#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSG00000108691	uniprotkb:P55347	intact:EBI-10040871	intact:EBI-1373569|uniprotkb:O00528|uniprotkb:Q8IWT7|ensembl:ENSP00000291547	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:pknx1_human(display_long)|uniprotkb:PBX/knotted homeobox 1(gene name synonym)|uniprotkb:Homeobox protein PREP-1(gene name synonym)|uniprotkb:PKNOX1(gene name)|psi-mi:PKNOX1(display_short)|uniprotkb:PREP1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296012|imex:IM-27583-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004562.2|ensembl:ENSG00000160199(gene)|ensembl:ENST00000291547(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:1X2N|reactome:R-HSA-5617472	-	-	-	figure legend:Table 1, Fig. 2B|comment:"The TALE proteins bound to a greater extent to the -2578 G allele than to the -2578 A allele (Table 1)."|comment:"Mutation of the upstream TALE site reduced binding by both PREP1 and PBX2 for both the -2578 A and G alleles (Figure 2B, C, F and G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/17	-	rogid:Lg1nUBFHfBFWvGVk9elIXobm5BA9606	-	false	sufficient binding region:?-?|mutation increasing interaction strength:?-?|mutation decreasing interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P31269	intact:EBI-10040871	intact:EBI-742314|uniprotkb:O43369|uniprotkb:O43429|uniprotkb:Q99820|ensembl:ENSP00000343619	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:hxa9_human(display_long)|uniprotkb:HOXA9(gene name)|psi-mi:HOXA9(display_short)|uniprotkb:HOX1G(gene name synonym)|uniprotkb:Homeobox protein Hox-1G(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296074|imex:IM-27583-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_689952.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060065"(uterus development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|ensembl:ENSG00000078399(gene)|ensembl:ENST00000343483(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006351"(transcription, DNA-templated)	-	-	-	figure legend:Table 1, Fig. 2D|comment:"In addition, we found that there was significantly greater binding of HoxA9 protein and increased binding of IRF1 to the -2578 A allele (Table 1)."|comment:"Mutation of the upstream TALE site reduced binding by both PREP1 and PBX2 for both the -2578 A and G alleles (Figure 2B, C, F and G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/17	-	rogid:04nr6zxW4HQtzJhTZNTajO6jmWY9606	-	false	sufficient binding region:?-?|mutation decreasing interaction strength:?-?|mutation disrupting interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P40425	intact:EBI-10040871	intact:EBI-348489|ensembl:ENSP00000372757|ensembl:ENSP00000390009|ensembl:ENSP00000391745|ensembl:ENSP00000397177|ensembl:ENSP00000403948|ensembl:ENSP00000410710|ensembl:ENSP00000364190|uniprotkb:A2BFJ2	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:pbx2_human(display_long)|uniprotkb:PBX2(gene name)|psi-mi:PBX2(display_short)|uniprotkb:G17(gene name synonym)|uniprotkb:Homeobox protein PBX2(gene name synonym)|uniprotkb:Protein G17(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296089|imex:IM-27583-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002577.2|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|ensembl:ENST00000375050(transcript)|ensembl:ENST00000383270(transcript)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0030326"(embryonic limb morphogenesis)|ensembl:ENST00000420432(transcript)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048568"(embryonic organ development)|ensembl:ENST00000431537(transcript)|ensembl:ENST00000433552(transcript)|ensembl:ENST00000453487(transcript)|ensembl:ENST00000453961(transcript)|go:"GO:0000785"(chromatin)|interpro:IPR001356(Homeobox)|interpro:IPR005542(PBX)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P40425|go:"GO:0048666"(neuron development)|ensembl:ENSG00000204304(gene)|ensembl:ENSG00000206315(gene)|ensembl:ENSG00000224952(gene)|ensembl:ENSG00000225987(gene)|ensembl:ENSG00000232005(gene)|ensembl:ENSG00000236353(gene)|ensembl:ENSG00000237344(gene)	-	-	-	figure legend:Table 1, Fig. 2C|comment:"The TALE proteins bound to a greater extent to the -2578 G allele than to the -2578 A allele (Table 1)."|comment:"Mutation of the upstream TALE site reduced binding by both PREP1 and PBX2 for both the -2578 A and G alleles (Figure 2B, C, F and G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/17	-	rogid:HvGKE7Hqw9Ed2yFQkYoIutQdBpE9606	-	false	mutation increasing interaction strength:?-?|mutation decreasing interaction strength:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P10914	intact:EBI-10040871	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296298|imex:IM-27583-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N	-	-	-	figure legend:Table 1, Fig. 2E|comment:"While the A and G alleles bind IRF1 equally when the upstream site is intact, mutation of the upstream TALE site leads to a 15-fold (Figure 2E) decrease in binding of the A allele as compared to a 1.5-fold decrease for the G allele (Figure 2I)."|comment:"In addition, we found that there was significantly greater binding of HoxA9 protein and increased binding of IRF1 to the -2578 A allele (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/18	-	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	-	false	sufficient binding region:?-?|mutation decreasing interaction strength:?-?