#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WV41	uniprotkb:P78325	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225576|imex:IM-27246-101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:1R7MAQJiSY50OgjNJ0A95cqnVIA	false	sufficient binding region:1..1-61..61(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5T0N5	uniprotkb:P78325	intact:EBI-714058|uniprotkb:J3QSS4|uniprotkb:Q5T0N6|uniprotkb:Q6B097|uniprotkb:Q6P653|uniprotkb:Q6R4Q4|uniprotkb:Q9NXG1|ensembl:ENSP00000271234	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:fbp1l_human(display_long)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:C1orf39(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225616|imex:IM-27246-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020119.1|refseq:NP_001157945.1|refseq:NP_060207.2|interpro:IPR030116|interpro:IPR031160|interpro:IPR035493|interpro:IPR035494|interpro:IPR036028|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013409|ensembl:ENSG00000137942(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045296"(cadherin binding)|ensembl:ENST00000271234(transcript)|go:"GO:0051020"(GTPase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060271"(cilium assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:yGpTAKXe5mYtBFc89aMiYFMy9RU9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:m+AoVETsHqhV5ZJcxq58uOeWyG4	false	sufficient binding region:538..538-599..599(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15642	uniprotkb:P78325	intact:EBI-739936|uniprotkb:O15184|uniprotkb:Q53G22|uniprotkb:Q5TZN1|uniprotkb:Q6FI24|uniprotkb:Q8NFL1|uniprotkb:Q8TCY1|uniprotkb:Q8TDX3|uniprotkb:Q96RJ1|uniprotkb:B2R8A6|uniprotkb:B7WP22|uniprotkb:D6W645|intact:EBI-28977062|ensembl:ENSP00000320117	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:cip4_human(display_long)|uniprotkb:TRIP10(gene name)|psi-mi:TRIP10(display_short)|uniprotkb:CIP4(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 10(gene name synonym)|uniprotkb:Protein Felic(gene name synonym)|uniprotkb:Salt tolerant protein(gene name synonym)|uniprotkb:STOT(gene name synonym)|uniprotkb:STP(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225631|imex:IM-27246-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000320117|ensembl:ENST00000313285|ensembl:ENSP00000320493|refseq:NP_004231.1|ensembl:ENSG00000125733(gene)|ensembl:ENST00000313244(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007154"(cell communication)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|interpro:IPR027267|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR028498|interpro:IPR031160|interpro:IPR036028|mint:Q15642|rcsb pdb:2CT4|rcsb pdb:2EFK|rcsb pdb:2KE4|reactome:R-HSA-8856828|reactome:R-HSA-9013406|refseq:NP_001275891.1|refseq:NP_001275892.1|dip:DIP-39840N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	crc64:A9BFE85520C7ABC5	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:6DvFGTlXvKhqvKlLcV1sRucCKzo9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:1Z7WCXbMW6Zc6hivkGtygvN1fEQ	false	sufficient binding region:540..540-601..601(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5X1	uniprotkb:P78325	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225646|imex:IM-27246-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:Bt3MU5Q7QAQHSgm5SbWUrKbReL0	false	sufficient binding region:1..1-62..62(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42680	uniprotkb:P78325	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225661|imex:IM-27246-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:0k0fZVWN8T2VHAll0WyDWzoWg7Y	false	sufficient binding region:179..179-239..239(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P12931	uniprotkb:P78325	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225676|imex:IM-27246-161	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:ylIqwczACfDvGgnqhdxS1OV5FrA	false	sufficient binding region:84..84-145..145(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14598	uniprotkb:P78325	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225693|imex:IM-27246-103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:gCLyuEEsu7I8MwrZqIUMMIyWtd4	false	sufficient binding region:156..156-215..215(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92882	uniprotkb:P78325	intact:EBI-1051152|uniprotkb:Q5W126|uniprotkb:Q96IJ4|ensembl:ENSP00000340836	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:ostf1_human(display_long)|uniprotkb:OSTF1(gene name)|psi-mi:OSTF1(display_short)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225717|imex:IM-27246-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036515.4|ensembl:ENSG00000134996(gene)|ensembl:ENST00000346234(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036770|mint:Q92882|rcsb pdb:1X2K|rcsb pdb:1ZLM|rcsb pdb:3EHQ|rcsb pdb:3EHR|reactome:R-HSA-6798695	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:0nz6SBCE9meig3C9vDuhLZTIq2s9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:DY0bGt5zX9RPS2PEtFRJN9MqJ4U	false	sufficient binding region:12..12-71..71(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:674-824|mutation:674-674	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WV41	uniprotkb:Q13443	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225732|imex:IM-27246-141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:dJM0LH2eBY1YMjBhq/+qVsKk36k	false	sufficient binding region:1..1-61..61(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5X1	uniprotkb:Q13443	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225753|imex:IM-27246-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:+4m9jn/Wj0oPSX0Dh/SUCH5GqHY	false	sufficient binding region:1..1-62..62(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42680	uniprotkb:Q13443	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225768|imex:IM-27246-105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:511MEra4A0Mtq88TmAT7aVzrBok	false	sufficient binding region:179..179-239..239(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96RF0	uniprotkb:Q13443	intact:EBI-298169|uniprotkb:Q05BB3|uniprotkb:Q0VG02|ensembl:ENSP00000342276|uniprotkb:B4E2B3|uniprotkb:H7BXX3	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:snx18_human(display_long)|uniprotkb:SNX18(gene name)|psi-mi:SNX18(display_short)|uniprotkb:SH3 and PX domain-containing protein 3B(gene name synonym)|uniprotkb:SH3PXD3B(gene name synonym)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225819|imex:IM-27246-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001096045.1|refseq:NP_001138899.1|refseq:NP_443102.2|ensembl:ENSG00000178996(gene)|go:"GO:0006897"(endocytosis)|ensembl:ENST00000343017(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028646|interpro:IPR035557|interpro:IPR035703|interpro:IPR036028|interpro:IPR036871|mint:Q96RF0|reactome:R-HSA-8856828	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:HpHLfTZ0EfhC6oMHeSr1GCgZaI49606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:wNZubBMtWSvD8O3WZJzFXpXh4cY	false	sufficient binding region:1..1-61..61(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14598	uniprotkb:Q13443	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225836|imex:IM-27246-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:J+EzWNFkFHZACaXgfvVTgx9TS+8	false	sufficient binding region:156..156-215..215(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P07948	uniprotkb:Q13443	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225857|imex:IM-27246-143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:FuOTLUhaN2xBLYOFR7L472Y7xVA	false	sufficient binding region:63..63-123..123(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O94875	uniprotkb:Q13443	intact:EBI-311323|intact:EBI-747334|uniprotkb:B7Z1G5|uniprotkb:C9JKV9|uniprotkb:G3XAI0|intact:EBI-2804177|uniprotkb:A6NEK9|uniprotkb:O60592|uniprotkb:O60593|uniprotkb:Q96EX0|uniprotkb:D3DP62|uniprotkb:D3DP63|intact:EBI-28977791|ensembl:ENSP00000284776|uniprotkb:B7Z3X6|uniprotkb:E9PAS5|uniprotkb:E9PAW4|uniprotkb:B3KPQ7|uniprotkb:H7BXR4|uniprotkb:J3KNZ5|intact:EBI-10983198|intact:EBI-10965282	