#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WZ55	uniprotkb:Q1W581	intact:EBI-7996695|intact:MINT-4536104|uniprotkb:Q6NT28|ensembl:ENSP00000498282	intact:EBI-22180783	psi-mi:bsnd_human(display_long)|uniprotkb:BSND(gene name)|psi-mi:BSND(display_short)|uniprotkb:BART(gene name synonym)	psi-mi:q1w581_rat(display_long)|uniprotkb:Clck2(gene name)|psi-mi:Clck2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Hayama et al. (2003)	pubmed:12761627|imex:IM-27461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22180792|imex:IM-27461-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476517.1|ensembl:ENSG00000162399(gene)|ensembl:ENST00000651561(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0032991"(protein-containing complex)|interpro:IPR029181|mint:Q8WZ55|reactome:R-HSA-2672351	interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR014743(Chloride channel, core)|interpro:IPR001807(Chloride channel, voltage gated)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0006821"(chloride transport)|go:"GO:0016021"(integral component of membrane)	-	comment:mint|function:Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter|function:"Defects in BSND are the cause of Bartter syndrome type 4 (BS4) [MIM:602522]; also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4 is associated with sensorineural deafness"	-	figure legend:Fig. 5a-d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/11/01	2019/11/01	rogid:mTzIUQyaEiIx0Yna0Ze52JqL2FM9606	rogid:alsHxUWzuT4G5Wi6tXdRaBuh0Wc10116	rigid:ottne3gTwuZpoY9wGN4QVhS7tak	false	mutation with no effect:98-98|mutation with no effect:8-8|mutation with no effect:10-10|myc tag:?-?|his tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q8WZ55	uniprotkb:Q1W581	intact:EBI-7996695|intact:MINT-4536104|uniprotkb:Q6NT28|ensembl:ENSP00000498282	intact:EBI-22180783	psi-mi:bsnd_human(display_long)|uniprotkb:BSND(gene name)|psi-mi:BSND(display_short)|uniprotkb:BART(gene name synonym)	psi-mi:q1w581_rat(display_long)|uniprotkb:Clck2(gene name)|psi-mi:Clck2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayama et al. (2003)	pubmed:12761627|imex:IM-27461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22180817|imex:IM-27461-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476517.1|ensembl:ENSG00000162399(gene)|ensembl:ENST00000651561(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0032991"(protein-containing complex)|interpro:IPR029181|mint:Q8WZ55|reactome:R-HSA-2672351	interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR014743(Chloride channel, core)|interpro:IPR001807(Chloride channel, voltage gated)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0006821"(chloride transport)|go:"GO:0016021"(integral component of membrane)	-	comment:mint|function:Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter|function:"Defects in BSND are the cause of Bartter syndrome type 4 (BS4) [MIM:602522]; also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4 is associated with sensorineural deafness"	-	figure legend:Fig. 6|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/11/01	2019/11/01	rogid:mTzIUQyaEiIx0Yna0Ze52JqL2FM9606	rogid:alsHxUWzuT4G5Wi6tXdRaBuh0Wc10116	rigid:ottne3gTwuZpoY9wGN4QVhS7tak	false	mutation with no effect:10-10|myc tag:?-?|mutation with no effect:98-98|mutation with no effect:8-8|his tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)