#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22056946|imex:IM-27404-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig.3A, Fig.S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/10/03	2019/10/03	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rigid:RMQCxMnMZTYKRNuAw4ySnK3TscY	false	sufficient binding region:76-145|glutathione s tranferase tag:?-?|flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22056999|imex:IM-27404-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig.3A, Fig.S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/10/03	2019/10/03	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rigid:RMQCxMnMZTYKRNuAw4ySnK3TscY	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057544|imex:IM-27404-5|wwpdb:5y3a	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Table 1, Fig. 1 and Fig. 2|3d-r-factors:"R work: 0.246 , R free: 0.288"|3d-resolution:2.9 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/11/26	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:50-161	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:Q9UHA4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057544|imex:IM-27404-5|wwpdb:5y3a	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Table 1, Fig. 1 and Fig. 2|3d-r-factors:"R work: 0.246 , R free: 0.288"|3d-resolution:2.9 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/11/26	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:50-161	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:Q0VGL1	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057544|imex:IM-27404-5|wwpdb:5y3a	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Table 1, Fig. 1 and Fig. 2|3d-r-factors:"R work: 0.246 , R free: 0.288"|3d-resolution:2.9 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/11/26	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:50-161	his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:O43504	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057544|imex:IM-27404-5|wwpdb:5y3a	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Table 1, Fig. 1 and Fig. 2|3d-r-factors:"R work: 0.246 , R free: 0.288"|3d-resolution:2.9 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/11/26	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:50-161	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43504	uniprotkb:Q0VGL1	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057576|imex:IM-27404-7|wwpdb:5y38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Table 1, Fig. 1|3d-r-factors:"R work: 0.215 , R free: 0.256"|3d-resolution:2.8 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/10/04	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rigid:vMIZ2Qg4+Vfr7SZWSuUhfaAvyL8	false	-	his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22062252|imex:IM-27404-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	-	-	-	figure legend:Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/10/04	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:76-145	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:Q9UHA4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22062252|imex:IM-27404-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/10/04	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:76-145	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:Q0VGL1	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22062252|imex:IM-27404-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/10/04	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:76-145	his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6IAA8	uniprotkb:O43504	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22062252|imex:IM-27404-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/10/04	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rigid:9LHo6/gEikkbfVeeoWXKzMdbISo	false	his tag:n-n|sumo tag:n-n|sufficient binding region:76-145	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43504	uniprotkb:Q0VGL1	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Zhang et al. (2017)	pubmed:29123114|imex:IM-27404	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22062267|imex:IM-27404-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/03	2019/10/04	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rigid:vMIZ2Qg4+Vfr7SZWSuUhfaAvyL8	false	-	his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)