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:srbs2_human(display_long)|uniprotkb:SORBS2(gene name)|psi-mi:SORBS2(display_short)|uniprotkb:ARGBP2(gene name synonym)|uniprotkb:KIAA0777(gene name synonym)|uniprotkb:Arg/Abl-interacting protein 2(gene name synonym)|uniprotkb:Sorbin(gene name synonym)|uniprotkb:Arg-binding protein 2(gene name synonym)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225890|imex:IM-27246-163	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000284776|ensembl:ENST00000319471|ensembl:ENSP00000322182|ensembl:ENST00000355634|ensembl:ENSP00000347852|ensembl:ENST00000393528|ensembl:ENSP00000377162|ensembl:ENST00000418609|ensembl:ENSP00000397482|ensembl:ENST00000437304|ensembl:ENSP00000396008|ensembl:ENST00000448662|ensembl:ENSP00000409158|ensembl:ENST00000449407|ensembl:ENSP00000397262|ensembl:ENSG00000154556(gene)|ensembl:ENST00000284776(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR028506|interpro:IPR036028|mint:O94875|rcsb pdb:5VEI|refseq:NP_001139142.1|refseq:NP_001139144.1|refseq:NP_001139145.1|refseq:NP_066547.1|refseq:NP_001139146.1|refseq:NP_001139143.1|refseq:NP_001257700.1|refseq:NP_003594.3|refseq:XP_005263369.1|refseq:XP_006714453.1|refseq:XP_016864260.1|dip:DIP-31634N	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:ficlNf23am8NpwQVRUKXeVUJTsQ9606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:+HMqwZ9hAAmNweg7Ml1sjFaqZhc	false	sufficient binding region:938..938-999..999(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:720-819	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P12931	uniprotkb:O43184	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225905|imex:IM-27246-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:Whilx0R1GVIboyz5V7bwK3OAANg	false	sufficient binding region:84..84-145..145(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15259	uniprotkb:O43184	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225949|imex:IM-27246-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:aDjEmYmkvsHhFZpwXe2Nc0L2Wek	false	sufficient binding region:152..152-212..212(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P07948	uniprotkb:O43184	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225965|imex:IM-27246-107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:asFFc7N/AgDORvcR82yzeEDORGU	false	sufficient binding region:63..63-123..123(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5TCZ1	uniprotkb:O43184	intact:EBI-2483234|uniprotkb:O43302|uniprotkb:Q5TCZ2|uniprotkb:Q5TDQ8|uniprotkb:D3DR98|ensembl:ENSP00000358789	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:spd2a_human(display_long)|uniprotkb:Tyrosine kinase substrate with five SH3 domains(gene name synonym)|uniprotkb:SH3PXD2A(gene name)|psi-mi:SH3PXD2A(display_short)|uniprotkb:FISH(gene name synonym)|uniprotkb:KIAA0418(gene name synonym)|uniprotkb:SH3MD1(gene name synonym)|uniprotkb:SH3 multiple domains protein 1(gene name synonym)|uniprotkb:Five SH3 domain-containing protein(gene name synonym)|uniprotkb:Adapter protein TKS5(gene name synonym)|uniprotkb:TKS5(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21225980|imex:IM-27246-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055446.2|refseq:XP_005270351.1|ensembl:ENSG00000107957(gene)|ensembl:ENST00000369774(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042995"(cell projection)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072675"(osteoclast fusion)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034917|interpro:IPR035449|interpro:IPR035450|interpro:IPR035452|interpro:IPR035453|interpro:IPR035454|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|rcsb pdb:2DNU|rcsb pdb:2EGA|rcsb pdb:2EGC|rcsb pdb:2EKH|mint:Q5TCZ1|reactome:R-HSA-8941237|reactome:R-HSA-9013148	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:XnTFFWWCeseePTNypWPnbkI+Y6I9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:Srgk/Ksnwj5XFEvkCc/rWiuDPGo	false	sufficient binding region:1072..1072-1133..1133(IPR035454)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08631	uniprotkb:O43184	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226002|imex:IM-27246-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:SxJpW5PJCdZcYfh+MwdMdIQbmao	false	sufficient binding region:78..78-138..138(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8N157	uniprotkb:O43184	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226016|imex:IM-27246-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:lHVaKd8lw77VeenoTzJo/Eh7jUY	false	sufficient binding region:1051..1051-1111..1111(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WV41	uniprotkb:O43184	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226041|imex:IM-27246-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:rew1F3A4K4wr9W/pmLXgrzrblnU	false	sufficient binding region:1..1-61..61(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5X1	uniprotkb:O43184	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226054|imex:IM-27246-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:/7omAC/vHgWjfCEcQGiqZGfNOtU	false	sufficient binding region:1..1-62..62(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:731-909	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WV41	uniprotkb:Q13444	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226082|imex:IM-27246-165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/02/28	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:Zxp7msTXt78N6BBwk6yyJw23APk	false	sufficient binding region:1..1-61..61(IPR001452)	biotin tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5TCZ1	uniprotkb:Q13444	intact:EBI-2483234|uniprotkb:O43302|uniprotkb:Q5TCZ2|uniprotkb:Q5TDQ8|uniprotkb:D3DR98|ensembl:ENSP00000358789	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:spd2a_human(display_long)|uniprotkb:Tyrosine kinase substrate with five SH3 domains(gene name synonym)|uniprotkb:SH3PXD2A(gene name)|psi-mi:SH3PXD2A(display_short)|uniprotkb:FISH(gene name synonym)|uniprotkb:KIAA0418(gene name synonym)|uniprotkb:SH3MD1(gene name synonym)|uniprotkb:SH3 multiple domains protein 1(gene name synonym)|uniprotkb:Five SH3 domain-containing protein(gene name synonym)|uniprotkb:Adapter protein TKS5(gene name synonym)|uniprotkb:TKS5(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226424|imex:IM-27246-167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055446.2|refseq:XP_005270351.1|ensembl:ENSG00000107957(gene)|ensembl:ENST00000369774(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042995"(cell projection)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072675"(osteoclast fusion)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034917|interpro:IPR035449|interpro:IPR035450|interpro:IPR035452|interpro:IPR035453|interpro:IPR035454|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|rcsb pdb:2DNU|rcsb pdb:2EGA|rcsb pdb:2EGC|rcsb pdb:2EKH|mint:Q5TCZ1|reactome:R-HSA-8941237|reactome:R-HSA-9013148	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:XnTFFWWCeseePTNypWPnbkI+Y6I9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:GNpbg+HgtQhz4PuIwLQvO1Bc5vY	false	sufficient binding region:1072..1072-1133..1133(IPR035454)|sufficient binding region:166..166-225..225(IPR035450)	biotin tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P12931	uniprotkb:Q13444	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226461|imex:IM-27246-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:pJZyq/5nKrOEmgGD5U2WfFqTuB0	false	sufficient binding region:84..84-145..145(IPR001452)	biotin tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y5X1	uniprotkb:Q13444	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226474|imex:IM-27246-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:oKZSabexIqr7KZRNAA5FgKCMNbA	