#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30871	uniprotkb:P0AEU7	intact:EBI-546664|uniprotkb:Q2M9F1|ensemblbacteria:AAC76090|ensemblbacteria:BAE77105	intact:EBI-548242|uniprotkb:P11457|ensemblbacteria:AAC73289|ensemblbacteria:BAA77853	psi-mi:3pase_ecoli(display_long)|uniprotkb:ygiF(gene name)|psi-mi:ygiF(display_short)|uniprotkb:b3054(locus name)|uniprotkb:ORFXE(gene name synonym)|uniprotkb:JW3026(locus name)	psi-mi:skp_ecoli(display_long)|uniprotkb:skp(gene name)|psi-mi:skp(display_short)|uniprotkb:ompH(gene name synonym)|uniprotkb:hlpA(gene name synonym)|uniprotkb:b0178(locus name)|uniprotkb:Seventeen kilodalton protein(gene name synonym)|uniprotkb:Histone-like protein HLP-1(gene name synonym)|uniprotkb:DNA-binding 17 kDa protein(gene name synonym)|uniprotkb:JW0173(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981872|imex:IM-27227-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417526.1|ensemblbacteria:AAC76090(transcript)|ensemblbacteria:b3054(gene)|ensemblbacteria:BAE77105(gene)|ensemblbacteria:BAE77105(transcript)|go:"GO:0046872"(metal ion binding)|go:"GO:0050355"(triphosphatase activity)|interpro:IPR007899(CHAD)|interpro:IPR023577|interpro:IPR033469|interpro:IPR039013|rcsb pdb:5A60|rcsb pdb:5A61|refseq:WP_000046281.1|dip:DIP-12218N	refseq:NP_414720.1|refseq:WP_000758956.1|dip:DIP-36210N|ensemblbacteria:AAC73289(transcript)|ensemblbacteria:b0178(gene)|ensemblbacteria:BAA77853(gene)|ensemblbacteria:BAA77853(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0042802"(identical protein binding)|go:"GO:0043165"(Gram-negative-bacterium-type cell outer membrane assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005632("Outer membrane chaperone Skp (OmpH)")|interpro:IPR024930|rcsb pdb:1SG2|rcsb pdb:1U2M	-	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:5REganvqgbl+HPaI+5h131G7Wi483333	rogid:lsR04hlxzICLK46Ni0vFHrA6/mQ83333	rigid:F8q5pJjcQZHt5bisWCUAC/mjwck	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEB5	uniprotkb:P0AFP0	intact:EBI-9141361|uniprotkb:P77253|ensemblbacteria:AAC74412|ensemblbacteria:BAA14923	intact:EBI-21977477|uniprotkb:P37027|ensemblbacteria:AAC73268|ensemblbacteria:BAB96734	psi-mi:ynai_ecoli(display_long)|uniprotkb:JW1323(locus name)|uniprotkb:b1330(locus name)|uniprotkb:ynaI(gene name)|psi-mi:ynaI(display_short)	psi-mi:yads_ecoli(display_long)|uniprotkb:b0157(locus name)|uniprotkb:JW0153(locus name)|uniprotkb:yadS(gene name)|psi-mi:yadS(display_short)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981865|imex:IM-27227-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415846.1|refseq:WP_000559900.1|dip:DIP-12740N|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR006685(Mechanosensitive ion channel MscS)|interpro:IPR006686(Mechanosensitive ion channel MscS, conserved site)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR011014(Mechanosensitive ion channel MscS, transmembrane-2)|interpro:IPR011066(Mechanosensitive ion channel MscS, C-terminal)|interpro:IPR023408|rcsb pdb:6URT|rcsb pdb:6ZYD|rcsb pdb:6ZYE|ensemblbacteria:AAC74412(transcript)|ensemblbacteria:b1330(gene)|ensemblbacteria:BAA14923(gene)|ensemblbacteria:BAA14923(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)	refseq:NP_414699.1|refseq:WP_000964221.1|interpro:IPR005115(Protein of unknown function UPF0126)|ensemblbacteria:AAC73268(transcript)|ensemblbacteria:b0157(gene)|ensemblbacteria:BAB96734(gene)|ensemblbacteria:BAB96734(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:6I4BWg4FbY45yN/34D2DwhBNfwg83333	rogid:MeM2P0i+kvnHznwel1Oh7P/U9oo83333	rigid:2eCKMXqCI7YypXOBtOkOIu+FVyE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P77364	uniprotkb:P77328	intact:EBI-1118134|uniprotkb:Q2MBR4|ensemblbacteria:AAC73616|ensemblbacteria:BAE76292	intact:EBI-21977549|uniprotkb:Q2MBR5|ensemblbacteria:AAC73615|ensemblbacteria:BAE76291	psi-mi:glxk2_ecoli(display_long)|uniprotkb:Glycerate kinase 2(gene name synonym)|uniprotkb:ybbZ(gene name synonym)|uniprotkb:glxK(gene name)|psi-mi:glxK(display_short)|uniprotkb:glxB5(gene name synonym)|uniprotkb:b0514(locus name)|uniprotkb:JW0502(locus name)|uniprotkb:D-Glycerate-3-kinase(gene name synonym)	psi-mi:ybby_ecoli(display_long)|uniprotkb:ybbY(gene name)|psi-mi:ybbY(display_short)|uniprotkb:glxB4(gene name synonym)|uniprotkb:b0513(locus name)|uniprotkb:JW0501(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981893|imex:IM-27227-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC73616(transcript)|ensemblbacteria:b0514(gene)|ensemblbacteria:BAE76292(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0008887"(glycerate kinase activity)|go:"GO:0009436"(glyoxylate catabolic process)|go:"GO:0031388"(organic acid phosphorylation)|go:"GO:0043798"(glycerate 2-kinase activity)|go:"GO:0046296"(glycolate catabolic process)|ensemblbacteria:BAE76292(transcript)|refseq:WP_001333621.1|interpro:IPR036129|refseq:NP_415047.1|interpro:IPR018193|interpro:IPR004381(Glycerate kinase)|interpro:IPR018197	interpro:IPR006043(Xanthine/uracil/vitamin C permease)|refseq:NP_415046.4|refseq:WP_001302767.1|ensemblbacteria:AAC73615(transcript)|ensemblbacteria:b0513(gene)|ensemblbacteria:BAE76291(gene)|ensemblbacteria:BAE76291(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042906"(xanthine transport)|go:"GO:0042907"(xanthine transmembrane transporter activity)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:s0NaBP9KIX4ZPWlg1itft31qNZo83333	rogid:/7tOuz0ebTaox15HZeq3upgReWw83333	rigid:viLRJPw9AnlHkYgGiS+sxeeS2nA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15047	uniprotkb:P23877	intact:EBI-1118936|uniprotkb:P77100|uniprotkb:Q2MBK5|ensemblbacteria:AAC73697|ensemblbacteria:BAE76351	intact:EBI-21464313|uniprotkb:P77587|uniprotkb:Q2MBL2|ensemblbacteria:AAC73690|ensemblbacteria:BAE76344	psi-mi:enta_ecoli(display_long)|uniprotkb:entA(gene name)|psi-mi:entA(display_short)|uniprotkb:Trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase(gene name synonym)|uniprotkb:JW0588(locus name)|uniprotkb:b0596(locus name)	psi-mi:fepg_ecoli(display_long)|uniprotkb:fepG(gene name)|psi-mi:fepG(display_short)|uniprotkb:b0589(locus name)|uniprotkb:JW0581(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981907|imex:IM-27227-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415128.1|ensemblbacteria:AAC73697(transcript)|ensemblbacteria:b0596(gene)|ensemblbacteria:BAE76351(gene)|ensemblbacteria:BAE76351(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008667"(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity)|go:"GO:0009239"(enterobactin biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR003560(2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase)|interpro:IPR020904|interpro:IPR036291|rcsb pdb:2FWM|refseq:WP_000347651.1|dip:DIP-9511N	dip:DIP-9597N|refseq:NP_415121.1|refseq:WP_000640988.1|ensemblbacteria:AAC73690(transcript)|ensemblbacteria:b0589(gene)|ensemblbacteria:BAE76344(gene)|ensemblbacteria:BAE76344(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015620"(ferric-enterobactin transmembrane transporter activity)|go:"GO:0015685"(ferric-enterobactin import into cell)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0033214"(siderophore-dependent iron import into cell)|interpro:IPR000522(Bacterial transport system permease protein)|interpro:IPR037294	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:xOemoPizq7i1Dfn1CiSE9dnEPww83333	rogid:SkgSAeMY5yAv3uqpPjVxoYsXnrI83333	rigid:yAwOfybYG/51T1TiNHfSzabJEmQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P71298	uniprotkb:P0AE45	intact:EBI-1131530|uniprotkb:Q2MCE1|ensemblbacteria:AAC73384|ensemblbacteria:BAE76065	intact:EBI-15775666|ensemblbacteria:BAE78219|ensemblbacteria:AAC77175|uniprotkb:P39319|uniprotkb:Q2M687	psi-mi:intf_ecoli(display_long)|uniprotkb:intF(gene name)|psi-mi:intF(display_short)|uniprotkb:b0281(locus name)|uniprotkb:JW0275(locus name)|uniprotkb:yagO(gene name synonym)|uniprotkb:Putative prophage CP4-6 integrase(gene name synonym)	psi-mi:paea_ecoli(display_long)|uniprotkb:paeA(gene name)|psi-mi:paeA(display_short)|uniprotkb:ytfL(gene name synonym)|uniprotkb:JW4177(locus name)|uniprotkb:b4218(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981879|imex:IM-27227-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013762(Integrase-like, catalytic core, phage)|interpro:IPR002104(Integrase, catalytic core, phage)|refseq:NP_414815.1|interpro:IPR038488|ensemblbacteria:AAC73384(transcript)|ensemblbacteria:b0281(gene)|ensemblbacteria:BAE76065(gene)|ensemblbacteria:BAE76065(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006310"(DNA recombination)|go:"GO:0010165"(response to X-ray)|go:"GO:0015074"(DNA integration)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0075713"(establishment of integrated proviral latency)|interpro:IPR025166|refseq:WP_001407714.1|interpro:IPR044068	ensemblbacteria:AAC77175(transcript)|ensemblbacteria:b4218(gene)|ensemblbacteria:BAE78219(gene)|ensemblbacteria:BAE78219(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR002550(Protein of unknown function DUF21)|interpro:IPR005170(Transporter-associated region)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR044751|refseq:NP_418639.1|refseq:WP_000935036.1|dip:DIP-48233N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:Fgfr0u31zFkvWoGuDouoRbXaz1883333	rogid:8IFqAnhxa3gt9L6xjyit5WJWeFA83333	rigid:/h9MklGSjtK9EaRWaLDdgzRbBGo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AFF4	uniprotkb:P21865	intact:EBI-21977584|uniprotkb:P09452|uniprotkb:P76653|uniprotkb:Q2M9M9|ensemblbacteria:AAC76001|ensemblbacteria:BAE77027	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	psi-mi:nupg_ecoli(display_long)|uniprotkb:Nucleoside-transport system protein NupG(gene name synonym)|uniprotkb:JW2932(locus name)|uniprotkb:b2964(locus name)|uniprotkb:nupG(gene name)|psi-mi:nupG(display_short)	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981914|imex:IM-27227-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417439.4|refseq:WP_001049791.1|interpro:IPR020846|interpro:IPR036259|interpro:IPR004740("Nucleoside:H+ symporter")|interpro:IPR033667|rcsb pdb:7DL9|rcsb pdb:7DLA|ensemblbacteria:AAC76001(transcript)|ensemblbacteria:b2964(gene)|ensemblbacteria:BAE77027(gene)|ensemblbacteria:BAE77027(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015212"(cytidine transmembrane transporter activity)|go:"GO:0015213"(uridine transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015506"("nucleoside:proton symporter activity")|go:"GO:0015860"(purine nucleoside transmembrane transport)|go:"GO:0015862"(uridine transport)|go:"GO:0015864"(pyrimidine nucleoside transport)|go:"GO:0032238"(adenosine transport)|go:"GO:0071702"(organic substance transport)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:5CYRcczH0B0S5oyIv65oiDuEfv083333	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rigid:ihr9C5/Mvo8URYTfSrEuELLnZYU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24207	uniprotkb:P02920	intact:EBI-561869|ensemblbacteria:AAC73677|ensemblbacteria:BAA35216|uniprotkb:P77090	intact:EBI-21977510|uniprotkb:Q2MC81|ensemblbacteria:AAC73446|ensemblbacteria:BAE76125	psi-mi:phep_ecoli(display_long)|uniprotkb:pheP(gene name)|psi-mi:pheP(display_short)|uniprotkb:b0576(locus name)|uniprotkb:JW0565(locus name)	psi-mi:lacy_ecoli(display_long)|uniprotkb:lacY(gene name)|psi-mi:lacY(display_short)|uniprotkb:Lactose-proton symport(gene name synonym)|uniprotkb:JW0334(locus name)|uniprotkb:b0343(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981886|imex:IM-27227-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415108.1|ensemblbacteria:AAC73677(transcript)|ensemblbacteria:b0576(gene)|ensemblbacteria:BAA35216(gene)|ensemblbacteria:BAA35216(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0055085"(transmembrane transport)|interpro:IPR004840(Amino acid permease, conserved site)|interpro:IPR004841(Amino acid permease-associated region)|refseq:WP_000786319.1|dip:DIP-10479N	refseq:NP_414877.1|refseq:WP_000291549.1|dip:DIP-10080N|ensemblbacteria:AAC73446(transcript)|ensemblbacteria:b0343(gene)|ensemblbacteria:BAE76125(gene)|ensemblbacteria:BAE76125(transcript)|go:"GO:0005351"("carbohydrate:proton symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015528"("lactose:proton symporter activity")|go:"GO:0015767"(lactose transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030395"(lactose binding)|go:"GO:0071702"(organic substance transport)|interpro:IPR000576(Proton/sugar symporter, LacY)|interpro:IPR018457|interpro:IPR020846|interpro:IPR036259|rcsb