#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02763	uniprotkb:Q16678	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-1055133|uniprotkb:Q93089|uniprotkb:Q9H316|uniprotkb:Q5TZW8|ensembl:ENSP00000478561|ensembl:ENSP00000483678	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:cp1b1_human(display_long)|uniprotkb:CYPIB1(gene name synonym)|uniprotkb:CYP1B1(gene name)|psi-mi:CYP1B1(display_short)|uniprotkb:Hydroperoxy icosatetraenoate dehydratase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kabra et al. (2017)	pubmed:28620713|imex:IM-27171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21923824|imex:IM-27171-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	refseq:NP_000095.2|ensembl:ENSG00000138061(gene)|ensembl:ENST00000610745(transcript)|ensembl:ENST00000614273(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002930"(trabecular meshwork development)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070330"(aromatase activity)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0106256"(hydroperoxy icosatetraenoate dehydratase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR032971|interpro:IPR036396|rcsb pdb:3PM0|rcsb pdb:6IQ5|reactome:R-HSA-211976|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-5579000|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)	-	-	-	figure legend:Fig. 2, Supplemental Figure 3a-b|comment:"Low, yet detectable HA-TEK-n (amino acids 1-815) could also be pulled down with GFP-CYP1B1."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/18	2020/10/06	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:2VJK4lLtHFWOsLQPBDXweKplk+09606	rigid:oF88ErjknzsIkwCPjL/m9ixoau8	false	ha tag:?-?|sufficient binding region:816-1124	green fluorescent protein tag:?-?|mutation disrupting interaction strength:115-115|mutation decreasing interaction strength:368-368	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q16678	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-1055133|uniprotkb:Q93089|uniprotkb:Q9H316|uniprotkb:Q5TZW8|ensembl:ENSP00000478561|ensembl:ENSP00000483678	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:cp1b1_human(display_long)|uniprotkb:CYPIB1(gene name synonym)|uniprotkb:CYP1B1(gene name)|psi-mi:CYP1B1(display_short)|uniprotkb:Hydroperoxy icosatetraenoate dehydratase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kabra et al. (2017)	pubmed:28620713|imex:IM-27171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26686535|imex:IM-27171-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	refseq:NP_000095.2|ensembl:ENSG00000138061(gene)|ensembl:ENST00000610745(transcript)|ensembl:ENST00000614273(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002930"(trabecular meshwork development)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070330"(aromatase activity)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0106256"(hydroperoxy icosatetraenoate dehydratase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR032971|interpro:IPR036396|rcsb pdb:3PM0|rcsb pdb:6IQ5|reactome:R-HSA-211976|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-5579000|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)	-	-	-	figure legend:Fig. 2 lane set II|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/18	2021/02/24	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:2VJK4lLtHFWOsLQPBDXweKplk+09606	rigid:oF88ErjknzsIkwCPjL/m9ixoau8	false	mutation disrupting interaction strength:103-103|ha tag:?-?	mutation disrupting interaction strength:115-115|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q16678	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-1055133|uniprotkb:Q93089|uniprotkb:Q9H316|uniprotkb:Q5TZW8|ensembl:ENSP00000478561|ensembl:ENSP00000483678	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:cp1b1_human(display_long)|uniprotkb:CYPIB1(gene name synonym)|uniprotkb:CYP1B1(gene name)|psi-mi:CYP1B1(display_short)|uniprotkb:Hydroperoxy icosatetraenoate dehydratase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kabra et al. (2017)	pubmed:28620713|imex:IM-27171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26686568|imex:IM-27171-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	refseq:NP_000095.2|ensembl:ENSG00000138061(gene)|ensembl:ENST00000610745(transcript)|ensembl:ENST00000614273(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002930"(trabecular meshwork development)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070330"(aromatase activity)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0106256"(hydroperoxy icosatetraenoate dehydratase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR032971|interpro:IPR036396|rcsb pdb:3PM0|rcsb pdb:6IQ5|reactome:R-HSA-211976|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-5579000|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)	-	-	-	figure legend:Fig. 2 lane set III|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/18	2021/02/24	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:2VJK4lLtHFWOsLQPBDXweKplk+09606	rigid:oF88ErjknzsIkwCPjL/m9ixoau8	false	ha tag:?-?|mutation disrupting interaction strength:214-214	green fluorescent protein tag:?-?