#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UBK2	uniprotkb:P11474	intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867	intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851	psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym)	psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Schreiber et al. (2003)	pubmed:12522104|imex:IM-26389	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20198009|imex:IM-26389-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616	refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902	-	-	-	figure legend:Figure 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/04/26	rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606	rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606	rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY	false	sufficient binding region:91-408|mutation decreasing interaction strength:147-148|mutation decreasing interaction strength:210-211|mutation disrupting interaction strength:210-211,147-148	sufficient binding region:221-423(IPR000536)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBK2	uniprotkb:P37231	intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867	intact:EBI-781384|uniprotkb:Q96J12|uniprotkb:O00684|uniprotkb:O00710|uniprotkb:O14515|uniprotkb:Q15178|uniprotkb:Q15179|uniprotkb:Q15180|uniprotkb:Q15832|uniprotkb:Q86U60|uniprotkb:A8K3G6|uniprotkb:B5BUA1|uniprotkb:Q0QJH8|ensembl:ENSP00000287820	psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym)	psi-mi:pparg_human(display_long)|uniprotkb:Nuclear receptor subfamily 1 group C member 3(gene name synonym)|uniprotkb:PPARG(gene name)|psi-mi:PPARG(display_short)|uniprotkb:NR1C3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Schreiber et al. (2003)	pubmed:12522104|imex:IM-26389	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20198370|imex:IM-26389-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616	refseq:NP_005028.4|refseq:NP_056953.2|refseq:NP_619725.2|refseq:NP_619726.2|refseq:XP_011532143.1|dip:DIP-35528N|ensembl:ENSG00000132170(gene)|ensembl:ENST00000287820(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004955"(prostaglandin receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033993"(response to lipid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060392"(negative regulation of SMAD protein signal transduction)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060694"(regulation of cholesterol transporter activity)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904893"(negative regulation of receptor signaling pathway via STAT)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:2000272"(negative regulation of signaling receptor activity)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003077(Peroxisome proliferator-activated receptor, gamma)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR022590|interpro:IPR035500|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1I7I|rcsb pdb:1K74|rcsb pdb:1KNU|rcsb pdb:1NYX|rcsb pdb:1PRG|rcsb pdb:1RDT|rcsb pdb:1WM0|rcsb pdb:1ZEO|rcsb pdb:1ZGY|rcsb pdb:2ATH|rcsb pdb:2F4B|rcsb pdb:2FVJ|rcsb pdb:2G0G|rcsb pdb:2G0H|rcsb pdb:2GTK|rcsb pdb:2HFP|rcsb pdb:2HWQ|rcsb pdb:2HWR|rcsb pdb:2I4J|rcsb pdb:2I4P|rcsb pdb:2I4Z|rcsb pdb:2OM9|rcsb pdb:2P4Y|rcsb pdb:2POB|rcsb pdb:2PRG|rcsb pdb:2Q59|rcsb pdb:2Q5P|rcsb pdb:2Q5S|rcsb pdb:2Q61|rcsb pdb:2Q6R|rcsb pdb:2Q6S|rcsb pdb:2Q8S|rcsb pdb:2QMV|rcsb pdb:2VST|rcsb pdb:2VV0|rcsb pdb:2VV1|rcsb pdb:2VV2|rcsb pdb:2VV3|rcsb pdb:2VV4|rcsb pdb:2XKW|rcsb pdb:2YFE|rcsb pdb:2ZK0|rcsb pdb:2ZK1|rcsb pdb:2ZK2|rcsb pdb:2ZK3|rcsb pdb:2ZK4|rcsb pdb:2ZK5|rcsb pdb:2ZK6|rcsb pdb:2ZNO|rcsb pdb:2ZVT|rcsb pdb:3ADS|rcsb pdb:3ADT|rcsb pdb:3ADU|rcsb pdb:3ADV|rcsb pdb:3ADW|rcsb pdb:3ADX|rcsb pdb:3AN3|rcsb pdb:3AN4|rcsb pdb:3B0Q|rcsb pdb:3B0R|rcsb pdb:3B1M|rcsb pdb:3B3K|rcsb pdb:3BC5|rcsb pdb:3CDP|rcsb pdb:3CDS|rcsb pdb:3CS8|rcsb pdb:3CWD|rcsb