pdb:1M2U|rcsb pdb:1PV6|rcsb pdb:1PV7|rcsb pdb:2CFP|rcsb pdb:2CFQ|rcsb pdb:2V8N|rcsb pdb:2Y5Y|rcsb pdb:4ZYR|rcsb pdb:5GXB|rcsb pdb:6C9W	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:mSNSfvSbOaEagEuPyDx+7mHNtJw83333	rogid:Yh82s5qkLwuizBILJmieZNr6fp483333	rigid:l+gikvnMjh44wy6mR8D56FSVibo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30859	uniprotkb:P38054	intact:EBI-1120651|uniprotkb:P77640|ensemblbacteria:AAC73950|ensemblbacteria:BAA35577	intact:EBI-1126317|uniprotkb:P77767|ensemblbacteria:AAC73676|ensemblbacteria:BAA35215	psi-mi:arti_ecoli(display_long)|uniprotkb:artI(gene name)|psi-mi:artI(display_short)|uniprotkb:b0863(locus name)|uniprotkb:JW0847(locus name)	psi-mi:cusa_ecoli(display_long)|uniprotkb:cusA(gene name)|psi-mi:cusA(display_short)|uniprotkb:b0575(locus name)|uniprotkb:JW0564(locus name)|uniprotkb:ybdE(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981900|imex:IM-27227-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001320(Ionotropic glutamate receptor)|refseq:WP_000756569.1|refseq:NP_415384.1|interpro:IPR005768(Lysine-arginine-ornithine-binding periplasmic protein)|interpro:IPR001638(Bacterial extracellular solute-binding protein, family 3)|interpro:IPR018313|ensemblbacteria:AAC73950(transcript)|ensemblbacteria:b0863(gene)|ensemblbacteria:BAA35577(gene)|ensemblbacteria:BAA35577(transcript)|go:"GO:0006865"(amino acid transport)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)	refseq:WP_000573945.1|refseq:NP_415107.1|ensemblbacteria:AAC73676(transcript)|ensemblbacteria:b0575(gene)|ensemblbacteria:BAA35215(gene)|ensemblbacteria:BAA35215(transcript)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0010272"(response to silver ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0015080"(silver ion transmembrane transporter activity)|go:"GO:0015673"(silver ion transport)|go:"GO:0015679"(plasma membrane copper ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046688"(response to copper ion)|go:"GO:0060003"(copper ion export)|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR004763(Heavy metal efflux pump CzcA)|interpro:IPR027463|rcsb pdb:3K07|rcsb pdb:3K0I|rcsb pdb:3KSO|rcsb pdb:3KSS|rcsb pdb:3NE5|rcsb pdb:3T51|rcsb pdb:3T53|rcsb pdb:3T56|rcsb pdb:4DNR|rcsb pdb:4DOP|rcsb pdb:7KF5|rcsb pdb:7KF6|rcsb pdb:7KF7|rcsb pdb:7KF8|rcsb pdb:4DNT|dip:DIP-9345N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:STSJxWSvQdo03YJARtppMBju03083333	rogid:coMDgbW/gzb+pH6r7G4SG5A0/DU83333	rigid:yZPnZlpeIBWDfW/zDAoeQ0vNELQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16700	uniprotkb:P75853	intact:EBI-560567|ensemblbacteria:AAC75478|ensemblbacteria:BAA16299	intact:EBI-21450516|uniprotkb:Q9R7Q5|ensemblbacteria:AAC74022|ensemblbacteria:BAA35691	psi-mi:cysp_ecoli(display_long)|uniprotkb:cysP(gene name)|psi-mi:cysP(display_short)|uniprotkb:b2425(locus name)|uniprotkb:JW2418(locus name)	psi-mi:ssua_ecoli(display_long)|uniprotkb:ssuA(gene name)|psi-mi:ssuA(display_short)|uniprotkb:ycbO(gene name synonym)|uniprotkb:b0936(locus name)|uniprotkb:JW0919(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981935|imex:IM-27227-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416920.1|refseq:WP_000290230.1|dip:DIP-9384N|ensemblbacteria:AAC75478(transcript)|ensemblbacteria:b2425(gene)|ensemblbacteria:BAA16299(gene)|ensemblbacteria:BAA16299(transcript)|go:"GO:0006790"(sulfur compound metabolic process)|go:"GO:0008272"(sulfate transport)|go:"GO:0015419"(ABC-type sulfate transporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036173"(thiosulfate binding)|go:"GO:0043199"(sulfate binding)|interpro:IPR000957(Sulphate/thiosulphate-binding, conserved site)|interpro:IPR005669(Thiosulphate-binding protein)|interpro:IPR034408	interpro:IPR001638(Bacterial extracellular solute-binding protein, family 3)|interpro:IPR015168(NMT1/THI5 like)|refseq:NP_415456.4|refseq:WP_001244308.1|rcsb pdb:2X26|interpro:IPR010067(ABC transporter, substrate-binding protein, aliphatic sulphonates)|ensemblbacteria:AAC74022(transcript)|ensemblbacteria:b0936(gene)|ensemblbacteria:BAA35691(gene)|ensemblbacteria:BAA35691(transcript)|go:"GO:0006790"(sulfur compound metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042597"(periplasmic space)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042918"(alkanesulfonate transport)|go:"GO:0042959"(alkanesulfonate transmembrane transporter activity)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:FlFG2kV8skzMucgfcTyD+cGbRMs83333	rogid:6cDZQZ49uoIxTgOSLyaRz+QF+Nc83333	rigid:i9y1N62ZhcG3QM7frguD7SqrliY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P75830	uniprotkb:P23886	intact:EBI-551961|ensemblbacteria:AAC73965|ensemblbacteria:BAA35597	intact:EBI-1115859|ensemblbacteria:AAC73972|ensemblbacteria:BAA35611	psi-mi:maca_ecoli(display_long)|uniprotkb:macA(gene name)|psi-mi:macA(display_short)|uniprotkb:b0878(locus name)|uniprotkb:ybjY(gene name synonym)|uniprotkb:JW0862(locus name)	psi-mi:cydc_ecoli(display_long)|uniprotkb:cydC(gene name)|psi-mi:cydC(display_short)|uniprotkb:mdrA(gene name synonym)|uniprotkb:mdrH(gene name synonym)|uniprotkb:surB(gene name synonym)|uniprotkb:b0886(locus name)|uniprotkb:JW0869(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981928|imex:IM-27227-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415399.4|refseq:WP_000746442.1|dip:DIP-11460N|ensemblbacteria:AAC73965(transcript)|ensemblbacteria:b0878(gene)|ensemblbacteria:BAA35597(gene)|ensemblbacteria:BAA35597(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990196"(MacAB-TolC complex)|go:"GO:1990281"(efflux pump complex)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR006143(Secretion protein HlyD)|interpro:IPR030190|interpro:IPR032317|rcsb pdb:3FPP|rcsb pdb:5NIK|rcsb pdb:5NIL	refseq:WP_001202177.1|ensemblbacteria:AAC73972(transcript)|ensemblbacteria:b0886(gene)|ensemblbacteria:BAA35611(gene)|ensemblbacteria:BAA35611(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033228"(cysteine export across plasma membrane)|go:"GO:0034775"(glutathione transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070453"(regulation of heme biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR014223("ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC")|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|refseq:NP_415406.1|dip:DIP-9362N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:Xj1hcSaeRW/gtgzklUnnRv/9Yvw83333	rogid:ef62OeRlZzoqFHG8V6f71tB0rkY83333	rigid:ZH5+KPFaRaZVHyOBqx5KQSPxh4Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19934	uniprotkb:P0ABV6	intact:EBI-1120026|ensemblbacteria:BAA35405|ensemblbacteria:AAC73833	intact:EBI-558394|uniprotkb:P05829|ensemblbacteria:AAC73832|ensemblbacteria:BAA35404	psi-mi:tola_ecoli(display_long)|uniprotkb:tolA(gene name)|psi-mi:tolA(display_short)|uniprotkb:cim(gene name synonym)|uniprotkb:excC(gene name synonym)|uniprotkb:lky(gene name synonym)|uniprotkb:b0739(locus name)|uniprotkb:JW0729(locus name)	psi-mi:tolr_ecoli(display_long)|uniprotkb:tolR(gene name)|psi-mi:tolR(display_short)|uniprotkb:b0738(locus name)|uniprotkb:JW0728(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981921|imex:IM-27227-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415267.1|ensemblbacteria:b0739(gene)|ensemblbacteria:BAA35405(gene)|ensemblbacteria:BAA35405(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017038"(protein import)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032153"(cell division site)|go:"GO:0043213"(bacteriocin transport)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0051301"(cell division)|go:"GO:0071237"(cellular response to bacteriocin)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR014161(Tol-Pal system, TolA)|rcsb pdb:1S62|rcsb pdb:1TOL|rcsb pdb:3QDP|rcsb pdb:3QDR|refseq:WP_000030637.1|ensemblbacteria:AAC73833(transcript)|mint:P19934|dip:DIP-11005N	refseq:NP_415266.1|refseq:WP_000090097.1|dip:DIP-48143N|ensemblbacteria:AAC73832(transcript)|ensemblbacteria:b0738(gene)|ensemblbacteria:BAA35404(gene)|ensemblbacteria:BAA35404(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0032153"(cell division site)|go:"GO:0043213"(bacteriocin transport)|go:"GO:0051301"(cell division)|interpro:IPR003400(Biopolymer transport protein ExbD/TolR)|interpro:IPR014168(Biopolymer transport, TolR)|rcsb pdb:5BY4	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:NdgYXCwaUWUIQNGWLfbJF8XIlY483333	rogid:CjnuJL1FOBfFnmvK1w1tN+qw6Do83333	rigid:SPbn2YFYQZq15A0KpTVrCrKL7nE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P77754	uniprotkb:P36554	intact:EBI-1121716|ensemblbacteria:AAC74813|ensemblbacteria:BAA15531	intact:EBI-556378|uniprotkb:P76400|uniprotkb:Q54A55|ensemblbacteria:AAC75138|ensemblbacteria:BAA15933	psi-mi:spy_ecoli(display_long)|uniprotkb:Spheroplast protein Y(gene name synonym)|uniprotkb:JW1732(locus name)|uniprotkb:b1743(locus name)|uniprotkb:spy(gene name)|psi-mi:spy(display_short)	psi-mi:mdtd_ecoli(display_long)|uniprotkb:mdtD(gene name)|psi-mi:mdtD(display_short)|uniprotkb:b2077(locus name)|uniprotkb:yegB(gene name synonym)|uniprotkb:JW2062(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981942|imex:IM-27227-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001228984.1|ensemblbacteria:AAC74813(transcript)|ensemblbacteria:b1743(gene)|ensemblbacteria:BAA15531(gene)|ensemblbacteria:BAA15531(transcript)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1990507"(obsolete ATP-independent chaperone mediated protein folding)|interpro:IPR012899(Region of unknown function, Spy-related)|rcsb pdb:5WNW|rcsb pdb:5WO1|rcsb pdb:5WO2|rcsb pdb:5WO3|rcsb pdb:6BIE|rcsb pdb:6OWX|rcsb pdb:6OWY|rcsb pdb:6OWZ|refseq:NP_416257.1|dip:DIP-10914N	refseq:NP_416581.1|refseq:WP_000130850.1|dip:DIP-11876N|interpro:IPR020846|interpro:IPR023721|interpro:IPR036259|interpro:IPR011701(Major facilitator superfamily MFS-1)|ensemblbacteria:AAC75138(transcript)|ensemblbacteria:b2077(gene)|ensemblbacteria:BAA15933(gene)|go:"GO:0055085"(transmembrane transport)|interpro:IPR004638(Drug resistance transporter EmrB/QacA subfamily)|ensemblbacteria:BAA15933(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0022857"(transmembrane transporter activity)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:ZK/XSrX9n+PJSELHp/iQTeQqYCg83333	rogid:drtbYHMZRCnoCYC8dT9tPwLe2ac83333	rigid:66KKSXHEQZDGJEOK2EWMojb0CDc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P76344	uniprotkb:P02924	intact:EBI-1132958|uniprotkb:Q2MAZ5|ensemblbacteria:AAC75039|ensemblbacteria:BAE76561	intact:EBI-1112983|ensemblbacteria:AAC74971|ensemblbacteria:BAA15721	psi-mi:zint_ecoli(display_long)|uniprotkb:zinT(gene name)|psi-mi:zinT(display_short)|uniprotkb:yodA(gene name synonym)|uniprotkb:b1973(locus name)|uniprotkb:JW1956(locus name)|uniprotkb:Cadmium-induced protein ZinT(gene name synonym)	psi-mi:araf_ecoli(display_long)|uniprotkb:araF(gene name)|psi-mi:araF(display_short)|uniprotkb:b1901(locus name)|uniprotkb:JW1889(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981949|imex:IM-27227-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416482.1|interpro:IPR012674(Calycin)|interpro:IPR015304(YodA)|rcsb pdb:1OEE|rcsb pdb:1OEJ|rcsb pdb:1OEK|refseq:WP_001007805.1|rcsb pdb:1S7D|rcsb pdb:1TXL|rcsb pdb:5AQ6|ensemblbacteria:AAC75039(transcript)|ensemblbacteria:b1973(gene)|ensemblbacteria:BAE76561(gene)|ensemblbacteria:BAE76561(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0034224"(cellular response to zinc ion starvation)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|rcsb pdb:5YXC|rcsb pdb:5XM5|rcsb pdb:6LM2	interpro:IPR026266|refseq:WP_000548675.1|refseq:NP_416414.1|interpro:IPR001761(Periplasmic binding protein/LacI transcriptional regulator)|rcsb pdb:1ABE|rcsb pdb:1ABF|rcsb pdb:1APB|rcsb pdb:1BAP|rcsb pdb:2WRZ|rcsb pdb:5ABP|rcsb pdb:6ABP|rcsb pdb:7ABP|rcsb pdb:8ABP|rcsb pdb:9ABP|ensemblbacteria:AAC74971(transcript)|ensemblbacteria:b1901(gene)|ensemblbacteria:BAA15721(gene)|ensemblbacteria:BAA15721(transcript)|go:"GO:0015407"(ABC-type monosaccharide transporter activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042882"(L-arabinose transmembrane transport)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR028082	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:cMy1ogt3SvLbMZvLCqfoWsvAvRw83333	rogid:uyyggvmI7ZtHFYhFAlXNLvvCcIw83333	rigid:wuaJEkNKQprYYmWcRGJeFfIX5vI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33340	uniprotkb:P33342	intact:EBI-21977658|ensemblbacteria:AAC75169|ensemblbacteria:BAA15974	intact:EBI-1117072|uniprotkb:Q2MAW8|ensemblbacteria:AAC75171|ensemblbacteria:BAE76588	