#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A2AST1 uniprotkb:Q9NRI5-3 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-21925300|ensembl:ENSP00000355596 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:"MI:0018"(two hybrid) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21925298|imex:IM-27181-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) - - - figure legend:no figure|comment:Using the CAMDI coiled-coil domain as bait, several CAMDI-binding candidates were found including MRLC 2a.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/06/06 2019/07/22 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rigid:8Gi1HCTm3A7uOh6maHWwb9aRAAE false sufficient binding region:67..67-1000..1000 sufficient binding region:366..366-678..678 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9CQ19 uniprotkb:Q9NRI5-3 intact:EBI-8350881|uniprotkb:Q80X77|intact:MINT-4102187|uniprotkb:Q3TW15|ensembl:ENSMUSP00000085913 intact:EBI-21925300|ensembl:ENSP00000355596 psi-mi:myl9_mouse(display_long)|uniprotkb:Myl9(gene name)|psi-mi:Myl9(display_short)|uniprotkb:Myrl2(gene name synonym)|uniprotkb:Myosin regulatory light chain 9(gene name synonym)|uniprotkb:Myosin regulatory light chain 2, smooth muscle isoform(gene name synonym) psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:"MI:0018"(two hybrid) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926256|imex:IM-27181-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_742116.1|refseq:XP_006500516.1|ensembl:ENSMUSG00000067818(gene)|ensembl:ENSMUST00000088552(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005938"(cell cortex)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9CQ19|reactome:R-MMU-445355|reactome:R-MMU-5627123 ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) - comment:mint|function:Plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity - figure legend:no figure|comment:Using the CAMDI coiled-coil domain as bait, several CAMDI-binding candidates were found including MRLC 2a.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/06/06 2019/07/25 rogid:nXiR+TNJkxH7OenpwZ0v8tXqjzQ10090 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rigid:YPc4P94mZ8GxNEjpU1RW4JsvkGw false - sufficient binding region:366..366-678..678 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2AST1 uniprotkb:Q9NRI5-3 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-21925300|ensembl:ENSP00000355596 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926184|imex:IM-27181-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) - - - figure legend:figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2019/06/06 2019/07/23 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rigid:8Gi1HCTm3A7uOh6maHWwb9aRAAE false flag tag:n-n enhanced green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NRI5-3 uniprotkb:A2AST1 intact:EBI-21925300|ensembl:ENSP00000355596 intact:EBI-20565696|ensembl:ENSMUSP00000052945 psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926711|imex:IM-27181-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 - - - figure legend:figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2019/06/06 2019/08/08 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rigid:8Gi1HCTm3A7uOh6maHWwb9aRAAE false enhanced green fluorescent protein tag:n-n sufficient binding region:707-906|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A2AST1 uniprotkb:Q811T9 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-2298259|uniprotkb:Q7TQ21|uniprotkb:Q8CF87|uniprotkb:Q8CF88|uniprotkb:Q8CHP1|uniprotkb:Q8CHP2|ensembl:ENSMUSP00000095914|ensembl:ENSMUSP00000112410 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:disc1_mouse(display_long)|uniprotkb:Disc1(gene name)|psi-mi:Disc1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926226|imex:IM-27181-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 refseq:XP_011246690.1|refseq:NP_777278.2|refseq:NP_777279.2|dip:DIP-54914N|ensembl:ENSMUSG00000043051(gene)|ensembl:ENSMUST00000098311(transcript)|ensembl:ENSMUST00000118942(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007399"(nervous system development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021852"(pyramidal neuron migration to cerebral cortex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031929"(TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097546"(ciliary