figure 4, Supplementary figure 2. Lane 4. Bands D 1-8|comment:"Resin bound FXIII-B in the presence of  FXIII-A.   For Lane 4, the Table under figure 4A states that the source of FXIII-A/B is from recombinant  rFXIII-A2B2 (Zedira) , but the methods section states \"Additionally, a resin was prepared with a-FXIII-B antibody that was bound to FXIII-A2B2 complex purified from FibrogamminP and exposed to FXIII-DP\"; the authors have confirmed that the source of FXIII-A/B is from human plasma (FXIIIA2B2 from FibrogaminP) which was further purified to remove additional proteins (which included SFH, A2MG, Albumin).  There is no detection of Factor  FXIII-A by Mass-Spec."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/24	2019/12/16	rogid:sDd4NLMaD/iINhklI6btLubFgnY9606	rogid:cbcOBnZB/W/Y7eE/IxM2HfZHpK49606	rigid:eh7FV1mMON8ERvCqzjigkLNKQcI	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)