#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37288	uniprotkb:P25106	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21298965|imex:IM-26950-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Figure 2A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/01	2019/04/08	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rigid:iqpPTosDJuMCxFJTDK1V+RSCt60	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37288	uniprotkb:P25106	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21298980|imex:IM-26950-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Figure 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/01	2019/04/08	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rigid:iqpPTosDJuMCxFJTDK1V+RSCt60	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P37288	uniprotkb:P25106	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21298995|imex:IM-26950-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Figure 2D/E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/01	2019/08/20	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rigid:iqpPTosDJuMCxFJTDK1V+RSCt60	false	renilla luciferase protein tag:c-c	enhanced yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P25106	uniprotkb:P37288	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-6656842|ensembl:ENSP00000299178	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299013|imex:IM-26950-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 3 A/B/C, 4 B/D, 6A/B, 7, 8 A/B|comment:"Signals corresponding to ACKR3 : AVPR1A and ACKR3 : CXCR4 heteromers in hVSMC incubated with ACKR3 siRNA were reduced  when compared with hVSMC incubated with NT-siRNA.  CXCR4 silencing did not affect the number of PLA signals for ACKR3 : AVPR1A interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/08	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rigid:iqpPTosDJuMCxFJTDK1V+RSCt60	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P61073	uniprotkb:P37288	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	intact:EBI-6656842|ensembl:ENSP00000299178	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299237|imex:IM-26950-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 3A/B,4B/D, 6A/B, 7, 8A/B|antagonist:ACKR3 -Uniprot  P25106|comment:"As shown In figure 3, signals for CXCR4 : AVPR1A interactions were indistinguishable from negative control experiments.  When hVSMCs were incubated with ACKR3 siRNA, PLA signals corresponding to CXCR4 : AVPR1A interactions increased to 510% of PLA signals in hVSMC incubated with NT-siRNA."|comment:"Addition of TM 2/4/7 (ACKR3) peptides had no effect on this interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rigid:6IlLIIaeKE3SjrSd36lSSrmftmY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299245|imex:IM-26950-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 4 B/D, 7,8 A/B|comment:"Signals corresponding to ACKR3 : AVPR1A and ACKR3 : CXCR4 heteromers in hVSMC incubated with ACKR3 siRNA were reduced  when compared with hVSMC incubated with NT-siRNA."|comment:Weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:KZJSQYFy/EzS9XFFNc8Lk6nJ8AQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	intact:EBI-21284692	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	-	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:tm2_peptide(display_short)|psi-mi:EBI-21284692(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299385|imex:IM-26950-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	uniprotkb:P25106(see-also)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 7,8 A/B|comment:"The TM2 and TM4 peptides reduced PLA signals for AVPR1A : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:olQf2CAI416PuiRTealdyKoG3Jw-2	rigid:E4J3PnmDa23zLXea162a8N0ofoc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	uniprotkb:P37288	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-6656842|ensembl:ENSP00000299178	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299385|imex:IM-26950-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 7,8 A/B|comment:"The TM2 and TM4 peptides reduced PLA signals for AVPR1A : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rigid:E4J3PnmDa23zLXea162a8N0ofoc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	intact:EBI-21284695	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	-	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:tm4_peptide(display_short)|psi-mi:EBI-21284695(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299393|imex:IM-26950-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	uniprotkb:P25106(see-also)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 7,8 A/Bi|comment:"The TM2 and TM4 peptides reduced PLA signals for AVPR1A : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:dLr0EeGinG0JrQoac9oal8fiW84-2	rigid:wuvaor41G6cA1+isc4OeffUrhG4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	uniprotkb:P37288	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-6656842|ensembl:ENSP00000299178	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299393|imex:IM-26950-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 7,8 A/Bi|comment:"The TM2 and TM4 peptides reduced PLA signals for AVPR1A : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rigid:wuvaor41G6cA1+isc4OeffUrhG4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299400|imex:IM-26950-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure  7,8 