false	sufficient binding region:1..1-62..62(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15259	uniprotkb:Q13444	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226487|imex:IM-27246-169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:6FXEg6bu+JuDGyOhU5ivMRAKtwE	false	sufficient binding region:152..152-212..212(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08631	uniprotkb:Q13444	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226500|imex:IM-27246-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:23Q7lAt8RYbepLGtBb/H+EXExCE	false	sufficient binding region:78..78-138..138(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42680	uniprotkb:Q13444	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226513|imex:IM-27246-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:Bv98W/6IkmhAr2+U46LqzMOHFUI	false	sufficient binding region:179..179-239..239(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P07948	uniprotkb:Q13444	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226526|imex:IM-27246-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:I1Iy+7VrPyAc3Ssfp4hnbmDJ6q4	false	sufficient binding region:63..63-123..123(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P27986	uniprotkb:Q13444	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226542|imex:IM-27246-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:j8rVo5tycV24xSOFKVpheH/FLA0	false	sufficient binding region:3..3-79..79(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q06187	uniprotkb:Q13444	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226555|imex:IM-27246-171	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:h4T5QdbkG+2aXGKO6yUQMSsNiG4	false	sufficient binding region:214..214-274..274(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14598	uniprotkb:Q13444	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226582|imex:IM-27246-109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:6HlgB9z+p8iKJKAFJGqh28F5fdk	false	sufficient binding region:156..156-215..215(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92882	uniprotkb:Q13444	intact:EBI-1051152|uniprotkb:Q5W126|uniprotkb:Q96IJ4|ensembl:ENSP00000340836	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:ostf1_human(display_long)|uniprotkb:OSTF1(gene name)|psi-mi:OSTF1(display_short)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226595|imex:IM-27246-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036515.4|ensembl:ENSG00000134996(gene)|ensembl:ENST00000346234(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036770|mint:Q92882|rcsb pdb:1X2K|rcsb pdb:1ZLM|rcsb pdb:3EHQ|rcsb pdb:3EHR|reactome:R-HSA-6798695	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:0nz6SBCE9meig3C9vDuhLZTIq2s9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:vcOAYKFXz4bUfTsOv9Ty8Zu372g	false	sufficient binding region:12..12-71..71(IPR001452)	mcherry fluorescent protein tag:n-n|biotin tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15811	uniprotkb:Q13444	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226632|imex:IM-27246-145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:4LQ9lL5V+u6YqqjY4PHxBxWwGNc	false	sufficient binding region:1002..1002-1060..1060(IPR001452)	biotin tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:710-863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:Q5TCZ1	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-2483234|uniprotkb:O43302|uniprotkb:Q5TCZ2|uniprotkb:Q5TDQ8|uniprotkb:D3DR98|ensembl:ENSP00000358789	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:spd2a_human(display_long)|uniprotkb:Tyrosine kinase substrate with five SH3 domains(gene name synonym)|uniprotkb:SH3PXD2A(gene name)|psi-mi:SH3PXD2A(display_short)|uniprotkb:FISH(gene name synonym)|uniprotkb:KIAA0418(gene name synonym)|uniprotkb:SH3MD1(gene name synonym)|uniprotkb:SH3 multiple domains protein 1(gene name synonym)|uniprotkb:Five SH3 domain-containing protein(gene name synonym)|uniprotkb:Adapter protein TKS5(gene name synonym)|uniprotkb:TKS5(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226649|imex:IM-27246-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_055446.2|refseq:XP_005270351.1|ensembl:ENSG00000107957(gene)|ensembl:ENST00000369774(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042995"(cell projection)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072675"(osteoclast fusion)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034917|interpro:IPR035449|interpro:IPR035450|interpro:IPR035452|interpro:IPR035453|interpro:IPR035454|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|rcsb pdb:2DNU|rcsb pdb:2EGA|rcsb pdb:2EGC|rcsb pdb:2EKH|mint:Q5TCZ1|reactome:R-HSA-8941237|reactome:R-HSA-9013148	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:XnTFFWWCeseePTNypWPnbkI+Y6I9606	rigid:9F/neagbCuuDElDdtCfbj/sgdr4	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:166..166-225..225(IPR035450)|sufficient binding region:1072..1072-1133..1133(IPR035454)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:P12931	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226684|imex:IM-27246-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rigid:NHJ2xmwqaZ+BhuLJ6le1UZFbFdc	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:84..84-145..145(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:Q9Y5X1	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226697|imex:IM-27246-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rigid:+WLzaznFDXAjT8dfKv2m4L71jlA	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:1..1-62..62(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:O95153	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-5915931|uniprotkb:O75111|uniprotkb:Q8N5W3|ensembl:ENSP00000345824|intact:EBI-28971165	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:rimb1_human(display_long)|uniprotkb:TSPOAP1(gene name)|psi-mi:TSPOAP1(display_short)|uniprotkb:BZRAP1(gene name synonym)|uniprotkb:KIAA0612(gene name synonym)|uniprotkb:Peripheral benzodiazepine receptor-interacting protein(gene name synonym)|uniprotkb:RBP1(gene name synonym)|uniprotkb:RIMBP1(gene name synonym)|uniprotkb:RIMS-binding protein 1(gene name synonym)|uniprotkb:TSPO-associated protein 1(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226715|imex:IM-27246-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	ensembl:ENST00000268893|ensembl:ENSP00000268893|ensembl:ENSP00000345824|refseq:XP_006722236.1|refseq:NP_001248764.1|refseq:NP_004749.2|refseq:NP_077729.1|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325|mint:O95153|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-196108|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0030156"(benzodiazepine receptor binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|interpro:IPR001452(Src homology-3)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000005379(gene)|ensembl:ENST00000343736(transcript)|go:"GO:0005737"(cytoplasm)	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:nOwDlLr5DTjN2tJNR3h0zxrU1Z49606	rigid:Gu2Lomuy2YkeS+1i5BJeKTBXHxA	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:1764..1764-1831..1831(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8TE68	uniprotkb:Q9H013	intact:EBI-7487998|uniprotkb:Q9GZQ2|uniprotkb:Q9NXH0|intact:MINT-4829629|uniprotkb:Q9BSQ2|uniprotkb:Q8NC10|uniprotkb:Q96BB7|uniprotkb:Q71RE2|ensembl:ENSP00000201647	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	psi-mi:es8l1_human(display_long)|uniprotkb:EPS8L1(gene name)|psi-mi:EPS8L1(display_short)|uniprotkb:DRC3(gene name synonym)|uniprotkb:EPS8R1(gene name synonym)|uniprotkb:PP10566(orf name)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 1(gene name synonym)	