#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:15351"	chebi:"CHEBI:133341"	intact:EBI-1254731	intact:EBI-21280179	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:choline chloride(display_short)|psi-mi:"CHEBI:133341"(display_long)|intact:"(2-Hydroxyethyl)trimethylammonium chloride"(synonym)|intact:"(beta-Hydroxyethyl)trimethylammonium chloride"(synonym)|intact:2-Hydroxy-N,N,N,-trimethylethanaminium chloride(synonym)|intact:Bilineurin chloride(synonym)|intact:Biocolina(synonym)|intact:Biocoline(synonym)|intact:Chloride de choline(synonym)|intact:Chlorure de choline(synonym)|intact:Choline chlorhydrate(synonym)|intact:choline chloride(synonym)|intact:Choline hydrochloride(synonym)|intact:Cholini chloridum(synonym)|intact:Cholinium chloride(synonym)|intact:Cloruro de colina(synonym)|intact:Hepacholine(synonym)|intact:Lipotril(synonym)|intact:Luridin chloride(synonym)|intact:Paresan(synonym)|intact:"Trimethyl(2-hydroxyethyl)ammonium chloride"(synonym)|intact:2-hydroxy-N,N,N-trimethylethanaminium chloride(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280204|imex:IM-27244-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004102"(choline O-acetyltransferase activity)	-	-	figure legend:Figs. 1-5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	uniprotkb:P28329	intact:EBI-1254731	intact:EBI-21026206|ensembl:ENSP00000337103|uniprotkb:A2BDF4|uniprotkb:A2BDF5|uniprotkb:Q16488|uniprotkb:Q9BQ23|uniprotkb:Q9BQ35|uniprotkb:Q9BQE1	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:clat_human(display_long)|uniprotkb:CHAT(gene name)|psi-mi:CHAT(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280204|imex:IM-27244-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000070748(gene)|ensembl:ENST00000337653(transcript)|go:"GO:0004102"(choline O-acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008292"(acetylcholine biosynthetic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|mint:P28329|rcsb pdb:2FY2|rcsb pdb:2FY3|rcsb pdb:2FY4|rcsb pdb:2FY5|rcsb pdb:7AMD|reactome:R-HSA-1483191|reactome:R-HSA-264642|refseq:NP_001136401.1|refseq:NP_001136405.1|refseq:NP_001136406.1|refseq:NP_065574.3|refseq:NP_066264.3|refseq:NP_066265.3|refseq:NP_066266.3	go:"GO:0004102"(choline O-acetyltransferase activity)	-	-	figure legend:Figs. 1-5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	rogid:ULsiid1KJJCaCgKcQT+4iWXcSHQ9606	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	chebi:"CHEBI:133341"	intact:EBI-1254731	intact:EBI-21280179	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:choline chloride(display_short)|psi-mi:"CHEBI:133341"(display_long)|intact:"(2-Hydroxyethyl)trimethylammonium chloride"(synonym)|intact:"(beta-Hydroxyethyl)trimethylammonium chloride"(synonym)|intact:2-Hydroxy-N,N,N,-trimethylethanaminium chloride(synonym)|intact:Bilineurin chloride(synonym)|intact:Biocolina(synonym)|intact:Biocoline(synonym)|intact:Chloride de choline(synonym)|intact:Chlorure de choline(synonym)|intact:Choline chlorhydrate(synonym)|intact:choline chloride(synonym)|intact:Choline hydrochloride(synonym)|intact:Cholini chloridum(synonym)|intact:Cholinium chloride(synonym)|intact:Cloruro de colina(synonym)|intact:Hepacholine(synonym)|intact:Lipotril(synonym)|intact:Luridin chloride(synonym)|intact:Paresan(synonym)|intact:"Trimethyl(2-hydroxyethyl)ammonium chloride"(synonym)|intact:2-hydroxy-N,N,N-trimethylethanaminium chloride(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280233|imex:IM-27244-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004102"(choline O-acetyltransferase activity)	-	-	figure legend:Figs. 1-5|kinetics:EC50 value of approximately 0.07 ng/mL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	uniprotkb:P28329	intact:EBI-1254731	intact:EBI-21026206|ensembl:ENSP00000337103|uniprotkb:A2BDF4|uniprotkb:A2BDF5|uniprotkb:Q16488|uniprotkb:Q9BQ23|uniprotkb:Q9BQ35|uniprotkb:Q9BQE1	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:clat_human(display_long)|uniprotkb:CHAT(gene name)|psi-mi:CHAT(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280233|imex:IM-27244-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000070748(gene)|ensembl:ENST00000337653(transcript)|go:"GO:0004102"(choline O-acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008292"(acetylcholine