A/B|comment:"All TM peptide analogues reduced PLA signals for CXCR4 : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:CmcyOOrSkVQWpxzeXa8MXWhxinE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	intact:EBI-21284692	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	-	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:tm2_peptide(display_short)|psi-mi:EBI-21284692(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299400|imex:IM-26950-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	uniprotkb:P25106(see-also)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure  7,8 A/B|comment:"All TM peptide analogues reduced PLA signals for CXCR4 : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:olQf2CAI416PuiRTealdyKoG3Jw-2	rigid:CmcyOOrSkVQWpxzeXa8MXWhxinE	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299409|imex:IM-26950-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure  7,8 A/Bi|comment:"All TM peptide analogues reduced PLA signals for CXCR4 : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:a/9a7+/cr1eQsGf5pEwBzIF2Em4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	intact:EBI-21284695	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	-	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:tm4_peptide(display_short)|psi-mi:EBI-21284695(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299409|imex:IM-26950-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	uniprotkb:P25106(see-also)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure  7,8 A/Bi|comment:"All TM peptide analogues reduced PLA signals for CXCR4 : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:dLr0EeGinG0JrQoac9oal8fiW84-2	rigid:a/9a7+/cr1eQsGf5pEwBzIF2Em4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	uniprotkb:P61073	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299416|imex:IM-26950-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure  7,8 A/Bii|comment:"All TM peptide analogues reduced PLA signals for CXCR4 : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:h4nAvpgzLnhORYf/jivebK0bVMs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P25106	intact:EBI-21284698	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	-	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:tm7_peptide(display_short)|psi-mi:EBI-21284698(display_long)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299416|imex:IM-26950-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	uniprotkb:P25106(see-also)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure  7,8 A/Bii|comment:"All TM peptide analogues reduced PLA signals for CXCR4 : ACKR3 interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/09	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rogid:s/yIvWof35gx3yZrGirdj/qUqJs-2	rigid:h4nAvpgzLnhORYf/jivebK0bVMs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37288	uniprotkb:P61073	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299039|imex:IM-26950-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 3D-G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/08	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rigid:7eI31pW+A8eERdaNu7MVSSFTS8Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37288	uniprotkb:P25106	intact:EBI-6656842|ensembl:ENSP00000299178	intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928	psi-mi:v1ar_human(display_long)|uniprotkb:AVPR1A(gene name)|psi-mi:AVPR1A(display_short)|uniprotkb:AVPR1(gene name synonym)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299039|imex:IM-26950-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166148(gene)|ensembl:ENST00000299178(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0150104"(transport across blood-brain barrier)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1YTV|reactome:R-HSA-388479|reactome:R-HSA-416476|reactome:R-HSA-5619099|refseq:NP_000697.1	refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 3D-G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-smooth muscle)|taxid:9606(Homo sapiens)	-	2019/04/01	2019/04/08	rogid:5abwd21TO9yfkHn1yTWTQlFE1489606	rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606	rigid:7eI31pW+A8eERdaNu7MVSSFTS8Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O89039	uniprotkb:P30560	intact:EBI-21299265|ensembl:ENSRNOP00000026558|uniprotkb:Q9JLZ0	intact:EBI-21299313|ensembl:ENSRNOP00000005829|uniprotkb:Q5M8D1|uniprotkb:Q62874|uniprotkb:Q9QW18	psi-mi:ackr3_rat(display_long)|uniprotkb:Ackr3(gene name)|psi-mi:Ackr3(display_short)|uniprotkb:Cmkor1(gene name synonym)|uniprotkb:Cxcr7(gene name synonym)|uniprotkb:Rdc1(gene name synonym)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)	psi-mi:v1ar_rat(display_long)|uniprotkb:Avpr1a(gene name)|psi-mi:Avpr1a(display_short)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299259|imex:IM-26950-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000019622(gene)|ensembl:ENSRNOT00000026558(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-380108|reactome:R-RNO-418594|go:"GO:0016494"(C-X-C chemokine receptor activity)|refseq:NP_445804.1|refseq:XP_006245541.1|rgd:620601	go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051459"(regulation of corticotropin secretion)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-388479|reactome:R-RNO-416476|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035810"(positive regulation of urine volume)|ensembl:ENSRNOG00000004400(gene)|ensembl:ENSRNOT00000005829(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|refseq:NP_444178.2|rgd:2185	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 5 B/D|comment:"Signals corresponding to ACKR3 : AVPR1A and ACKR3 : CXCR4 heteromers in cells incubated with ACKR3 siRNA were reduced  when compared with cells incubated with NT-siRNA."