psi-mi:yeha_ecoli(display_long)|uniprotkb:yehA(gene name)|psi-mi:yehA(display_short)|uniprotkb:b2108(locus name)|uniprotkb:JW2095(locus name)	psi-mi:yehc_ecoli(display_long)|uniprotkb:yehC(gene name)|psi-mi:yehC(display_short)|uniprotkb:b2110(locus name)|uniprotkb:JW2097(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981963|imex:IM-27227-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416611.1|refseq:WP_000405713.1|interpro:IPR000259(Fimbrial protein)|interpro:IPR036937|interpro:IPR016959(Uncharacterised conserved protein UCP030811)|interpro:IPR008966(Adhesion, bacterial)|ensemblbacteria:AAC75169(transcript)|ensemblbacteria:b2108(gene)|ensemblbacteria:BAA15974(gene)|ensemblbacteria:BAA15974(transcript)|go:"GO:0009289"(pilus)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)	interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_416613.1|interpro:IPR008962(PapD-like)|interpro:IPR001829(Pili assembly chaperone, bacterial)|interpro:IPR016148(Pili assembly chaperone, C-terminal, bacterial)|interpro:IPR018046|interpro:IPR016147(Pili assembly chaperone, N-terminal, bacterial)|ensemblbacteria:AAC75171(transcript)|ensemblbacteria:b2110(gene)|ensemblbacteria:BAE76588(gene)|ensemblbacteria:BAE76588(transcript)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071555"(cell wall organization)|interpro:IPR036316	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:LVoLrQXJ2E+fFSIm8VIhvhTiSKg83333	rogid:haFXSa3CfFOcGIMWVTCe+joSw+083333	rigid:NEEuahsqwpEMlgq6SaaeXs62q4s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0T5	uniprotkb:P33358	intact:EBI-1133286|uniprotkb:P14007|ensemblbacteria:AAC75388|ensemblbacteria:BAA16184	intact:EBI-1127668|uniprotkb:Q2MAV3|ensemblbacteria:AAC75188|ensemblbacteria:BAE76603	psi-mi:mepa_ecoli(display_long)|uniprotkb:D-alanyl-D-alanine-endopeptidase(gene name synonym)|uniprotkb:mepA(gene name)|psi-mi:mepA(display_short)|uniprotkb:b2328(locus name)|uniprotkb:JW2325(locus name)	psi-mi:mlra_ecoli(display_long)|uniprotkb:yehV(gene name synonym)|uniprotkb:MerR-like regulator A(gene name synonym)|uniprotkb:mlrA(gene name)|psi-mi:mlrA(display_short)|uniprotkb:b2127(locus name)|uniprotkb:JW2115(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981970|imex:IM-27227-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416831.1|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR005073(Peptidase M74, penicillin-insensitive murein endopeptidase)|rcsb pdb:1TZP|rcsb pdb:1U10|refseq:WP_001043825.1|ensemblbacteria:AAC75388(transcript)|ensemblbacteria:b2328(gene)|ensemblbacteria:BAA16184(gene)|ensemblbacteria:BAA16184(transcript)|go:"GO:0000270"(peptidoglycan metabolic process)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding)	refseq:NP_416631.1|interpro:IPR009061(Putative DNA binding)|interpro:IPR000551(Bacterial regulatory protein, MerR)|refseq:WP_001240401.1|ensemblbacteria:b2127(gene)|ensemblbacteria:BAE76603(gene)|ensemblbacteria:BAE76603(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|ensemblbacteria:AAC75188(transcript)|mint:P33358	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:G5Px1jH+l+h9+ZVk7m7zfk9/R3o83333	rogid:gzJgKnruazPYG9CIb46TIMYA9pg83333	rigid:dmAvK/xCftfRGx8f+bJPZiMyQWo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08331	uniprotkb:P09551	intact:EBI-560014|uniprotkb:Q2M692|ensemblbacteria:AAC77170|ensemblbacteria:BAE78214	intact:EBI-15775597|ensemblbacteria:AAC75370|ensemblbacteria:BAA16156|uniprotkb:P77476	psi-mi:cpdb_ecoli(display_long)|uniprotkb:cpdB(gene name)|psi-mi:cpdB(display_short)|uniprotkb:b4213(locus name)|uniprotkb:JW4171(locus name)	psi-mi:argt_ecoli(display_long)|uniprotkb:b2310(locus name)|uniprotkb:argT(gene name)|psi-mi:argT(display_short)|uniprotkb:JW2307(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981977|imex:IM-27227-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418634.1|refseq:WP_000589431.1|dip:DIP-9311N|ensemblbacteria:AAC77170(transcript)|ensemblbacteria:b4213(gene)|ensemblbacteria:BAE78214(gene)|ensemblbacteria:BAE78214(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008254"(3'-nucleotidase activity)|go:"GO:0008663"(2',3'-cyclic-nucleotide 2'-phosphodiesterase activity)|go:"GO:0009166"(nucleotide catabolic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)|go:"GO:0046872"(metal ion binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006146(5'-Nucleotidase, conserved site)|interpro:IPR006179(5'-Nucleotidase and apyrase)|interpro:IPR006294(2 ,3 -cyclic-nucleotide 2 -phosphodiesterase)|interpro:IPR008334(5'-Nucleotidase, C-terminal)|interpro:IPR029052|interpro:IPR036907|interpro:IPR041827	ensemblbacteria:AAC75370(transcript)|ensemblbacteria:b2310(gene)|ensemblbacteria:BAA16156(gene)|ensemblbacteria:BAA16156(transcript)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015822"(ornithine transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:1902022"(L-lysine transport)|interpro:IPR001638(Bacterial extracellular solute-binding protein, family 3)|interpro:IPR005768(Lysine-arginine-ornithine-binding periplasmic protein)|interpro:IPR018313|refseq:NP_416813.1|refseq:WP_000748271.1|dip:DIP-9148N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:Nh6PQ9kR4wf2L2W5RV/s4f3Asig83333	rogid:F8d54UUuskBQjbm0e6zYyJp7NOE83333	rigid:XDk0LrA7WSMtun88kim93vPQpt4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P76398	uniprotkb:P76399	intact:EBI-561416|uniprotkb:O08005|ensemblbacteria:AAC75136|ensemblbacteria:BAA15929	intact:EBI-1116694|uniprotkb:O08006|ensemblbacteria:AAC75137|ensemblbacteria:BAA15932	psi-mi:mdtb_ecoli(display_long)|uniprotkb:yegN(gene name synonym)|uniprotkb:Multidrug transporter MdtB(gene name synonym)|uniprotkb:mdtB(gene name)|psi-mi:mdtB(display_short)|uniprotkb:b2075(locus name)|uniprotkb:JW2060(locus name)	psi-mi:mdtc_ecoli(display_long)|uniprotkb:mdtC(gene name)|psi-mi:mdtC(display_short)|uniprotkb:b2076(locus name)|uniprotkb:JW2061(locus name)|uniprotkb:yegO(gene name synonym)|uniprotkb:Multidrug transporter MdtC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981956|imex:IM-27227-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416579.1|refseq:WP_001197875.1|dip:DIP-11884N|ensemblbacteria:AAC75136(transcript)|ensemblbacteria:b2075(gene)|ensemblbacteria:BAA15929(gene)|ensemblbacteria:BAA15929(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR022831|interpro:IPR027463	refseq:WP_000667481.1|refseq:NP_416580.1|interpro:IPR001036(Acriflavin resistance protein)|interpro:IPR023931|interpro:IPR027463|ensemblbacteria:AAC75137(transcript)|ensemblbacteria:b2076(gene)|ensemblbacteria:BAA15932(gene)|ensemblbacteria:BAA15932(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:1902600"(proton transmembrane transport)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:SPlZZZFwSV1ZUrKC0MEx8YSp1s083333	rogid:/xxHvltfPA+7reRJKWkMyqaGpJ883333	rigid:u/j5Mxeaie8EzOqngnN6Fgs5fCM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEB0	uniprotkb:P31440	intact:EBI-552215|uniprotkb:P16702|uniprotkb:P76534|ensemblbacteria:AAC75476|ensemblbacteria:BAA16297	intact:EBI-21977693|uniprotkb:P76726|uniprotkb:Q2M7X7|ensemblbacteria:AAC76687|ensemblbacteria:BAE77629	psi-mi:cysw_ecoli(display_long)|uniprotkb:cysW(gene name)|psi-mi:cysW(display_short)|uniprotkb:b2423(locus name)|uniprotkb:JW2416(locus name)	psi-mi:adeq_ecoli(display_long)|uniprotkb:adeQ(gene name)|psi-mi:adeQ(display_short)|uniprotkb:yicO(gene name synonym)|uniprotkb:b3664(locus name)|uniprotkb:JW5636(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981984|imex:IM-27227-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_026168.2|refseq:WP_000852686.1|dip:DIP-9388N|ensemblbacteria:AAC75476(transcript)|ensemblbacteria:b2423(gene)|ensemblbacteria:BAA16297(gene)|ensemblbacteria:BAA16297(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015419"(ABC-type sulfate transporter activity)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR005667(Sulphate ABC transporter permease protein 2)|interpro:IPR011866(Sulphate ABC transporter, permease protein CysW)|interpro:IPR035906	refseq:NP_418120.2|refseq:WP_001403836.1|interpro:IPR026033|interpro:IPR006043(Xanthine/uracil/vitamin C permease)|ensemblbacteria:AAC76687(transcript)|ensemblbacteria:b3664(gene)|ensemblbacteria:BAE77629(gene)|ensemblbacteria:BAE77629(transcript)|go:"GO:0005345"(purine nucleobase transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0015853"(adenine transport)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:Lnd3erlRqJNKPhuJvZYXI1ly54M83333	rogid:wh0sm8i1sex3OHzklPRgTDLokyY83333	rigid:KLM1GwRCeZ6qdE96y24uLXa/I4Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32137	uniprotkb:P05458	intact:EBI-9147817|uniprotkb:Q2M8H4|ensemblbacteria:AAC76874|ensemblbacteria:BAE77432	intact:EBI-1115056|uniprotkb:P78106|uniprotkb:Q2MA16|ensemblbacteria:AAC75860|ensemblbacteria:BAE76890	psi-mi:yihp_ecoli(display_long)|uniprotkb:JW3848(locus name)|uniprotkb:b3877(locus name)|uniprotkb:yihP(gene name)|psi-mi:yihP(display_short)	psi-mi:ptra_ecoli(display_long)|uniprotkb:Protease III(gene name synonym)|uniprotkb:Pitrilysin(gene name synonym)|uniprotkb:Protease pi(gene name synonym)|uniprotkb:ptrA(gene name)|psi-mi:ptrA(display_short)|uniprotkb:ptr(gene name synonym)|uniprotkb:b2821(locus name)|uniprotkb:JW2789(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981991|imex:IM-27227-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001927("Sodium:galactoside symporter")|interpro:IPR018043|refseq:NP_418313.4|refseq:WP_000018380.1|interpro:IPR036259|interpro:IPR039672|ensemblbacteria:AAC76874(transcript)|ensemblbacteria:b3877(gene)|ensemblbacteria:BAE77432(gene)|ensemblbacteria:BAE77432(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0015293"(symporter activity)|go:"GO:0071702"(organic substance transport)	interpro:IPR032632|refseq:NP_417298.1|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|rcsb pdb:1Q2L|refseq:WP_001138201.1|ensemblbacteria:AAC75860(transcript)|ensemblbacteria:b2821(gene)|ensemblbacteria:BAE76890(gene)|ensemblbacteria:BAE76890(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:E3SPGcBMeIj0mhnA0SIFHSH7eFg83333	rogid:tRSbFvf5F0deBUjl+KNG/bwzAIw83333	rigid:uvkvxD2UmHiAO2PcxHLeL6jNpD4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45544	uniprotkb:P0AG80	intact:EBI-562481|ensemblbacteria:AAC76400|ensemblbacteria:BAE77916|uniprotkb:Q2M740	intact:EBI-546637|uniprotkb:P10904|uniprotkb:Q2M7B6|ensemblbacteria:AAC76478|ensemblbacteria:BAE77840	psi-mi:frlr_ecoli(display_long)|uniprotkb:yhfR(gene name synonym)|uniprotkb:b3375(locus name)|uniprotkb:frlR(gene name)|psi-mi:frlR(display_short)|uniprotkb:HTH-type transcriptional regulator FrlR(gene name synonym)|uniprotkb:JW5698(locus name)	psi-mi:ugpb_ecoli(display_long)|uniprotkb:ugpB(gene name)|psi-mi:ugpB(display_short)|uniprotkb:b3453(locus name)|uniprotkb:JW3418(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982005|imex:IM-27227-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC76400(transcript)|ensemblbacteria:b3375(gene)|ensemblbacteria:BAE77916(gene)|ensemblbacteria:BAE77916(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000524(Bacterial regulatory protein GntR, HTH)|interpro:IPR011663(UbiC transcription regulator-associated)|interpro:IPR028978|interpro:IPR036388|interpro:IPR036390|refseq:NP_417834.6|refseq:WP_001276847.1|dip:DIP-12327N	refseq:NP_417910.1|ensemblbacteria:AAC76478(transcript)|ensemblbacteria:b3453(gene)|ensemblbacteria:BAE77840(gene)|ensemblbacteria:BAE77840(transcript)|go:"GO:0001407"(glycerophosphodiester transmembrane transport)|go:"GO:0015794"(glycerol-3-phosphate transmembrane transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:4AQ4|rcsb pdb:6X84|refseq:WP_000803190.1|dip:DIP-35942N	-	-	crc64:E0B9B5885B240C8D	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:m0eungRbNeAj9G2msmQFaPyOA0s83333	rogid:dvmwM+GcbrvXAryRDFptmpNpY5g83333	rigid:AoTS5Mmv53sczYmXGHQ362YFJFM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ADV1	uniprotkb:P0AEN1	intact:EBI-1132001|uniprotkb:P38685|uniprotkb:Q2M912|ensemblbacteria:AAC76232|ensemblbacteria:BAE77244	intact:EBI-1116005|uniprotkb:P23486|uniprotkb:P76768|uniprotkb:Q2M8E7|ensemblbacteria:AAC76847|ensemblbacteria:BAE77459	psi-mi:lpta_ecoli(display_long)|uniprotkb:lptA(gene name)|psi-mi:lptA(display_short)|uniprotkb:b3200(locus name)|uniprotkb:JW3167(locus name)|uniprotkb:yhbN(gene name synonym)	psi-mi:fre_ecoli(display_long)|uniprotkb:FMN reductase(gene name synonym)|uniprotkb:"NAD(P)H:flavin