pdb:3D6D|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3ET0|rcsb pdb:3ET3|rcsb pdb:3FEJ|rcsb pdb:3FUR|rcsb pdb:3G9E|rcsb pdb:3GBK|rcsb pdb:3H0A|rcsb pdb:3HO0|rcsb pdb:3HOD|rcsb pdb:3IA6|rcsb pdb:3K8S|rcsb pdb:3KMG|rcsb pdb:3LMP|rcsb pdb:3NOA|rcsb pdb:3OSI|rcsb pdb:3OSW|rcsb pdb:3PBA|rcsb pdb:3PO9|rcsb pdb:3PRG|rcsb pdb:3QT0|rcsb pdb:3R5N|rcsb pdb:3R8A|rcsb pdb:3R8I|rcsb pdb:3S9S|rcsb pdb:3SZ1|rcsb pdb:3T03|rcsb pdb:3TY0|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:3V9Y|rcsb pdb:3VJH|rcsb pdb:3VJI|rcsb pdb:3VN2|rcsb pdb:3VSO|rcsb pdb:3VSP|rcsb pdb:3WJ4|rcsb pdb:3WJ5|rcsb pdb:3WMH|rcsb pdb:3X1H|rcsb pdb:3X1I|rcsb pdb:4A4V|rcsb pdb:4A4W|rcsb pdb:4CI5|rcsb pdb:4E4K|rcsb pdb:4E4Q|rcsb pdb:4EM9|rcsb pdb:2VSR|rcsb pdb:4EMA|rcsb pdb:4F9M|rcsb pdb:4FGY|rcsb pdb:4HEE|rcsb pdb:4JAZ|rcsb pdb:4JL4|rcsb pdb:4L96|rcsb pdb:4L98|rcsb pdb:4O8F|rcsb pdb:4OJ4|rcsb pdb:4PRG|rcsb pdb:4PVU|rcsb pdb:4PWL|rcsb pdb:4R06|rcsb pdb:4R2U|rcsb pdb:4R6S|rcsb pdb:4XLD|rcsb pdb:4XTA|rcsb pdb:4XUH|rcsb pdb:4XUM|rcsb pdb:4Y29|rcsb pdb:4YT1|rcsb pdb:5AZV|rcsb pdb:5DSH|rcsb pdb:5DV3|rcsb pdb:5DV6|rcsb pdb:5DV8|rcsb pdb:5DVC|rcsb pdb:5DWL|rcsb pdb:5F9B|rcsb pdb:5GTN|rcsb pdb:5GTO|rcsb pdb:5GTP|rcsb pdb:5HZC|rcsb pdb:5JI0|rcsb pdb:5LSG|rcsb pdb:5TTO|rcsb pdb:5TWO|rcsb pdb:5U5L|rcsb pdb:5UGM|rcsb pdb:5WQX|rcsb pdb:5WR0|rcsb pdb:5WR1|rcsb pdb:5Y2O|rcsb pdb:5Y2T|rcsb pdb:5YCN|rcsb pdb:5YCP|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6AN1|rcsb pdb:6AUG|rcsb pdb:6AVI|rcsb pdb:6C1I|rcsb pdb:6C5Q|rcsb pdb:6C5T|rcsb pdb:6D3E|rcsb pdb:6D8X|rcsb pdb:6D94|rcsb pdb:6DBH|rcsb pdb:6DCU|rcsb pdb:6DGL|rcsb pdb:6DGO|rcsb pdb:6DGP|rcsb pdb:6DGQ|rcsb pdb:6DGR|rcsb pdb:6DH9|rcsb pdb:6DHA|rcsb pdb:6E5A|rcsb pdb:6ENQ|rcsb pdb:6F2L|rcsb pdb:6FZF|rcsb pdb:6FZG|rcsb pdb:6FZJ|rcsb pdb:6FZP|rcsb pdb:6FZY|rcsb pdb:6ICJ|rcsb pdb:6IJR|rcsb pdb:6IJS|rcsb pdb:6ILQ|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6JEY|rcsb pdb:6JF0|rcsb pdb:6JQ7|rcsb pdb:6K0T|rcsb pdb:6KTM|rcsb pdb:6KTN|rcsb pdb:6L89|rcsb pdb:6L8B|rcsb pdb:6MCZ|rcsb pdb:6MD0|rcsb pdb:6MD1|rcsb pdb:6MD2|rcsb pdb:6MD4|rcsb pdb:6MS7|rcsb pdb:6O67|rcsb pdb:6O68|rcsb pdb:6ONI|rcsb pdb:6ONJ|rcsb pdb:6PDZ|rcsb pdb:6QJ5|rcsb pdb:6T1S|rcsb pdb:6T1V|rcsb pdb:6T6B|rcsb pdb:6T9C|rcsb pdb:6TDC|rcsb pdb:6TSG|rcsb pdb:6VZL|rcsb pdb:6VZM|rcsb pdb:6VZN|rcsb pdb:6VZO|rcsb pdb:6Y3U|rcsb pdb:6ZLY|rcsb pdb:7AHJ|rcsb pdb:7AWC|rcsb pdb:7AWD|rcsb pdb:7EFQ|rcsb pdb:7JQG|rcsb pdb:7LOT|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8943724|reactome:R-HSA-9022707	-	-	-	figure legend:Figure 4A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/04/26	rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606	rogid:HdszD4mfXGBad/qiDqQQJtATY2I9606	rigid:7BO+iEw24VvpxffOyCxfwIdvT/o	false	sufficient binding region:91-408|mutation disrupting interaction strength:147-148|mutation decreasing interaction strength:210-211|mutation disrupting interaction strength:210-211,147-148	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBK2	uniprotkb:P19793	intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867	intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692	psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym)	psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Schreiber et al. (2003)	pubmed:12522104|imex:IM-26389	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20198401|imex:IM-26389-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616	refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29	-	-	-	figure legend:Figure 4A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/04/26	rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606	rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606	rigid:R7tP1RBo+sFwOnBkkHLyT1fz804	false	mutation disrupting interaction strength:147-148|sufficient binding region:91-408|mutation decreasing interaction strength:210-211|mutation disrupting interaction strength:210-211,147-148	sufficient binding