base)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR026081|rcsb pdb:5YI4|rcsb pdb:6IRR - - - figure legend:figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2019/06/06 2019/07/23 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:UfsMePjEeOVJHilw8WbAmeBkQ3g10090 rigid:vmqEKnJf9anicMz5tCsg1agiOqY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CQ19 uniprotkb:A2AST1 intact:EBI-8350881|uniprotkb:Q80X77|intact:MINT-4102187|uniprotkb:Q3TW15|ensembl:ENSMUSP00000085913 intact:EBI-20565696|ensembl:ENSMUSP00000052945 psi-mi:myl9_mouse(display_long)|uniprotkb:Myl9(gene name)|psi-mi:Myl9(display_short)|uniprotkb:Myrl2(gene name synonym)|uniprotkb:Myosin regulatory light chain 9(gene name synonym)|uniprotkb:Myosin regulatory light chain 2, smooth muscle isoform(gene name synonym) psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926701|imex:IM-27181-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_742116.1|refseq:XP_006500516.1|ensembl:ENSMUSG00000067818(gene)|ensembl:ENSMUST00000088552(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005938"(cell cortex)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9CQ19|reactome:R-MMU-445355|reactome:R-MMU-5627123 ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 - comment:mint|function:Plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity - figure legend:figure 4A|comment:"The antibody used to detect \"p-MRLC\" is not stated;Cell Signalling sell several antibodies which detect both MRLC phosphorylated at pSer 20 only, but also phosphorylated at both Thr19 and Ser20. Thus Thr19 may also be phosphorylated."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2019/06/06 2019/07/24 rogid:nXiR+TNJkxH7OenpwZ0v8tXqjzQ10090 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rigid:0mASmwSauG6UiIks9iSN/vbOO8E false phosphorylated residue:20-20 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A2AST1 uniprotkb:Q9NRI5-3 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-21925300|ensembl:ENSP00000355596 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:"MI:0096"(pull down) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926276|imex:IM-27181-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) - - - figure legend:figure 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/06 2019/07/23 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rigid:8Gi1HCTm3A7uOh6maHWwb9aRAAE false flag tag:n-n glutathione s tranferase tag:?-?|sufficient binding region:446-507 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A2AST1 uniprotkb:Q9NRI5-3 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-21925300|ensembl:ENSP00000355596 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:"MI:0663"(confocal microscopy) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21926641|imex:IM-27181-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) go:"GO:0005813"(centrosome) - - figure legend:figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2019/06/06 2019/07/24 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rigid:8Gi1HCTm3A7uOh6maHWwb9aRAAE false flag tag:n-n enhanced green fluorescent protein tag:n-n - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:A2AST1 uniprotkb:P24844 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-716193|uniprotkb:Q9BQL9|uniprotkb:Q9BUF9|uniprotkb:Q9H136|uniprotkb:E1P5T6|ensembl:ENSP00000279022 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:myl9_human(display_long)|uniprotkb:Myosin regulatory light chain 9(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC1(gene name synonym)|uniprotkb:Myosin regulatory light chain 2, smooth muscle isoform(gene name synonym)|uniprotkb:Myosin RLC(gene name synonym)|uniprotkb:MLC-2C(gene name synonym)|uniprotkb:20 kDa myosin light chain(gene name synonym)|uniprotkb:MYL9(gene name)|psi-mi:MYL9(display_short)|uniprotkb:MRLC1(gene name synonym)|uniprotkb:MYRL2(gene name synonym)|uniprotkb:MLC2(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21926686|imex:IM-27181-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 refseq:NP_006088.2|refseq:NP_852667.1|ensembl:ENSG00000101335(gene)|ensembl:ENST00000279022(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005938"(cell cortex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0070527"(platelet aggregation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P24844|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-8936459|dip:DIP-60525N go:"GO:0005813"(centrosome) - - figure legend:figure 4C|comment:"The antibody used to detect \"p-MRLC\" is not stated;Cell Signalling sell several antibodies which detect both MRLC phosphorylated at pSer 20 only, but also phosphorylated at both Thr19 and Ser20. Thus Thr19 may also be phosphorylated."