oxidoreductase"(gene name synonym)|uniprotkb:Ferrisiderophore reductase C(gene name synonym)|uniprotkb:fre(gene name)|psi-mi:fre(display_short)|uniprotkb:fadI(gene name synonym)|uniprotkb:flrD(gene name synonym)|uniprotkb:fsrC(gene name synonym)|uniprotkb:ubiB(gene name synonym)|uniprotkb:b3844(locus name)|uniprotkb:JW3820(locus name)|uniprotkb:"Riboflavin reductase [NAD(P)H]"(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21981998|imex:IM-27227-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000669785.1|ensemblbacteria:AAC76232(transcript)|ensemblbacteria:b3200(gene)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0017089"(glycolipid transfer activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0043165"(Gram-negative-bacterium-type cell outer membrane assembly)|go:"GO:1990351"(transporter complex)|interpro:IPR005653(OstA-like protein)|interpro:IPR014340(Cell envelope biogenesis YhbN)|rcsb pdb:2R19|rcsb pdb:2R1A|rcsb pdb:6GD5|ensemblbacteria:BAE77244(gene)|ensemblbacteria:BAE77244(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|refseq:NP_417667.1|dip:DIP-12262N	refseq:WP_000209826.1|go:"GO:0006811"(ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0030091"(protein repair)|go:"GO:0042602"("riboflavin reductase (NADPH) activity")|go:"GO:0052875"("riboflavin reductase (NADH) activity")|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC76847(transcript)|ensemblbacteria:b3844(gene)|ensemblbacteria:BAE77459(gene)|ensemblbacteria:BAE77459(transcript)|refseq:NP_418286.1|interpro:IPR017927|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR017938|rcsb pdb:1QFJ|interpro:IPR039261	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:KCXWBKqCf9DdH08tKTCxb6Gc+u883333	rogid:WAOeLxjCU1JlsTS/nSskm3854pY83333	rigid:mhD/48HE+MgFj7tDeqBiNnGzLOw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33222	uniprotkb:P0AF80	intact:EBI-21977772|uniprotkb:Q2M6B9|ensemblbacteria:AAC77143|ensemblbacteria:BAE78187	intact:EBI-21977759|uniprotkb:P39294|uniprotkb:Q2M6C1|ensemblbacteria:AAC77141|ensemblbacteria:BAE78185	psi-mi:yjfc_ecoli(display_long)|uniprotkb:yjfC(gene name)|psi-mi:yjfC(display_short)|uniprotkb:b4186(locus name)|uniprotkb:JW4144(locus name)	psi-mi:yjfl_ecoli(display_long)|uniprotkb:yjfL(gene name)|psi-mi:yjfL(display_short)|uniprotkb:b4184(locus name)|uniprotkb:JW4142(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982033|imex:IM-27227-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418607.1|refseq:WP_000943959.1|interpro:IPR005494(Glutathionylspermidine synthase)|interpro:IPR016185(PreATP-grasp-like fold)|ensemblbacteria:AAC77143(transcript)|ensemblbacteria:b4186(gene)|ensemblbacteria:BAE78187(gene)|ensemblbacteria:BAE78187(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0016874"(ligase activity)|go:"GO:0046872"(metal ion binding)	refseq:NP_418605.1|refseq:WP_000547760.1|interpro:IPR007140(Protein of unknown function DUF350)|ensemblbacteria:AAC77141(transcript)|ensemblbacteria:b4184(gene)|ensemblbacteria:BAE78185(gene)|ensemblbacteria:BAE78185(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:yPO2yN3rF/2UZJgL1F4CdKgL1Bw83333	rogid:GAN2P+siJJ7+8mQcQONQ9dnnoWQ83333	rigid:iM4okyQx5izUY7n07EEJIBmsZqw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07658	uniprotkb:P39265	intact:EBI-1121603|uniprotkb:P78137|uniprotkb:Q2M6M5	intact:EBI-906901|uniprotkb:Q2M6L5|ensemblbacteria:AAC77049|ensemblbacteria:BAE78091	psi-mi:fdhf_ecoli(display_long)|uniprotkb:Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide(gene name synonym)|uniprotkb:Formate dehydrogenase-H subunit alpha(gene name synonym)|uniprotkb:fdhF(gene name)|psi-mi:fdhF(display_short)|uniprotkb:b4079(locus name)|uniprotkb:JW4040(locus name)	psi-mi:alsb_ecoli(display_long)|uniprotkb:alsB(gene name)|psi-mi:alsB(display_short)|uniprotkb:b4088(locus name)|uniprotkb:yjcX(gene name synonym)|uniprotkb:JW4049(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982026|imex:IM-27227-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0008863"("formate dehydrogenase (NAD+) activity")|go:"GO:0015944"(formate oxidation)|go:"GO:0019628"(urate catabolic process)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045272"(plasma membrane respiratory chain complex I)|go:"GO:0045333"(cellular respiration)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006478(Formate dehydrogenase, alpha subunit)|interpro:IPR006655(Molybdopterin oxidoreductase, prokaryotic, conserved site)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006657(Molydopterin dinucleotide-binding region)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027467|interpro:IPR041924|interpro:IPR041925|rcsb pdb:1AA6|rcsb pdb:1FDI|rcsb pdb:1FDO|rcsb pdb:2IV2|refseq:WP_001300547.1|refseq:NP_418503.1|dip:DIP-9572N	interpro:IPR025997|interpro:IPR028082|refseq:NP_418512.1|rcsb pdb:1GUB|rcsb pdb:1GUD|rcsb pdb:1RPJ|refseq:WP_001046187.1|ensemblbacteria:AAC77049(transcript)|ensemblbacteria:b4088(gene)|ensemblbacteria:BAE78091(gene)|ensemblbacteria:BAE78091(transcript)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0016020"(membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0048029"(monosaccharide binding)	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:zccIV3Xvzfk8vW6zGUDcNzhqssM83333	rogid:hP/IZFoOBn4LIxqH8pztVvH5ysg83333	rigid:F7x0bX2jb67gdxHmy8cZy91Oh6w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37642	uniprotkb:P39293	intact:EBI-552490|uniprotkb:Q2M7I4|ensemblbacteria:AAC76547|ensemblbacteria:BAE77772	intact:EBI-546677|uniprotkb:Q2M6C2|ensemblbacteria:BAE78184|ensemblbacteria:AAC77140	psi-mi:yhjd_ecoli(display_long)|uniprotkb:yhjD(gene name)|psi-mi:yhjD(display_short)|uniprotkb:b3522(locus name)|uniprotkb:JW3490(locus name)	psi-mi:yjfk_ecoli(display_long)|uniprotkb:yjfK(gene name)|psi-mi:yjfK(display_short)|uniprotkb:b4183(locus name)|uniprotkb:JW4141(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982012|imex:IM-27227-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417979.1|refseq:WP_000191237.1|dip:DIP-12379N|ensemblbacteria:AAC76547(transcript)|ensemblbacteria:b3522(gene)|ensemblbacteria:BAE77772(gene)|ensemblbacteria:BAE77772(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015920"(lipopolysaccharide transport)|interpro:IPR005274(Conserved hypothetical protein CHP00766, YhjD)|interpro:IPR017039(Ribonuclease BN)	refseq:NP_418604.1|ensemblbacteria:b4183(gene)|ensemblbacteria:BAE78184(gene)|ensemblbacteria:BAE78184(transcript)|interpro:IPR019621|ensemblbacteria:AAC77140(transcript)|refseq:WP_000012550.1|dip:DIP-12589N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:ls18t8B093rrpiS7rX6QX893zNE83333	rogid:PyYy59u8UB4PQ566TZld/+kRaxs83333	rigid:MWbrlz9UTnNcD8hx8cJh+kkT2fI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02916	uniprotkb:P68183	intact:EBI-1118919|uniprotkb:Q2M6S1|ensemblbacteria:AAC77003|ensemblbacteria:BAE78035	intact:EBI-6400985|ensemblbacteria:AAC77002|ensemblbacteria:BAE78034|uniprotkb:P07622|uniprotkb:Q2M6S2	psi-mi:malf_ecoli(display_long)|uniprotkb:malF(gene name)|psi-mi:malF(display_short)|uniprotkb:b4033(locus name)|uniprotkb:JW3993(locus name)	psi-mi:malg_ecoli(display_long)|uniprotkb:JW3992(locus name)|uniprotkb:b4032(locus name)|uniprotkb:malG(gene name)|psi-mi:malG(display_short)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982019|imex:IM-27227-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC77003(transcript)|ensemblbacteria:b4033(gene)|ensemblbacteria:BAE78035(gene)|ensemblbacteria:BAE78035(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR029345|interpro:IPR030156|interpro:IPR035277|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KHZ|rcsb pdb:4KI0|refseq:NP_418457.1|refseq:WP_001297290.1|dip:DIP-10142N	refseq:WP_001252058.1|ensemblbacteria:AAC77002(transcript)|ensemblbacteria:b4032(gene)|ensemblbacteria:BAE78034(gene)|ensemblbacteria:BAE78034(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015423"(ABC-type maltose transporter activity)|go:"GO:0015768"(maltose transport)|go:"GO:0016020"(membrane)|go:"GO:0042956"(maltodextrin transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:1990060"(maltose transport complex)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR035906|rcsb pdb:2R6G|rcsb pdb:3FH6|rcsb pdb:3PUV|rcsb pdb:3PUW|rcsb pdb:3PUX|rcsb pdb:3PUY|rcsb pdb:3PUZ|rcsb pdb:3PV0|rcsb pdb:3RLF|rcsb pdb:4JBW|rcsb pdb:4KI0|refseq:NP_418456.1|dip:DIP-59709N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:wYFw3rvr0kQXggDify4+jU6Lsfs83333	rogid:JslgyRfgqSfHJ0QTLpej9DnSoUw83333	rigid:7KklraCTEgn1hYFt4eh/w29PoOE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ADE4	uniprotkb:P39321	intact:EBI-1114298|uniprotkb:P39320|uniprotkb:Q2M685|ensemblbacteria:AAC77177|ensemblbacteria:BAE78221	intact:EBI-1117885|uniprotkb:P39322|uniprotkb:P76802|uniprotkb:Q2M684|ensemblbacteria:AAC77178|ensemblbacteria:BAE78222	psi-mi:tama_ecoli(display_long)|uniprotkb:tamA(gene name)|psi-mi:tamA(display_short)|uniprotkb:Autotransporter assembly factor TamA(gene name synonym)|uniprotkb:yftM(gene name synonym)|uniprotkb:ytfM(gene name synonym)|uniprotkb:JW4179(locus name)|uniprotkb:b4220(locus name)	psi-mi:tamb_ecoli(display_long)|uniprotkb:tamB(gene name)|psi-mi:tamB(display_short)|uniprotkb:Autotransporter assembly factor TamB(gene name synonym)|uniprotkb:ytfN(gene name synonym)|uniprotkb:ytfO(gene name synonym)|uniprotkb:JW4180(locus name)|uniprotkb:b4221(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982040|imex:IM-27227-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:BAE78221(transcript)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009306"(protein secretion)|go:"GO:0045203"(integral component of cell outer membrane)|go:"GO:0089705"(protein localization to outer membrane)|go:"GO:0097347"(TAM protein secretion complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR010827(Surface antigen variable number)|interpro:IPR034746|interpro:IPR035243|interpro:IPR039910|rcsb pdb:2LY3|rcsb pdb:4BZA|rcsb pdb:4C00|ensemblbacteria:AAC77177(transcript)|ensemblbacteria:b4220(gene)|ensemblbacteria:BAE78221(gene)|refseq:WP_001269327.1|refseq:NP_418641.1|dip:DIP-51058N	ensemblbacteria:AAC77178(transcript)|ensemblbacteria:b4221(gene)|ensemblbacteria:BAE78222(gene)|ensemblbacteria:BAE78222(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009306"(protein secretion)|go:"GO:0089705"(protein localization to outer membrane)|go:"GO:0097347"(TAM protein secretion complex)|interpro:IPR007452(Protein of unknown function DUF490)|rcsb pdb:5VTG|refseq:WP_000060911.1|refseq:NP_418642.1|dip:DIP-12942N	-	-	-	figure legend:Table S2 and Table S3|comment:B2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/08/06	2019/08/21	rogid:cZSA5/l8EaPgfqqs3H8RXjovoI083333	rogid:21/3Ve7oO8R6kO6PTTpoXgEB00Y83333	rigid:Ti7fbcW25O8UYZ+7/1F337doTwM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06136	uniprotkb:P0AEN4	intact:EBI-1130157|ensemblbacteria:BAB96661|ensemblbacteria:AAC73204	intact:EBI-1119082|uniprotkb:P22187|uniprotkb:Q8KMX6|ensemblbacteria:AAC73194|ensemblbacteria:BAB96651	psi-mi:ftsq_ecoli(display_long)|uniprotkb:ftsQ(gene name)|psi-mi:ftsQ(display_short)|uniprotkb:b0093(locus name)|uniprotkb:JW0091(locus name)	psi-mi:ftsl_ecoli(display_long)|uniprotkb:ftsL(gene name)|psi-mi:ftsL(display_short)|uniprotkb:mraR(gene name synonym)|uniprotkb:b0083(locus name)|uniprotkb:JW0081(locus name)|uniprotkb:yabD(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982053|imex:IM-27227-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000075748.1|refseq:NP_414635.1|ensemblbacteria:BAB96661(transcript)|go:"GO:0000917"(division septum assembly)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensemblbacteria:BAB96661(gene)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032153"(cell division site)|go:"GO:0042802"(identical protein binding)|go:"GO:0043093"(FtsZ-dependent cytokinesis)|go:"GO:0051301"(cell division)|interpro:IPR005548(Cell division protein FtsQ)|interpro:IPR013685(Polypeptide-transport-associated, FtsQ-type)|interpro:IPR026579|interpro:IPR034746|rcsb pdb:2VH1|rcsb pdb:4UE4|rcsb pdb:4V6M|rcsb pdb:5Z2W|rcsb pdb:6H9N|rcsb pdb:6H9O|ensemblbacteria:AAC73204(transcript)|ensemblbacteria:b0093(gene)|mint:P06136|dip:DIP-9706N	ensemblbacteria:AAC73194(transcript)|ensemblbacteria:b0083(gene)|ensemblbacteria:BAB96651(gene)|ensemblbacteria:BAB96651(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0032153"(cell division site)|go:"GO:0043093"(FtsZ-dependent cytokinesis)|interpro:IPR011922(Cell division protein, FtsL -like)|refseq:WP_000625658.1|refseq:NP_414625.1|mint:P0AEN4|dip:DIP-47987N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:j1yOCAymvXJP5cUtdZYhJilT4iE83333	rogid:yDhk71DiRIlAEIv80kZxDalskg483333	rigid:30gIh90L076DQnwzjopTERiws0A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30871	uniprotkb:P0AEU7	intact:EBI-546664|uniprotkb:Q2M9F1|ensemblbacteria:AAC76090|ensemblbacteria:BAE77105	intact:EBI-548242|uniprotkb:P11457|ensemblbacteria:AAC73289|ensemblbacteria:BAA77853	psi-mi:3pase_ecoli(display_long)|uniprotkb:ygiF(gene name)|psi-mi:ygiF(display_short)|uniprotkb:b3054(locus name)|uniprotkb:ORFXE(gene name synonym)|uniprotkb:JW3026(locus name)	psi-mi:skp_ecoli(display_long)|uniprotkb:skp(gene name)|psi-mi:skp(display_short)|uniprotkb:ompH(gene name synonym)|uniprotkb:hlpA(gene name synonym)|uniprotkb:b0178(locus name)|uniprotkb:Seventeen kilodalton protein(gene name synonym)|uniprotkb:Histone-like protein HLP-1(gene name synonym)|uniprotkb:DNA-binding 17 kDa protein(gene name synonym)|uniprotkb:JW0173(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982060|imex:IM-27227-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417526.1|ensemblbacteria:AAC76090(transcript)|ensemblbacteria:b3054(gene)|ensemblbacteria:BAE77105(gene)|ensemblbacteria:BAE77105(transcript)|go:"GO:0046872"(metal ion binding)|go:"GO:0050355"(triphosphatase activity)|interpro:IPR007899(CHAD)|interpro:IPR023577|interpro:IPR033469|interpro:IPR039013|rcsb pdb:5A60|rcsb pdb:5A61|refseq:WP_000046281.1|dip:DIP-12218N	refseq:NP_414720.1|refseq:WP_000758956.1|dip:DIP-36210N|ensemblbacteria:AAC73289(transcript)|ensemblbacteria:b0178(gene)|ensemblbacteria:BAA77853(gene)|ensemblbacteria:BAA77853(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0042802"(identical protein binding)|go:"GO:0043165"(Gram-negative-bacterium-type cell outer membrane assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005632("Outer membrane chaperone Skp (OmpH)")|interpro:IPR024930|rcsb pdb:1SG2|rcsb pdb:1U2M	-	-	caution:This sequence has been withdrawn from Uniprot.	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:5REganvqgbl+HPaI+5h131G7Wi483333	rogid:lsR04hlxzICLK46Ni0vFHrA6/mQ83333	rigid:F8q5pJjcQZHt5bisWCUAC/mjwck	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AFF4	uniprotkb:P21865	intact:EBI-21977584|uniprotkb:P09452|uniprotkb:P76653|uniprotkb:Q2M9M9|ensemblbacteria:AAC76001|ensemblbacteria:BAE77027	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	psi-mi:nupg_ecoli(display_long)|uniprotkb:Nucleoside-transport system protein NupG(gene name synonym)|uniprotkb:JW2932(locus name)|uniprotkb:b2964(locus name)|uniprotkb:nupG(gene name)|psi-mi:nupG(display_short)	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982067|imex:IM-27227-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417439.4|refseq:WP_001049791.1|interpro:IPR020846|interpro:IPR036259|interpro:IPR004740("Nucleoside:H+ symporter")|interpro:IPR033667|rcsb pdb:7DL9|rcsb pdb:7DLA|ensemblbacteria:AAC76001(transcript)|ensemblbacteria:b2964(gene)|ensemblbacteria:BAE77027(gene)|ensemblbacteria:BAE77027(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015212"(cytidine transmembrane transporter activity)|go:"GO:0015213"(uridine transmembrane transporter activity)|go:"GO:0015214"(pyrimidine nucleoside transmembrane transporter activity)|go:"GO:0015506"("nucleoside:proton symporter activity")|go:"GO:0015860"(purine nucleoside transmembrane transport)|go:"GO:0015862"(uridine transport)|go:"GO:0015864"(pyrimidine nucleoside transport)|go:"GO:0032238"(adenosine transport)|go:"GO:0071702"(organic substance transport)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:5CYRcczH0B0S5oyIv65oiDuEfv083333	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rigid:ihr9C5/Mvo8URYTfSrEuELLnZYU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02930	uniprotkb:P75780	intact:EBI-875614|uniprotkb:Q2M9G5|ensemblbacteria:AAC76071|ensemblbacteria:BAE77091	intact:EBI-1120371|ensemblbacteria:AAC73892|ensemblbacteria:BAA35471	psi-mi:tolc_ecoli(display_long)|uniprotkb:tolC(gene name)|psi-mi:tolC(display_short)|uniprotkb:mtcB(gene name synonym)|uniprotkb:mukA(gene name synonym)|uniprotkb:refI(gene name synonym)|uniprotkb:Multidrug efflux pump subunit TolC(gene name synonym)|uniprotkb:Outer membrane factor TolC(gene name synonym)|uniprotkb:colE1-i(gene name synonym)|uniprotkb:toc(gene name synonym)|uniprotkb:weeA(gene name synonym)|uniprotkb:JW5503(locus name)|uniprotkb:b3035(locus name)	psi-mi:fiu_ecoli(display_long)|uniprotkb:fiu(gene name)|psi-mi:fiu(display_short)|uniprotkb:ybiL(gene name synonym)|uniprotkb:b0805(locus name)|uniprotkb:JW0790(locus name)|uniprotkb:TonB-dependent receptor Fiu(gene name synonym)|uniprotkb:Ferric iron uptake protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982074|imex:IM-27227-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417507.2|refseq:WP_000735278.1|dip:DIP-11007N|ensemblbacteria:AAC76071(transcript)|ensemblbacteria:b3035(gene)|ensemblbacteria:BAE77091(gene)|ensemblbacteria:BAE77091(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042930"(enterobactin transport)|go:"GO:0045203"(integral component of cell outer membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:1990196"(MacAB-TolC complex)|go:"GO:1990281"(efflux pump complex)|interpro:IPR003423(Outer membrane efflux protein)|interpro:IPR010130(Type I secretion outer membrane protein, TolC)|rcsb pdb:1EK9|rcsb pdb:1TQQ|rcsb pdb:2VDD|rcsb pdb:2VDE|rcsb pdb:2WMZ|rcsb pdb:2XMN|rcsb pdb:5NG5|rcsb pdb:5NIK|rcsb pdb:5NIL|rcsb pdb:5O66|rcsb pdb:5V5S|rcsb pdb:6WXH|rcsb pdb:6WXI	refseq:NP_415326.1|refseq:WP_000430057.1|ensemblbacteria:AAC73892(transcript)|ensemblbacteria:b0805(gene)|ensemblbacteria:BAA35471(gene)|ensemblbacteria:BAA35471(transcript)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015344"(siderophore uptake transmembrane transporter activity)|go:"GO:0015891"(siderophore transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042884"(microcin transport)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR000531(TonB-dependent receptor, beta-barrel)|interpro:IPR010105(TonB-dependent siderophore receptor)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR012910(TonB-dependent receptor, plug)|interpro:IPR030148|interpro:IPR036942|interpro:IPR037066|interpro:IPR039423|rcsb pdb:6BPM|rcsb pdb:6BPN|rcsb pdb:6BPO|dip:DIP-11432N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:67LQDsYiAt6tDwigzlhM3Pp5+JA83333	rogid:fq2g06/31IQkk+DCzZku2wOz7w483333	rigid:F76M4QIly/4j7mK5WTud62LwVxw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P75830	uniprotkb:P23886	intact:EBI-551961|ensemblbacteria:AAC73965|ensemblbacteria:BAA35597	intact:EBI-1115859|ensemblbacteria:AAC73972|ensemblbacteria:BAA35611	psi-mi:maca_ecoli(display_long)|uniprotkb:macA(gene name)|psi-mi:macA(display_short)|uniprotkb:b0878(locus name)|uniprotkb:ybjY(gene name synonym)|uniprotkb:JW0862(locus name)	psi-mi:cydc_ecoli(display_long)|uniprotkb:cydC(gene name)|psi-mi:cydC(display_short)|uniprotkb:mdrA(gene name synonym)|uniprotkb:mdrH(gene name synonym)|uniprotkb:surB(gene name synonym)|uniprotkb:b0886(locus name)|uniprotkb:JW0869(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982081|imex:IM-27227-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415399.4|refseq:WP_000746442.1|dip:DIP-11460N|ensemblbacteria:AAC73965(transcript)|ensemblbacteria:b0878(gene)|ensemblbacteria:BAA35597(gene)|ensemblbacteria:BAA35597(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990196"(MacAB-TolC complex)|go:"GO:1990281"(efflux pump complex)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR006143(Secretion protein HlyD)|interpro:IPR030190|interpro:IPR032317|rcsb pdb:3FPP|rcsb pdb:5NIK|rcsb pdb:5NIL	refseq:WP_001202177.1|ensemblbacteria:AAC73972(transcript)|ensemblbacteria:b0886(gene)|ensemblbacteria:BAA35611(gene)|ensemblbacteria:BAA35611(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033228"(cysteine export across plasma membrane)|go:"GO:0034775"(glutathione transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070453"(regulation of heme biosynthetic process)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR014223("ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC")|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|refseq:NP_415406.1|dip:DIP-9362N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:Xj1hcSaeRW/gtgzklUnnRv/9Yvw83333	rogid:ef62OeRlZzoqFHG8V6f71tB0rkY83333	rigid:ZH5+KPFaRaZVHyOBqx5KQSPxh4Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25907	uniprotkb:P77747	intact:EBI-9146330|uniprotkb:P76862|uniprotkb:P76089|uniprotkb:P76860|ensemblbacteria:AAC74489|ensemblbacteria:BAA15022	intact:EBI-21977841|uniprotkb:P76854|ensemblbacteria:AAC74459|ensemblbacteria:BAA14981	psi-mi:ydbd_ecoli(display_long)|uniprotkb:JW5221(locus name)|uniprotkb:b1407(locus name)|uniprotkb:ydbD(gene name)|psi-mi:ydbD(display_short)	psi-mi:ompn_ecoli(display_long)|uniprotkb:Outer membrane protein N(gene name synonym)|uniprotkb:Porin OmpN(gene name synonym)|uniprotkb:ompN(gene name)|psi-mi:ompN(display_short)|uniprotkb:ynaG(gene name synonym)|uniprotkb:b1377(locus name)|uniprotkb:JW1371(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982088|imex:IM-27227-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024497|refseq:NP_415925.2|refseq:WP_000910026.1|ensemblbacteria:AAC74489(transcript)|ensemblbacteria:b1407(gene)|ensemblbacteria:BAA15022(gene)|ensemblbacteria:BAA15022(transcript)	refseq:NP_415895.1|refseq:WP_000837921.1|dip:DIP-10400N|ensemblbacteria:AAC74459(transcript)|ensemblbacteria:b1377(gene)|ensemblbacteria:BAA14981(gene)|ensemblbacteria:BAA14981(transcript)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0034219"(carbohydrate transmembrane transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0046930"(pore complex)|interpro:IPR001702(Porin, Gram-negative type)|interpro:IPR001897(Porin, bacterial type)|interpro:IPR023614|interpro:IPR033900	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:nzKk9iGLL+/s2azhJtahCSJO9tE83333	rogid:tdhAh52sPdGI8kjATn4oeMhVAVY83333	rigid:cxU3pSTt9J/LY45idL6+b1+lb60	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P76175	uniprotkb:P77747	intact:EBI-554760|uniprotkb:P77195|ensemblbacteria:AAC74664|ensemblbacteria:BAA15316	intact:EBI-21977841|uniprotkb:P76854|ensemblbacteria:AAC74459|ensemblbacteria:BAA14981	psi-mi:clcb_ecoli(display_long)|uniprotkb:ynfJ(gene name synonym)|uniprotkb:clcB(gene name)|psi-mi:clcB(display_short)|uniprotkb:mriT(gene name synonym)|uniprotkb:b1592(locus name)|uniprotkb:JW5263(locus name)	psi-mi:ompn_ecoli(display_long)|uniprotkb:Outer membrane protein N(gene name synonym)|uniprotkb:Porin OmpN(gene name synonym)|uniprotkb:ompN(gene name)|psi-mi:ompN(display_short)|uniprotkb:ynaG(gene name synonym)|uniprotkb:b1377(locus name)|uniprotkb:JW1371(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982095|imex:IM-27227-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416109.2|dip:DIP-28065N|ensemblbacteria:AAC74664(transcript)|ensemblbacteria:b1592(gene)|ensemblbacteria:BAA15316(gene)|ensemblbacteria:BAA15316(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR014743(Chloride channel, core)|interpro:IPR023790	refseq:NP_415895.1|refseq:WP_000837921.1|dip:DIP-10400N|ensemblbacteria:AAC74459(transcript)|ensemblbacteria:b1377(gene)|ensemblbacteria:BAA14981(gene)|ensemblbacteria:BAA14981(transcript)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015288"(porin activity)|go:"GO:0016020"(membrane)|go:"GO:0034219"(carbohydrate transmembrane transport)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0046930"(pore complex)|interpro:IPR001702(Porin, Gram-negative type)|interpro:IPR001897(Porin, bacterial type)|interpro:IPR023614|interpro:IPR033900	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:eVDAQWhBmsc67+AlTWm5eRbdOXQ83333	rogid:tdhAh52sPdGI8kjATn4oeMhVAVY83333	rigid:CaJSwJvkFMg6jx9/KFYyIzesprw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33340	uniprotkb:P33342	intact:EBI-21977658|ensemblbacteria:AAC75169|ensemblbacteria:BAA15974	intact:EBI-1117072|uniprotkb:Q2MAW8|ensemblbacteria:AAC75171|ensemblbacteria:BAE76588	psi-mi:yeha_ecoli(display_long)|uniprotkb:yehA(gene name)|psi-mi:yehA(display_short)|uniprotkb:b2108(locus name)|uniprotkb:JW2095(locus name)	psi-mi:yehc_ecoli(display_long)|uniprotkb:yehC(gene name)|psi-mi:yehC(display_short)|uniprotkb:b2110(locus name)|uniprotkb:JW2097(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982102|imex:IM-27227-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416611.1|refseq:WP_000405713.1|interpro:IPR000259(Fimbrial