#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P67701	uniprotkb:P64578	intact:EBI-1131548|uniprotkb:P42594|uniprotkb:Q2M9C4|ensemblbacteria:AAC76117|ensemblbacteria:BAE77132	intact:EBI-1135071|uniprotkb:P42595|uniprotkb:Q2M9C3|ensemblbacteria:AAC76118|ensemblbacteria:BAE77133	psi-mi:higa_ecoli(display_long)|uniprotkb:higA(gene name)|psi-mi:higA(display_short)|uniprotkb:b3082(locus name)|uniprotkb:JW3053(locus name)|uniprotkb:ygjM(gene name synonym)	psi-mi:higb_ecoli(display_long)|uniprotkb:higB(gene name)|psi-mi:higB(display_short)|uniprotkb:b3083(locus name)|uniprotkb:JW3054(locus name)|uniprotkb:ygjN(gene name synonym)|uniprotkb:Endoribonuclease HigB(gene name synonym)|uniprotkb:Toxin HigB(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Yang et al. (2016)	pubmed:27601326|imex:IM-27576	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21405469|wwpdb:5IFG|imex:IM-27576-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000560266.1|ensemblbacteria:AAC76117(transcript)|ensemblbacteria:b3082(gene)|ensemblbacteria:BAE77132(gene)|ensemblbacteria:BAE77132(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_417553.1|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:6JQ4|rcsb pdb:5IFG|interpro:IPR039060	refseq:WP_000550189.1|interpro:IPR018669|refseq:NP_417554.1|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:5IFG|ensemblbacteria:AAC76118(transcript)|ensemblbacteria:b3083(gene)|ensemblbacteria:BAE77133(gene)|ensemblbacteria:BAE77133(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043488"(regulation of mRNA stability)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/22	2019/05/22	rogid:dwOTzJVHCh4M0KF8Q4lJ/eevDg083333	rogid:pi1jO3t3L+h3X/Mx7fhRPVJ/E8Y83333	rigid:vF5JtOF2imk23lwnINTawtso5I4	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P67701	uniprotkb:P64578	intact:EBI-1131548|uniprotkb:P42594|uniprotkb:Q2M9C4|ensemblbacteria:AAC76117|ensemblbacteria:BAE77132	intact:EBI-1135071|uniprotkb:P42595|uniprotkb:Q2M9C3|ensemblbacteria:AAC76118|ensemblbacteria:BAE77133	psi-mi:higa_ecoli(display_long)|uniprotkb:higA(gene name)|psi-mi:higA(display_short)|uniprotkb:b3082(locus name)|uniprotkb:JW3053(locus name)|uniprotkb:ygjM(gene name synonym)	psi-mi:higb_ecoli(display_long)|uniprotkb:higB(gene name)|psi-mi:higB(display_short)|uniprotkb:b3083(locus name)|uniprotkb:JW3054(locus name)|uniprotkb:ygjN(gene name synonym)|uniprotkb:Endoribonuclease HigB(gene name synonym)|uniprotkb:Toxin HigB(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Yang et al. (2016)	pubmed:27601326|imex:IM-27576	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21405480|imex:IM-27576-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000560266.1|ensemblbacteria:AAC76117(transcript)|ensemblbacteria:b3082(gene)|ensemblbacteria:BAE77132(gene)|ensemblbacteria:BAE77132(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_417553.1|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:6JQ4|rcsb pdb:5IFG|interpro:IPR039060	refseq:WP_000550189.1|interpro:IPR018669|refseq:NP_417554.1|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:5IFG|ensemblbacteria:AAC76118(transcript)|ensemblbacteria:b3083(gene)|ensemblbacteria:BAE77133(gene)|ensemblbacteria:BAE77133(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043488"(regulation of mRNA stability)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/22	2019/05/22	rogid:dwOTzJVHCh4M0KF8Q4lJ/eevDg083333	rogid:pi1jO3t3L+h3X/Mx7fhRPVJ/E8Y83333	rigid:vF5JtOF2imk23lwnINTawtso5I4	false	sufficient binding region:1-90	his tag:n-n	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P67701	uniprotkb:P64578	intact:EBI-1131548|uniprotkb:P42594|uniprotkb:Q2M9C4|ensemblbacteria:AAC76117|ensemblbacteria:BAE77132	intact:EBI-1135071|uniprotkb:P42595|uniprotkb:Q2M9C3|ensemblbacteria:AAC76118|ensemblbacteria:BAE77133	psi-mi:higa_ecoli(display_long)|uniprotkb:higA(gene name)|psi-mi:higA(display_short)|uniprotkb:b3082(locus name)|uniprotkb:JW3053(locus name)|uniprotkb:ygjM(gene name synonym)	psi-mi:higb_ecoli(display_long)|uniprotkb:higB(gene name)|psi-mi:higB(display_short)|uniprotkb:b3083(locus name)|uniprotkb:JW3054(locus name)|uniprotkb:ygjN(gene name synonym)|uniprotkb:Endoribonuclease HigB(gene name synonym)|uniprotkb:Toxin HigB(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Yang et al. (2016)	pubmed:27601326|imex:IM-27576	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21405485|imex:IM-27576-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_000560266.1|ensemblbacteria:AAC76117(transcript)|ensemblbacteria:b3082(gene)|ensemblbacteria:BAE77132(gene)|ensemblbacteria:BAE77132(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_417553.1|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:6JQ4|rcsb