#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21728	uniprotkb:P30542	intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ginés et al. (2000)	pubmed:10890919|imex:IM-27011	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21402527|imex:IM-27011-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Figure 1|antagonist:"SKF-38393, a  D1R agonist.   A1R agonist R-PIA (CHEMBL139000) reversed this effect."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-l cells)|taxid:10090(Mus musculus embryo fibroblast, Moloney Sarcoma Virus transformed)	-	2019/04/17	2019/05/13	rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rigid:1ih7X+gq++FqU8sx186ActrmXFg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P21728	uniprotkb:P30542	intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym)	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Ginés et al. (2000)	pubmed:10890919|imex:IM-27011	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21402605|imex:IM-27011-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 2|antagonist:"SKF-38393, a  D1R agonist separately or combined with   A1R agonist R-PIA (CHEMBL139000)."|agonist:R-PIA induced the aggregation of both proteins in clusters seen as punctate fluorescence, where colocalizations between adenosine and dopamine receptors approach 100%|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-l cells)|taxid:10090(Mus musculus embryo fibroblast, Moloney Sarcoma Virus transformed)	-	2019/04/17	2019/05/13	rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rigid:1ih7X+gq++FqU8sx186ActrmXFg	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)