|comment:Co-expression of CAMDI with DISC1 induced p-MRLC accumulation at/around the centrosome.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2019/06/06 2019/07/24 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:FeJb0ac0n3hkVmRDnxeGSlL2/A89606 rigid:/YHYGv6AWuj3P9j5wr6NnT3LDTs false flag tag:n-n phosphorylated residue:20-20 - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:A2AST1 uniprotkb:P24844 intact:EBI-20565696|ensembl:ENSMUSP00000052945 intact:EBI-716193|uniprotkb:Q9BQL9|uniprotkb:Q9BUF9|uniprotkb:Q9H136|uniprotkb:E1P5T6|ensembl:ENSP00000279022 psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:myl9_human(display_long)|uniprotkb:Myosin regulatory light chain 9(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC1(gene name synonym)|uniprotkb:Myosin regulatory light chain 2, smooth muscle isoform(gene name synonym)|uniprotkb:Myosin RLC(gene name synonym)|uniprotkb:MLC-2C(gene name synonym)|uniprotkb:20 kDa myosin light chain(gene name synonym)|uniprotkb:MYL9(gene name)|psi-mi:MYL9(display_short)|uniprotkb:MRLC1(gene name synonym)|uniprotkb:MYRL2(gene name synonym)|uniprotkb:MLC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926663|imex:IM-27181-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 refseq:NP_006088.2|refseq:NP_852667.1|ensembl:ENSG00000101335(gene)|ensembl:ENST00000279022(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005938"(cell cortex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0070527"(platelet aggregation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P24844|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-8936459|dip:DIP-60525N - - - figure legend:figure 4 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2019/06/06 2019/07/24 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rogid:FeJb0ac0n3hkVmRDnxeGSlL2/A89606 rigid:/YHYGv6AWuj3P9j5wr6NnT3LDTs false flag tag:n-n mutation disrupting interaction strength:19-20|ha tag:?-?|mutation increasing interaction strength:19-20 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NRI5-3 uniprotkb:P24844 intact:EBI-21925300|ensembl:ENSP00000355596 intact:EBI-716193|uniprotkb:Q9BQL9|uniprotkb:Q9BUF9|uniprotkb:Q9H136|uniprotkb:E1P5T6|ensembl:ENSP00000279022 psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:myl9_human(display_long)|uniprotkb:Myosin regulatory light chain 9(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC1(gene name synonym)|uniprotkb:Myosin regulatory light chain 2, smooth muscle isoform(gene name synonym)|uniprotkb:Myosin RLC(gene name synonym)|uniprotkb:MLC-2C(gene name synonym)|uniprotkb:20 kDa myosin light chain(gene name synonym)|uniprotkb:MYL9(gene name)|psi-mi:MYL9(display_short)|uniprotkb:MRLC1(gene name synonym)|uniprotkb:MYRL2(gene name synonym)|uniprotkb:MLC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926736|imex:IM-27181-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) refseq:NP_006088.2|refseq:NP_852667.1|ensembl:ENSG00000101335(gene)|ensembl:ENST00000279022(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005938"(cell cortex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0070527"(platelet aggregation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P24844|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-8936459|dip:DIP-60525N - - - figure legend:figure 4 D|comment:DISC1 was found to interact with MRLC in a CAMDI-dependent manner.