#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02647	uniprotkb:P02647	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	intact:EBI-701692|uniprotkb:Q6LDN9|uniprotkb:Q6Q785|uniprotkb:A8K866|uniprotkb:Q9UCS8|uniprotkb:Q9UCT8|ensembl:ENSP00000236850|ensembl:ENSP00000352471|ensembl:ENSP00000364469|ensembl:ENSP00000364472	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:apoa1_human(display_long)|uniprotkb:APOA1(gene name)|psi-mi:APOA1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Petrlova et al. (2012)	pubmed:22184756|imex:IM-27417	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22080580|imex:IM-27417-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	refseq:NP_000030.1|refseq:NP_001304946.1|refseq:NP_001304947.1|refseq:NP_001304950.1|dip:DIP-29619N|ensembl:ENSG00000118137(gene)|ensembl:ENST00000236850(transcript)|ensembl:ENST00000359492(transcript)|ensembl:ENST00000375320(transcript)|ensembl:ENST00000375323(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02647|rcsb pdb:1AV1|rcsb pdb:1GW3|rcsb pdb:1GW4|rcsb pdb:1ODP|rcsb pdb:1ODQ|rcsb pdb:1ODR|rcsb pdb:2MSC|rcsb pdb:2MSD|rcsb pdb:2MSE|rcsb pdb:2N5E|rcsb pdb:3K2S|rcsb pdb:3R2P|rcsb pdb:4V6M|rcsb pdb:6CC9|rcsb pdb:6CCH|rcsb pdb:6CCX|rcsb pdb:6CLZ|rcsb pdb:6CM1|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6W4E|rcsb pdb:6W4F|rcsb pdb:7KJR|reactome:R-HSA-114608|reactome:R-HSA-1369062|reactome:R-HSA-1989781|reactome:R-HSA-2168880|reactome:R-HSA-3000471|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-5682113|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963896|reactome:R-HSA-8963901|reactome:R-HSA-8964011|reactome:R-HSA-8964058|reactome:R-HSA-9707616|reactome:R-HSA-975634|reactome:R-HSA-977225	-	-	-	figure legend:Fig. 4|comment:"L178H and WT solutions were examined by negative stain electron microscopy to determine the ultra structure of the formed aggregates (Fig. 4). Fibrillar structures ranging in length from 30 to 120 nm with a 10 nm diameter were observed for L178H incubated at 37°C for 30 days. Under the same conditions, WT solutions did not produce fibrils, although small spherical aggregates were observed. The studies show that the L178H form insoluble aggregates with a fibril morphology partly consistent with the characteristics of fibril-forming proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/10/08	2019/10/16	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	rogid:yEzPDeU8Uu/43dkLLOBAy6ey1vs9606	rigid:WRUQaMHXGmnC/H/BzyolIfyaa7Y	false	his tag:n-n|mutation with complex effect:202-202	his tag:n-n|mutation with complex effect:202-202	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)