#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41958	uniprotkb:P30429-2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211591|imex:IM-25224-1|dip:DIP-66E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:HlKK/8lKPd0Rx02Fn4id4c7psIw	false	au1 tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13323	uniprotkb:Q07817-1	intact:EBI-700794|uniprotkb:Q16582|uniprotkb:Q6FH93|ensembl:ENSP00000216115	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bik_human(display_long)|uniprotkb:Apoptosis inducer NBK(gene name synonym)|uniprotkb:BP4(gene name synonym)|uniprotkb:BIP1(gene name synonym)|uniprotkb:BIK(gene name)|psi-mi:BIK(display_short)|uniprotkb:NBK(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211614|imex:IM-25224-2|dip:DIP-78750E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188.1|dip:DIP-928N|ensembl:ENSG00000100290(gene)|ensembl:ENST00000216115(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0008584"(male gonad development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|interpro:IPR020728|interpro:IPR024579|rcsb pdb:2IPE	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:M34Yl66KzkhNSq7e3WKQMb6WDqU9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:xHxd6wrTICkFbEL5w0b+XaG4wfw	false	ha tag:n-n	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q07817-1	uniprotkb:P30429-2	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211635|imex:IM-25224-3|dip:DIP-63576E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:QPvi1EQTb0v7ediJ+umoj3Nar40	false	myc tag:c-c|mutation disrupting interaction:134-136	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41958	uniprotkb:P30429-2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211661|imex:IM-25224-4|dip:DIP-66E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:HlKK/8lKPd0Rx02Fn4id4c7psIw	false	au1 tag:c-c|necessary binding region:160-280	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211686|imex:IM-25224-5|dip:DIP-67E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14790	uniprotkb:P30429-2	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211709|imex:IM-25224-6|dip:DIP-200837E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:xu5feOPHj2QXURV6tMj2Xxjq6lI	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:Q07817-1	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211732|imex:IM-25224-7|dip:DIP-62900E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:FRmYa5YKFIiI1hSR1a0/71ki46o	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q16611	uniprotkb:Q07817-1	intact:EBI-519866|ensembl:ENSP00000363591|uniprotkb:Q92533|uniprotkb:Q6I9T6|uniprotkb:C0H5Y7	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bak_human(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bcl-2-like protein 7(gene name synonym)|uniprotkb:BAK1(gene name)|psi-mi:BAK1(display_short)|uniprotkb:BAK(gene name synonym)|uniprotkb:BCL2L7(gene name synonym)|uniprotkb:CDN1(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211803|imex:IM-25224-10|dip:DIP-61901E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001179.1|ensembl:ENSG00000030110(gene)|ensembl:ENST00000374467(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|mint:Q16611|rcsb pdb:1BXL|rcsb pdb:2IMS|rcsb pdb:2IMT|rcsb pdb:2JBY|rcsb pdb:2JCN|rcsb pdb:2LP8|rcsb pdb:2M5B|rcsb pdb:2XPX|rcsb pdb:2YV6|rcsb pdb:3I1H|rcsb pdb:3QBR|rcsb pdb:4D2L|rcsb pdb:4U2U|rcsb pdb:4U2V|rcsb pdb:4UF1|rcsb pdb:5AJK|rcsb pdb:5FMI|rcsb pdb:5FMK|rcsb pdb:5VWV|rcsb pdb:5VWW|rcsb pdb:5VWX|rcsb pdb:5VWY|rcsb pdb:5VWZ|rcsb pdb:5VX0|rcsb pdb:5VX1|rcsb pdb:6ODH|rcsb pdb:6UXM|rcsb pdb:6UXN|rcsb pdb:6UXO|rcsb pdb:6UXP|rcsb pdb:6UXQ|rcsb pdb:6UXR|rcsb pdb:7K02|rcsb pdb:7OFM|rcsb pdb:7OFO|reactome:R-HSA-111452|reactome:R-HSA-111457|reactome:R-HSA-5620971|refseq:XP_011513081.1|dip:DIP-935N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:F13a6H/g/tv/Pr90ehCDePpcSB49606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:Vsl19lBLoL75CYE+wO3EE44R3hE	false	ha tag:n-n	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41958	uniprotkb:P30429-2	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211778|imex:IM-25224-9|dip:DIP-66E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:HlKK/8lKPd0Rx02Fn4id4c7psIw	false	au1 tag:c-c|necessary binding region:160-280	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211753|imex:IM-25224-8|dip:DIP-67E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	flag tag:c-c	myc tag:?-?|sufficient binding region:1-301	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P41958	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494110|ensemblmetazoa:T07C4.8.