protein)|interpro:IPR036937|interpro:IPR016959(Uncharacterised conserved protein UCP030811)|interpro:IPR008966(Adhesion, bacterial)|ensemblbacteria:AAC75169(transcript)|ensemblbacteria:b2108(gene)|ensemblbacteria:BAA15974(gene)|ensemblbacteria:BAA15974(transcript)|go:"GO:0009289"(pilus)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)	interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_416613.1|interpro:IPR008962(PapD-like)|interpro:IPR001829(Pili assembly chaperone, bacterial)|interpro:IPR016148(Pili assembly chaperone, C-terminal, bacterial)|interpro:IPR018046|interpro:IPR016147(Pili assembly chaperone, N-terminal, bacterial)|ensemblbacteria:AAC75171(transcript)|ensemblbacteria:b2110(gene)|ensemblbacteria:BAE76588(gene)|ensemblbacteria:BAE76588(transcript)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071555"(cell wall organization)|interpro:IPR036316	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:LVoLrQXJ2E+fFSIm8VIhvhTiSKg83333	rogid:haFXSa3CfFOcGIMWVTCe+joSw+083333	rigid:NEEuahsqwpEMlgq6SaaeXs62q4s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45544	uniprotkb:P0AG80	intact:EBI-562481|ensemblbacteria:AAC76400|ensemblbacteria:BAE77916|uniprotkb:Q2M740	intact:EBI-546637|uniprotkb:P10904|uniprotkb:Q2M7B6|ensemblbacteria:AAC76478|ensemblbacteria:BAE77840	psi-mi:frlr_ecoli(display_long)|uniprotkb:yhfR(gene name synonym)|uniprotkb:b3375(locus name)|uniprotkb:frlR(gene name)|psi-mi:frlR(display_short)|uniprotkb:HTH-type transcriptional regulator FrlR(gene name synonym)|uniprotkb:JW5698(locus name)	psi-mi:ugpb_ecoli(display_long)|uniprotkb:ugpB(gene name)|psi-mi:ugpB(display_short)|uniprotkb:b3453(locus name)|uniprotkb:JW3418(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982137|imex:IM-27227-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC76400(transcript)|ensemblbacteria:b3375(gene)|ensemblbacteria:BAE77916(gene)|ensemblbacteria:BAE77916(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000524(Bacterial regulatory protein GntR, HTH)|interpro:IPR011663(UbiC transcription regulator-associated)|interpro:IPR028978|interpro:IPR036388|interpro:IPR036390|refseq:NP_417834.6|refseq:WP_001276847.1|dip:DIP-12327N	refseq:NP_417910.1|ensemblbacteria:AAC76478(transcript)|ensemblbacteria:b3453(gene)|ensemblbacteria:BAE77840(gene)|ensemblbacteria:BAE77840(transcript)|go:"GO:0001407"(glycerophosphodiester transmembrane transport)|go:"GO:0015794"(glycerol-3-phosphate transmembrane transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|interpro:IPR006059(Bacterial extracellular solute-binding, family 1)|interpro:IPR006061(Bacterial extracellular solute-binding family 1, conserved site)|rcsb pdb:4AQ4|rcsb pdb:6X84|refseq:WP_000803190.1|dip:DIP-35942N	-	-	crc64:E0B9B5885B240C8D	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:m0eungRbNeAj9G2msmQFaPyOA0s83333	rogid:dvmwM+GcbrvXAryRDFptmpNpY5g83333	rigid:AoTS5Mmv53sczYmXGHQ362YFJFM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C0T5	uniprotkb:P33358	intact:EBI-1133286|uniprotkb:P14007|ensemblbacteria:AAC75388|ensemblbacteria:BAA16184	intact:EBI-1127668|uniprotkb:Q2MAV3|ensemblbacteria:AAC75188|ensemblbacteria:BAE76603	psi-mi:mepa_ecoli(display_long)|uniprotkb:D-alanyl-D-alanine-endopeptidase(gene name synonym)|uniprotkb:mepA(gene name)|psi-mi:mepA(display_short)|uniprotkb:b2328(locus name)|uniprotkb:JW2325(locus name)	psi-mi:mlra_ecoli(display_long)|uniprotkb:yehV(gene name synonym)|uniprotkb:MerR-like regulator A(gene name synonym)|uniprotkb:mlrA(gene name)|psi-mi:mlrA(display_short)|uniprotkb:b2127(locus name)|uniprotkb:JW2115(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982109|imex:IM-27227-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416831.1|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR005073(Peptidase M74, penicillin-insensitive murein endopeptidase)|rcsb pdb:1TZP|rcsb pdb:1U10|refseq:WP_001043825.1|ensemblbacteria:AAC75388(transcript)|ensemblbacteria:b2328(gene)|ensemblbacteria:BAA16184(gene)|ensemblbacteria:BAA16184(transcript)|go:"GO:0000270"(peptidoglycan metabolic process)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding)	refseq:NP_416631.1|interpro:IPR009061(Putative DNA binding)|interpro:IPR000551(Bacterial regulatory protein, MerR)|refseq:WP_001240401.1|ensemblbacteria:b2127(gene)|ensemblbacteria:BAE76603(gene)|ensemblbacteria:BAE76603(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|ensemblbacteria:AAC75188(transcript)|mint:P33358	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:G5Px1jH+l+h9+ZVk7m7zfk9/R3o83333	rogid:gzJgKnruazPYG9CIb46TIMYA9pg83333	rigid:dmAvK/xCftfRGx8f+bJPZiMyQWo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25737	uniprotkb:P23890	intact:EBI-6401655|ensemblbacteria:AAC75217|ensemblbacteria:BAE76633|uniprotkb:Q2MAS3	intact:EBI-6401662|ensemblbacteria:AAC77094|ensemblbacteria:BAE78136|uniprotkb:Q2M6H0	psi-mi:lysp_ecoli(display_long)|uniprotkb:JW2143(locus name)|uniprotkb:b2156(locus name)|uniprotkb:lysP(gene name)|psi-mi:lysP(display_short)|uniprotkb:cadR(gene name synonym)	psi-mi:cadc_ecoli(display_long)|uniprotkb:JW4094(locus name)|uniprotkb:b4133(locus name)|uniprotkb:cadC(gene name)|psi-mi:cadC(display_short)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982116|imex:IM-27227-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC75217(transcript)|ensemblbacteria:b2156(gene)|ensemblbacteria:BAE76633(gene)|ensemblbacteria:BAE76633(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015189"(L-lysine transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0097639"(L-lysine import across plasma membrane)|refseq:WP_000253273.1|interpro:IPR004840(Amino acid permease, conserved site)|interpro:IPR004841(Amino acid permease-associated region)|refseq:NP_416661.1	ensemblbacteria:AAC77094(transcript)|ensemblbacteria:b4133(gene)|ensemblbacteria:BAE78136(gene)|ensemblbacteria:BAE78136(transcript)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016032(Signal transduction response regulator, C-terminal effector)|interpro:IPR036388|interpro:IPR039420|interpro:IPR040970|rcsb pdb:3LY7|rcsb pdb:3LY8|rcsb pdb:3LY9|rcsb pdb:3LYA|rcsb pdb:5JU7|refseq:WP_001187173.1|refseq:NP_418557.1|dip:DIP-9239N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:++x7DEvrEhIThkSmHrP1VRtxI2483333	rogid:N8d6LRxpXsiVjYYJD4ZhtBFhGkg83333	rigid:efb1Pnv0tov20hNXSyrW6GTEPs8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08331	uniprotkb:P09551	intact:EBI-560014|uniprotkb:Q2M692|ensemblbacteria:AAC77170|ensemblbacteria:BAE78214	intact:EBI-15775597|ensemblbacteria:AAC75370|ensemblbacteria:BAA16156|uniprotkb:P77476	psi-mi:cpdb_ecoli(display_long)|uniprotkb:cpdB(gene name)|psi-mi:cpdB(display_short)|uniprotkb:b4213(locus name)|uniprotkb:JW4171(locus name)	psi-mi:argt_ecoli(display_long)|uniprotkb:b2310(locus name)|uniprotkb:argT(gene name)|psi-mi:argT(display_short)|uniprotkb:JW2307(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982123|imex:IM-27227-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418634.1|refseq:WP_000589431.1|dip:DIP-9311N|ensemblbacteria:AAC77170(transcript)|ensemblbacteria:b4213(gene)|ensemblbacteria:BAE78214(gene)|ensemblbacteria:BAE78214(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008254"(3'-nucleotidase activity)|go:"GO:0008663"(2',3'-cyclic-nucleotide 2'-phosphodiesterase activity)|go:"GO:0009166"(nucleotide catabolic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)|go:"GO:0046872"(metal ion binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006146(5'-Nucleotidase, conserved site)|interpro:IPR006179(5'-Nucleotidase and apyrase)|interpro:IPR006294(2 ,3 -cyclic-nucleotide 2 -phosphodiesterase)|interpro:IPR008334(5'-Nucleotidase, C-terminal)|interpro:IPR029052|interpro:IPR036907|interpro:IPR041827	ensemblbacteria:AAC75370(transcript)|ensemblbacteria:b2310(gene)|ensemblbacteria:BAA16156(gene)|ensemblbacteria:BAA16156(transcript)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015822"(ornithine transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:1902022"(L-lysine transport)|interpro:IPR001638(Bacterial extracellular solute-binding protein, family 3)|interpro:IPR005768(Lysine-arginine-ornithine-binding periplasmic protein)|interpro:IPR018313|refseq:NP_416813.1|refseq:WP_000748271.1|dip:DIP-9148N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:Nh6PQ9kR4wf2L2W5RV/s4f3Asig83333	rogid:F8d54UUuskBQjbm0e6zYyJp7NOE83333	rigid:XDk0LrA7WSMtun88kim93vPQpt4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ADV1	uniprotkb:P0AEN1	intact:EBI-1132001|uniprotkb:P38685|uniprotkb:Q2M912|ensemblbacteria:AAC76232|ensemblbacteria:BAE77244	intact:EBI-1116005|uniprotkb:P23486|uniprotkb:P76768|uniprotkb:Q2M8E7|ensemblbacteria:AAC76847|ensemblbacteria:BAE77459	psi-mi:lpta_ecoli(display_long)|uniprotkb:lptA(gene name)|psi-mi:lptA(display_short)|uniprotkb:b3200(locus name)|uniprotkb:JW3167(locus name)|uniprotkb:yhbN(gene name synonym)	psi-mi:fre_ecoli(display_long)|uniprotkb:FMN reductase(gene name synonym)|uniprotkb:"NAD(P)H:flavin oxidoreductase"(gene name synonym)|uniprotkb:Ferrisiderophore reductase C(gene name synonym)|uniprotkb:fre(gene name)|psi-mi:fre(display_short)|uniprotkb:fadI(gene name synonym)|uniprotkb:flrD(gene name synonym)|uniprotkb:fsrC(gene name synonym)|uniprotkb:ubiB(gene name synonym)|uniprotkb:b3844(locus name)|uniprotkb:JW3820(locus name)|uniprotkb:"Riboflavin reductase [NAD(P)H]"(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982130|imex:IM-27227-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000669785.1|ensemblbacteria:AAC76232(transcript)|ensemblbacteria:b3200(gene)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0017089"(glycolipid transfer activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0043165"(Gram-negative-bacterium-type cell outer membrane assembly)|go:"GO:1990351"(transporter complex)|interpro:IPR005653(OstA-like protein)|interpro:IPR014340(Cell envelope biogenesis YhbN)|rcsb pdb:2R19|rcsb pdb:2R1A|rcsb pdb:6GD5|ensemblbacteria:BAE77244(gene)|ensemblbacteria:BAE77244(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|refseq:NP_417667.1|dip:DIP-12262N	refseq:WP_000209826.1|go:"GO:0006811"(ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0030091"(protein repair)|go:"GO:0042602"("riboflavin reductase (NADPH) activity")|go:"GO:0052875"("riboflavin reductase (NADH) activity")|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC76847(transcript)|ensemblbacteria:b3844(gene)|ensemblbacteria:BAE77459(gene)|ensemblbacteria:BAE77459(transcript)|refseq:NP_418286.1|interpro:IPR017927|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR017938|rcsb pdb:1QFJ|interpro:IPR039261	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:KCXWBKqCf9DdH08tKTCxb6Gc+u883333	rogid:WAOeLxjCU1JlsTS/nSskm3854pY83333	rigid:mhD/48HE+MgFj7tDeqBiNnGzLOw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37665	uniprotkb:P15067	intact:EBI-2370591|uniprotkb:Q2M7L3|uniprotkb:Q6BF24|ensemblbacteria:AAT48190|ensemblbacteria:BAE77743	intact:EBI-1132788|uniprotkb:P76693|uniprotkb:Q2M795|ensemblbacteria:AAC76456|ensemblbacteria:BAE77861	psi-mi:yiad_ecoli(display_long)|uniprotkb:yiaD(gene name)|psi-mi:yiaD(display_short)|uniprotkb:b3552(locus name)|uniprotkb:JW5657(locus name)	psi-mi:glgx_ecoli(display_long)|uniprotkb:Limit dextrin alpha-1,6-maltotetraose-hydrolase(gene name synonym)|uniprotkb:Glycogen operon protein GlgX(gene name synonym)|uniprotkb:glgX(gene name)|psi-mi:glgX(display_short)|uniprotkb:glyX(gene name synonym)|uniprotkb:b3431(locus name)|uniprotkb:JW3394(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982144|imex:IM-27227-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000747625.1|refseq:YP_026228.1|interpro:IPR006664(Outer membrane protein, bacterial)|interpro:IPR006690(Outer membrane protein, OmpA-like, conserved site)|interpro:IPR006665(Outer membrane protein, OmpA/MotB, C-terminal)|rcsb pdb:2K1S|rcsb pdb:2N48|interpro:IPR036737|interpro:IPR039567|ensemblbacteria:AAT48190(transcript)|ensemblbacteria:b3552(gene)|ensemblbacteria:BAE77743(gene)|ensemblbacteria:BAE77743(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009279"(cell outer membrane)|go:"GO:0016021"(integral component of membrane)	refseq:WP_000192523.1|interpro:IPR040784|refseq:NP_417889.1|interpro:IPR006047(Glycosyl hydrolase, family 13, catalytic region)|interpro:IPR004193(Glycoside hydrolase, family 13, N-terminal)|interpro:IPR022844|interpro:IPR011837(Glycogen