#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70326	uniprotkb:P46152	intact:EBI-8411807|uniprotkb:Q9R003|intact:MINT-4137187|ensembl:ENSMUSP00000018407	intact:EBI-9257939|ensembl:ENSRNOP00000014320	psi-mi:tbx5_mouse(display_long)|uniprotkb:Tbx5(gene name)|psi-mi:Tbx5(display_short)	psi-mi:gata4_rat(display_long)|uniprotkb:Gata4(gene name)|psi-mi:Gata4(display_short)|uniprotkb:DNA-binding protein GATA-GT2(gene name synonym)|uniprotkb:GATA-binding factor 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Khalil et al. (2017)	pubmed:28469241|imex:IM-26806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21196028|imex:IM-26806-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246493.1|refseq:NP_035667.1|refseq:XP_006530343.1|refseq:XP_006530344.1|refseq:XP_006530345.1|refseq:XP_006530346.1|refseq:XP_017176276.1|dip:DIP-48887N|ensembl:ENSMUSG00000018263(gene)|ensembl:ENSMUST00000018407(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003166"(bundle of His development)|go:"GO:0003167"(atrioventricular bundle cell differentiation)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003218"(cardiac left ventricle formation)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048513"(animal organ development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060039"(pericardium development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086054"(bundle of His cell to Purkinje myocyte communication by electrical coupling)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903781"(positive regulation of cardiac conduction)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|mint:P70326|rcsb pdb:5FLV|reactome:R-MMU-2032785	rgd:2665|refseq:NP_653331.1|dip:DIP-60791N|ensembl:ENSRNOG00000010708(gene)|ensembl:ENSRNOT00000014320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033189"(response to vitamin A)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060464"(lung lobe formation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071371"(cellular response to gonadotropin stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1905204"(negative regulation of connective tissue replacement)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|reactome:R-RNO-983231	-	function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation|comment:mint	-	figure legend:Figure 3c|affected interaction:"Thalidomide (CHEBI:9513) was not able to suppress the interaction between TBX5 and GATA4"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/07	2019/02/08	rogid:i1XrRIxNM++VvPUapK4t789c+f410090	rogid:/Eioiv9DiqnhUGqX6wsmHZDSpf810116	rigid:CR+qk6gYk0OQ+/t4XOnK9jb1u2c	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P70326	uniprotkb:Q61039	intact:EBI-8411807|uniprotkb:Q9R003|intact:MINT-4137187|ensembl:ENSMUSP00000018407	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:tbx5_mouse(display_long)|uniprotkb:Tbx5(gene name)|psi-mi:Tbx5(display_short)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Khalil et al. (2017)	pubmed:28469241|imex:IM-26806	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21197178|imex:IM-26806-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011246493.1|refseq:NP_035667.1|refseq:XP_006530343.1|refseq:XP_006530344.1|refseq:XP_006530345.1|refseq:XP_006530346.1|refseq:XP_017176276.1|dip:DIP-48887N|ensembl:ENSMUSG00000018263(gene)|ensembl:ENSMUST00000018407(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003166"(bundle of His development)|go:"GO:0003167"(atrioventricular bundle cell differentiation)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003218"(cardiac left ventricle formation)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048513"(animal organ development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060039"(pericardium development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086054"(bundle of His cell to Purkinje myocyte communication by electrical coupling)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903781"(positive regulation of cardiac conduction)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|mint:P70326|rcsb pdb:5FLV|reactome:R-MMU-2032785	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	-	function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation|comment:mint	-	figure legend:Figure 7b, Figure 4c|antagonist:"Thalidomide (CHEBI:9513) dramatically  inhibited the interaction up-to 80%"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/07	2019/02/11	rogid:i1XrRIxNM++VvPUapK4t789c+f410090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rigid:qWkmGedMZ2CIKItOWdC7GH1EOzA	false	ha tag:?-?	flag tag:?-?|mutation decreasing interaction strength:202-202	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)