#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P14618-2 uniprotkb:Q05996 intact:EBI-6694361|uniprotkb:P14786-1|ensembl:ENSP00000320171|ensembl:ENSP00000456970 intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971 psi-mi:p14618-2(display_long)|uniprotkb:M1-PK(isoform synonym)|uniprotkb:PKM1(isoform synonym)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:OIP3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273108|imex:IM-26897-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-353408(isoform-parent)|ensembl:ENSG00000067225(gene)|ensembl:ENST00000319622(transcript)|ensembl:ENST00000568459(transcript)|uniprotkb:P14618-2(isoform-parent) refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:Y4GmK6T2kMgo7CZg0FDlWbO3Pok9606 rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606 rigid:w0St9lCquolCFxwiZSjBrldBbnI false - sufficient binding region:39-638|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P06733 uniprotkb:Q05996 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971 psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273125|imex:IM-26897-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606 rigid:EKAG5451QVh50QlqcfvmtBnzs6s false - sufficient binding region:39-638|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14556 uniprotkb:Q05996 intact:EBI-1057431|uniprotkb:O60823|uniprotkb:Q6JTT9|uniprotkb:Q9HCU6|uniprotkb:B2RC82|ensembl:ENSP00000222286 intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971 psi-mi:g3pt_human(display_long)|uniprotkb:GAPDHS(gene name)|psi-mi:GAPDHS(display_short)|uniprotkb:GAPD2(gene name synonym)|uniprotkb:GAPDH2(gene name synonym)|uniprotkb:GAPDS(gene name synonym)|uniprotkb:HSD35(orf name)|uniprotkb:HSD-35(orf name)|uniprotkb:Spermatogenic glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2(gene name synonym) psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273134|imex:IM-26897-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055179.1|ensembl:ENSG00000105679(gene)|ensembl:ENST00000222286(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:O14556|rcsb pdb:3H9E|rcsb pdb:3PFW|rcsb pdb:5C7L|rcsb pdb:5C7O|reactome:R-HSA-390471|reactome:R-HSA-70171|reactome:R-HSA-70263 refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:R2wl89TyWYfD57yzx6up8t7LfDE9606 rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606 rigid:mZkRSbu2NiW81gfKZv5kHuk8QbM false - sufficient binding region:39-638|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P36969 uniprotkb:Q05996 intact:EBI-2510844|uniprotkb:O43381|uniprotkb:Q9UPK2|uniprotkb:Q6PJ59|ensembl:ENSP00000346103 intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971 psi-mi:gpx4_human(display_long)|uniprotkb:GPX4(gene name)|psi-mi:GPX4(display_short)|uniprotkb:Glutathione peroxidase 4(gene name synonym) psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273142|imex:IM-26897-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002076.2|refseq:NP_001034936.1|dip:DIP-53543N|reactome:R-HSA-9023661|reactome:R-HSA-9020265|ensembl:ENSG00000167468(gene)|ensembl:ENST00000354171(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008430"(selenium binding)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051258"(protein polymerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0110076"(negative regulation of ferroptosis)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|rcsb pdb:2GS3|rcsb pdb:2OBI|rcsb pdb:5H5Q|rcsb pdb:5H5R|rcsb pdb:5H5S|rcsb pdb:6ELW|rcsb pdb:6HKQ|rcsb pdb:6HN3|reactome:R-HSA-2142688|reactome:R-HSA-2142712|reactome:R-HSA-2142770|reactome:R-HSA-9018676|reactome:R-HSA-9018896 refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:SUjUUl4rV/SKmLkV6WOiM+nusio9606 rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606 rigid:tQPY/KNLaprx7QzrE1J3M/4JJJ0 false - sufficient binding region:39-638|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P45880-3 uniprotkb:Q05996 intact:EBI-11614013|ensembl:ENSP00000361686|ensembl:ENSP00000443092 intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971 psi-mi:p45880-3(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273159|imex:IM-26897-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-354022(isoform-parent)|ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript) refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606 rigid:I8RmuTJZsZ0N79u26Id1zn4Pkzw false - sufficient binding region:39-638|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P45880-3 uniprotkb:P21754 