#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01139	uniprotkb:P01139	intact:EBI-9826976|uniprotkb:Q63864|uniprotkb:Q6LDB7|ensembl:ENSMUSP00000040345	intact:EBI-9826976|uniprotkb:Q63864|uniprotkb:Q6LDB7|ensembl:ENSMUSP00000040345	psi-mi:ngf_mouse(display_long)|uniprotkb:Ngf(gene name)|psi-mi:Ngf(display_short)|uniprotkb:Ngfb(gene name synonym)	psi-mi:ngf_mouse(display_long)|uniprotkb:Ngf(gene name)|psi-mi:Ngf(display_short)|uniprotkb:Ngfb(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	McDonald et al. (1991)	imex:IM-27460|pubmed:1956407	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22016990|imex:IM-27460-1|pdbe:1bet	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106168.1|refseq:NP_038637.1|refseq:XP_006501171.1|dip:DIP-59840N|ensembl:ENSMUSG00000027859(gene)|ensembl:ENSMUST00000035952(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031904"(endosome lumen)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048666"(neuron development)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|interpro:IPR029034|rcsb pdb:1BET|rcsb pdb:1BTG|rcsb pdb:1SGF|rcsb pdb:3IJ2|rcsb pdb:4EAX|rcsb pdb:4XPJ|rcsb pdb:5LSD|rcsb pdb:6FFY|reactome:R-MMU-167060|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-177504|reactome:R-MMU-187042|reactome:R-MMU-198203|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:0031954"(positive regulation of protein autophosphorylation)	refseq:NP_001106168.1|refseq:NP_038637.1|refseq:XP_006501171.1|dip:DIP-59840N|ensembl:ENSMUSG00000027859(gene)|ensembl:ENSMUST00000035952(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031904"(endosome lumen)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048666"(neuron development)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|interpro:IPR029034|rcsb pdb:1BET|rcsb pdb:1BTG|rcsb pdb:1SGF|rcsb pdb:3IJ2|rcsb pdb:4EAX|rcsb pdb:4XPJ|rcsb pdb:5LSD|rcsb pdb:6FFY|reactome:R-MMU-167060|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-177504|reactome:R-MMU-187042|reactome:R-MMU-198203|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:0031954"(positive regulation of protein autophosphorylation)	-	-	-	figure legend:Fig.1a and b, Fig.2, Fig.3, Table 1|3d-resolution:2.3A|3d-r-factors:Rwork=0.22  Rfree=not available|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/12	2019/09/12	rogid:0iMgi2FIeSIisDsL1KEKr37dtWE10090	rogid:0iMgi2FIeSIisDsL1KEKr37dtWE10090	rigid:6X3x3FjELOFxYWRwdRR2dLx4uaU	false	sufficient binding region:131-237	sufficient binding region:131-237	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)