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2019/06/06 2019/07/24 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rogid:FeJb0ac0n3hkVmRDnxeGSlL2/A89606 rigid:J3vORC5D6TrHcxhpVvti3Kujm4Q false enhanced green fluorescent protein tag:n-n ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NRI5-3 uniprotkb:A2AST1 intact:EBI-21925300|ensembl:ENSP00000355596 intact:EBI-20565696|ensembl:ENSMUSP00000052945 psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:a2ast1_mouse(display_long)|uniprotkb:Ccdc141(gene name)|psi-mi:Ccdc141(display_short)|uniprotkb:CAMDI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926736|imex:IM-27181-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) ensembl:ENSMUSG00000044033(gene)|ensembl:ENSMUST00000049544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0030424"(axon)|go:"GO:0051642"(centrosome localization)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR036179|interpro:IPR043204 - - - figure legend:figure 4 D|comment:DISC1 was found to interact with MRLC in a CAMDI-dependent manner.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2019/06/06 2019/07/24 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rogid:G5NjGx9ciT7nKS84gNYMv3uGdPg10090 rigid:J3vORC5D6TrHcxhpVvti3Kujm4Q false enhanced green fluorescent protein tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZP82 uniprotkb:P24844 intact:EBI-928795|uniprotkb:Q8N8H3|uniprotkb:H7C0P1|uniprotkb:J3KNW6 intact:EBI-716193|uniprotkb:Q9BQL9|uniprotkb:Q9BUF9|uniprotkb:Q9H136|uniprotkb:E1P5T6|ensembl:ENSP00000279022 psi-mi:cc141_human(display_long)|uniprotkb:CCDC141(gene name)|psi-mi:CCDC141(display_short)|uniprotkb:Coiled-coil protein associated with myosin II and DISC1(gene name synonym)|uniprotkb:CAMDI(gene name synonym) psi-mi:myl9_human(display_long)|uniprotkb:Myosin regulatory light chain 9(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC1(gene name synonym)|uniprotkb:Myosin regulatory light chain 2, smooth muscle isoform(gene name synonym)|uniprotkb:Myosin RLC(gene name synonym)|uniprotkb:MLC-2C(gene name synonym)|uniprotkb:20 kDa myosin light chain(gene name synonym)|uniprotkb:MYL9(gene name)|psi-mi:MYL9(display_short)|uniprotkb:MRLC1(gene name synonym)|uniprotkb:MYRL2(gene name synonym)|uniprotkb:MLC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926964|imex:IM-27181-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000443758|ensembl:ENSP00000390190|ensembl:ENSG00000163492|refseq:NP_775919.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0043005"(neuron projection)|go:"GO:0051642"(centrosome localization) refseq:NP_006088.2|refseq:NP_852667.1|ensembl:ENSG00000101335(gene)|ensembl:ENST00000279022(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005938"(cell cortex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0070527"(platelet aggregation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P24844|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-8936459|dip:DIP-60525N - - - figure legend:figure 5B|comment:the interaction of R828W with MRLC or MRLC-DD was significantly attenuated.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2019/06/06 2019/07/24 rogid:WKgnBWIkZsyOYma0rbtbY4zCwZg9606 rogid:FeJb0ac0n3hkVmRDnxeGSlL2/A89606 rigid:yr1nnbA4EaS0JU/ryUT/ML+z8Ao false sufficient binding region:576-1450|flag tag:n-n|mutation disrupting interaction strength:828-828 ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6ZP82 uniprotkb:Q9NRI5-3 intact:EBI-928795|uniprotkb:Q8N8H3|uniprotkb:H7C0P1|uniprotkb:J3KNW6 intact:EBI-21925300|ensembl:ENSP00000355596 psi-mi:cc141_human(display_long)|uniprotkb:CCDC141(gene name)|psi-mi:CCDC141(display_short)|uniprotkb:Coiled-coil protein associated with myosin II and DISC1(gene name synonym)|uniprotkb:CAMDI(gene name synonym) psi-mi:q9nri5-3(display_long)|uniprotkb:DISC1(gene name)|psi-mi:DISC1(display_short)|uniprotkb:KIAA0457(gene name synonym)|uniprotkb:S(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fukuda et al. (2010) pubmed:20956536|imex:IM-27181 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21926978|imex:IM-27181-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000443758|ensembl:ENSP00000390190|ensembl:ENSG00000163492|refseq:NP_775919.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0043005"(neuron projection)|go:"GO:0051642"(centrosome localization) ensembl:ENSG00000162946(gene)|ensembl:ENST00000366636(transcript)|intact:EBI-529989(isoform-parent) - - - figure legend:figure 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2019/06/06 2019/07/24 rogid:WKgnBWIkZsyOYma0rbtbY4zCwZg9606 rogid:KA/kW3786FpTpexvbWYtJmiL4qk9606 rigid:1Q8I4QkkkcWeInNnT8s2HiURJjA false sufficient binding region:576-1450|flag tag:n-n|mutation with no effect:828-828 enhanced green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)