intact:EBI-11614013|ensembl:ENSP00000361686|ensembl:ENSP00000443092 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:p45880-3(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273168|imex:IM-26897-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-354022(isoform-parent)|ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:shnepUgrq3pjDvJZ0KZ00RS9dOg false - sufficient binding region:23-383|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5BJF6-5 uniprotkb:P21754 intact:EBI-7874692|intact:MINT-7901952|ensembl:ENSP00000361877 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:q5bjf6-5(display_long)|uniprotkb:ODF2(gene name)|psi-mi:ODF2(display_short)|uniprotkb:Cenexin(gene name synonym)|uniprotkb:Outer dense fiber of sperm tails protein 2(gene name synonym)|uniprotkb:Cenexin 1(isoform synonym)|uniprotkb:ODF2/1(isoform synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273190|imex:IM-26897-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8744243(isoform-parent)|ensembl:ENSG00000136811(gene)|ensembl:ENST00000372791(transcript) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - isoform-comment:Major.|comment:mint - figure legend:Figure 1, Figure 3, Table 1-7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:FxZOqhUrD5cgjE3xewyCN6GXm1k9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:z6wNoXl8mdiIc5RbkO6tvKsym+I false - sufficient binding region:23-383|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60174-1 uniprotkb:P21754 intact:EBI-11161383|ensembl:ENSP00000379933 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:p60174-1(display_long)|uniprotkb:TPI1(gene name)|psi-mi:TPI1(display_short)|uniprotkb:TPI(gene name synonym)|uniprotkb:Triose-phosphate isomerase(gene name synonym)|uniprotkb:Methylglyoxal synthase(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273198|imex:IM-26897-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-717475(isoform-parent)|ensembl:ENSG00000111669(gene)|ensembl:ENST00000396705(transcript) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:FaLt6wGI1Bz2Z81gX35p7sOiMbE9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:sGZEYTOp810eaqyMKOQ47WV1GYs false - sufficient binding region:23-383|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P21266 uniprotkb:P21754 intact:EBI-350350|uniprotkb:O60550|uniprotkb:Q96HA3|ensembl:ENSP00000354357|ensembl:ENSP00000256594 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:gstm3_human(display_long)|uniprotkb:GSTM3(gene name)|psi-mi:GSTM3(display_short)|uniprotkb:GST5(gene name synonym)|uniprotkb:GSTM3-3(gene name synonym)|uniprotkb:GST class-mu 3(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273206|imex:IM-26897-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000840.2|interpro:IPR036282|interpro:IPR040079|rcsb pdb:3GTU|reactome:R-HSA-156590|ensembl:ENST00000256594(transcript)|ensembl:ENST00000361066(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|ensembl:ENSG00000134202(gene)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0018916"(nitrobenzene metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0045171"(intercellular bridge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|interpro:IPR003081(Glutathione S-transferase, Mu class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-9|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:9hGeWmuSdPCn0RGJo4mQ/w9tKzo9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:rhuUc7wBwww9ZIH+zT/5tsod4u8 false - sufficient binding region:23-383|his tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14556 uniprotkb:P21754 intact:EBI-1057431|uniprotkb:O60823|uniprotkb:Q6JTT9|uniprotkb:Q9HCU6|uniprotkb:B2RC82|ensembl:ENSP00000222286 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:g3pt_human(display_long)|uniprotkb:GAPDHS(gene name)|psi-mi:GAPDHS(display_short)|uniprotkb:GAPD2(gene name synonym)|uniprotkb:GAPDH2(gene name synonym)|uniprotkb:GAPDS(gene name synonym)|uniprotkb:HSD35(orf name)|uniprotkb:HSD-35(orf name)|uniprotkb:Spermatogenic glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273218|imex:IM-26897-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055179.1|ensembl:ENSG00000105679(gene)|ensembl:ENST00000222286(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:O14556|rcsb pdb:3H9E|rcsb pdb:3PFW|rcsb pdb:5C7L|rcsb pdb:5C7O|reactome:R-HSA-390471|reactome:R-HSA-70171|reactome:R-HSA-70263 