debranching enzyme GlgX)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:2WSK|ensemblbacteria:AAC76456(transcript)|ensemblbacteria:b3431(gene)|ensemblbacteria:BAE77861(gene)|ensemblbacteria:BAE77861(transcript)|go:"GO:0004133"(glycogen debranching enzyme activity)|go:"GO:0004135"(amylo-alpha-1,6-glucosidase activity)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|interpro:IPR044505|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:v0rq1c4hQvOiB+Gqn2XImjCjOq883333	rogid:xK8NYNUlTpFcbOkSofjPTevVBkQ83333	rigid:Eb5Lg08rM5DE+ZL8HTkmUuVbbEU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27844	uniprotkb:P27842	intact:EBI-21977942|uniprotkb:Q2M8C4|ensemblbacteria:AAT48220|ensemblbacteria:BAE77482	intact:EBI-21977931|uniprotkb:Q2M8C2|ensemblbacteria:AAC76820|ensemblbacteria:BAE77484	psi-mi:rard_ecoli(display_long)|uniprotkb:rarD(gene name)|psi-mi:rarD(display_short)|uniprotkb:b3819(locus name)|uniprotkb:JW5589(locus name)	psi-mi:yigf_ecoli(display_long)|uniprotkb:yigF(gene name)|psi-mi:yigF(display_short)|uniprotkb:b3817(locus name)|uniprotkb:JW3790(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982158|imex:IM-27227-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000339104.1|refseq:YP_026262.1|interpro:IPR000620(Protein of unknown function DUF6, transmembrane)|interpro:IPR004626(RarD protein)|ensemblbacteria:AAT48220(transcript)|ensemblbacteria:b3819(gene)|ensemblbacteria:BAE77482(gene)|ensemblbacteria:BAE77482(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016021"(integral component of membrane)	refseq:NP_418261.1|refseq:WP_000032581.1|interpro:IPR024399|ensemblbacteria:AAC76820(transcript)|ensemblbacteria:b3817(gene)|ensemblbacteria:BAE77484(gene)|ensemblbacteria:BAE77484(transcript)|go:"GO:0005886"(plasma membrane)	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:C59b2Nw3u5+y6Sp4jUDnzRDJsA883333	rogid:ymTZ828wkwvD0eD0d1m8OhFLqh483333	rigid:eTQIQoT1uMGuWkN5ieDQwizX7y4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DM85	uniprotkb:P33591	intact:EBI-1114491|uniprotkb:Q2M6J5|intact:EBI-9136966|ensemblbacteria:AAC77070|ensemblbacteria:BAE78111|uniprotkb:P16694	intact:EBI-21455530|uniprotkb:Q2M7E0|ensemblbacteria:AAC76502|ensemblbacteria:BAE77816	psi-mi:crfc_ecoli(display_long)|uniprotkb:crfC(gene name)|psi-mi:crfC(display_short)|uniprotkb:Clamp-binding sister replication fork colocalization protein(gene name synonym)|uniprotkb:yjdA(gene name synonym)|uniprotkb:JW4070(locus name)|uniprotkb:b4109(locus name)	psi-mi:nikb_ecoli(display_long)|uniprotkb:nikB(gene name)|psi-mi:nikB(display_short)|uniprotkb:b3477(locus name)|uniprotkb:JW3442(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982151|imex:IM-27227-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027417|refseq:NP_418533.1|interpro:IPR022812|refseq:WP_000288603.1|interpro:IPR030381|go:"GO:0006260"(DNA replication)|go:"GO:0007059"(chromosome segregation)|go:"GO:0043022"(ribosome binding)|go:"GO:0005829"(cytosol)|ensemblbacteria:AAC77070(transcript)|ensemblbacteria:b4109(gene)|ensemblbacteria:BAE78111(gene)|ensemblbacteria:BAE78111(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005525"(GTP binding)	dip:DIP-10341N|refseq:NP_417934.1|refseq:WP_000947068.1|ensemblbacteria:AAC76502(transcript)|ensemblbacteria:b3477(gene)|ensemblbacteria:BAE77816(gene)|ensemblbacteria:BAE77816(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015099"(nickel cation transmembrane transporter activity)|go:"GO:0016151"(nickel cation binding)|go:"GO:0071916"(dipeptide transmembrane transporter activity)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR014156(Nickel ABC transporter, permease subunit NikB)|interpro:IPR035906	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:XXYZ1zjuFrKfMsc4mhMEIeQSCM083333	rogid:uxN3X/2WS1z4U6Unu3FrKmXXu8883333	rigid:uc+r6j2eBf6XmJQSe1ThwvNCYa4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06136	uniprotkb:P0ABG4	intact:EBI-1130157|ensemblbacteria:BAB96661|ensemblbacteria:AAC73204	intact:EBI-1214767|uniprotkb:P16457|ensemblbacteria:AAC73200|ensemblbacteria:BAB96657	psi-mi:ftsq_ecoli(display_long)|uniprotkb:ftsQ(gene name)|psi-mi:ftsQ(display_short)|uniprotkb:b0093(locus name)|uniprotkb:JW0091(locus name)	psi-mi:ftsw_ecoli(display_long)|uniprotkb:ftsW(gene name)|psi-mi:ftsW(display_short)|uniprotkb:Cell division protein FtsW(gene name synonym)|uniprotkb:Cell wall polymerase(gene name synonym)|uniprotkb:Lipid II flippase FtsW(gene name synonym)|uniprotkb:Peptidoglycan polymerase(gene name synonym)|uniprotkb:JW0087(locus name)|uniprotkb:b0089(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982172|imex:IM-27227-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000075748.1|refseq:NP_414635.1|ensemblbacteria:BAB96661(transcript)|go:"GO:0000917"(division septum assembly)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensemblbacteria:BAB96661(gene)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032153"(cell division site)|go:"GO:0042802"(identical protein binding)|go:"GO:0043093"(FtsZ-dependent cytokinesis)|go:"GO:0051301"(cell division)|interpro:IPR005548(Cell division protein FtsQ)|interpro:IPR013685(Polypeptide-transport-associated, FtsQ-type)|interpro:IPR026579|interpro:IPR034746|rcsb pdb:2VH1|rcsb pdb:4UE4|rcsb pdb:4V6M|rcsb pdb:5Z2W|rcsb pdb:6H9N|rcsb pdb:6H9O|ensemblbacteria:AAC73204(transcript)|ensemblbacteria:b0093(gene)|mint:P06136|dip:DIP-9706N	refseq:NP_414631.1|refseq:WP_001295532.1|mint:P0ABG4|dip:DIP-47989N|ensemblbacteria:AAC73200(transcript)|ensemblbacteria:b0089(gene)|ensemblbacteria:BAB96657(gene)|ensemblbacteria:BAB96657(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008955"(peptidoglycan glycosyltransferase activity)|go:"GO:0009252"(peptidoglycan biosynthetic process)|go:"GO:0015648"(lipid-linked peptidoglycan transporter activity)|go:"GO:0032153"(cell division site)|go:"GO:0043093"(FtsZ-dependent cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0071555"(cell wall organization)|interpro:IPR001182(Cell cycle protein)|interpro:IPR013437(Cell division protein FtsW)|interpro:IPR018365	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:j1yOCAymvXJP5cUtdZYhJilT4iE83333	rogid:gJo0gwDLBv3gJfNlOleO+1ttrWQ83333	rigid:SvGz+J7CId9q0/Tzn/j4/1Kgr54	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ADV1	uniprotkb:P31554	intact:EBI-1132001|uniprotkb:P38685|uniprotkb:Q2M912|ensemblbacteria:AAC76232|ensemblbacteria:BAE77244	intact:EBI-549369|uniprotkb:P75631|ensemblbacteria:AAC73165|ensemblbacteria:BAB96622	psi-mi:lpta_ecoli(display_long)|uniprotkb:lptA(gene name)|psi-mi:lptA(display_short)|uniprotkb:b3200(locus name)|uniprotkb:JW3167(locus name)|uniprotkb:yhbN(gene name synonym)	psi-mi:lptd_ecoli(display_long)|uniprotkb:lptD(gene name)|psi-mi:lptD(display_short)|uniprotkb:ostA(gene name synonym)|uniprotkb:b0054(locus name)|uniprotkb:yabG(gene name synonym)|uniprotkb:Organic solvent tolerance protein(gene name synonym)|uniprotkb:JW0053(locus name)|uniprotkb:imp(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982165|imex:IM-27227-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000669785.1|ensemblbacteria:AAC76232(transcript)|ensemblbacteria:b3200(gene)|go:"GO:0009279"(cell outer membrane)|go:"GO:0015920"(lipopolysaccharide transport)|go:"GO:0017089"(glycolipid transfer activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0043165"(Gram-negative-bacterium-type cell outer membrane assembly)|go:"GO:1990351"(transporter complex)|interpro:IPR005653(OstA-like protein)|interpro:IPR014340(Cell envelope biogenesis YhbN)|rcsb pdb:2R19|rcsb pdb:2R1A|rcsb pdb:6GD5|ensemblbacteria:BAE77244(gene)|ensemblbacteria:BAE77244(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|refseq:NP_417667.1|dip:DIP-12262N	refseq:NP_414596.1|refseq:WP_000746151.1|dip:DIP-10029N|ensemblbacteria:AAC73165(transcript)|ensemblbacteria:b0054(gene)|ensemblbacteria:BAB96622(gene)|ensemblbacteria:BAB96622(transcript)|go:"GO:0009279"(cell outer membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0015921"(lipopolysaccharide export)|go:"GO:0043165"(Gram-negative-bacterium-type cell outer membrane assembly)|go:"GO:1990351"(transporter complex)|interpro:IPR005653(OstA-like protein)|interpro:IPR007543(Organic solvent tolerance protein)|interpro:IPR020889|rcsb pdb:4RHB	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:KCXWBKqCf9DdH08tKTCxb6Gc+u883333	rogid:WTpy+Vfx0UGoA1gvFSpdBKYq28o83333	rigid:bADlIsTv5lSxFBgOKzYfBKnZpQE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69739	uniprotkb:P19931	intact:EBI-9124108|uniprotkb:P19928|ensemblbacteria:AAC74057|ensemblbacteria:BAA35737	intact:EBI-1121314|ensemblbacteria:AAC74061|ensemblbacteria:BAA35741	psi-mi:mbhs_ecoli(display_long)|uniprotkb:Membrane-bound hydrogenase 1 small subunit(gene name synonym)|uniprotkb:NiFe hydrogenase(gene name synonym)|uniprotkb:JW0954(locus name)|uniprotkb:b0972(locus name)|uniprotkb:hyaA(gene name)|psi-mi:hyaA(display_short)	psi-mi:hyae_ecoli(display_long)|uniprotkb:hyaE(gene name)|psi-mi:hyaE(display_short)|uniprotkb:b0976(locus name)|uniprotkb:JW0958(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982193|imex:IM-27227-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415491.1|refseq:WP_001058323.1|dip:DIP-47848N|ensemblbacteria:AAC74057(transcript)|ensemblbacteria:b0972(gene)|ensemblbacteria:BAA35737(gene)|ensemblbacteria:BAA35737(transcript)|go:"GO:0006113"(fermentation)|go:"GO:0008901"(ferredoxin hydrogenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0009375"(ferredoxin hydrogenase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:5A4I|rcsb pdb:5A4M|rcsb pdb:5ADU|rcsb pdb:5JRD|rcsb pdb:6FPI|rcsb pdb:6FPW|rcsb pdb:6G7R|rcsb pdb:6GAL|rcsb pdb:6RP2|go:"GO:0031237"(intrinsic component of periplasmic side of plasma membrane)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001821([Ni-Fe]-hydrogenase, small subunit)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006311(Twin-arginine translocation pathway signal)|interpro:IPR019546|interpro:IPR027394|interpro:IPR037024|interpro:IPR037148|rcsb pdb:3UQY|rcsb pdb:3USC|rcsb pdb:3USE|rcsb pdb:4GD3|rcsb pdb:4UE3|rcsb pdb:5A4F	refseq:NP_415495.1|refseq:WP_000063978.1|ensemblbacteria:AAC74061(transcript)|ensemblbacteria:b0976(gene)|ensemblbacteria:BAA35741(gene)|ensemblbacteria:BAA35741(transcript)|go:"GO:0005048"(signal sequence binding)|interpro:IPR010893(Hydrogenase-1 expression HyaE)|interpro:IPR036249|rcsb pdb:2HFD|dip:DIP-9961N	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:E43AQkd5RVOzn1UE4JbHrcVKERM83333	rogid:q3GCd+uMtUe/lXsYKXWXmcqkDmE83333	rigid:I+ieWuK7ODSS7SEJNJdqSK/kPbw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27550	uniprotkb:P39176	intact:EBI-1120362|uniprotkb:Q2M6N5|ensemblbacteria:AAC77039|ensemblbacteria:BAE78071	intact:EBI-555707|ensemblbacteria:AAC75051|ensemblbacteria:BAA15807	psi-mi:acsa_ecoli(display_long)|uniprotkb:acs(gene name)|psi-mi:acs(display_short)|uniprotkb:b4069(locus name)|uniprotkb:JW4030(locus name)|uniprotkb:yfaC(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:erfk_ecoli(display_long)|uniprotkb:yeeG(gene name synonym)|uniprotkb:yzzT(gene name synonym)|uniprotkb:erfK(gene name)|psi-mi:erfK(display_short)|uniprotkb:b1990(locus name)|uniprotkb:JW1968(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982200|imex:IM-27227-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418493.1|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR000873(AMP-dependent synthetase and ligase)|refseq:WP_000078239.1|interpro:IPR032387|ensemblbacteria:AAC77039(transcript)|ensemblbacteria:b4069(gene)|ensemblbacteria:BAE78071(gene)|ensemblbacteria:BAE78071(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006935"(chemotaxis)|go:"GO:0016208"(AMP binding)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034421"(post-translational protein acetylation)|go:"GO:0045733"(acetate catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050218"(propionate-CoA ligase activity)|go:"GO:0005829"(cytosol)|interpro:IPR025110|interpro:IPR042099	refseq:NP_416494.1|dip:DIP-9522N|ensemblbacteria:AAC75051(transcript)|ensemblbacteria:b1990(gene)|ensemblbacteria:BAA15807(gene)|ensemblbacteria:BAA15807(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0018104"(peptidoglycan-protein cross-linking)|go:"GO:0042597"(periplasmic space)|go:"GO:0071555"(cell wall organization)|go:"GO:0071972"(peptidoglycan L,D-transpeptidase activity)|interpro:IPR005490(ErfK/YbiS/YcfS/YnhG)|interpro:IPR038063|interpro:IPR041597	