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226738|imex:IM-27246-147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573441.2|refseq:NP_060199.3|ensembl:ENSG00000131037(gene)|ensembl:ENST00000201647(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q8TE68|rcsb pdb:2K2M|rcsb pdb:2ROL	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	-	comment:mint|function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:+6FNaPhLMckwu8jRsJiBKKWYYOI9606	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rigid:WNFvMTEm/aONQSfVW2vlGJrLtvg	false	sufficient binding region:478..478-537..537(IPR001452)	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:P14598	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226773|imex:IM-27246-149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rigid:gyLdlJranAEMrX9quIal6U7/yEE	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:156..156-215..215(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:P42680	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226787|imex:IM-27246-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	rigid:uioZc/qJZeBRqcfmElbT3hyv/QE	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:179..179-239..239(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:P07948	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226800|imex:IM-27246-151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rigid:WrJeUnyqwl1QK+FiSqydBax0hYU	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:63..63-123..123(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:P27986	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226814|imex:IM-27246-153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rigid:88mwC1tmfS+TsWiaUCYSWUSoC3w	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:3..3-79..79(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:O15259	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226827|imex:IM-27246-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	rigid:RPueQjEitvQqTHRLZeEcC7c/6P8	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:152..152-212..212(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:Q8WV41	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226840|imex:IM-27246-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rigid:ShTl2XvLsmIRQOj3Kv2nzKvapVA	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:1..1-61..61(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:Q5T0N5	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-714058|uniprotkb:J3QSS4|uniprotkb:Q5T0N6|uniprotkb:Q6B097|uniprotkb:Q6P653|uniprotkb:Q6R4Q4|uniprotkb:Q9NXG1|ensembl:ENSP00000271234	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:fbp1l_human(display_long)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:C1orf39(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226856|imex:IM-27246-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_001020119.1|refseq:NP_001157945.1|refseq:NP_060207.2|interpro:IPR030116|interpro:IPR031160|interpro:IPR035493|interpro:IPR035494|interpro:IPR036028|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013409|ensembl:ENSG00000137942(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045296"(cadherin binding)|ensembl:ENST00000271234(transcript)|go:"GO:0051020"(GTPase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060271"(cilium assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:yGpTAKXe5mYtBFc89aMiYFMy9RU9606	rigid:7qA09qbbIHtJUVpiB9O4SrZoe7E	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:538..538-599..599(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H013	uniprotkb:P08631	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0084"(phage display)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226869|imex:IM-27246-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rigid:J9l82WK4CAzwtT/a1v5TexvUUx4	false	biotin tag:n-n|green fluorescent protein tag:n-n|sufficient binding region:721..721-955	sufficient binding region:78..78-138..138(IPR001452)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96RF0	uniprotkb:P78325	intact:EBI-298169|uniprotkb:Q05BB3|uniprotkb:Q0VG02|ensembl:ENSP00000342276|uniprotkb:B4E2B3|uniprotkb:H7BXX3	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:snx18_human(display_long)|uniprotkb:SNX18(gene name)|psi-mi:SNX18(display_short)|uniprotkb:SH3 and PX domain-containing protein 3B(gene name synonym)|uniprotkb:SH3PXD3B(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226922|imex:IM-27246-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001096045.1|refseq:NP_001138899.1|refseq:NP_443102.2|ensembl:ENSG00000178996(gene)|go:"GO:0006897"(endocytosis)|ensembl:ENST00000343017(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028646|interpro:IPR035557|interpro:IPR035703|interpro:IPR036028|interpro:IPR036871|mint:Q96RF0|reactome:R-HSA-8856828	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:HpHLfTZ0EfhC6oMHeSr1GCgZaI49606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:luQQGsgIJbF4PhJ2JLVjB55BX50	false	sufficient binding region:1..1-61..61(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:773-789	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P42680	uniprotkb:P78325	intact:EBI-1383480|uniprotkb:Q3MIS5|uniprotkb:B7ZKZ6|ensembl:ENSP00000370912	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:tec_human(display_long)|uniprotkb:PSCTK4(gene name synonym)|uniprotkb:TEC(gene name)|psi-mi:TEC(display_short)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21226993|imex:IM-27246-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003206.2|ensembl:ENSG00000135605(gene)|ensembl:ENST00000381501(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860|mint:P42680|rcsb pdb:2LUL|reactome:R-HSA-1433557|reactome:R-HSA-2871809|reactome:R-HSA-512988	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:eZR8Xggl8x1HB+0gUnzBPpbcK3Y9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:0k0fZVWN8T2VHAll0WyDWzoWg7Y	false	sufficient binding region:179..179-239..239(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:773-789	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q5T0N5	uniprotkb:P78325	intact:EBI-714058|uniprotkb:J3QSS4|uniprotkb:Q5T0N6|uniprotkb:Q6B097|uniprotkb:Q6P653|uniprotkb:Q6R4Q4|uniprotkb:Q9NXG1|ensembl:ENSP00000271234	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:fbp1l_human(display_long)|uniprotkb:Transducer of Cdc42-dependent actin assembly protein 1(gene name synonym)|uniprotkb:FNBP1L(gene name)|psi-mi:FNBP1L(display_short)|uniprotkb:TOCA1(gene name synonym)|uniprotkb:C1orf39(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227005|imex:IM-27246-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020119.1|refseq:NP_001157945.1|refseq:NP_060207.2|interpro:IPR030116|interpro:IPR031160|interpro:IPR035493|interpro:IPR035494|interpro:IPR036028|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013409|ensembl:ENSG00000137942(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045296"(cadherin binding)|ensembl:ENST00000271234(transcript)|go:"GO:0051020"(GTPase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060271"(cilium assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:yGpTAKXe5mYtBFc89aMiYFMy9RU9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:m+AoVETsHqhV5ZJcxq58uOeWyG4	false	sufficient binding region:538..538-599..599(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:773-789	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q15642	uniprotkb:P78325	intact:EBI-739936|uniprotkb:O15184|uniprotkb:Q53G22|uniprotkb:Q5TZN1|uniprotkb:Q6FI24|uniprotkb:Q8NFL1|uniprotkb:Q8TCY1|uniprotkb:Q8TDX3|uniprotkb:Q96RJ1|uniprotkb:B2R8A6|uniprotkb:B7WP22|uniprotkb:D6W645|intact:EBI-28977062|ensembl:ENSP00000320117	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:cip4_human(display_long)|uniprotkb:TRIP10(gene name)|psi-mi:TRIP10(display_short)|uniprotkb:CIP4(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 10(gene name synonym)|uniprotkb:Protein Felic(gene name synonym)|uniprotkb:Salt