#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28223-1	uniprotkb:P28335-1	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-21299643	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:p28335-1(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:1204"(split firefly luciferase complementation)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299641|imex:IM-26952-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	intact:EBI-994141(isoform-parent)	-	-	-	figure legend:Figure 1 D/E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/09	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	firefly-c:c-c	firefly-n:c-c	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P28223-1	uniprotkb:P28335-1	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-21299643	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:p28335-1(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:1204"(split firefly luciferase complementation)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299839|imex:IM-26952-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	intact:EBI-994141(isoform-parent)	-	-	-	figure legend:Figure 1 D/E, 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	firefly-c:c-c	-	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P28223-1	uniprotkb:P28335-1	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-21299643	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:p28335-1(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:1204"(split firefly luciferase complementation)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299839|imex:IM-26952-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	intact:EBI-994141(isoform-parent)	-	-	-	figure legend:Figure 1 D/E, 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	firefly-c:c-c	firefly-n:c-c	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P28223-1	uniprotkb:P28223-1	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:1204"(split firefly luciferase complementation)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299848|imex:IM-26952-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	-	-	-	figure legend:Figure 1 D/E, 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	-	firefly-c:c-c	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P28223-1	uniprotkb:P28335-1	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-21299643	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:p28335-1(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:1204"(split firefly luciferase complementation)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299848|imex:IM-26952-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	intact:EBI-994141(isoform-parent)	-	-	-	figure legend:Figure 1 D/E, 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	-	firefly-n:c-c	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P28223	uniprotkb:P28335	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299864|imex:IM-26952-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Figure 3 B/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho_k1)|taxid:10029(Cricetulus griseus ovary K1)	-	2019/04/03	2019/04/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P28223	uniprotkb:P28335	intact:EBI-6656333|ensembl:ENSP00000437737|uniprotkb:B2RAC5|uniprotkb:B4DZ79|uniprotkb:F5GWE8|uniprotkb:Q5T8C0	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:5ht2a_human(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299879|imex:IM-26952-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070852"(cell body fiber)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6A93|rcsb pdb:6A94|rcsb pdb:6WGT|rcsb pdb:6WH4|rcsb pdb:6WHA|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051378"(serotonin binding)|refseq:NP_000612.1|refseq:NP_001159419.1|dip:DIP-41844N	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Figure 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/08/19	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:WfOeWAzn+I4JJD7366YqXf4uYNM	false	ha tag:n-n|renilla luciferase protein tag:c-c	enhanced yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P07550	uniprotkb:P28335	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-994141|uniprotkb:Q5VUF8|uniprotkb:Q9NP28|ensembl:ENSP00000276198|ensembl:ENSP00000361018|ensembl:ENSP00000361019|uniprotkb:B1AMW4	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:5ht2c_human(display_long)|uniprotkb:5-hydroxytryptamine receptor 1C(gene name synonym)|uniprotkb:Serotonin receptor 2C(gene name synonym)|uniprotkb:HTR2C(gene name)|psi-mi:HTR2C(display_short)|uniprotkb:HTR1C(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Felsing et al. (2017)	pubmed:30157263|imex:IM-26952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299889|imex:IM-26952-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	refseq:NP_000859.1|ensembl:ENSG00000147246(gene)|ensembl:ENST00000276198(transcript)|ensembl:ENST00000371950(transcript)|ensembl:ENST00000371951(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000377(5-Hydroxytryptamine 2C receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P28335|rcsb pdb:6BQG|rcsb pdb:6BQH|reactome:R-HSA-390666|reactome:R-HSA-416476|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0032098"(regulation of appetite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043397"(regulation of corticotropin-releasing hormone secretion)|go:"GO:0045202"(synapse)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|refseq:NP_001243690.1|refseq:NP_001243689.1	-	-	-	figure legend:Figure 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/08/19	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:ceYfyf8EendInDxAeD6T+az1XBE9606	rigid:SOzMWtJpuxuitLDUqq4ylyFKwq0	false	ha tag:n-n|renilla luciferase protein tag:c-c	enhanced yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)