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-10|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:R2wl89TyWYfD57yzx6up8t7LfDE9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:9OsJsm16zwoEeFp8x0QZZzkXxjM false - his tag:c-c|sufficient binding region:23-383 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P36969 uniprotkb:P21754 intact:EBI-2510844|uniprotkb:O43381|uniprotkb:Q9UPK2|uniprotkb:Q6PJ59|ensembl:ENSP00000346103 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:gpx4_human(display_long)|uniprotkb:GPX4(gene name)|psi-mi:GPX4(display_short)|uniprotkb:Glutathione peroxidase 4(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273226|imex:IM-26897-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002076.2|refseq:NP_001034936.1|dip:DIP-53543N|reactome:R-HSA-9023661|reactome:R-HSA-9020265|ensembl:ENSG00000167468(gene)|ensembl:ENST00000354171(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008430"(selenium binding)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051258"(protein polymerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0110076"(negative regulation of ferroptosis)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|rcsb pdb:2GS3|rcsb pdb:2OBI|rcsb pdb:5H5Q|rcsb pdb:5H5R|rcsb pdb:5H5S|rcsb pdb:6ELW|rcsb pdb:6HKQ|rcsb pdb:6HN3|reactome:R-HSA-2142688|reactome:R-HSA-2142712|reactome:R-HSA-2142770|reactome:R-HSA-9018676|reactome:R-HSA-9018896 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-11|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:SUjUUl4rV/SKmLkV6WOiM+nusio9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:0xl7JD8YfYFXlpNtr+WKGbUMgRM false - his tag:c-c|sufficient binding region:23-383 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P14618-2 uniprotkb:P21754 intact:EBI-6694361|uniprotkb:P14786-1|ensembl:ENSP00000320171|ensembl:ENSP00000456970 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:p14618-2(display_long)|uniprotkb:M1-PK(isoform synonym)|uniprotkb:PKM1(isoform synonym)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:OIP3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273234|imex:IM-26897-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-353408(isoform-parent)|ensembl:ENSG00000067225(gene)|ensembl:ENST00000319622(transcript)|ensembl:ENST00000568459(transcript)|uniprotkb:P14618-2(isoform-parent) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-12|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:Y4GmK6T2kMgo7CZg0FDlWbO3Pok9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:xDszIgQ6jAOxim2eSoxKItKmi1Y false - his tag:c-c|sufficient binding region:23-383 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P06733 uniprotkb:P21754 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273242|imex:IM-26897-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-13|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:1kPVJmA47ff0VBNWt2DKZFfEk1c false - his tag:c-c|sufficient binding region:23-383 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P06733 uniprotkb:Q12836 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273250|imex:IM-26897-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-14|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:UBe5XjlLXNe/EVbHuQdvKoxPCN0 false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14556 uniprotkb:Q12836 intact:EBI-1057431|uniprotkb:O60823|uniprotkb:Q6JTT9|uniprotkb:Q9HCU6|uniprotkb:B2RC82|ensembl:ENSP00000222286 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:g3pt_human(display_long)|uniprotkb:GAPDHS(gene name)|psi-mi:GAPDHS(display_short)|uniprotkb:GAPD2(gene name synonym)|uniprotkb:GAPDH2(gene name synonym)|uniprotkb:GAPDS(gene name synonym)|uniprotkb:HSD35(orf name)|uniprotkb:HSD-35(orf name)|uniprotkb:Spermatogenic glyceraldehyde-3-phosphate dehydrogenase(gene name synonym)|uniprotkb:Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273259|imex:IM-26897-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055179.1|ensembl:ENSG00000105679(gene)|ensembl:ENST00000222286(transcript)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:O14556|rcsb pdb:3H9E|rcsb pdb:3PFW|rcsb pdb:5C7L|rcsb pdb:5C7O|reactome:R-HSA-390471|reactome:R-HSA-70171|reactome:R-HSA-70263 refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-15|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:R2wl89TyWYfD57yzx6up8t7LfDE9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:NOTT0NnTO47ZOZYLF23CZYPM770 false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P36969 uniprotkb:Q12836 