tolerant protein(gene name synonym)|uniprotkb:STOT(gene name synonym)|uniprotkb:STP(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227061|imex:IM-27246-137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000320117|ensembl:ENST00000313285|ensembl:ENSP00000320493|refseq:NP_004231.1|ensembl:ENSG00000125733(gene)|ensembl:ENST00000313244(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007154"(cell communication)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|interpro:IPR027267|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR028498|interpro:IPR031160|interpro:IPR036028|mint:Q15642|rcsb pdb:2CT4|rcsb pdb:2EFK|rcsb pdb:2KE4|reactome:R-HSA-8856828|reactome:R-HSA-9013406|refseq:NP_001275891.1|refseq:NP_001275892.1|dip:DIP-39840N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	crc64:A9BFE85520C7ABC5	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:6DvFGTlXvKhqvKlLcV1sRucCKzo9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:1Z7WCXbMW6Zc6hivkGtygvN1fEQ	false	sufficient binding region:540..540-601..601(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:773-789	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q96RU3	uniprotkb:P78325	intact:EBI-1111248|uniprotkb:O60301|uniprotkb:Q3MIN8|uniprotkb:Q5TC87|uniprotkb:Q5TC88|uniprotkb:Q6P658|uniprotkb:Q7LGG2|uniprotkb:Q9H8H8|uniprotkb:Q9NWD1|intact:EBI-2948562|intact:EBI-28979204|ensembl:ENSP00000413625|uniprotkb:B7ZL12|uniprotkb:E9PGQ4	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:fnbp1_human(display_long)|uniprotkb:FNBP1(gene name)|psi-mi:FNBP1(display_short)|uniprotkb:FBP17(gene name synonym)|uniprotkb:Formin-binding protein 17(gene name synonym)|uniprotkb:KIAA0554(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227072|imex:IM-27246-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055848.1|refseq:XP_005251881.1|ensembl:ENST00000355681|ensembl:ENSP00000347907|ensembl:ENST00000420781|ensembl:ENSP00000407548|ensembl:ENSP00000413625|ensembl:ENSG00000187239(gene)|ensembl:ENST00000446176(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR027267|interpro:IPR028532|interpro:IPR031160|interpro:IPR036028|interpro:IPR037449|mint:Q96RU3|rcsb pdb:2EFL|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696270|refseq:XP_005251880.1|refseq:XP_005251886.1|dip:DIP-35355N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:K6RjzNBPFl/RJmcv98TGEUCghfw9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:pT7Y5khVbX5DBughzO2MsCPYIB4	false	sufficient binding region:550..550-611..611(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:773-789	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14598	uniprotkb:P78325	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	intact:EBI-2625954|ensembl:ENSP00000453302|uniprotkb:H0YLR0|uniprotkb:B4DVM6|uniprotkb:H0YL36|uniprotkb:H0YN39	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:adam8_human(display_long)|uniprotkb:ADAM8(gene name)|psi-mi:ADAM8(display_short)|uniprotkb:MS2(gene name synonym)|uniprotkb:Cell surface antigen MS2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227098|imex:IM-27246-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N	refseq:NP_001157961.1|refseq:NP_001157962.1|ensembl:ENSG00000151651(gene)|ensembl:ENST00000445355(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:4DD8|reactome:R-HSA-1474228|reactome:R-HSA-6798695|refseq:NP_001100.3	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rogid:Rxnd3ddZ63hoe3s5wrXKDEoPx2Y9606	rigid:gCLyuEEsu7I8MwrZqIUMMIyWtd4	false	sufficient binding region:156..156-215..215(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:773-789	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q96RF0	uniprotkb:Q13443	intact:EBI-298169|uniprotkb:Q05BB3|uniprotkb:Q0VG02|ensembl:ENSP00000342276|uniprotkb:B4E2B3|uniprotkb:H7BXX3	intact:EBI-77903|uniprotkb:B7ZLN7|ensembl:ENSP00000419446|uniprotkb:Q10718|uniprotkb:Q8NFM6	psi-mi:snx18_human(display_long)|uniprotkb:SNX18(gene name)|psi-mi:SNX18(display_short)|uniprotkb:SH3 and PX domain-containing protein 3B(gene name synonym)|uniprotkb:SH3PXD3B(gene name synonym)	psi-mi:adam9_human(display_long)|uniprotkb:ADAM9(gene name)|psi-mi:ADAM9(display_short)|uniprotkb:KIAA0021(gene name synonym)|uniprotkb:MCMP(gene name synonym)|uniprotkb:MDC9(gene name synonym)|uniprotkb:Myeloma cell metalloproteinase(gene name synonym)|uniprotkb:Meltrin-gamma(gene name synonym)|uniprotkb:Cellular disintegrin-related protein(gene name synonym)|uniprotkb:Metalloprotease/disintegrin/cysteine-rich protein 9(gene name synonym)|uniprotkb:MLTNG(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227390|imex:IM-27246-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001096045.1|refseq:NP_001138899.1|refseq:NP_443102.2|ensembl:ENSG00000178996(gene)|go:"GO:0006897"(endocytosis)|ensembl:ENST00000343017(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028646|interpro:IPR035557|interpro:IPR035703|interpro:IPR036028|interpro:IPR036871|mint:Q96RF0|reactome:R-HSA-8856828	go:"GO:0007160"(cell-matrix adhesion)|ensembl:ENSG00000168615(gene)|ensembl:ENST00000487273(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031233"(intrinsic component of external side of plasma membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0042117"(monocyte activation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|rcsb pdb:1M1V|reactome:R-HSA-1442490|refseq:NP_003807.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:HpHLfTZ0EfhC6oMHeSr1GCgZaI49606	rogid:cgdFZLtfiaqZ+oJvDARR1AbFA+I9606	rigid:wNZubBMtWSvD8O3WZJzFXpXh4cY	false	sufficient binding region:1..1-61..61(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:785-798	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P62993	uniprotkb:O43184	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227439|imex:IM-27246-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:HB67NWZfd7qelN0gquZd52vLeE4	false	sufficient binding region:156..156-215..215(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P12931	uniprotkb:O43184	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227450|imex:IM-27246-173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:Whilx0R1GVIboyz5V7bwK3OAANg	false	sufficient binding region:84..84-145..145(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P07948	uniprotkb:O43184	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227461|imex:IM-27246-175	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:asFFc7N/AgDORvcR82yzeEDORGU	false	sufficient binding region:63..63-123..123(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08631	uniprotkb:O43184	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227520|imex:IM-27246-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:SxJpW5PJCdZcYfh+MwdMdIQbmao	false	sufficient binding region:78..78-138..138(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06241	uniprotkb:O43184	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227531|imex:IM-27246-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:obXrdcu4d+OxQtMV1vcqSAvuMKI	false	sufficient binding region:82..82-143..143(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N157	uniprotkb:O43184	intact:EBI-1049056|uniprotkb:Q504T3|uniprotkb:Q5TCP9|uniprotkb:Q6P098|uniprotkb:Q6PIT6|uniprotkb:Q8NDX0|uniprotkb:Q9H0H2|uniprotkb:Q4FD35|uniprotkb:E1P584|ensembl:ENSP00000265602|ensembl:ENSP00000356774|ensembl:ENSP00000388650|ensembl:ENSP00000504965|ensembl:ENSP00000505121|ensembl:ENSP00000505666|ensembl:ENSP00000506005|ensembl:ENSP00000506604	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:ahi1_human(display_long)|uniprotkb:Abelson helper integration site 1 protein homolog(gene name synonym)|uniprotkb:AHI1(gene