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced9_caeel(display_long)|uniprotkb:Cell death protein 9(gene name synonym)|uniprotkb:ced-9(gene name)|psi-mi:ced-9(display_short)|uniprotkb:T07C4.8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211824|imex:IM-25224-11|dip:DIP-200838E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_499284.1|wormbase:T07C4.8|ensemblmetazoa:T07C4.8.1(transcript)|ensemblmetazoa:WBGene00000423(gene)|go:"GO:0000422"(autophagy of mitochondrion)|reactome:R-CEL-9648002|dip:DIP-250N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031090"(organelle membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0090727"(positive regulation of brood size)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098793"(presynapse)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1OHU|rcsb pdb:1TY4|rcsb pdb:2A5Y	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:0nKuipvqQOKHVeaoNXbSFYJNPhM6239	rigid:6q84PUXbkiyJ9N/4tmFdYGRrszs	false	flag tag:c-c	au1 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211824|imex:IM-25224-11|dip:DIP-200838E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:6q84PUXbkiyJ9N/4tmFdYGRrszs	false	flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q07817-1	uniprotkb:P30429-2	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211850|imex:IM-25224-12|dip:DIP-63576E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:QPvi1EQTb0v7ediJ+umoj3Nar40	false	myc tag:c-c|mutation disrupting interaction:134-136	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211876|imex:IM-25224-13|dip:DIP-67E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0465"(dip)	-	isoform-comment:Major transcript.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:1-130|sufficient binding region:99-502|flag tag:c-c	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14790	uniprotkb:Q07817-1	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211903|imex:IM-25224-14|dip:DIP-200839E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:mU8VMZQn9RRf0u7Cb9xxqd96jJU	false	flag tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07812	uniprotkb:Q07817-1	intact:EBI-516580|uniprotkb:P55269|uniprotkb:Q07814|uniprotkb:Q07815|uniprotkb:Q8WZ49|uniprotkb:Q9NR76|uniprotkb:Q9UQD6|uniprotkb:Q9NYG7|uniprotkb:Q9UCZ6|uniprotkb:Q9UCZ7|uniprotkb:A8K4W1|intact:EBI-8995042|ensembl:ENSP00000263262	intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443	psi-mi:bax_human(display_long)|uniprotkb:BAX(gene name)|psi-mi:BAX(display_short)|uniprotkb:BCL2L4(gene name synonym)|uniprotkb:Bcl-2-like protein 4(gene name synonym)	psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chinnaiyan et al. (1997)	pubmed:9027312|doi:10.1126/science.275.5303.1122|imex:IM-25224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211924|imex:IM-25224-15|dip:DIP-62900E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004315.1|refseq:NP_620116.1|refseq:NP_620118.1|refseq:NP_620119.2|refseq:XP_016882566.1|refseq:NP_001278357.1|refseq:NP_001278360.1|dip:DIP-232N|ensembl:ENSG00000087088(gene)|ensembl:ENST00000345358(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001764"(neuron migration)|go:"GO:0001777"(T cell homeostatic proliferation)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001844"(protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008289"(lipid binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009651"(response to salt stress)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032976"(release of matrix enzymes from mitochondria)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045136"(development of secondary sexual characteristics)|go:"GO:0046666"(retinal cell programmed cell death)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051087"(chaperone binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097144"(BAX complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0021854"(hypothalamus development)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1990117"(B cell receptor apoptotic signaling pathway)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026304|interpro:IPR036834|mint:Q07812|rcsb pdb:1F16|rcsb pdb:2G5B|rcsb pdb:2K7W|rcsb pdb:2LR1|rcsb pdb:3PK1|rcsb pdb:3PL7|rcsb pdb:4BD2|rcsb pdb:4BD6|rcsb pdb:4BD7|rcsb pdb:4BD8|rcsb pdb:4BDU|rcsb pdb:4S0O|rcsb pdb:4S0P|rcsb pdb:4UF2|rcsb pdb:4ZIE|rcsb pdb:4ZIF|rcsb pdb:4ZIG|rcsb pdb:4ZIH|rcsb pdb:4ZII|rcsb pdb:5W5X|rcsb pdb:5W5Z|rcsb pdb:5W60|rcsb pdb:5W61|rcsb pdb:6EB6|rcsb pdb:6L8V|rcsb pdb:6L95|rcsb pdb:6TRR|rcsb pdb:6XY6|reactome:R-HSA-111457|reactome:R-HSA-114294|reactome:R-HSA-5620971|reactome:R-HSA-6803204|reactome:R-HSA-6804114|reactome:R-HSA-8878166|reactome:R-HSA-9603505|go:"GO:0097193"(intrinsic apoptotic signaling pathway)	intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:+Fz2No3HFxN4vZ+KGhDcgPQhpLo9606	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:FRmYa5YKFIiI1hSR1a0/71ki46o	false	ha tag:n-n	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)