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-a7r5)|taxid:10116(Rattus norvegicus)	-	2019/04/01	2019/04/09	rogid:UhL8mmOGqww+snQ/A9BWgv9tQ0Y10116	rogid:/K0a+/YosBzCvvCZqWy32iP/YLQ10116	rigid:mtFJJXZ8xcVbhf4oa+DeaYjOJiA	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O89039	uniprotkb:O08565	intact:EBI-21299265|ensembl:ENSRNOP00000026558|uniprotkb:Q9JLZ0	intact:EBI-11167786|ensembl:ENSRNOP00000005143|uniprotkb:F1LPN8|uniprotkb:Q8VD47	psi-mi:ackr3_rat(display_long)|uniprotkb:Ackr3(gene name)|psi-mi:Ackr3(display_short)|uniprotkb:Cmkor1(gene name synonym)|uniprotkb:Cxcr7(gene name synonym)|uniprotkb:Rdc1(gene name synonym)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)	psi-mi:cxcr4_rat(display_long)|uniprotkb:Cxcr4(gene name)|psi-mi:Cxcr4(display_short)|uniprotkb:Cmkar4(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299371|imex:IM-26950-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000019622(gene)|ensembl:ENSRNOT00000026558(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-380108|reactome:R-RNO-418594|go:"GO:0016494"(C-X-C chemokine receptor activity)|refseq:NP_445804.1|refseq:XP_006245541.1|rgd:620601	rgd:620465|ensembl:ENSRNOG00000003866(gene)|ensembl:ENSRNOT00000005143(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008354"(germ cell migration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0035904"(aorta development)|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048699"(generation of neurons)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:O08565|reactome:R-RNO-380108|reactome:R-RNO-418594|refseq:NP_071541.2	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 5 B/D|comment:"Signals corresponding to ACKR3 : AVPR1A and ACKR3 : CXCR4 heteromers in cells incubated with ACKR3 siRNA were reduced  when compared with cells incubated with NT-siRNA."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-a7r5)|taxid:10116(Rattus norvegicus)	-	2019/04/01	2019/04/09	rogid:UhL8mmOGqww+snQ/A9BWgv9tQ0Y10116	rogid:fF6oeliArkzJegdJf8Kwdcx/Zcc10116	rigid:XYiUIULNeYmUvo+5TCwXnqa4ZRs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O08565	uniprotkb:P30560	intact:EBI-11167786|ensembl:ENSRNOP00000005143|uniprotkb:F1LPN8|uniprotkb:Q8VD47	intact:EBI-21299313|ensembl:ENSRNOP00000005829|uniprotkb:Q5M8D1|uniprotkb:Q62874|uniprotkb:Q9QW18	psi-mi:cxcr4_rat(display_long)|uniprotkb:Cxcr4(gene name)|psi-mi:Cxcr4(display_short)|uniprotkb:Cmkar4(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)	psi-mi:v1ar_rat(display_long)|uniprotkb:Avpr1a(gene name)|psi-mi:Avpr1a(display_short)|uniprotkb:AVPR V1a(gene name synonym)|uniprotkb:Antidiuretic hormone receptor 1a(gene name synonym)|uniprotkb:Vascular/hepatic-type arginine vasopressin receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Albee et al. (2018)	pubmed:29386406|imex:IM-26950	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21299377|imex:IM-26950-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620465|ensembl:ENSRNOG00000003866(gene)|ensembl:ENSRNOT00000005143(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008354"(germ cell migration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0035904"(aorta development)|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048699"(generation of neurons)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:O08565|reactome:R-RNO-380108|reactome:R-RNO-418594|refseq:NP_071541.2	go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0042631"(cellular response to water deprivation)|go:"GO:0042711"(maternal behavior)|go:"GO:0042713"(sperm ejaculation)|go:"GO:0043084"(penile erection)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051459"(regulation of corticotropin secretion)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001224(Vasopressin V1A receptor)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR015076(Region of unknown function DUF1856)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-388479|reactome:R-RNO-416476|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031894"(V1A vasopressin receptor binding)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0035176"(social behavior)|go:"GO:0035810"(positive regulation of urine volume)|ensembl:ENSRNOG00000004400(gene)|ensembl:ENSRNOT00000005829(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0002125"(maternal aggressive behavior)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007621"(negative regulation of female receptivity)|go:"GO:0007625"(grooming behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|refseq:NP_444178.2|rgd:2185	go:"GO:0009986"(cell surface)	-	-	figure legend:Figure 5 B/D|antagonist:ACKR3 -Uniprot  O89039|comment:"When cells were incubated with ACKR3 siRNA, PLA signals corresponding to CXCR4 : AVPR1A interactions increased to 276%  of PLA signals in cells incubated with NT-siRNA."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-a7r5)|taxid:10116(Rattus norvegicus)	-	2019/04/01	2019/04/09	rogid:fF6oeliArkzJegdJf8Kwdcx/Zcc10116	rogid:/K0a+/YosBzCvvCZqWy32iP/YLQ10116	rigid:LkgkGtq0DLyyc9R1osiAAbI0D8I	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)