#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:18408"	uniprotkb:P22033	intact:EBI-22304549|chebi:"CHEBI:13739"|chebi:"CHEBI:23340"|chebi:"CHEBI:3797"	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:cobamamide(display_short)|psi-mi:"CHEBI:18408"(display_long)|intact:"(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:"(5,6-dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:5'-Deoxy-5'-adenosyl vitamin B12(synonym)|intact:5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-Deoxy-5'-adenosylcobalamin(synonym)|intact:5'-deoxyadenosyl vitamin B12(synonym)|intact:5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-deoxyadenosylcobalamin(synonym)|intact:5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide(synonym)|intact:5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide(synonym)|intact:"adenosylcob(III)alamin"(synonym)|intact:"Adenosylcob(III)alamin"(synonym)|intact:Adenosylcobalamin(synonym)|intact:adenosylcobalamin(synonym)|intact:AdoCbl(synonym)|intact:"alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:Calomide(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide"(synonym)|intact:Cobalamin coenzyme(synonym)|intact:cobamamid(synonym)|intact:cobamamida(synonym)|intact:Cobamamide(synonym)|intact:cobamamide(synonym)|intact:cobamamidum(synonym)|intact:cobamide coenzyme(synonym)|intact:coenzyme B-12(synonym)|intact:Coenzyme B12(synonym)|intact:DBC coenzyme(synonym)|intact:Deoxyadenosylcobalamin(synonym)|intact:Dibencozide(synonym)|intact:DMBC coenzyme(synonym)|intact:Funacomide(synonym)|intact:Vitamin B12 coenzyme(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide"(iupac name)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276192|wwpdb:2XIJ|imex:IM-27562-1	-	-	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:TABLE 1|3d-resolution:1.95Å|3d-r-factors:"Rwork:0.158  Rfree:0.199"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/13	-	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	-	false	-	sufficient binding region:12-750	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18408"	chebi:"CHEBI:15531"	intact:EBI-22304549|chebi:"CHEBI:13739"|chebi:"CHEBI:23340"|chebi:"CHEBI:3797"	intact:EBI-22304602|chebi:"CHEBI:43979"|chebi:"CHEBI:6661"|chebi:"CHEBI:14565"|chebi:"CHEBI:25135"	psi-mi:cobamamide(display_short)|psi-mi:"CHEBI:18408"(display_long)|intact:"(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:"(5,6-dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:5'-Deoxy-5'-adenosyl vitamin B12(synonym)|intact:5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-Deoxy-5'-adenosylcobalamin(synonym)|intact:5'-deoxyadenosyl vitamin B12(synonym)|intact:5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-deoxyadenosylcobalamin(synonym)|intact:5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide(synonym)|intact:5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide(synonym)|intact:"adenosylcob(III)alamin"(synonym)|intact:"Adenosylcob(III)alamin"(synonym)|intact:Adenosylcobalamin(synonym)|intact:adenosylcobalamin(synonym)|intact:AdoCbl(synonym)|intact:"alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:Calomide(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide"(synonym)|intact:Cobalamin coenzyme(synonym)|intact:cobamamid(synonym)|intact:cobamamida(synonym)|intact:Cobamamide(synonym)|intact:cobamamide(synonym)|intact:cobamamidum(synonym)|intact:cobamide coenzyme(synonym)|intact:coenzyme B-12(synonym)|intact:Coenzyme B12(synonym)|intact:DBC coenzyme(synonym)|intact:Deoxyadenosylcobalamin(synonym)|intact:Dibencozide(synonym)|intact:DMBC coenzyme(synonym)|intact:Funacomide(synonym)|intact:Vitamin B12 coenzyme(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide"(iupac name)	psi-mi:malonyl-coa(display_short)|psi-mi:"CHEBI:15531"(display_long)|intact:"Coenzyme A, S-(hydrogen propanedioate)"(synonym)|intact:Malonyl coenzyme A(synonym)|intact:Malonyl-CoA(synonym)|intact:"S-(Hydrogen malonyl)coenzyme A"(synonym)|intact:"3'-phosphoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxyacetyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}"(iupac name)	psi-mi:"MI:0114"(x-ray crystallography)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304594|wwpdb:2XIQ|imex:IM-27562-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	figure legend:TABLE 1|3d-resolution:1.95Å|3d-r-factors:"Rwork:0.161  Rfree:0.201"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/13	-	-	-	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18408"	uniprotkb:P22033	intact:EBI-22304549|chebi:"CHEBI:13739"|chebi:"CHEBI:23340"|chebi:"CHEBI:3797"	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:cobamamide(display_short)|psi-mi:"CHEBI:18408"(display_long)|intact:"(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:"(5,6-dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:5'-Deoxy-5'-adenosyl vitamin