region:10-462	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBK2	uniprotkb:P11474	intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867	intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851	psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym)	psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Schreiber et al. (2003)	pubmed:12522104|imex:IM-26389	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20198673|imex:IM-26389-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616	refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902	-	-	-	figure legend:Figure 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/04/26	rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606	rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606	rigid:Qqj0KhfD1Ho+X4XZWFUF8XD4+gY	false	mutation with no effect:147-148|mutation with no effect:210-211|mutation disrupting interaction strength:210-211,147-148	sufficient binding region:178-423(IPR035500)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBK2	uniprotkb:P03372	intact:EBI-765486|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16|uniprotkb:Q4W5M7|uniprotkb:Q3LIG1|intact:EBI-28970000|ensembl:ENSP00000264867	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym)	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Schreiber et al. (2003)	pubmed:12522104|imex:IM-26389	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20198756|imex:IM-26389-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000264867|ensembl:ENST00000506055|ensembl:ENSP00000423075|ensembl:ENST00000513205|ensembl:ENSP00000421632|ensembl:ENST00000613098|ensembl:ENSP00000481498|refseq:XP_011512073.1|refseq:NP_001317681.1|refseq:NP_001317682.1|refseq:NP_037393.1|refseq:NP_001317680.1|dip:DIP-38449N|ensembl:ENSG00000109819(gene)|ensembl:ENST00000264867(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007586"(digestion)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008380"(RNA splicing)|go:"GO:0009409"(response to cold)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014850"(response to muscle activity)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0021549"(cerebellum development)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043201"(response to leucine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901558"(response to metformin)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|go:"GO:1904635"(positive regulation of glomerular visceral epithelial cell apoptotic process)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:1904640"(response to methionine)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000184"(positive regulation of progesterone biosynthetic process)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034605|interpro:IPR034625|interpro:IPR034833|interpro:IPR035979|mint:Q9UBK2|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|rcsb pdb:3U9Q|rcsb pdb:3V9T|rcsb pdb:3V9V|rcsb pdb:4QJR|rcsb pdb:4QK4|rcsb pdb:5Q0I|rcsb pdb:5UNJ|rcsb pdb:5Z5S|rcsb pdb:5Z6S|rcsb pdb:6AD9|rcsb pdb:6FZF|rcsb pdb:6FZP|rcsb pdb:6IZM|rcsb pdb:6IZN|rcsb pdb:6K0T|rcsb pdb:6KXX|rcsb pdb:6KXY|rcsb pdb:6LN4|rcsb pdb:6MS7|rcsb pdb:6NWK|rcsb pdb:6NWL|rcsb pdb:6T1V|rcsb pdb:6W9K|rcsb pdb:6W9L|rcsb pdb:7E2E|rcsb pdb:7KHT|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2151209|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-8939902|reactome:R-HSA-9615017|rcsb pdb:5TWO|reactome:R-HSA-9707616	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	-	-	-	figure legend:Figure 4B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/04/26	rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	rigid:18aRFaR1BUjnF3i0AtEsH8emVt0	false	mutation decreasing interaction strength:147-148|mutation with no effect:210-211|mutation disrupting interaction strength:210-211,147-148	sufficient binding region:280-595(IPR035500)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)