|mutation disrupting interaction strength:229-229	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q16678	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-1055133|uniprotkb:Q93089|uniprotkb:Q9H316|uniprotkb:Q5TZW8|ensembl:ENSP00000478561|ensembl:ENSP00000483678	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:cp1b1_human(display_long)|uniprotkb:CYPIB1(gene name synonym)|uniprotkb:CYP1B1(gene name)|psi-mi:CYP1B1(display_short)|uniprotkb:Hydroperoxy icosatetraenoate dehydratase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kabra et al. (2017)	pubmed:28620713|imex:IM-27171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26686619|imex:IM-27171-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	refseq:NP_000095.2|ensembl:ENSG00000138061(gene)|ensembl:ENST00000610745(transcript)|ensembl:ENST00000614273(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002930"(trabecular meshwork development)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070330"(aromatase activity)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0106256"(hydroperoxy icosatetraenoate dehydratase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR032971|interpro:IPR036396|rcsb pdb:3PM0|rcsb pdb:6IQ5|reactome:R-HSA-211976|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-5579000|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)	-	-	-	figure legend:Fig. 2 lane set IV|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/18	2021/02/24	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:2VJK4lLtHFWOsLQPBDXweKplk+09606	rigid:oF88ErjknzsIkwCPjL/m9ixoau8	false	ha tag:?-?|mutation with no effect:743-743	mutation with no effect:229-229|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q16678	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-1055133|uniprotkb:Q93089|uniprotkb:Q9H316|uniprotkb:Q5TZW8|ensembl:ENSP00000478561|ensembl:ENSP00000483678	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:cp1b1_human(display_long)|uniprotkb:CYPIB1(gene name synonym)|uniprotkb:CYP1B1(gene name)|psi-mi:CYP1B1(display_short)|uniprotkb:Hydroperoxy icosatetraenoate dehydratase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kabra et al. (2017)	pubmed:28620713|imex:IM-27171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26686652|imex:IM-27171-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	refseq:NP_000095.2|ensembl:ENSG00000138061(gene)|ensembl:ENST00000610745(transcript)|ensembl:ENST00000614273(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002930"(trabecular meshwork development)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070330"(aromatase activity)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0106256"(hydroperoxy icosatetraenoate dehydratase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR032971|interpro:IPR036396|rcsb pdb:3PM0|rcsb pdb:6IQ5|reactome:R-HSA-211976|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-5579000|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)	-	-	-	figure legend:Fig. 2 lane set V|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/18	2021/02/24	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:2VJK4lLtHFWOsLQPBDXweKplk+09606	rigid:oF88ErjknzsIkwCPjL/m9ixoau8	false	ha tag:?-?|mutation decreasing interaction strength:148-148	green fluorescent protein tag:?-?|mutation decreasing interaction strength:368-368	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q16678	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-1055133|uniprotkb:Q93089|uniprotkb:Q9H316|uniprotkb:Q5TZW8|ensembl:ENSP00000478561|ensembl:ENSP00000483678	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:cp1b1_human(display_long)|uniprotkb:CYPIB1(gene name synonym)|uniprotkb:CYP1B1(gene name)|psi-mi:CYP1B1(display_short)|uniprotkb:Hydroperoxy icosatetraenoate dehydratase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kabra et al. (2017)	pubmed:28620713|imex:IM-27171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26686685|imex:IM-27171-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	refseq:NP_000095.2|ensembl:ENSG00000138061(gene)|ensembl:ENST00000610745(transcript)|ensembl:ENST00000614273(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002930"(trabecular meshwork development)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006725"(cellular aromatic compound metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016125"(sterol metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070330"(aromatase activity)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0106256"(hydroperoxy icosatetraenoate dehydratase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR032971|interpro:IPR036396|rcsb pdb:3PM0|rcsb pdb:6IQ5|reactome:R-HSA-211976|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-5579000|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)	-	-	-	figure legend:Fig.2, Supplemental Figure 3a-b|comment:"Low, yet detectable HA-TEK-n (amino acids 1-815) could also be pulled down with GFP-CYP1B1."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/18	2021/02/24	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:2VJK4lLtHFWOsLQPBDXweKplk+09606	rigid:oF88ErjknzsIkwCPjL/m9ixoau8	false	sufficient binding region:816-1124|mutation disrupting interaction strength:103-103|ha tag:?-?|mutation disrupting interaction strength:148-148	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)