name)|psi-mi:AHI1(display_short)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227550|imex:IM-27246-155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128302.1|refseq:NP_001128303.1|refseq:NP_001128304.1|refseq:NP_060121.3|refseq:XP_011534212.1|refseq:XP_011534213.1|refseq:XP_016866466.1|refseq:XP_016866473.1|ensembl:ENSG00000135541(gene)|ensembl:ENST00000265602(transcript)|ensembl:ENST00000367800(transcript)|ensembl:ENST00000457866(transcript)|ensembl:ENST00000681022(transcript)|ensembl:ENST00000681340(transcript)|ensembl:ENST00000681365(transcript)|ensembl:ENST00000681522(transcript)|ensembl:ENST00000681841(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0010842"(retina layer formation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030862"(positive regulation of polarized epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035844"(cloaca development)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0039008"(pronephric nephron tubule morphogenesis)|go:"GO:0039023"(pronephric duct morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050795"(regulation of behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0065001"(specification of axis polarity)|go:"GO:0070121"(Kupffer's vesicle development)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071599"(otic vesicle development)|go:"GO:0097730"(non-motile cilium)|interpro:IPR001452(Src homology-3)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR035832|interpro:IPR036028|interpro:IPR036322|rcsb pdb:4ESR|reactome:R-HSA-5620912	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:T5wpoUyP0fVpKmJw1bu+80PEtw09606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:lHVaKd8lw77VeenoTzJo/Eh7jUY	false	sufficient binding region:1051..1051-1111..1111(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P27986	uniprotkb:O43184	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227561|imex:IM-27246-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:r97HziLRrcrZPdsXn158b1pBWnw	false	sufficient binding region:3..3-79..79(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NZM3	uniprotkb:O43184	intact:EBI-308689|uniprotkb:O95062|uniprotkb:Q15812|uniprotkb:Q9HAK4|uniprotkb:Q9NXE6|uniprotkb:Q9NYG0|uniprotkb:Q9NZM2|uniprotkb:Q9ULG4|ensembl:ENSP00000347244	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:itsn2_human(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227572|imex:IM-27246-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000347244|ensembl:ENST00000361999|ensembl:ENSP00000354561|ensembl:ENST00000406921|ensembl:ENSP00000384499|ensembl:ENSG00000198399(gene)|ensembl:ENST00000355123(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR027029|interpro:IPR035737|interpro:IPR035738|interpro:IPR035739|interpro:IPR035740|interpro:IPR035741|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|rcsb pdb:1J3T|rcsb pdb:1UDL|rcsb pdb:1UE9|rcsb pdb:1UFF|rcsb pdb:1UHF|rcsb pdb:3GF9|rcsb pdb:3JZY|rcsb pdb:4IIO|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_006268.2|refseq:NP_062541.3|refseq:NP_671494.2	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:dxUqeWmW1uwOqgZ89UhT98/pt809606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:2AD5yIanjitcf/cOSGToCBCmipo	false	sufficient binding region:981..981-1039..1039(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q15811	uniprotkb:O43184	intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227583|imex:IM-27246-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:/VBNSrRFCvg5JIO0Dx7VvBJjfwU	false	sufficient binding region:1002..1009-1060..1060(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15034	uniprotkb:O43184	intact:EBI-2512648|intact:EBI-28983594|ensembl:ENSP00000261655|uniprotkb:Q96ID2	intact:EBI-2625825|uniprotkb:O60470|uniprotkb:Q5JRP0|uniprotkb:Q5JRP1|uniprotkb:Q6P9E3|uniprotkb:Q6UWB0|ensembl:ENSP00000357668	psi-mi:rimb2_human(display_long)|uniprotkb:RIMBP2(gene name)|psi-mi:RIMBP2(display_short)|uniprotkb:KIAA0318(gene name synonym)|uniprotkb:RBP2(gene name synonym)	psi-mi:ada12_human(display_long)|uniprotkb:ADAM12(gene name)|psi-mi:ADAM12(display_short)|uniprotkb:MLTN(gene name synonym)|uniprotkb:Meltrin-alpha(gene name synonym)|uniprotkb:UNQ346/PRO545(orf name)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227606|imex:IM-27246-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000060709(gene)|ensembl:ENST00000261655(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0045202"(synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR035519|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325|rcsb pdb:1WIE|rcsb pdb:2CSI|rcsb pdb:2CSP|rcsb pdb:2CSQ|ensembl:ENSP00000261655|refseq:NP_056162.4	refseq:NP_003465.3|refseq:NP_067673.2|refseq:NP_001275903.1|refseq:NP_001275904.1|ensembl:ENSG00000148848(gene)|ensembl:ENST00000368679(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:O43184|reactome:R-HSA-177929|reactome:R-HSA-8941237	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:poJ/MI+hMdizT9v0sb3u5blhZgY9606	rogid:BxY61EDGsWcXVsb7i8+zzf7Q12c9606	rigid:ocSx1Q4cuGyhXY4UYIoj3+//EjU	false	sufficient binding region:952..952-1019..1019(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:826-841	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15259	uniprotkb:Q13444	intact:EBI-953828|uniprotkb:O14837|ensembl:ENSP00000376953	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:nphp1_human(display_long)|uniprotkb:Juvenile nephronophthisis 1 protein(gene name synonym)|uniprotkb:NPHP1(gene name)|psi-mi:NPHP1(display_short)|uniprotkb:NPH1(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227652|imex:IM-27246-183	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000263.2|refseq:NP_001121650.1|refseq:NP_001121651.1|refseq:NP_997064.2|ensembl:ENSG00000144061(gene)|ensembl:ENST00000393272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0007632"(visual behavior)|go:"GO:0016020"(membrane)|go:"GO:0030030"(cell projection organization)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090251"(protein localization involved in establishment of planar polarity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR030642|interpro:IPR036028|interpro:IPR039687|mint:O15259|rcsb pdb:1S1N|rcsb pdb:6O1Q|reactome:R-HSA-5620912	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:OPdzsagqWWni+dWU+VLoygacfcg9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:6FXEg6bu+JuDGyOhU5ivMRAKtwE	false	sufficient binding region:152..152-212..212(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:766-781	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q5TCZ1	uniprotkb:Q13444	intact:EBI-2483234|uniprotkb:O43302|uniprotkb:Q5TCZ2|uniprotkb:Q5TDQ8|uniprotkb:D3DR98|ensembl:ENSP00000358789	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:spd2a_human(display_long)|uniprotkb:Tyrosine kinase substrate with five SH3 domains(gene name synonym)|uniprotkb:SH3PXD2A(gene name)|psi-mi:SH3PXD2A(display_short)|uniprotkb:FISH(gene name synonym)|uniprotkb:KIAA0418(gene name synonym)|uniprotkb:SH3MD1(gene name synonym)|uniprotkb:SH3 multiple domains protein 1(gene name synonym)|uniprotkb:Five SH3 domain-containing protein(gene name synonym)|uniprotkb:Adapter protein TKS5(gene name synonym)|uniprotkb:TKS5(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227663|imex:IM-27246-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055446.2|refseq:XP_005270351.1|ensembl:ENSG00000107957(gene)|ensembl:ENST00000369774(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042995"(cell projection)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072675"(osteoclast fusion)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034917|interpro:IPR035449|interpro:IPR035450|interpro:IPR035452|interpro:IPR035453|interpro:IPR035454|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|rcsb pdb:2DNU|rcsb pdb:2EGA|rcsb pdb:2EGC|rcsb pdb:2EKH|mint:Q5TCZ1|reactome:R-HSA-8941237|reactome:R-HSA-9013148	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:XnTFFWWCeseePTNypWPnbkI+Y6I9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:GNpbg+HgtQhz4PuIwLQvO1Bc5vY	false	sufficient binding region:166..166-225..225(IPR035450)|glutathione