#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:15996"	uniprotkb:Q8IVH4	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0419"(gtpase assay)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21464621|imex:IM-27152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	go:"GO:0003924"(GTPase activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp. Table 3, Fig. 3 a/c, Table 2|stimulant:"MUT protein (UniProt identifier: P22033)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:12.06x1^1 ~0.3(second -1)|km:42.0x10^-6 ~9.0(molar)	2019/07/05	2020/07/16	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	mutation disrupting interaction rate:98-98|mutation disrupting interaction rate:147-147|mutation disrupting interaction rate:188-188|mutation disrupting interaction rate:192-192|mutation disrupting interaction rate:196-196|mutation disrupting interaction rate:207-207|mutation disrupting interaction rate:209-209|mutation disrupting interaction rate:218-218|mutation disrupting interaction rate:220-220|mutation disrupting interaction rate:243-243|mutation disrupting interaction rate:250-250|mutation disrupting interaction rate:274-274|mutation disrupting interaction rate:276-276|mutation disrupting interaction rate:292-292|mutation disrupting interaction rate:359-359|sufficient binding region:73-418	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:P22033	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21464621|imex:IM-27152-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	go:"GO:0003924"(GTPase activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp. Table 3, Fig. 3 a/c, Table 2|stimulant:"MUT protein (UniProt identifier: P22033)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:12.06x1^1 ~0.3(second -1)|km:42.0x10^-6 ~9.0(molar)	2019/07/05	2020/07/16	-	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	-	false	-	sufficient binding region:12-750|his tag:c-c|flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:Q8IVH4	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0419"(gtpase assay)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25757716|imex:IM-27152-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	go:"GO:0003924"(GTPase activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Fig. 3b, Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/05	2020/07/16	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	mutation decreasing interaction rate:98-98|mutation decreasing interaction rate:147-147|mutation with no effect:188-188|mutation with no effect:192-192|mutation with no effect:196-196|mutation decreasing interaction rate:207-207|mutation decreasing interaction rate:209-209|mutation with no effect:218-218|mutation with no effect:220-220|mutation with no effect:243-243|mutation with no effect:250-250|mutation decreasing interaction rate:274-274|mutation decreasing interaction rate:276-276|mutation decreasing interaction rate:292-292|mutation with no effect:359-359|sufficient binding region:73-418|mutation decreasing interaction rate:290-290,292-292	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22033	uniprotkb:Q8IVH4	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0071"(molecular sieving)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21913377|imex:IM-27152-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig 4a, S3, S4|stimulant:"GMPPNP (CHEBI:78408) - non-hydrolysable analogue of GTP"|stimulant:Mg2+|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/05	2019/07/11	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rigid:PcH6AQ2zRkKJXDnt1gBlZSRDuo0	false	sufficient binding region:12-750|his tag:c-c|flag tag:c-c	mutation decreasing interaction strength:192-192|mutation with no effect:196-196|mutation decreasing interaction strength:250-250|mutation decreasing interaction strength:274-274|mutation decreasing interaction strength:276-276|mutation decreasing interaction strength:359-359|mutation disrupting interaction strength:98-98|mutation disrupting interaction strength:188-188|mutation disrupting interaction strength:218-218|mutation disrupting interaction strength:147-147|mutation disrupting interaction strength:207-207|mutation disrupting interaction strength:209-209|mutation disrupting interaction strength:220-220|mutation disrupting interaction strength:292-292|mutation disrupting interaction strength:243-243(rs1553958417)|sufficient binding region:73-418	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P22033	uniprotkb:Q8IVH4	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21913486|imex:IM-27152-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig 4b, Supp. Figure S5|stimulant:"GMPPNP (CHEBI:78408)"|stimulant:Mg2+|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/07/05	2019/07/11	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rigid:PcH6AQ2zRkKJXDnt1gBlZSRDuo0	false	-	mutation decreasing interaction strength:192-192|mutation disrupting interaction strength:243-243|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
chebi:"CHEBI:145560"	uniprotkb:Q8IVH4	intact:EBI-22235688	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:mant-gtp(display_short)|psi-mi:"CHEBI:145560"(display_long)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22235649|imex:IM-27152-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. S1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:35.0x10^-6 ~7.0(molar)	2019/07/05	2019/12/02	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	mutation decreasing interaction strength:292-292|mutation disrupting interaction strength:292-292,290-290|sufficient binding region:73-418	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17552"	uniprotkb:Q8IVH4	intact:EBI-1265684	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22235737|imex:IM-27152-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. 2a, 2c, Suppl. table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/05	2019/12/02	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	mutation with no effect:207-207|mutation with no effect:209-209|mutation with no effect:220-220|mutation with no effect:218-218|mutation with no effect:243-243|mutation with no effect:250-250|mutation decreasing interaction strength:290-290,292-292|mutation disrupting interaction strength:292-292|mutation with no effect:98-98|mutation with no effect:147-147|mutation with no effect:188-188|mutation with no effect:192-192|mutation with no effect:196-196|mutation with no effect:274-274|mutation with no effect:276-276|mutation with no effect:359-359|sufficient binding region:73-418	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:Q8IVH4	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Plessl et al. (2017)	pubmed:28497574|imex:IM-27152	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25759841|imex:IM-27152-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. 2b/c, Suppl. table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/05	2020/07/20	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	mutation with no effect:207-207|mutation with no effect:209-209|mutation with no effect:220-220|mutation with no effect:218-218|mutation with no effect:243-243|mutation with no effect:250-250|mutation decreasing interaction strength:292-292,290-290|mutation disrupting interaction strength:292-292|mutation with no effect:98-98|mutation with no effect:147-147|mutation with no effect:188-188|mutation with no effect:192-192|mutation with no effect:196-196|mutation with no effect:274-274|mutation with no effect:276-276|mutation with no effect:359-359|sufficient binding region:73-418	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)