#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51159	uniprotkb:Q70J99	intact:EBI-716881|uniprotkb:O00195|uniprotkb:Q6FI40|uniprotkb:Q9UIR9|uniprotkb:Q9Y5U3|ensembl:ENSP00000337761|ensembl:ENSP00000379601|ensembl:ENSP00000455012|ensembl:ENSP00000456059	intact:EBI-11479429|uniprotkb:B4DWG9|uniprotkb:Q9H7K5|ensembl:ENSP00000207549	psi-mi:rb27a_human(display_long)|uniprotkb:GTP-binding protein Ram(gene name synonym)|uniprotkb:RAB27A(gene name)|psi-mi:RAB27A(display_short)|uniprotkb:RAB27(gene name synonym)	psi-mi:un13d_human(display_long)|uniprotkb:UNC13D(gene name)|psi-mi:UNC13D(display_short)|uniprotkb:Munc13-4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cetica et al. (2015)	pubmed:25312756|imex:IM-27373	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22054996|imex:IM-27373-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004571.2|refseq:NP_899057.1|refseq:NP_899058.1|refseq:NP_899059.1|refseq:XP_011520154.1|refseq:XP_011520156.1|refseq:XP_011520157.1|refseq:XP_011520158.1|refseq:XP_005254633.1|ensembl:ENST00000396307(transcript)|ensembl:ENST00000564609(transcript)|ensembl:ENST00000569493(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|mint:P51159|rcsb pdb:6HUF|reactome:R-HSA-264876|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000069974(gene)|ensembl:ENST00000336787(transcript)|dip:DIP-44244N	refseq:NP_954712.1|ensembl:ENSG00000092929(gene)|ensembl:ENST00000207549(transcript)|go:"GO:0002432"(granuloma formation)|go:"GO:0002467"(germinal center formation)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR035892|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 3a, 3c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/09/26	2019/09/30	rogid:xHjWV0BbHEEl7KwP1IWzMV7WRuE9606	rogid:caA8/VwktSz+pczqvN/tFLatKWo9606	rigid:ecjCFT5tlXSDQp/uAtLg/7FXI84	false	mutation decreasing interaction strength:163-163|mutation decreasing interaction strength:141-142(rs1478402636)|mutation disrupting interaction strength:159-159|mutation:78-78|mutation decreasing interaction strength:76-76|green fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BV36	uniprotkb:P51159	intact:EBI-7042162|uniprotkb:B4DKW7|intact:MINT-3388002|uniprotkb:Q9HA71|uniprotkb:B3KSS2|uniprotkb:G5E9G5|ensembl:ENSP00000264605	intact:EBI-716881|uniprotkb:O00195|uniprotkb:Q6FI40|uniprotkb:Q9UIR9|uniprotkb:Q9Y5U3|ensembl:ENSP00000337761|ensembl:ENSP00000379601|ensembl:ENSP00000455012|ensembl:ENSP00000456059	psi-mi:melph_human(display_long)|uniprotkb:MLPH(gene name)|psi-mi:MLPH(display_short)|uniprotkb:SLAC2A(gene name synonym)|uniprotkb:Exophilin-3(gene name synonym)|uniprotkb:Synaptotagmin-like protein 2a(gene name synonym)|uniprotkb:Slp homolog lacking C2 domains a(gene name synonym)	psi-mi:rb27a_human(display_long)|uniprotkb:GTP-binding protein Ram(gene name synonym)|uniprotkb:RAB27A(gene name)|psi-mi:RAB27A(display_short)|uniprotkb:RAB27(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cetica et al. (2015)	pubmed:25312756|imex:IM-27373	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055012|imex:IM-27373-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077006.1|refseq:NP_001035932.1|refseq:NP_001268402.1|refseq:NP_001268403.1|dip:DIP-44046N|ensembl:ENSG00000115648(gene)|ensembl:ENST00000264605(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017022"(myosin binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006788("Myelin-associated oligodendrocytic basic protein (MOBP)")|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR037442|interpro:IPR041282|mint:Q9BV36	refseq:NP_004571.2|refseq:NP_899057.1|refseq:NP_899058.1|refseq:NP_899059.1|refseq:XP_011520154.1|refseq:XP_011520156.1|refseq:XP_011520157.1|refseq:XP_011520158.1|refseq:XP_005254633.1|ensembl:ENST00000396307(transcript)|ensembl:ENST00000564609(transcript)|ensembl:ENST00000569493(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|mint:P51159|rcsb pdb:6HUF|reactome:R-HSA-264876|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000069974(gene)|ensembl:ENST00000336787(transcript)|dip:DIP-44244N	-	comment:mint|function:Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A|function:"Defects in MLPH are a cause of Griscelli syndrome type-3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations"	-	figure legend:Fig 3b, 3d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/09/26	2019/09/30	rogid:g6+punuQGoilMzUlkOu+V73nUHc9606	rogid:xHjWV0BbHEEl7KwP1IWzMV7WRuE9606	rigid:w0Jcy9lHsIIFmKC/TX8SbtyBPcY	false	green fluorescent protein tag:?-?	mutation:78-78|mutation with no effect:159-159|mutation decreasing interaction strength:163-163|mutation with no effect:141-142(rs1478402636)|green fluorescent protein tag:?-?|mutation with no effect:76-76	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)