intact:EBI-2510844|uniprotkb:O43381|uniprotkb:Q9UPK2|uniprotkb:Q6PJ59|ensembl:ENSP00000346103 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:gpx4_human(display_long)|uniprotkb:GPX4(gene name)|psi-mi:GPX4(display_short)|uniprotkb:Glutathione peroxidase 4(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273267|imex:IM-26897-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002076.2|refseq:NP_001034936.1|dip:DIP-53543N|reactome:R-HSA-9023661|reactome:R-HSA-9020265|ensembl:ENSG00000167468(gene)|ensembl:ENST00000354171(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008430"(selenium binding)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051258"(protein polymerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0110076"(negative regulation of ferroptosis)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|rcsb pdb:2GS3|rcsb pdb:2OBI|rcsb pdb:5H5Q|rcsb pdb:5H5R|rcsb pdb:5H5S|rcsb pdb:6ELW|rcsb pdb:6HKQ|rcsb pdb:6HN3|reactome:R-HSA-2142688|reactome:R-HSA-2142712|reactome:R-HSA-2142770|reactome:R-HSA-9018676|reactome:R-HSA-9018896 refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-16|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:SUjUUl4rV/SKmLkV6WOiM+nusio9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:6c8i4o5LBkrYWVGa1oSQoXmi92k false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P14618-2 uniprotkb:Q12836 intact:EBI-6694361|uniprotkb:P14786-1|ensembl:ENSP00000320171|ensembl:ENSP00000456970 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:p14618-2(display_long)|uniprotkb:M1-PK(isoform synonym)|uniprotkb:PKM1(isoform synonym)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:OIP3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273275|imex:IM-26897-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-353408(isoform-parent)|ensembl:ENSG00000067225(gene)|ensembl:ENST00000319622(transcript)|ensembl:ENST00000568459(transcript)|uniprotkb:P14618-2(isoform-parent) refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-17|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:Y4GmK6T2kMgo7CZg0FDlWbO3Pok9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:h7l29U4N9PSBtWLLyo12HzzgZ8c false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04075 uniprotkb:Q12836 intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273283|imex:IM-26897-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263 refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-18|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:4lb9AdKf71gyKZ4XWbmaJ9epb+c false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P60174-1 uniprotkb:Q12836 intact:EBI-11161383|ensembl:ENSP00000379933 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:p60174-1(display_long)|uniprotkb:TPI1(gene name)|psi-mi:TPI1(display_short)|uniprotkb:TPI(gene name synonym)|uniprotkb:Triose-phosphate isomerase(gene name synonym)|uniprotkb:Methylglyoxal synthase(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273291|imex:IM-26897-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-717475(isoform-parent)|ensembl:ENSG00000111669(gene)|ensembl:ENST00000396705(transcript) refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-19|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:FaLt6wGI1Bz2Z81gX35p7sOiMbE9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:IQkvI3ZW4crBGPT9dweBjWNryjY false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P21266 uniprotkb:Q12836 intact:EBI-350350|uniprotkb:O60550|uniprotkb:Q96HA3|ensembl:ENSP00000354357|ensembl:ENSP00000256594 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:gstm3_human(display_long)|uniprotkb:GSTM3(gene name)|psi-mi:GSTM3(display_short)|uniprotkb:GST5(gene name synonym)|uniprotkb:GSTM3-3(gene name synonym)|uniprotkb:GST class-mu 3(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273302|imex:IM-26897-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000840.2|interpro:IPR036282|interpro:IPR040079|rcsb pdb:3GTU|reactome:R-HSA-156590|ensembl:ENST00000256594(transcript)|ensembl:ENST00000361066(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|ensembl:ENSG00000134202(gene)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0018916"(nitrobenzene metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0045171"(intercellular bridge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|interpro:IPR003081(Glutathione S-transferase, Mu class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249 refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 1, Figure 3, Table 