#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5H8C1	uniprotkb:Q5SZK8	intact:EBI-21460642|uniprotkb:B7ZBX4|uniprotkb:Q5VV00|uniprotkb:Q5VV01|uniprotkb:Q6MZI4|uniprotkb:Q8NEG9|uniprotkb:Q96LI3|ensembl:ENSP00000370262	intact:EBI-20737564|ensembl:ENSP00000280481|uniprotkb:Q4QQG1|uniprotkb:Q5H9N8|uniprotkb:Q5T6Q1|uniprotkb:Q6N057|uniprotkb:Q6ZSB4|uniprotkb:Q7Z305|uniprotkb:Q7Z341	psi-mi:frem1_human(display_long)|uniprotkb:Protein QBRICK(gene name synonym)|uniprotkb:FREM1(gene name)|psi-mi:FREM1(display_short)|uniprotkb:C9orf143(gene name synonym)|uniprotkb:C9orf145(gene name synonym)|uniprotkb:C9orf154(gene name synonym)	psi-mi:frem2_human(display_long)|uniprotkb:ECM3 homolog(gene name synonym)|uniprotkb:FREM2(gene name)|psi-mi:FREM2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yu et al. (2018)	pubmed:29688405|imex:IM-27130	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21460684|imex:IM-27130-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171175.1|refseq:NP_659403.4|refseq:XP_005251439.1|refseq:XP_005251441.1|refseq:XP_006716792.1|ensembl:ENSG00000164946(gene)|ensembl:ENST00000380880(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097094"(craniofacial suture morphogenesis)|interpro:IPR001304(C-type lectin)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR032825|interpro:IPR038081|interpro:IPR039005	ensembl:ENSG00000150893(gene)|ensembl:ENST00000280481(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007155"(cell adhesion)|go:"GO:0007507"(heart development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR038081|interpro:IPR039005|refseq:NP_997244.4	-	-	-	figure legend:Figures 3d, S3b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2019/06/28	2019/07/01	rogid:sluc5yh/QoaNI67P4eXwjC9aJGI9606	rogid:XHvsmEms0+5ADcyhtfZSHYuzazk9606	rigid:ZpMx7ulqd1KU1NBlPfB72bGYuyg	false	-	mutation decreasing interaction strength:2167-2167|mutation disrupting interaction strength:1972-1972	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5H8C1	uniprotkb:Q5SZK8	intact:EBI-21460642|uniprotkb:B7ZBX4|uniprotkb:Q5VV00|uniprotkb:Q5VV01|uniprotkb:Q6MZI4|uniprotkb:Q8NEG9|uniprotkb:Q96LI3|ensembl:ENSP00000370262	intact:EBI-20737564|ensembl:ENSP00000280481|uniprotkb:Q4QQG1|uniprotkb:Q5H9N8|uniprotkb:Q5T6Q1|uniprotkb:Q6N057|uniprotkb:Q6ZSB4|uniprotkb:Q7Z305|uniprotkb:Q7Z341	psi-mi:frem1_human(display_long)|uniprotkb:Protein QBRICK(gene name synonym)|uniprotkb:FREM1(gene name)|psi-mi:FREM1(display_short)|uniprotkb:C9orf143(gene name synonym)|uniprotkb:C9orf145(gene name synonym)|uniprotkb:C9orf154(gene name synonym)	psi-mi:frem2_human(display_long)|uniprotkb:ECM3 homolog(gene name synonym)|uniprotkb:FREM2(gene name)|psi-mi:FREM2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yu et al. (2018)	pubmed:29688405|imex:IM-27130	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22051334|imex:IM-27130-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171175.1|refseq:NP_659403.4|refseq:XP_005251439.1|refseq:XP_005251441.1|refseq:XP_006716792.1|ensembl:ENSG00000164946(gene)|ensembl:ENST00000380880(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097094"(craniofacial suture morphogenesis)|interpro:IPR001304(C-type lectin)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR032825|interpro:IPR038081|interpro:IPR039005	ensembl:ENSG00000150893(gene)|ensembl:ENST00000280481(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007154"(cell communication)|go:"GO:0007155"(cell adhesion)|go:"GO:0007507"(heart development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR038081|interpro:IPR039005|refseq:NP_997244.4	-	-	-	figure legend:Figure S3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2019/06/28	2019/09/25	rogid:sluc5yh/QoaNI67P4eXwjC9aJGI9606	rogid:XHvsmEms0+5ADcyhtfZSHYuzazk9606	rigid:ZpMx7ulqd1KU1NBlPfB72bGYuyg	false	mutation disrupting interaction strength:1324-1324|mutation disrupting interaction strength:649-649	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)