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:0wF/wvY5GLYf+clsDiyX3ClG9wQ83333	rogid:NZTY/Zh2pLJCbFHabYZJND33kRM83333	rigid:nVNlEh5eSE7IP5D9nJY202BqSGY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P77239	uniprotkb:P77211	intact:EBI-1118842|ensemblbacteria:AAC73675|ensemblbacteria:BAA35208	intact:EBI-9539649|uniprotkb:Q9L5Y3|uniprotkb:Q9X444|ensemblbacteria:AAC73673|ensemblbacteria:BAA35206	psi-mi:cusb_ecoli(display_long)|uniprotkb:cusB(gene name)|psi-mi:cusB(display_short)|uniprotkb:b0574(locus name)|uniprotkb:JW0563(locus name)|uniprotkb:ylcD(gene name synonym)	psi-mi:cusc_ecoli(display_long)|uniprotkb:cusC(gene name)|psi-mi:cusC(display_short)|uniprotkb:ibeB(gene name synonym)|uniprotkb:ylcB(gene name synonym)|uniprotkb:b0572(locus name)|uniprotkb:JW0561(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982179|imex:IM-27227-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC73675(transcript)|ensemblbacteria:b0574(gene)|ensemblbacteria:BAA35208(gene)|ensemblbacteria:BAA35208(transcript)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0010272"(response to silver ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0015679"(plasma membrane copper ion transport)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0030313"(cell envelope)|go:"GO:0046688"(response to copper ion)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060003"(copper ion export)|interpro:IPR006143(Secretion protein HlyD)|interpro:IPR032317|interpro:IPR043602|rcsb pdb:3H94|rcsb pdb:3NE5|rcsb pdb:3OOC|rcsb pdb:3OPO|rcsb pdb:3OW7|rcsb pdb:3T51|rcsb pdb:3T53|rcsb pdb:3T56|rcsb pdb:4DNR|rcsb pdb:4DNT|rcsb pdb:4DOP|refseq:WP_000717157.1|refseq:NP_415106.1|dip:DIP-9346N	refseq:WP_000074234.1|refseq:NP_415104.1|dip:DIP-9347N|ensemblbacteria:AAC73673(transcript)|ensemblbacteria:b0572(gene)|ensemblbacteria:BAA35206(gene)|ensemblbacteria:BAA35206(transcript)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0009279"(cell outer membrane)|go:"GO:0010272"(response to silver ion)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0015288"(porin activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0046688"(response to copper ion)|go:"GO:0046930"(pore complex)|go:"GO:0060003"(copper ion export)|go:"GO:0070207"(protein homotrimerization)|interpro:IPR003423(Outer membrane efflux protein)|interpro:IPR010131(RND efflux system, outer membrane lipoprotein, NodT)|rcsb pdb:3PIK|rcsb pdb:4K34|rcsb pdb:4K7K|rcsb pdb:4K7R	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:SK7ZwGaDq/1bNsGe5STc/cT6KKs83333	rogid:A3CA1zvyZ2Wm7zVWfXbCnepRcts83333	rigid:mw84dW5fNYtt9F7HCLwk71dcNSM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEG1	uniprotkb:P37313	intact:EBI-548667|uniprotkb:P37315|uniprotkb:Q2M7K4|ensemblbacteria:AAC76567|ensemblbacteria:BAE77752	intact:EBI-849273|uniprotkb:Q2M7K2|ensemblbacteria:AAC76565|ensemblbacteria:BAE77754	psi-mi:dppc_ecoli(display_long)|uniprotkb:dppC(gene name)|psi-mi:dppC(display_short)|uniprotkb:b3542(locus name)|uniprotkb:JW3511(locus name)	psi-mi:dppf_ecoli(display_long)|uniprotkb:dppF(gene name)|psi-mi:dppF(display_short)|uniprotkb:dppE(gene name synonym)|uniprotkb:b3540(locus name)|uniprotkb:JW3509(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982214|imex:IM-27227-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417999.1|refseq:WP_000084677.1|dip:DIP-9469N|ensemblbacteria:AAC76567(transcript)|ensemblbacteria:b3542(gene)|ensemblbacteria:BAE77752(gene)|ensemblbacteria:BAE77752(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071916"(dipeptide transmembrane transporter activity)|interpro:IPR000515(Binding-protein-dependent transport systems inner membrane component)|interpro:IPR025966|interpro:IPR035906	refseq:NP_417997.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR013563(Oligopeptide/dipeptide ABC transporter, C-terminal)|refseq:WP_000107012.1|interpro:IPR027417|ensemblbacteria:AAC76565(transcript)|ensemblbacteria:b3540(gene)|ensemblbacteria:BAE77754(gene)|ensemblbacteria:BAE77754(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0015031"(protein transport)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:Hh1vAyQyZ8XzIm8L9MFZKUoQRQ483333	rogid:nFtEUBISp/vMg0IsUA58GWnfBIg83333	rigid:18NPvqKtskrkFtMYT+V+CDmqcZM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69741	uniprotkb:P0AAN1	intact:EBI-552619|uniprotkb:Q2M9J8|uniprotkb:Q46847|ensemblbacteria:AAC76033|ensemblbacteria:BAE77058	intact:EBI-552588|uniprotkb:P37183|uniprotkb:Q2M9K3|ensemblbacteria:AAC76028|ensemblbacteria:BAE77053	psi-mi:mbht_ecoli(display_long)|uniprotkb:yghV(gene name synonym)|uniprotkb:Membrane-bound hydrogenase 2 small subunit(gene name synonym)|uniprotkb:NiFe hydrogenase(gene name synonym)|uniprotkb:hybO(gene name)|psi-mi:hybO(display_short)|uniprotkb:b2997(locus name)|uniprotkb:JW2965(locus name)	psi-mi:hybe_ecoli(display_long)|uniprotkb:hybE(gene name)|psi-mi:hybE(display_short)|uniprotkb:b2992(locus name)|uniprotkb:JW2960(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982207|imex:IM-27227-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417471.1|refseq:WP_000145410.1|ensemblbacteria:AAC76033(transcript)|ensemblbacteria:b2997(gene)|ensemblbacteria:BAE77058(gene)|ensemblbacteria:BAE77058(transcript)|go:"GO:0008901"(ferredoxin hydrogenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0009375"(ferredoxin hydrogenase complex)|go:"GO:0016020"(membrane)|go:"GO:0031236"(extrinsic component of periplasmic side of plasma membrane)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0042597"(periplasmic space)|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001821([Ni-Fe]-hydrogenase, small subunit)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006311(Twin-arginine translocation pathway signal)|interpro:IPR019546|interpro:IPR027394|interpro:IPR037024|interpro:IPR037148|rcsb pdb:6EHQ|rcsb pdb:6EHS|rcsb pdb:6EN9|rcsb pdb:6G7M|rcsb pdb:6GAM|rcsb pdb:6GAN|rcsb pdb:6SYO|rcsb pdb:6SYX|rcsb pdb:6SZD|rcsb pdb:6SZK|dip:DIP-36024N	refseq:NP_417466.1|refseq:WP_000134014.1|dip:DIP-35795N|ensemblbacteria:AAC76028(transcript)|ensemblbacteria:b2992(gene)|ensemblbacteria:BAE77053(gene)|ensemblbacteria:BAE77053(transcript)|go:"GO:0051604"(protein maturation)|go:"GO:0070678"(preprotein binding)|interpro:IPR023994|interpro:IPR038530|rcsb pdb:2KC5	-	crc64:C5821096BBAF9C66	crc64:CFDAEA3D47BE9516	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:q3mPMVF7Qd4HSkzFGtPodT7/4Bo83333	rogid:ygiFIogsROT5Sqp8Cc4yI4dELTI83333	rigid:fki+YUT0d+OuU/nTq5q1mvrDDJc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29018	uniprotkb:P75830	intact:EBI-1129376|uniprotkb:P77275|uniprotkb:Q47656|ensemblbacteria:AAC73973|ensemblbacteria:BAA35612	intact:EBI-551961|ensemblbacteria:AAC73965|ensemblbacteria:BAA35597	psi-mi:cydd_ecoli(display_long)|uniprotkb:cydD(gene name)|psi-mi:cydD(display_short)|uniprotkb:htrD(gene name synonym)|uniprotkb:b0887(locus name)|uniprotkb:JW0870(locus name)	psi-mi:maca_ecoli(display_long)|uniprotkb:macA(gene name)|psi-mi:macA(display_short)|uniprotkb:b0878(locus name)|uniprotkb:ybjY(gene name synonym)|uniprotkb:JW0862(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982186|imex:IM-27227-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001043598.1|refseq:NP_415407.1|ensemblbacteria:AAC73973(transcript)|ensemblbacteria:b0887(gene)|ensemblbacteria:BAA35612(gene)|ensemblbacteria:BAA35612(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0033228"(cysteine export across plasma membrane)|go:"GO:0034775"(glutathione transmembrane transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR014216("ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD")|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|dip:DIP-9363N	refseq:NP_415399.4|refseq:WP_000746442.1|dip:DIP-11460N|ensemblbacteria:AAC73965(transcript)|ensemblbacteria:b0878(gene)|ensemblbacteria:BAA35597(gene)|ensemblbacteria:BAA35597(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990196"(MacAB-TolC complex)|go:"GO:1990281"(efflux pump complex)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR006143(Secretion protein HlyD)|interpro:IPR030190|interpro:IPR032317|rcsb pdb:3FPP|rcsb pdb:5NIK|rcsb pdb:5NIL	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:v9LVWZq88BGOPV0CXM1yQ/XjYhk83333	rogid:Xj1hcSaeRW/gtgzklUnnRv/9Yvw83333	rigid:iY0w814I1Ei7E9y7cwRyAUMS3j4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23847	uniprotkb:P37313	intact:EBI-554666|uniprotkb:Q2M7K6|ensemblbacteria:AAC76569|ensemblbacteria:BAE77750	intact:EBI-849273|uniprotkb:Q2M7K2|ensemblbacteria:AAC76565|ensemblbacteria:BAE77754	psi-mi:dppa_ecoli(display_long)|uniprotkb:dppA(gene name)|psi-mi:dppA(display_short)|uniprotkb:Periplasmic dipeptide transport protein(gene name synonym)|uniprotkb:JW3513(locus name)|uniprotkb:b3544(locus name)	psi-mi:dppf_ecoli(display_long)|uniprotkb:dppF(gene name)|psi-mi:dppF(display_short)|uniprotkb:dppE(gene name synonym)|uniprotkb:b3540(locus name)|uniprotkb:JW3509(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982222|imex:IM-27227-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418001.1|refseq:WP_001222883.1|dip:DIP-9467N|ensemblbacteria:AAC76569(transcript)|ensemblbacteria:b3544(gene)|ensemblbacteria:BAE77750(gene)|ensemblbacteria:BAE77750(transcript)|go:"GO:0006935"(chemotaxis)|go:"GO:0015031"(protein transport)|go:"GO:0015833"(peptide transport)|go:"GO:0020037"(heme binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042277"(peptide binding)|go:"GO:0042938"(dipeptide transport)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071916"(dipeptide transmembrane transporter activity)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR000914(Bacterial extracellular solute-binding protein, family 5)|interpro:IPR023765|interpro:IPR030678|interpro:IPR039424|rcsb pdb:1DPE|rcsb pdb:1DPP	refseq:NP_417997.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR013563(Oligopeptide/dipeptide ABC transporter, C-terminal)|refseq:WP_000107012.1|interpro:IPR027417|ensemblbacteria:AAC76565(transcript)|ensemblbacteria:b3540(gene)|ensemblbacteria:BAE77754(gene)|ensemblbacteria:BAE77754(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0015031"(protein transport)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:uwA90iqwYavKG+YRx4E6wg0rzFE83333	rogid:nFtEUBISp/vMg0IsUA58GWnfBIg83333	rigid:pzFu1JAx5/hnSg7wN2LFGuSW4iQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08331	uniprotkb:P39315	intact:EBI-560014|uniprotkb:Q2M692|ensemblbacteria:AAC77170|ensemblbacteria:BAE78214	intact:EBI-553903|uniprotkb:Q2M694|ensemblbacteria:AAC77168|ensemblbacteria:BAE78212	psi-mi:cpdb_ecoli(display_long)|uniprotkb:cpdB(gene name)|psi-mi:cpdB(display_short)|uniprotkb:b4213(locus name)|uniprotkb:JW4171(locus name)	psi-mi:qor2_ecoli(display_long)|uniprotkb:qorB(gene name)|psi-mi:qorB(display_short)|uniprotkb:b4211(locus name)|uniprotkb:qor2(gene name synonym)|uniprotkb:ytfG(gene name synonym)|uniprotkb:JW4169(locus name)	psi-mi:"MI:0397"(two hybrid array)	Babu et al. (2018)	imex:IM-27227|pubmed:29176613|doi:10.1038/nbt.4024	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982229|imex:IM-27227-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418634.1|refseq:WP_000589431.1|dip:DIP-9311N|ensemblbacteria:AAC77170(transcript)|ensemblbacteria:b4213(gene)|ensemblbacteria:BAE78214(gene)|ensemblbacteria:BAE78214(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008254"(3'-nucleotidase activity)|go:"GO:0008663"(2',3'-cyclic-nucleotide 2'-phosphodiesterase activity)|go:"GO:0009166"(nucleotide catabolic process)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042597"(periplasmic space)|go:"GO:0046872"(metal ion binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006146(5'-Nucleotidase, conserved site)|interpro:IPR006179(5'-Nucleotidase and apyrase)|interpro:IPR006294(2 ,3 -cyclic-nucleotide 2 -phosphodiesterase)|interpro:IPR008334(5'-Nucleotidase, C-terminal)|interpro:IPR029052|interpro:IPR036907|interpro:IPR041827	refseq:NP_418632.1|refseq:WP_000560561.1|dip:DIP-12935N|ensemblbacteria:AAC77168(transcript)|ensemblbacteria:b4211(gene)|ensemblbacteria:BAE78212(gene)|ensemblbacteria:BAE78212(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|interpro:IPR008030(NmrA-like)|interpro:IPR036291|rcsb pdb:2ZCU|rcsb pdb:2ZCV	-	-	-	figure legend:Table S2 and Table S3|comment:Y2H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/06	2019/08/21	rogid:Nh6PQ9kR4wf2L2W5RV/s4f3Asig83333	rogid:Loitm2D2wA39gWD69cY+rXIhSb883333	rigid:axgdZoJGGE2kqI+fuOQselRhI/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)