1-20|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:9hGeWmuSdPCn0RGJo4mQ/w9tKzo9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:DAR/aQde7aaiz+o2xLMxsCgqvG8 false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5BJF6-5 uniprotkb:Q12836 intact:EBI-7874692|intact:MINT-7901952|ensembl:ENSP00000361877 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:q5bjf6-5(display_long)|uniprotkb:ODF2(gene name)|psi-mi:ODF2(display_short)|uniprotkb:Cenexin(gene name synonym)|uniprotkb:Outer dense fiber of sperm tails protein 2(gene name synonym)|uniprotkb:Cenexin 1(isoform synonym)|uniprotkb:ODF2/1(isoform synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0047"(far western blotting) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273315|imex:IM-26897-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8744243(isoform-parent)|ensembl:ENSG00000136811(gene)|ensembl:ENST00000372791(transcript) refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - isoform-comment:Major.|comment:mint - figure legend:Figure 1, Figure 3, Table 1-21|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:FxZOqhUrD5cgjE3xewyCN6GXm1k9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:zKDpq1wGvCpF7GSnnOo2+OaCt4w false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P21266 uniprotkb:Q12836 intact:EBI-350350|uniprotkb:O60550|uniprotkb:Q96HA3|ensembl:ENSP00000354357|ensembl:ENSP00000256594 intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304 psi-mi:gstm3_human(display_long)|uniprotkb:GSTM3(gene name)|psi-mi:GSTM3(display_short)|uniprotkb:GST5(gene name synonym)|uniprotkb:GSTM3-3(gene name synonym)|uniprotkb:GST class-mu 3(gene name synonym) psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym) psi-mi:"MI:0096"(pull down) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273343|imex:IM-26897-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000840.2|interpro:IPR036282|interpro:IPR040079|rcsb pdb:3GTU|reactome:R-HSA-156590|ensembl:ENST00000256594(transcript)|ensembl:ENST00000361066(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|ensembl:ENSG00000134202(gene)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0018916"(nitrobenzene metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0045171"(intercellular bridge)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|interpro:IPR003081(Glutathione S-transferase, Mu class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249 refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 4A|comment:"GSTM preferentially co-precipitated with rhZP4 when compared with rhZP2 and rhZP3 (Fig.4A)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:9hGeWmuSdPCn0RGJo4mQ/w9tKzo9606 rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606 rigid:DAR/aQde7aaiz+o2xLMxsCgqvG8 false - his tag:c-c|sufficient binding region:19-463 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P45880-3 uniprotkb:Q05996 intact:EBI-11614013|ensembl:ENSP00000361686|ensembl:ENSP00000443092 intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971 psi-mi:p45880-3(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym) psi-mi:"MI:0096"(pull down) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273354|imex:IM-26897-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-354022(isoform-parent)|ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript) refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 5A-Lane A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606 rigid:I8RmuTJZsZ0N79u26Id1zn4Pkzw false - sufficient binding region:39-638|his tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P45880-3 uniprotkb:P21754 intact:EBI-11614013|ensembl:ENSP00000361686|ensembl:ENSP00000443092 intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326 psi-mi:p45880-3(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym) psi-mi:"MI:0096"(pull down) Petit et al. (2013) pubmed:23355646|imex:IM-26897 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21273362|imex:IM-26897-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-354022(isoform-parent)|ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript) refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343 - - - figure legend:Figure 5A-Lane C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/03/14 2019/03/15 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606 rigid:shnepUgrq3pjDvJZ0KZ00RS9dOg false - sufficient binding region:23-383|his tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)