|mutation disrupting interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P10914	intact:EBI-10040871	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296315|imex:IM-27583-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N	-	-	-	figure legend:Fig. 2I|comment:"While the A and G alleles bind IRF1 equally when the upstream site is intact, mutation of the upstream TALE site leads to a 15-fold (Figure 2E) decrease in binding of the A allele as compared to a 1.5-fold decrease for the G allele (Figure 2I)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/18	-	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	-	false	sufficient binding region:?-?|mutation:?-?|mutation decreasing interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P55347	intact:EBI-10040871	intact:EBI-1373569|uniprotkb:O00528|uniprotkb:Q8IWT7|ensembl:ENSP00000291547	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:pknx1_human(display_long)|uniprotkb:PBX/knotted homeobox 1(gene name synonym)|uniprotkb:Homeobox protein PREP-1(gene name synonym)|uniprotkb:PKNOX1(gene name)|psi-mi:PKNOX1(display_short)|uniprotkb:PREP1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296358|imex:IM-27583-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_004562.2|ensembl:ENSG00000160199(gene)|ensembl:ENST00000291547(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:1X2N|reactome:R-HSA-5617472	-	-	-	figure legend:Fig. 2F|comment:"Mutation of the upstream TALE site reduced binding by both PREP1 and PBX2 for both the -2578 A and G alleles (Figure 2B, C, F and G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/18	-	rogid:Lg1nUBFHfBFWvGVk9elIXobm5BA9606	-	false	sufficient binding region:?-?|mutation:?-?|mutation disrupting interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P40425	intact:EBI-10040871	intact:EBI-348489|ensembl:ENSP00000372757|ensembl:ENSP00000390009|ensembl:ENSP00000391745|ensembl:ENSP00000397177|ensembl:ENSP00000403948|ensembl:ENSP00000410710|ensembl:ENSP00000364190|uniprotkb:A2BFJ2	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:pbx2_human(display_long)|uniprotkb:PBX2(gene name)|psi-mi:PBX2(display_short)|uniprotkb:G17(gene name synonym)|uniprotkb:Homeobox protein PBX2(gene name synonym)|uniprotkb:Protein G17(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296372|imex:IM-27583-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002577.2|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|ensembl:ENST00000375050(transcript)|ensembl:ENST00000383270(transcript)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0030326"(embryonic limb morphogenesis)|ensembl:ENST00000420432(transcript)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048568"(embryonic organ development)|ensembl:ENST00000431537(transcript)|ensembl:ENST00000433552(transcript)|ensembl:ENST00000453487(transcript)|ensembl:ENST00000453961(transcript)|go:"GO:0000785"(chromatin)|interpro:IPR001356(Homeobox)|interpro:IPR005542(PBX)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P40425|go:"GO:0048666"(neuron development)|ensembl:ENSG00000204304(gene)|ensembl:ENSG00000206315(gene)|ensembl:ENSG00000224952(gene)|ensembl:ENSG00000225987(gene)|ensembl:ENSG00000232005(gene)|ensembl:ENSG00000236353(gene)|ensembl:ENSG00000237344(gene)	-	-	-	figure legend:Fig. 2G|comment:"Mutation of the upstream TALE site reduced binding by both PREP1 and PBX2 for both the -2578 A and G alleles (Figure 2B, C, F and G)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/18	-	rogid:HvGKE7Hqw9Ed2yFQkYoIutQdBpE9606	-	false	sufficient binding region:?-?|mutation:?-?|mutation disrupting interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSG00000108691	uniprotkb:P31269	intact:EBI-10040871	intact:EBI-742314|uniprotkb:O43369|uniprotkb:O43429|uniprotkb:Q99820|ensembl:ENSP00000343619	uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|intact:HC11(synonym)|intact:Monocyte chemoattractant protein 1(synonym)|intact:Monocyte chemotactic and activating factor(synonym)|intact:Monocyte chemotactic protein 1(synonym)|intact:Monocyte secretory protein JE(synonym)|intact:Small-inducible cytokine A2(synonym)|ensembl:ccl2_human_gene(shortlabel)|psi-mi:ENSG00000108691(display_long)	psi-mi:hxa9_human(display_long)|uniprotkb:HOXA9(gene name)|psi-mi:HOXA9(display_short)|uniprotkb:HOX1G(gene name synonym)|uniprotkb:Homeobox protein Hox-1G(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Page et al. (2010)	imex:IM-27583|pubmed:21760952	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25296386|imex:IM-27583-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_689952.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060065"(uterus development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|ensembl:ENSG00000078399(gene)|ensembl:ENST00000343483(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006351"(transcription, DNA-templated)	-	-	-	figure legend:Fig. 2H|comment:"Since HOXA9 protein has been shown to form complexes with PBX2 is was not surprising that mutation of the upstream TALE site significantly reduced the amount of CCL2 promoter DNA immunoprecipitated by HoxA9 antibody for both the -2578 A and -2578 G alleles (Figure 2D and H)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u87)|taxid:9606(Human U-87 MG glioblastoma cell line)	-	2019/12/16	2019/12/18	-	rogid:04nr6zxW4HQtzJhTZNTajO6jmWY9606	-	false	sufficient binding region:?-?|mutation:?-?|mutation disrupting interaction strength:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)