B12(synonym)|intact:5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-Deoxy-5'-adenosylcobalamin(synonym)|intact:5'-deoxyadenosyl vitamin B12(synonym)|intact:5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-deoxyadenosylcobalamin(synonym)|intact:5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide(synonym)|intact:5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide(synonym)|intact:"adenosylcob(III)alamin"(synonym)|intact:"Adenosylcob(III)alamin"(synonym)|intact:Adenosylcobalamin(synonym)|intact:adenosylcobalamin(synonym)|intact:AdoCbl(synonym)|intact:"alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:Calomide(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide"(synonym)|intact:Cobalamin coenzyme(synonym)|intact:cobamamid(synonym)|intact:cobamamida(synonym)|intact:Cobamamide(synonym)|intact:cobamamide(synonym)|intact:cobamamidum(synonym)|intact:cobamide coenzyme(synonym)|intact:coenzyme B-12(synonym)|intact:Coenzyme B12(synonym)|intact:DBC coenzyme(synonym)|intact:Deoxyadenosylcobalamin(synonym)|intact:Dibencozide(synonym)|intact:DMBC coenzyme(synonym)|intact:Funacomide(synonym)|intact:Vitamin B12 coenzyme(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide"(iupac name)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304594|wwpdb:2XIQ|imex:IM-27562-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:TABLE 1|3d-resolution:1.95Å|3d-r-factors:"Rwork:0.161  Rfree:0.201"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/13	-	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	-	false	-	sufficient binding region:12-750	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IVH4	uniprotkb:Q8IVH4	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25295584|wwpdb:2WWW|imex:IM-27562-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Table 1|3d-resolution:2.64Å|3d-r-factors:"Rwork: 0.182  Rfree: 0.222"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/19	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rigid:CwPXj5zQckZfygKWUGRIbxFiMng	false	sufficient binding region:70-418	sufficient binding region:70-418	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22033	uniprotkb:P22033	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25295596|wwpdb:3BIC|imex:IM-27562-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Table 1|3d-resolution:2.6Å|3d-r-factors:"Rwork: 0.217  Rfree: 0.243"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/19	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rigid:RQKiGCW3CifS7hxMJieJYrBJgG0	false	sufficient binding region:12-750	sufficient binding region:12-750	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:Q8IVH4	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0071"(molecular sieving)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304629|imex:IM-27562-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. S2, 5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/13	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	his tag:n-n|sufficient binding region:73-418|mutation disrupting interaction strength:188-188(218975)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:P22033	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304629|imex:IM-27562-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. S2, 5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/13	-	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	-	false	-	his tag:c-c|flag tag:c-c|sufficient binding region:12-750	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IVH4	uniprotkb:Q8IVH4	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0071"(molecular sieving)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25295520|imex:IM-27562-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. S2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/17	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rigid:CwPXj5zQckZfygKWUGRIbxFiMng	false	his tag:n-n|sufficient binding region:73-418|mutation with no effect:188-188(218975)	his tag:n-n|sufficient binding region:73-418|mutation with no effect:188-188(218975)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22033	uniprotkb:P22033	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25295547|imex:IM-27562-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. S2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/11	2019/12/19	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rigid:RQKiGCW3CifS7hxMJieJYrBJgG0	false	his tag:c-c|flag tag:c-c|sufficient binding region:12-750	his tag:c-c|flag tag:c-c|sufficient binding region:12-750	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:Q8IVH4	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0419"(gtpase assay)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304659|imex:IM-27562-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:TABLE 2, FIGURE 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:74.0x10^-6 ~8.0(molar)|kcat:900.0x1^1 ~0.6(second -1)	2019/12/11	