s tranferase tag:n-n|sufficient binding region:1072..1072-1133..1133(IPR035454)	sufficient binding region:766-781	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q92882	uniprotkb:Q13444	intact:EBI-1051152|uniprotkb:Q5W126|uniprotkb:Q96IJ4|ensembl:ENSP00000340836	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:ostf1_human(display_long)|uniprotkb:OSTF1(gene name)|psi-mi:OSTF1(display_short)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227677|imex:IM-27246-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036515.4|ensembl:ENSG00000134996(gene)|ensembl:ENST00000346234(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036028|interpro:IPR036770|mint:Q92882|rcsb pdb:1X2K|rcsb pdb:1ZLM|rcsb pdb:3EHQ|rcsb pdb:3EHR|reactome:R-HSA-6798695	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:0nz6SBCE9meig3C9vDuhLZTIq2s9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:vcOAYKFXz4bUfTsOv9Ty8Zu372g	false	sufficient binding region:12..12-71..71(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:766-781	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P62993	uniprotkb:Q13444	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227689|imex:IM-27246-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:cR/OCFUjsJpXbIca96VvY14cAqI	false	sufficient binding region:1..1-58..58(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:766-781	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9UFD9	uniprotkb:Q13444	intact:EBI-10182375|uniprotkb:Q9UFQ5|uniprotkb:Q8IYP7|uniprotkb:Q9BY94|intact:EBI-28984856|ensembl:ENSP00000483386	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:rim3a_human(display_long)|uniprotkb:RIMBP3(gene name)|psi-mi:RIMBP3(display_short)|uniprotkb:KIAA1666(gene name synonym)|uniprotkb:RIMBP3A(gene name synonym)|uniprotkb:RIMS-binding protein 3.1(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227716|imex:IM-27246-159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056487.1|ensembl:ENSP00000483386|ensembl:ENSG00000275793(gene)|ensembl:ENST00000619918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030156"(benzodiazepine receptor binding)|go:"GO:0045202"(synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR035515|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325|rcsb pdb:2EGE	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:iw34Gee4nqAH3pqUfCgQ6Jj++AA9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:1DNhE62ScFoqmThYPES6w5c1elE	false	sufficient binding region:1569..1569-1636..1636(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:766-781	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Y5X1	uniprotkb:Q13444	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227729|imex:IM-27246-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:oKZSabexIqr7KZRNAA5FgKCMNbA	false	sufficient binding region:1..1-62..62(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:843-858	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8WV41	uniprotkb:Q13444	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227740|imex:IM-27246-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:Zxp7msTXt78N6BBwk6yyJw23APk	false	sufficient binding region:1..1-61..61(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:843-858	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08881	uniprotkb:Q13444	intact:EBI-968552|intact:EBI-5773727|intact:EBI-28978067|ensembl:ENSP00000398655|uniprotkb:Q32ML7|uniprotkb:B2R752	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:itk_human(display_long)|uniprotkb:ITK(gene name)|psi-mi:ITK(display_short)|uniprotkb:EMT(gene name synonym)|uniprotkb:LYK(gene name synonym)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase Lyk(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Interleukin-2-inducible T-cell kinase(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227762|imex:IM-27246-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113263(gene)|ensembl:ENST00000422843(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042110"(T cell activation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q08881|rcsb pdb:1SM2|rcsb pdb:1SNU|rcsb pdb:1SNX|rcsb pdb:2E6I|rcsb pdb:2LMJ|rcsb pdb:2YUQ|rcsb pdb:3MIY|rcsb pdb:3MJ1|rcsb pdb:3MJ2|rcsb pdb:3QGW|rcsb pdb:3QGY|rcsb pdb:3T9T|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:3V5J|rcsb pdb:3V5L|rcsb pdb:3V8T|rcsb pdb:3V8W|rcsb pdb:4HCT|rcsb pdb:4HCU|rcsb pdb:4HCV|rcsb pdb:4KIO|rcsb pdb:4L7S|rcsb pdb:4M0Y|rcsb pdb:4M0Z|rcsb pdb:4M12|rcsb pdb:4M13|rcsb pdb:4M14|rcsb pdb:4M15|rcsb pdb:4MF0|rcsb pdb:4MF1|rcsb pdb:4PP9|rcsb pdb:4PPA|rcsb pdb:4PPB|rcsb pdb:4PPC|rcsb pdb:4PQN|rcsb pdb:4QD6|rcsb pdb:4RFM|reactome:R-HSA-202433|reactome:R-HSA-2871809|refseq:NP_005537.3|ensembl:ENSP00000398655|dip:DIP-29974N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:DbmEoJ3gxf6xJrG1Qn4mAXASfw89606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:gK69MtSnXmlre8+79IKxe4CzJ2w	false	sufficient binding region:171..171-231..231(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:843-858	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q06187	uniprotkb:Q13444	intact:EBI-624835|uniprotkb:Q32ML5|ensembl:ENSP00000308176|uniprotkb:B2RAW1	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:btk_human(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:BPK(gene name synonym)|uniprotkb:BTK(gene name)|psi-mi:BTK(display_short)|uniprotkb:AGMX1(gene name synonym)|uniprotkb:ATK(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227773|imex:IM-27246-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6S90|rcsb pdb:6TFP|rcsb pdb:6TSE|rcsb pdb:6TT2|rcsb pdb:6TVN|rcsb pdb:6VXQ|rcsb pdb:6W06|rcsb pdb:6W07|rcsb pdb:6W7O|rcsb pdb:6W8I|rcsb pdb:6X3N|rcsb pdb:6X3O|rcsb pdb:6X3P|rcsb pdb:6XE4|rcsb pdb:6YYF|rcsb pdb:6YYG|rcsb pdb:6YYK|rcsb pdb:7KXL|rcsb pdb:7KXM|rcsb pdb:7KXN|rcsb pdb:7KXO|rcsb pdb:7KXP|rcsb pdb:7KXQ|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-2029482|reactome:R-HSA-2424491|rcsb pdb:6TUH|reactome:R-HSA-2871809|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5603041|reactome:R-HSA-5663213|reactome:R-HSA-8964315|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-5602498|ensembl:ENSG00000010671(gene)|ensembl:ENST00000308731(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002721"(regulation of B cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|mint:Q06187|rcsb pdb:1AWW|rcsb pdb:1AWX|rcsb pdb:1B55|rcsb pdb:1BTK|rcsb pdb:1BWN|rcsb pdb:1K2P|rcsb pdb:1QLY|rcsb pdb:2GE9|rcsb pdb:2Z0P|rcsb pdb:3GEN|rcsb pdb:3K54|rcsb pdb:3OCS|rcsb pdb:3OCT|rcsb pdb:3P08|rcsb pdb:3PIX|rcsb pdb:3PIY|rcsb pdb:3PIZ|rcsb pdb:3PJ1|rcsb pdb:3PJ2|rcsb pdb:3PJ3|rcsb pdb:4NWM|rcsb pdb:4OT5|rcsb pdb:4OT6|rcsb pdb:4OTF|rcsb pdb:4OTQ|rcsb pdb:4OTR|rcsb pdb:4RFY|rcsb pdb:4RFZ|rcsb pdb:4RG0|rcsb pdb:4RX5|rcsb pdb:4YHF|rcsb pdb:4Z3V|rcsb pdb:4ZLY|rcsb pdb:4ZLZ|rcsb pdb:5BPY|rcsb pdb:5BQ0|rcsb pdb:5FBN|rcsb pdb:5FBO|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007498"(mesoderm development)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|rcsb pdb:5JRS|rcsb pdb:5KUP|rcsb pdb:5P9F|rcsb pdb:5P9G|rcsb pdb:5P9H|rcsb pdb:5P9I|rcsb pdb:5P9J|rcsb pdb:5P9K|rcsb pdb:5P9L|rcsb pdb:5P9M|rcsb pdb:5T18|rcsb pdb:5U9D|rcsb pdb:5VFI|rcsb pdb:5VGO|rcsb pdb:5XYZ|rcsb pdb:5ZZ4|rcsb pdb:6AUA|rcsb pdb:6AUB|rcsb pdb:6BIK|rcsb pdb:6BKE|rcsb pdb:6BKH|rcsb pdb:6BKW|rcsb pdb:6BLN|rcsb pdb:6DI0|rcsb pdb:6DI1|rcsb pdb:6DI3|rcsb pdb:6DI5|rcsb pdb:6DI9|rcsb pdb:6E4F|rcsb pdb:6EP9|rcsb pdb:6HRP|rcsb pdb:6HRT|rcsb pdb:6HTF|rcsb pdb:6J6M|rcsb pdb:5J87|rcsb pdb:6N9P|rcsb pdb:6NFH|rcsb pdb:6NFI|rcsb pdb:6NZM|rcsb pdb:6O8I|rcsb pdb:6OMU|refseq:NP_000052.1|refseq:NP_001274274.1|refseq:NP_001274273.1|dip:DIP-34071N	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:Zqb1CQYac99t12LVwMCVK56IJQQ9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:h4T5QdbkG+2aXGKO6yUQMSsNiG4	false	sufficient binding