#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P55917	uniprotkb:Q9TU17	intact:EBI-21347179|uniprotkb:Q9MYL3	intact:EBI-21347162	psi-mi:cxa8_sheep(display_long)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)|uniprotkb:Connexin-49(gene name synonym)|uniprotkb:Lens fiber protein MP70(gene name synonym)|uniprotkb:MP38(gene name synonym)|uniprotkb:MP64(gene name synonym)	psi-mi:cxa3_sheep(display_long)|uniprotkb:GJA3(gene name)|psi-mi:GJA3(display_short)|uniprotkb:Connexin-44(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Myers et al. (2018)	pubmed:30542154|imex:IM-27622	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-22017021|imex:IM-27622-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)|refseq:NP_001123510.1|rcsb pdb:6MHY|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JJP|rcsb pdb:7JLW|rcsb pdb:7JM9|rcsb pdb:7JMC	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007601"(visual perception)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:1990349"(gap junction-mediated intercellular transport)|go:"GO:0005922"(connexin complex)|rcsb pdb:6MHQ|interpro:IPR000500(Connexins)|interpro:IPR002262("Gap junction alpha-3 protein (Cx46)")|interpro:IPR034634|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JKC|rcsb pdb:7JMD|rcsb pdb:7JN0|rcsb pdb:7JN1	-	-	-	figure legend:Ext. Fig. 1a,b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9940(sheep-eye)|taxid:9940(sheep eye)	-	2019/04/18	2019/10/11	rogid:8UH+7TVt/WB0fow3ejjgCKfgOLM9940	rogid:G3jm+vtIP9gSwrvthRkbTVf13KQ9940	rigid:gfuG1l5pQM9Dybiix/X74NaIPwg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55917	uniprotkb:Q9TU17	intact:EBI-21347179|uniprotkb:Q9MYL3	intact:EBI-21347162	psi-mi:cxa8_sheep(display_long)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)|uniprotkb:Connexin-49(gene name synonym)|uniprotkb:Lens fiber protein MP70(gene name synonym)|uniprotkb:MP38(gene name synonym)|uniprotkb:MP64(gene name synonym)	psi-mi:cxa3_sheep(display_long)|uniprotkb:GJA3(gene name)|psi-mi:GJA3(display_short)|uniprotkb:Connexin-44(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Myers et al. (2018)	pubmed:30542154|imex:IM-27622	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21347160|wwpdb:6MHQ|wwpdb:6MHY|emdb:9116|imex:IM-27622-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)|refseq:NP_001123510.1|rcsb pdb:6MHY|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JJP|rcsb pdb:7JLW|rcsb pdb:7JM9|rcsb pdb:7JMC	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007601"(visual perception)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:1990349"(gap junction-mediated intercellular transport)|go:"GO:0005922"(connexin complex)|rcsb pdb:6MHQ|interpro:IPR000500(Connexins)|interpro:IPR002262("Gap junction alpha-3 protein (Cx46)")|interpro:IPR034634|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JKC|rcsb pdb:7JMD|rcsb pdb:7JN0|rcsb pdb:7JN1	-	-	-	figure legend:Ext Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9940(sheep-eye)|taxid:9940(sheep eye)	-	2019/04/18	2019/12/16	rogid:8UH+7TVt/WB0fow3ejjgCKfgOLM9940	rogid:G3jm+vtIP9gSwrvthRkbTVf13KQ9940	rigid:gfuG1l5pQM9Dybiix/X74NaIPwg	false	cross linker:2-2|cross linker:143-143|cross linker:271-271	cross linker:2-2	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P55917	uniprotkb:P55917	intact:EBI-21347179|uniprotkb:Q9MYL3	intact:EBI-21347179|uniprotkb:Q9MYL3	psi-mi:cxa8_sheep(display_long)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)|uniprotkb:Connexin-49(gene name synonym)|uniprotkb:Lens fiber protein MP70(gene name synonym)|uniprotkb:MP38(gene name synonym)|uniprotkb:MP64(gene name synonym)	psi-mi:cxa8_sheep(display_long)|uniprotkb:GJA8(gene name)|psi-mi:GJA8(display_short)|uniprotkb:Connexin-49(gene name synonym)|uniprotkb:Lens fiber protein MP70(gene name synonym)|uniprotkb:MP38(gene name synonym)|uniprotkb:MP64(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Myers et al. (2018)	pubmed:30542154|imex:IM-27622	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25299912|wwpdb:6mhy|imex:IM-27622-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)|refseq:NP_001123510.1|rcsb pdb:6MHY|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JJP|rcsb pdb:7JLW|rcsb pdb:7JM9|rcsb pdb:7JMC	go:"GO:0005243"(gap junction channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005922"(connexin complex)|go:"GO:0007154"(cell communication)|go:"GO:1990349"(gap junction-mediated intercellular transport)|refseq:NP_001123510.1|rcsb pdb:6MHY|interpro:IPR000500(Connexins)|interpro:IPR002266("Gap junction alpha-8 protein (Cx50)")|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JJP|rcsb pdb:7JLW|rcsb pdb:7JM9|rcsb pdb:7JMC	-	-	-	figure legend:Ext. Fig. 1b,c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9940(sheep-eye)|taxid:9940(sheep eye)	-	2019/04/18	2020/01/06	rogid:8UH+7TVt/WB0fow3ejjgCKfgOLM9940	rogid:8UH+7TVt/WB0fow3ejjgCKfgOLM9940	rigid:3TQkoQf/6EW65etNaD68WcmXPfw	false	-	-	-	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9TU17	uniprotkb:Q9TU17	intact:EBI-21347162	intact:EBI-21347162	psi-mi:cxa3_sheep(display_long)|uniprotkb:GJA3(gene name)|psi-mi:GJA3(display_short)|uniprotkb:Connexin-44(gene name synonym)	psi-mi:cxa3_sheep(display_long)|uniprotkb:GJA3(gene name)|psi-mi:GJA3(display_short)|uniprotkb:Connexin-44(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Myers et al. (2018)	pubmed:30542154|imex:IM-27622	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25299917|wwpdb:6mhq|imex:IM-27622-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007601"(visual perception)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:1990349"(gap junction-mediated intercellular transport)|go:"GO:0005922"(connexin complex)|rcsb pdb:6MHQ|interpro:IPR000500(Connexins)|interpro:IPR002262("Gap junction alpha-3 protein (Cx46)")|interpro:IPR034634|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JKC|rcsb pdb:7JMD|rcsb pdb:7JN0|rcsb pdb:7JN1	go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007601"(visual perception)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:1990349"(gap junction-mediated intercellular transport)|go:"GO:0005922"(connexin complex)|rcsb pdb:6MHQ|interpro:IPR000500(Connexins)|interpro:IPR002262("Gap junction alpha-3 protein (Cx46)")|interpro:IPR034634|interpro:IPR019570|interpro:IPR017990|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR038359|rcsb pdb:7JKC|rcsb pdb:7JMD|rcsb pdb:7JN0|rcsb pdb:7JN1	-	-	-	figure legend:Ext. Fig. 1b,c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9940(sheep-eye)|taxid:9940(sheep eye)	-	2019/04/18	2020/01/06	rogid:G3jm+vtIP9gSwrvthRkbTVf13KQ9940	rogid:G3jm+vtIP9gSwrvthRkbTVf13KQ9940	rigid:bYRFmcxufVrVVjAeLwf5MDYY6d4	false	sufficient binding region:1-348	sufficient binding region:1-348	12	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)