2019/12/16	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	sufficient binding region:73-418|mutation decreasing interaction rate:188-188(218975)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:P22033	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304659|imex:IM-27562-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:TABLE 2, FIGURE 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:74.0x10^-6 ~8.0(molar)|kcat:900.0x1^1 ~0.6(second -1)	2019/12/11	2019/12/16	-	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	-	false	-	flag tag:c-c|flag tag:c-c|sufficient binding region:12-750	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:Q8IVH4	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0419"(gtpase assay)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304677|imex:IM-27562-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:TABLE 2, FIGURE 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:1210.0x10^-6 ~330.0(molar)|kcat:1.8x1^1 ~0.18(second -1)	2019/12/11	2019/12/16	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	sufficient binding region:73-418|his tag:n-n|mutation increasing interaction rate:188-188(218975)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18408"	chebi:"CHEBI:15996"	intact:EBI-22304549|chebi:"CHEBI:13739"|chebi:"CHEBI:23340"|chebi:"CHEBI:3797"	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	psi-mi:cobamamide(display_short)|psi-mi:"CHEBI:18408"(display_long)|intact:"(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:"(5,6-dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:5'-Deoxy-5'-adenosyl vitamin B12(synonym)|intact:5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-Deoxy-5'-adenosylcobalamin(synonym)|intact:5'-deoxyadenosyl vitamin B12(synonym)|intact:5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-deoxyadenosylcobalamin(synonym)|intact:5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide(synonym)|intact:5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide(synonym)|intact:"adenosylcob(III)alamin"(synonym)|intact:"Adenosylcob(III)alamin"(synonym)|intact:Adenosylcobalamin(synonym)|intact:adenosylcobalamin(synonym)|intact:AdoCbl(synonym)|intact:"alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:Calomide(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide"(synonym)|intact:Cobalamin coenzyme(synonym)|intact:cobamamid(synonym)|intact:cobamamida(synonym)|intact:Cobamamide(synonym)|intact:cobamamide(synonym)|intact:cobamamidum(synonym)|intact:cobamide coenzyme(synonym)|intact:coenzyme B-12(synonym)|intact:Coenzyme B12(synonym)|intact:DBC coenzyme(synonym)|intact:Deoxyadenosylcobalamin(synonym)|intact:Dibencozide(synonym)|intact:DMBC coenzyme(synonym)|intact:Funacomide(synonym)|intact:Vitamin B12 coenzyme(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide"(iupac name)	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:"MI:0419"(gtpase assay)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304687|imex:IM-27562-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	figure legend:TABLE 2, FIGURE 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:185.0x10^-6 ~28.0(molar)|kcat:2.22x1^1 ~0.06(second -1)	2019/12/11	2019/12/16	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18408"	uniprotkb:Q8IVH4	intact:EBI-22304549|chebi:"CHEBI:13739"|chebi:"CHEBI:23340"|chebi:"CHEBI:3797"	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:cobamamide(display_short)|psi-mi:"CHEBI:18408"(display_long)|intact:"(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:"(5,6-dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:5'-Deoxy-5'-adenosyl vitamin B12(synonym)|intact:5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-Deoxy-5'-adenosylcobalamin(synonym)|intact:5'-deoxyadenosyl vitamin B12(synonym)|intact:5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-deoxyadenosylcobalamin(synonym)|intact:5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide(synonym)|intact:5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide(synonym)|intact:"adenosylcob(III)alamin"(synonym)|intact:"Adenosylcob(III)alamin"(synonym)|intact:Adenosylcobalamin(synonym)|intact:adenosylcobalamin(synonym)|intact:AdoCbl(synonym)|intact:"alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:Calomide(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide"(synonym)|intact:Cobalamin coenzyme(synonym)|intact:cobamamid(synonym)|intact:cobamamida(synonym)|intact:Cobamamide(synonym)|intact:cobamamide(synonym)|intact:cobamamidum(synonym)|intact:cobamide coenzyme(synonym)|intact:coenzyme B-12(synonym)|intact:Coenzyme B12(synonym)|intact:DBC coenzyme(synonym)|intact:Deoxyadenosylcobalamin(synonym)|intact:Dibencozide(synonym)|intact:DMBC coenzyme(synonym)|intact:Funacomide(synonym)|intact:Vitamin B12 coenzyme(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide"(iupac name)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0419"(gtpase