pdb:5IFG|interpro:IPR039060	refseq:WP_000550189.1|interpro:IPR018669|refseq:NP_417554.1|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:5IFG|ensemblbacteria:AAC76118(transcript)|ensemblbacteria:b3083(gene)|ensemblbacteria:BAE77133(gene)|ensemblbacteria:BAE77133(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043488"(regulation of mRNA stability)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/22	2019/05/22	rogid:dwOTzJVHCh4M0KF8Q4lJ/eevDg083333	rogid:pi1jO3t3L+h3X/Mx7fhRPVJ/E8Y83333	rigid:vF5JtOF2imk23lwnINTawtso5I4	false	sufficient binding region:1-3,19-138	his tag:n-n	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
ensemblgenomes:b3083	uniprotkb:P67701	intact:EBI-21405515	intact:EBI-1131548|uniprotkb:P42594|uniprotkb:Q2M9C4|ensemblbacteria:AAC76117|ensemblbacteria:BAE77132	psi-mi:higb_ecoli_gene(display_short)|psi-mi:b3083(display_long)	psi-mi:higa_ecoli(display_long)|uniprotkb:higA(gene name)|psi-mi:higA(display_short)|uniprotkb:b3082(locus name)|uniprotkb:JW3053(locus name)|uniprotkb:ygjM(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Yang et al. (2016)	pubmed:27601326|imex:IM-27576	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21405500|imex:IM-27576-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:WP_000560266.1|ensemblbacteria:AAC76117(transcript)|ensemblbacteria:b3082(gene)|ensemblbacteria:BAE77132(gene)|ensemblbacteria:BAE77132(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_417553.1|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:6JQ4|rcsb pdb:5IFG|interpro:IPR039060	-	-	-	figure legend:Fig 3, 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/22	2019/05/22	-	rogid:dwOTzJVHCh4M0KF8Q4lJ/eevDg083333	-	false	sufficient binding region:?-?	sufficient binding region:1-90|necessary binding region:91-138	-	-	psi-mi:"MI:0819"(molecular weight estimation by bromide staining)	psi-mi:"MI:0819"(molecular weight estimation by bromide staining)
ensemblgenomes:b3083	uniprotkb:P64578	intact:EBI-21405515	intact:EBI-1135071|uniprotkb:P42595|uniprotkb:Q2M9C3|ensemblbacteria:AAC76118|ensemblbacteria:BAE77133	psi-mi:higb_ecoli_gene(display_short)|psi-mi:b3083(display_long)	psi-mi:higb_ecoli(display_long)|uniprotkb:higB(gene name)|psi-mi:higB(display_short)|uniprotkb:b3083(locus name)|uniprotkb:JW3054(locus name)|uniprotkb:ygjN(gene name synonym)|uniprotkb:Endoribonuclease HigB(gene name synonym)|uniprotkb:Toxin HigB(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Yang et al. (2016)	pubmed:27601326|imex:IM-27576	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21405500|imex:IM-27576-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:WP_000550189.1|interpro:IPR018669|refseq:NP_417554.1|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:5IFG|ensemblbacteria:AAC76118(transcript)|ensemblbacteria:b3083(gene)|ensemblbacteria:BAE77133(gene)|ensemblbacteria:BAE77133(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043488"(regulation of mRNA stability)	-	-	-	figure legend:Fig 3, 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/22	2019/05/22	-	rogid:pi1jO3t3L+h3X/Mx7fhRPVJ/E8Y83333	-	false	sufficient binding region:?-?	his tag:n-n	-	-	psi-mi:"MI:0819"(molecular weight estimation by bromide staining)	psi-mi:"MI:0819"(molecular weight estimation by bromide staining)
uniprotkb:P67701	ensemblgenomes:b3083	intact:EBI-1131548|uniprotkb:P42594|uniprotkb:Q2M9C4|ensemblbacteria:AAC76117|ensemblbacteria:BAE77132	intact:EBI-21405515	psi-mi:higa_ecoli(display_long)|uniprotkb:higA(gene name)|psi-mi:higA(display_short)|uniprotkb:b3082(locus name)|uniprotkb:JW3053(locus name)|uniprotkb:ygjM(gene name synonym)	psi-mi:higb_ecoli_gene(display_short)|psi-mi:b3083(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Yang et al. (2016)	pubmed:27601326|imex:IM-27576	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21405567|imex:IM-27576-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:WP_000560266.1|ensemblbacteria:AAC76117(transcript)|ensemblbacteria:b3082(gene)|ensemblbacteria:BAE77132(gene)|ensemblbacteria:BAE77132(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_417553.1|interpro:IPR001387(Helix-turn-helix type 3)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|rcsb pdb:6KML|rcsb pdb:6KMQ|rcsb pdb:6JQ4|rcsb pdb:5IFG|interpro:IPR039060	-	-	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/22	2019/05/22	rogid:dwOTzJVHCh4M0KF8Q4lJ/eevDg083333	-	-	false	his tag:n-n	sufficient binding region:?-?	-	-	psi-mi:"MI:0819"(molecular weight estimation by bromide staining)	psi-mi:"MI:0819"(molecular weight estimation by bromide staining)