biosynthetic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|mint:P28329|rcsb pdb:2FY2|rcsb pdb:2FY3|rcsb pdb:2FY4|rcsb pdb:2FY5|rcsb pdb:7AMD|reactome:R-HSA-1483191|reactome:R-HSA-264642|refseq:NP_001136401.1|refseq:NP_001136405.1|refseq:NP_001136406.1|refseq:NP_065574.3|refseq:NP_066264.3|refseq:NP_066265.3|refseq:NP_066266.3	go:"GO:0004102"(choline O-acetyltransferase activity)	-	-	figure legend:Figs. 1-5|kinetics:EC50 value of approximately 0.07 ng/mL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	rogid:ULsiid1KJJCaCgKcQT+4iWXcSHQ9606	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	uniprotkb:P05067-PRO_0000000092	intact:EBI-1254731	intact:EBI-821758	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280233|imex:IM-27244-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-77613(chain-parent)	go:"GO:0004102"(choline O-acetyltransferase activity)	-	chain-seq-start:672|chain-seq-end:713	figure legend:Figs. 1-5|kinetics:EC50 value of approximately 0.07 ng/mL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	chebi:"CHEBI:133341"	intact:EBI-1254731	intact:EBI-21280179	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:choline chloride(display_short)|psi-mi:"CHEBI:133341"(display_long)|intact:"(2-Hydroxyethyl)trimethylammonium chloride"(synonym)|intact:"(beta-Hydroxyethyl)trimethylammonium chloride"(synonym)|intact:2-Hydroxy-N,N,N,-trimethylethanaminium chloride(synonym)|intact:Bilineurin chloride(synonym)|intact:Biocolina(synonym)|intact:Biocoline(synonym)|intact:Chloride de choline(synonym)|intact:Chlorure de choline(synonym)|intact:Choline chlorhydrate(synonym)|intact:choline chloride(synonym)|intact:Choline hydrochloride(synonym)|intact:Cholini chloridum(synonym)|intact:Cholinium chloride(synonym)|intact:Cloruro de colina(synonym)|intact:Hepacholine(synonym)|intact:Lipotril(synonym)|intact:Luridin chloride(synonym)|intact:Paresan(synonym)|intact:"Trimethyl(2-hydroxyethyl)ammonium chloride"(synonym)|intact:2-hydroxy-N,N,N-trimethylethanaminium chloride(iupac name)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280249|imex:IM-27244-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004102"(choline O-acetyltransferase activity)	-	-	figure legend:Figs. 1-5|kinetics:EC50 of  approximately 0.8 ng/mL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	uniprotkb:P28329	intact:EBI-1254731	intact:EBI-21026206|ensembl:ENSP00000337103|uniprotkb:A2BDF4|uniprotkb:A2BDF5|uniprotkb:Q16488|uniprotkb:Q9BQ23|uniprotkb:Q9BQ35|uniprotkb:Q9BQE1	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:clat_human(display_long)|uniprotkb:CHAT(gene name)|psi-mi:CHAT(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280249|imex:IM-27244-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000070748(gene)|ensembl:ENST00000337653(transcript)|go:"GO:0004102"(choline O-acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008292"(acetylcholine biosynthetic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|mint:P28329|rcsb pdb:2FY2|rcsb pdb:2FY3|rcsb pdb:2FY4|rcsb pdb:2FY5|rcsb pdb:7AMD|reactome:R-HSA-1483191|reactome:R-HSA-264642|refseq:NP_001136401.1|refseq:NP_001136405.1|refseq:NP_001136406.1|refseq:NP_065574.3|refseq:NP_066264.3|refseq:NP_066265.3|refseq:NP_066266.3	go:"GO:0004102"(choline O-acetyltransferase activity)	-	-	figure legend:Figs. 1-5|kinetics:EC50 of  approximately 0.8 ng/mL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	rogid:ULsiid1KJJCaCgKcQT+4iWXcSHQ9606	-	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15351"	uniprotkb:P05067-PRO_0000000093	intact:EBI-1254731	intact:EBI-2431589|intact:EBI-20772365	psi-mi:acetyl-coa(display_short)|psi-mi:"CHEBI:15351"(display_long)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kumar et al. (2017)	pubmed:30271321|imex:IM-27244	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21280249|imex:IM-27244-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-77613(chain-parent)	go:"GO:0004102"(choline O-acetyltransferase activity)	-	chain-seq-start:672|chain-seq-end:711	figure legend:Figs. 1-5|kinetics:EC50 of  approximately 0.8 ng/mL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/03/21	2019/03/22	-	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)