#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:87738" uniprotkb:P11712 intact:EBI-21444538|chebi:"CHEBI:45816" intact:EBI-2949686|uniprotkb:Q16756|uniprotkb:Q16872|uniprotkb:P11713|uniprotkb:Q5VX92|uniprotkb:Q6IRV8|uniprotkb:Q8WW80|ensembl:ENSP00000260682 psi-mi:"(s)-warfarin"(display_short)|psi-mi:"CHEBI:87738"(display_long)|intact:"(-)-Warfarin"(synonym)|intact:"(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone"(synonym)|intact:"4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-chromen-2-one"(synonym)|intact:levrowarfarin(synonym)|intact:"4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one"(iupac name) psi-mi:cp2c9_human(display_long)|uniprotkb:CYP2C9(gene name)|psi-mi:CYP2C9(display_short)|uniprotkb:CYP2C10(gene name synonym)|uniprotkb:"(R)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 6-monooxygenase"(gene name synonym)|uniprotkb:"(S)-limonene 7-monooxygenase"(gene name synonym)|uniprotkb:CYPIIC9(gene name synonym)|uniprotkb:Cytochrome P-450MP(gene name synonym)|uniprotkb:Cytochrome P450 MP-4(gene name synonym)|uniprotkb:Cytochrome P450 MP-8(gene name synonym)|uniprotkb:Cytochrome P450 PB-1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Williams et al. (2003) pubmed:12861225|imex:IM-27045 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21444549|pdbe:1OG5|imex:IM-27045-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_000762.2|refseq:XP_016871247.1|go:"GO:0008405"(arachidonic acid 11,12-epoxygenase activity)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0018675"("(S)-limonene 6-monooxygenase activity")|go:"GO:0018676"("(S)-limonene 7-monooxygenase activity")|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019627"(urea metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032787"(monocarboxylic acid metabolic process)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042737"|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043603"(cellular amide metabolic process)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0052741"("(R)-limonene 6-monooxygenase activity")|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1OG2|rcsb pdb:1OG5|rcsb pdb:1R9O|rcsb pdb:4NZ2|rcsb pdb:5A5I|rcsb pdb:5A5J|rcsb pdb:5K7K|rcsb pdb:5W0C|rcsb pdb:5X23|rcsb pdb:5X24|rcsb pdb:5XXI|rcsb pdb:6VLT|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|ensembl:ENSG00000138109(gene)|ensembl:ENST00000260682(transcript)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008404"(arachidonic acid 14,15-epoxygenase activity) - - - figure legend:Figure 3a,Table S1|3d-r-factors:"2R factor (%): 22.5 3Rfree (%): 25.6"|3d-resolution:"50-2.55Å (2.69-2.55Å)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/05/29 2019/05/29 - rogid:QFdeY5Oc6zrmlXGNB/gWuZIh7D89606 - false - mutation:206-206|mutation:215-215|mutation:216-216|mutation:220-220|mutation:221-221|mutation:222-222|mutation:223-223|mutation:1-29|his tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)