#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10153	uniprotkb:P13489	intact:EBI-12286629|ensembl:ENSP00000303276|uniprotkb:Q52M39|uniprotkb:Q9H2B7|uniprotkb:Q9UCG7	intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734	psi-mi:rnas2_human(display_long)|uniprotkb:RNASE2(gene name)|psi-mi:RNASE2(display_short)|uniprotkb:EDN(gene name synonym)|uniprotkb:Eosinophil-derived neurotoxin(gene name synonym)|uniprotkb:RNS2(gene name synonym)|uniprotkb:RNase UpI-2(gene name synonym)|uniprotkb:Ribonuclease 2(gene name synonym)|uniprotkb:Ribonuclease US(gene name synonym)	psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Iyer et al. (2005)	imex:IM-26880|pubmed:15755456	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21222893|imex:IM-26880-1|pdbe:2bex	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169385(gene)|ensembl:ENST00000304625(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004522"(ribonuclease A activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0016829"(lyase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1GQV|rcsb pdb:1HI2|rcsb pdb:2BEX|rcsb pdb:2BZZ|rcsb pdb:2C01|rcsb pdb:1HI3|rcsb pdb:1HI4|rcsb pdb:1HI5|rcsb pdb:1K2A|rcsb pdb:2C02|rcsb pdb:2C05|rcsb pdb:5E13|reactome:R-HSA-6798695|refseq:NP_002925.1	refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript)	-	-	-	figure legend:Table 1|3d-resolution:1.99Å|3d-r-factors:"Rwork: 0.206  Rfree: 0.243"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/22	2021/04/28	rogid:pCT/8jp/QGg9xdwe0J9S4JaoKL49606	rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606	rigid:grjMSvHJzXC3ugAqFmtMp/HOtBA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:171662"	uniprotkb:P13489	intact:EBI-26965105	intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734	psi-mi:6-fam-mamarcmama-dabcyl(display_short)|psi-mi:"CHEBI:171662"(display_long)	psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym)	psi-mi:"MI:0920"(ribonuclease assay)	Iyer et al. (2005)	imex:IM-26880|pubmed:15755456	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0902"(rna cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26965097|imex:IM-26880-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript)	-	-	-	figure legend:Table 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:6.7x10^-13 ~0.5(molar)	2019/02/22	2021/04/29	-	rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606	-	false	-	mutation decreasing interaction rate:458-458|mutation decreasing interaction rate:376-376|mutation decreasing interaction rate:402-402|mutation decreasing interaction rate:439-439,440-440,441-441	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:171662"	uniprotkb:P10153	intact:EBI-26965105	intact:EBI-12286629|ensembl:ENSP00000303276|uniprotkb:Q52M39|uniprotkb:Q9H2B7|uniprotkb:Q9UCG7	psi-mi:6-fam-mamarcmama-dabcyl(display_short)|psi-mi:"CHEBI:171662"(display_long)	psi-mi:rnas2_human(display_long)|uniprotkb:RNASE2(gene name)|psi-mi:RNASE2(display_short)|uniprotkb:EDN(gene name synonym)|uniprotkb:Eosinophil-derived neurotoxin(gene name synonym)|uniprotkb:RNS2(gene name synonym)|uniprotkb:RNase UpI-2(gene name synonym)|uniprotkb:Ribonuclease 2(gene name synonym)|uniprotkb:Ribonuclease US(gene name synonym)	psi-mi:"MI:0920"(ribonuclease assay)	Iyer et al. (2005)	imex:IM-26880|pubmed:15755456	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0902"(rna cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-26965097|imex:IM-26880-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000169385(gene)|ensembl:ENST00000304625(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004522"(ribonuclease A activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0016829"(lyase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1GQV|rcsb pdb:1HI2|rcsb pdb:2BEX|rcsb pdb:2BZZ|rcsb pdb:2C01|rcsb pdb:1HI3|rcsb pdb:1HI4|rcsb pdb:1HI5|rcsb pdb:1K2A|rcsb pdb:2C02|rcsb pdb:2C05|rcsb pdb:5E13|reactome:R-HSA-6798695|refseq:NP_002925.1	-	-	-	figure legend:Table 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ki:6.7x10^-13 ~0.5(molar)	2019/02/22	2021/04/29	-	rogid:pCT/8jp/QGg9xdwe0J9S4JaoKL49606	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)