assay)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304687|imex:IM-27562-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:TABLE 2, FIGURE 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:185.0x10^-6 ~28.0(molar)|kcat:2.22x1^1 ~0.06(second -1)	2019/12/11	2019/12/16	-	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	-	false	-	sufficient binding region:73-418	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18408"	uniprotkb:P22033	intact:EBI-22304549|chebi:"CHEBI:13739"|chebi:"CHEBI:23340"|chebi:"CHEBI:3797"	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	psi-mi:cobamamide(display_short)|psi-mi:"CHEBI:18408"(display_long)|intact:"(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:"(5,6-dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:5'-Deoxy-5'-adenosyl vitamin B12(synonym)|intact:5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-Deoxy-5'-adenosylcobalamin(synonym)|intact:5'-deoxyadenosyl vitamin B12(synonym)|intact:5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide(synonym)|intact:5'-deoxyadenosylcobalamin(synonym)|intact:5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide(synonym)|intact:5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide(synonym)|intact:"adenosylcob(III)alamin"(synonym)|intact:"Adenosylcob(III)alamin"(synonym)|intact:Adenosylcobalamin(synonym)|intact:adenosylcobalamin(synonym)|intact:AdoCbl(synonym)|intact:"alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme"(synonym)|intact:Calomide(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide"(synonym)|intact:Cobalamin coenzyme(synonym)|intact:cobamamid(synonym)|intact:cobamamida(synonym)|intact:Cobamamide(synonym)|intact:cobamamide(synonym)|intact:cobamamidum(synonym)|intact:cobamide coenzyme(synonym)|intact:coenzyme B-12(synonym)|intact:Coenzyme B12(synonym)|intact:DBC coenzyme(synonym)|intact:Deoxyadenosylcobalamin(synonym)|intact:Dibencozide(synonym)|intact:DMBC coenzyme(synonym)|intact:Funacomide(synonym)|intact:Vitamin B12 coenzyme(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide"(iupac name)	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304687|imex:IM-27562-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:TABLE 2, FIGURE 5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:185.0x10^-6 ~28.0(molar)|kcat:2.22x1^1 ~0.06(second -1)	2019/12/11	2019/12/16	-	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	-	false	-	flag tag:c-c|flag tag:c-c|sufficient binding region:12-750	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22033	uniprotkb:Q8IVH4	intact:EBI-2690467|uniprotkb:Q9UD64|uniprotkb:Q5SYZ3|uniprotkb:A8K953|uniprotkb:Q96B11|ensembl:ENSP00000274813	intact:EBI-10714945|uniprotkb:B3KX40|uniprotkb:Q495G7|ensembl:ENSP00000442284|ensembl:ENSP00000497008|ensembl:ENSP00000497046|ensembl:ENSP00000497680|ensembl:ENSP00000506503	psi-mi:muta_human(display_long)|uniprotkb:MMUT(gene name)|psi-mi:MMUT(display_short)|uniprotkb:MUT(gene name synonym)|uniprotkb:Methylmalonyl-CoA isomerase(gene name synonym)	psi-mi:mmaa_human(display_long)|uniprotkb:MMAA(gene name)|psi-mi:MMAA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Froese et al. (2010)	pubmed:20876572|imex:IM-27562	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304823|imex:IM-27562-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000246.2|refseq:XP_005249200.1|ensembl:ENSG00000146085(gene)|ensembl:ENST00000274813(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0004494"(methylmalonyl-CoA mutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009791"(post-embryonic development)|go:"GO:0031419"(cobalamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR006098(Methylmalonyl-CoA mutase, alpha chain, catalytic)|interpro:IPR006099(Methylmalonyl-CoA mutase, alpha and beta chain, catalytic)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR006159(Methylmalonyl-CoA mutase, C-terminal)|interpro:IPR016176("Cobalamin (vitamin B12)-dependent enzyme, catalytic")|interpro:IPR036724|rcsb pdb:2XIJ|rcsb pdb:2XIQ|rcsb pdb:3BIC|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	refseq:NP_758454.1|refseq:XP_011529986.1|refseq:XP_011529987.1|ensembl:ENSG00000151611(gene)|ensembl:ENST00000541599(transcript)|ensembl:ENST00000648388(transcript)|ensembl:ENST00000649156(transcript)|ensembl:ENST00000649704(transcript)|ensembl:ENST00000679563(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR005129(ArgK protein)|interpro:IPR027417|rcsb pdb:2WWW|reactome:R-HSA-196741|reactome:R-HSA-3359475|reactome:R-HSA-3359478|reactome:R-HSA-71032	-	-	-	figure legend:Fig. 5c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2019/12/11	2019/12/13	rogid:+MH7wKMIxDwO0Nt9736dvyqXr7w9606	rogid:gvb5ET29tQnZOjlK7MgeXg+CL8U9606	rigid:PcH6AQ2zRkKJXDnt1gBlZSRDuo0	false	-	flag tag:c-c|mutation disrupting interaction strength:188-188(rs864309729)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)