region:214..214-274..274(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:844-858	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8TE68	uniprotkb:Q9H013	intact:EBI-7487998|uniprotkb:Q9GZQ2|uniprotkb:Q9NXH0|intact:MINT-4829629|uniprotkb:Q9BSQ2|uniprotkb:Q8NC10|uniprotkb:Q96BB7|uniprotkb:Q71RE2|ensembl:ENSP00000201647	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	psi-mi:es8l1_human(display_long)|uniprotkb:EPS8L1(gene name)|psi-mi:EPS8L1(display_short)|uniprotkb:DRC3(gene name synonym)|uniprotkb:EPS8R1(gene name synonym)|uniprotkb:PP10566(orf name)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 1(gene name synonym)	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227797|imex:IM-27246-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573441.2|refseq:NP_060199.3|ensembl:ENSG00000131037(gene)|ensembl:ENST00000201647(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q8TE68|rcsb pdb:2K2M|rcsb pdb:2ROL	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	-	comment:mint|function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:+6FNaPhLMckwu8jRsJiBKKWYYOI9606	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rigid:WNFvMTEm/aONQSfVW2vlGJrLtvg	false	sufficient binding region:478..478-537..537(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:784-799	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9H013	uniprotkb:P16333	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227808|imex:IM-27246-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/03/01	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rigid:eJTU5UCrD/yrUGLmulCZUwTz/TE	false	sufficient binding region:784-799	sufficient binding region:2..2-61..61(IPR001452)|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06239	uniprotkb:Q13444	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-77818|uniprotkb:Q5SR69|ensembl:ENSP00000349436|uniprotkb:Q13493|uniprotkb:Q53XQ0|uniprotkb:Q96C78|uniprotkb:B3KQU5|uniprotkb:Q5SR68|uniprotkb:Q6R267|uniprotkb:Q71S61|uniprotkb:Q71S62|uniprotkb:Q71S63|uniprotkb:Q71S64|uniprotkb:Q71S65|uniprotkb:Q71S66|uniprotkb:Q71S67|uniprotkb:Q71S68|uniprotkb:Q71S69|uniprotkb:B4DLB5|uniprotkb:E9PN65|uniprotkb:B4DMH8|uniprotkb:U3KQL5	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:ada15_human(display_long)|uniprotkb:ADAM15(gene name)|psi-mi:ADAM15(display_short)|uniprotkb:MDC15(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(gene name synonym)|uniprotkb:Metalloprotease RGD disintegrin protein(gene name synonym)|uniprotkb:Metargidin(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227849|imex:IM-27246-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	ensembl:ENSG00000143537(gene)|ensembl:ENST00000356955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0042246"(tissue regeneration)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990910"(response to hypobaric hypoxia)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR033605|interpro:IPR034027|interpro:IPR036436|mint:Q13444|reactome:R-HSA-1474228|reactome:R-HSA-8941237|refseq:NP_003806.3|refseq:NP_997074.1|refseq:NP_997077.1|refseq:NP_997078.1|refseq:NP_997079.1|refseq:NP_997080.1|refseq:NP_001248394.1|refseq:NP_001248393.1|refseq:NP_001248395.1	-	-	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/10/22	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:wMQLjw9xepknd94XZXdmwnmEwhc9606	rigid:x0CKiWwdLTVdGRKUNToLqMV3IeE	false	sufficient binding region:61..61-121..121(IPR001452)|glutathione s tranferase tag:n-n	sufficient binding region:766-781	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9H013	uniprotkb:O95153	intact:EBI-8567699|ensembl:ENSP00000428654|uniprotkb:Q9BZL5|intact:MINT-246384|uniprotkb:Q9UHP2	intact:EBI-5915931|uniprotkb:O75111|uniprotkb:Q8N5W3|ensembl:ENSP00000345824|intact:EBI-28971165	psi-mi:ada19_human(display_long)|uniprotkb:ADAM19(gene name)|psi-mi:ADAM19(display_short)|uniprotkb:MLTNB(gene name synonym)|uniprotkb:Metalloprotease and disintegrin dendritic antigen marker(gene name synonym)|uniprotkb:FKSG34(orf name)|uniprotkb:Meltrin-beta(gene name synonym)	psi-mi:rimb1_human(display_long)|uniprotkb:TSPOAP1(gene name)|psi-mi:TSPOAP1(display_short)|uniprotkb:BZRAP1(gene name synonym)|uniprotkb:KIAA0612(gene name synonym)|uniprotkb:Peripheral benzodiazepine receptor-interacting protein(gene name synonym)|uniprotkb:RBP1(gene name synonym)|uniprotkb:RIMBP1(gene name synonym)|uniprotkb:RIMS-binding protein 1(gene name synonym)|uniprotkb:TSPO-associated protein 1(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21227984|imex:IM-27246-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135074(gene)|ensembl:ENST00000517905(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0010628"(positive regulation of gene expression)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR033596|interpro:IPR034027|interpro:IPR036436|reactome:R-HSA-8941237|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|refseq:NP_150377.1|refseq:XP_005266060.1	ensembl:ENST00000268893|ensembl:ENSP00000268893|ensembl:ENSP00000345824|refseq:XP_006722236.1|refseq:NP_001248764.1|refseq:NP_004749.2|refseq:NP_077729.1|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325|mint:O95153|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-196108|reactome:R-HSA-210500|reactome:R-HSA-212676|reactome:R-HSA-264642|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0030156"(benzodiazepine receptor binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|interpro:IPR001452(Src homology-3)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000005379(gene)|ensembl:ENST00000343736(transcript)|go:"GO:0005737"(cytoplasm)	-	comment:mint|function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone	-	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/28	2019/10/22	rogid:lcBXBOeXL6pKA9Wq5nVYajYuDSw9606	rogid:nOwDlLr5DTjN2tJNR3h0zxrU1Z49606	rigid:Gu2Lomuy2YkeS+1i5BJeKTBXHxA	false	sufficient binding region:861-876|sufficient binding region:870-885	sufficient binding region:1764..1764-1831..1831(IPR001452)|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q05910	uniprotkb:Q8WV41	intact:EBI-21228219|ensembl:ENSMUSP00000101684	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	psi-mi:adam8_mouse(display_long)|uniprotkb:Cell surface antigen MS2(gene name synonym)|uniprotkb:Macrophage cysteine-rich glycoprotein(gene name synonym)|uniprotkb:Adam8(gene name)|psi-mi:Adam8(display_short)|uniprotkb:Ms2(gene name synonym)	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kleino et al. (2014)	pubmed:25825872|imex:IM-27246	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21228217|imex:IM-27246-179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031429.1|ensembl:ENSMUSG00000025473(gene)|ensembl:ENSMUST00000106069(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0002102"(podosome)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0032010"(phagolysosome)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042581"(specific granule)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061025"(membrane fusion)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070820"(tertiary granule)|go:"GO:0071133"(alpha9-beta1 integrin-ADAM8 complex)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000399"(negative regulation of thymocyte aggregation)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000415"(positive regulation of fibronectin-dependent thymocyte migration)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR018358|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|reactome:R-MMU-1474228|reactome:R-MMU-6798695	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	-	-	-	figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/02/28	2019/03/04	rogid:XPDiFkfPKwtKcFsuKyPnqmDx5E810090	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rigid:Dm+/bJVy4t6pvDWjts+94wrjXc4	false	ha tag:c-c	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)