#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7Z2Z2	uniprotkb:Q9Y3A5	intact:EBI-2870376|uniprotkb:B7Z6I0|uniprotkb:A6NKY5|uniprotkb:Q9H8Z6|ensembl:ENSP00000268206	intact:EBI-1046471|ensembl:ENSP00000246868|uniprotkb:Q96FX0|uniprotkb:Q9NV53|uniprotkb:A8K0P4	psi-mi:efl1_human(display_long)|uniprotkb:EFL1(gene name)|psi-mi:EFL1(display_short)|uniprotkb:EFTUD1(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 1(gene name synonym)|uniprotkb:Elongation factor-like 1(gene name synonym)|uniprotkb:FAM42A(gene name synonym)|uniprotkb:Protein FAM42A(gene name synonym)	psi-mi:sbds_human(display_long)|uniprotkb:Shwachman-Bodian-Diamond syndrome protein(gene name synonym)|uniprotkb:SBDS(gene name)|psi-mi:SBDS(display_short)|uniprotkb:CGI-97(orf name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Gijsbers et al. (2018)	pubmed:30545121|imex:IM-27139	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21463457|imex:IM-27139-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035700.1|refseq:NP_078856.4|refseq:NP_001309774.1|ensembl:ENSG00000140598(gene)|ensembl:ENST00000268206(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR020568|interpro:IPR027417|interpro:IPR035647|interpro:IPR041095|rcsb pdb:5ANB|rcsb pdb:5ANC	ensembl:ENSG00000126524(gene)|ensembl:ENST00000246868(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008017"(microtubule binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0048539"(bone marrow development)|interpro:IPR002140(Shwachman-Bodian-Diamond syndrome related)|interpro:IPR018023|interpro:IPR018978|interpro:IPR019783|interpro:IPR036786|interpro:IPR037188|interpro:IPR039100|rcsb pdb:2KDO|rcsb pdb:2L9N|rcsb pdb:5AN9|rcsb pdb:5ANB|rcsb pdb:5ANC|rcsb pdb:6QKL|go:"GO:0007052"(mitotic spindle organization)|refseq:NP_057122.2	-	-	-	figure legend:Table 1, Figure 1, 2|comment:"A two distinct binding sites model with positive cooperativity best describes the interaction [Kd1-Domain 1 (residues 1-94); Kd2 - Domain 2 (residues 94-175): Kd1 (µM) = 5.4; Kd2 (µM) = 0.4]; Hill coefficient -1.8.  Mutations were tested on full length construct."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.4x10^-6 ~1.0(molar)|kd:0.4x10^-6 ~0.04(molar)	2019/07/03	2019/07/03	rogid:nrmPQn9cjI/pwEEAxZwpLWTPe149606	rogid:msVVYApBFrilDAGn8MafoJVhxsU9606	rigid:0TJY+uazbalQI/y1uZ3AkBnhqV4	false	his tag:c-c	mutation decreasing interaction strength:19-19|mutation decreasing interaction strength:67-67|fiash label:c-c|mutation decreasing interaction strength:126-126(rs113993995)|mutation disrupting interaction strength:143-143|mutation decreasing interaction strength:167-167|mutation decreasing interaction strength:175-175|mutation disrupting interaction strength:212-212(rs79344818)|binding-associated region:94-250|binding-associated region:1-174|binding-associated region:1-94|binding-associated region:94-175|xpress tag:n-n|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53893	uniprotkb:Q07953	intact:EBI-28980|uniprotkb:D6W119|ensemblfungi:YNL163C	intact:EBI-27124|uniprotkb:D6VY24|ensemblfungi:YLR022C	psi-mi:ria1_yeast(display_long)|uniprotkb:YNL163C(locus name)|uniprotkb:N1718(orf name)|uniprotkb:EFL1(gene name synonym)|uniprotkb:Elongation factor-like 1(gene name synonym)|uniprotkb:EF-2-like GTPase(gene name synonym)|uniprotkb:RIA1(gene name)|psi-mi:RIA1(display_short)	psi-mi:sdo1_yeast(display_long)|uniprotkb:YLR022C(locus name)|uniprotkb:SDO1(gene name)|psi-mi:SDO1(display_short)	psi-mi:"MI:0826"(x ray scattering)	Gijsbers et al. (2018)	pubmed:30545121|imex:IM-27139	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21463693|imex:IM-27139-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014236.1|sgd:S000005107|dip:DIP-2553N|mint:P53893|ensemblfungi:YNL163C(gene)|ensemblfungi:YNL163C_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR035647|interpro:IPR041095	refseq:NP_013122.1|sgd:S000004012|interpro:IPR018978|interpro:IPR018023|interpro:IPR019783|interpro:IPR002140(Shwachman-Bodian-Diamond syndrome related)|mint:Q07953|interpro:IPR036786|interpro:IPR037188|interpro:IPR039100|ensemblfungi:YLR022C(gene)|ensemblfungi:YLR022C_mRNA(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0042256"(mature ribosome assembly)	-	-	-	figure legend:Figures 3, 4; Supplementary tables 1, 2|comment:"Small Angle Biological Data Bank accession code: SASDET8"|3d-resolution:"Resolution (Å) - 38"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/03	2019/07/03	rogid:f42pOofRKcjr4zkN4Ifma9+JAVg559292	rogid:hneEs5QCkMZ63vvBEHQArADKpOw559292	rigid:+vcnHzLVPsHCcJ5pxuJ2U6tCQM0	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53893	uniprotkb:Q07953	intact:EBI-28980|uniprotkb:D6W119|ensemblfungi:YNL163C	intact:EBI-27124|uniprotkb:D6VY24|ensemblfungi:YLR022C	psi-mi:ria1_yeast(display_long)|uniprotkb:YNL163C(locus name)|uniprotkb:N1718(orf name)|uniprotkb:EFL1(gene name synonym)|uniprotkb:Elongation factor-like 1(gene name synonym)|uniprotkb:EF-2-like GTPase(gene name synonym)|uniprotkb:RIA1(gene name)|psi-mi:RIA1(display_short)	psi-mi:sdo1_yeast(display_long)|uniprotkb:YLR022C(locus name)|uniprotkb:SDO1(gene name)|psi-mi:SDO1(display_short)	psi-mi:"MI:0018"(two hybrid)	Gijsbers et al. (2018)	pubmed:30545121|imex:IM-27139	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21916392|imex:IM-27139-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014236.1|sgd:S000005107|dip:DIP-2553N|mint:P53893|ensemblfungi:YNL163C(gene)|ensemblfungi:YNL163C_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR035647|interpro:IPR041095	refseq:NP_013122.1|sgd:S000004012|interpro:IPR018978|interpro:IPR018023|interpro:IPR019783|interpro:IPR002140(Shwachman-Bodian-Diamond syndrome related)|mint:Q07953|interpro:IPR036786|interpro:IPR037188|interpro:IPR039100|ensemblfungi:YLR022C(gene)|ensemblfungi:YLR022C_mRNA(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0042256"(mature ribosome assembly)	-	-	-	figure legend:Supplemental figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/07/03	2019/07/15	rogid:f42pOofRKcjr4zkN4Ifma9+JAVg559292	rogid:hneEs5QCkMZ63vvBEHQArADKpOw559292	rigid:+vcnHzLVPsHCcJ5pxuJ2U6tCQM0	false	sufficient binding region:?-?	sufficient binding region:94-250("G3DSA:3.30.70.240")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)