#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P54784	uniprotkb:P21691	intact:EBI-12568|uniprotkb:D6VZA8|ensemblfungi:YML065W	intact:EBI-17211|uniprotkb:D6VXG2|ensemblfungi:YKR101W	psi-mi:orc1_yeast(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:YML065W(locus name)|uniprotkb:Origin recognition complex 120 kDa subunit(gene name synonym)	psi-mi:sir1_yeast(display_long)|uniprotkb:SIR1(gene name)|psi-mi:SIR1(display_short)|uniprotkb:YKR101W(locus name)|uniprotkb:Silent information regulator 1(gene name synonym)|uniprotkb:Heterochromatin protein SIR1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Triolo et al. (1996)	pubmed:8622770|doi:10.1038/381251a0|imex:IM-24890	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16210977|imex:IM-24890-1|dip:DIP-3056E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6WGG|rcsb pdb:6WGI|rcsb pdb:7MCA|reactome:R-SCE-68616|rcsb pdb:6WGC|reactome:R-SCE-68949|reactome:R-SCE-68962|ensemblfungi:YML065W(gene)|ensemblfungi:YML065W_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:1M4Z|rcsb pdb:1ZBX|rcsb pdb:1ZHI|rcsb pdb:5V8F|rcsb pdb:5ZR1|rcsb pdb:6OM3|rcsb pdb:6RQC|refseq:NP_013646.1|sgd:S000004530|dip:DIP-2284N|mint:P54784	refseq:NP_013027.4|sgd:S000001809|ensemblfungi:YKR101W(gene)|ensemblfungi:YKR101W_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031507"(heterochromatin assembly)|interpro:IPR021646|interpro:IPR037240|rcsb pdb:1Z1A|rcsb pdb:1ZBX|rcsb pdb:1ZHI|dip:DIP-2453N|mint:P21691	psi-mi:"MI:0465"(dip)	crc64:BDAA9D3E40B4B76A	crc64:00FEABD1BD35BC81	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ZTOvWqU+Rxwll7cRwOUsRqJC08M559292	rogid:CMVYYG4cMH7Z2Gmq21uNeDyFqqU559292	rigid:cgkzi05l/y5WCYjgaULTa6+b7JY	false	sufficient binding region:5-268	sufficient binding region:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P11978	uniprotkb:P21691	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	intact:EBI-17211|uniprotkb:D6VXG2|ensemblfungi:YKR101W	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:sir1_yeast(display_long)|uniprotkb:SIR1(gene name)|psi-mi:SIR1(display_short)|uniprotkb:YKR101W(locus name)|uniprotkb:Silent information regulator 1(gene name synonym)|uniprotkb:Heterochromatin protein SIR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Triolo et al. (1996)	pubmed:8622770|doi:10.1038/381251a0|imex:IM-24890	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211023|imex:IM-24890-3|dip:DIP-9822E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	refseq:NP_013027.4|sgd:S000001809|ensemblfungi:YKR101W(gene)|ensemblfungi:YKR101W_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031507"(heterochromatin assembly)|interpro:IPR021646|interpro:IPR037240|rcsb pdb:1Z1A|rcsb pdb:1ZBX|rcsb pdb:1ZHI|dip:DIP-2453N|mint:P21691	psi-mi:"MI:0465"(dip)	crc64:9C698765964F094E	crc64:00FEABD1BD35BC81	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	rogid:CMVYYG4cMH7Z2Gmq21uNeDyFqqU559292	rigid:yGBKXCCqPniu0PODL+7kPGGIUtQ	false	necessary binding region:563-1358	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54784	uniprotkb:P21691	intact:EBI-12568|uniprotkb:D6VZA8|ensemblfungi:YML065W	intact:EBI-17211|uniprotkb:D6VXG2|ensemblfungi:YKR101W	psi-mi:orc1_yeast(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:YML065W(locus name)|uniprotkb:Origin recognition complex 120 kDa subunit(gene name synonym)	psi-mi:sir1_yeast(display_long)|uniprotkb:SIR1(gene name)|psi-mi:SIR1(display_short)|uniprotkb:YKR101W(locus name)|uniprotkb:Silent information regulator 1(gene name synonym)|uniprotkb:Heterochromatin protein SIR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Triolo et al. (1996)	pubmed:8622770|doi:10.1038/381251a0|imex:IM-24890	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211002|imex:IM-24890-2|dip:DIP-3056E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6WGG|rcsb pdb:6WGI|rcsb pdb:7MCA|reactome:R-SCE-68616|rcsb pdb:6WGC|reactome:R-SCE-68949|reactome:R-SCE-68962|ensemblfungi:YML065W(gene)|ensemblfungi:YML065W_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:1M4Z|rcsb pdb:1ZBX|rcsb pdb:1ZHI|rcsb pdb:5V8F|rcsb pdb:5ZR1|rcsb pdb:6OM3|rcsb pdb:6RQC|refseq:NP_013646.1|sgd:S000004530|dip:DIP-2284N|mint:P54784	refseq:NP_013027.4|sgd:S000001809|ensemblfungi:YKR101W(gene)|ensemblfungi:YKR101W_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031507"(heterochromatin assembly)|interpro:IPR021646|interpro:IPR037240|rcsb pdb:1Z1A|rcsb pdb:1ZBX|rcsb pdb:1ZHI|dip:DIP-2453N|mint:P21691	psi-mi:"MI:0465"(dip)	crc64:BDAA9D3E40B4B76A	crc64:00FEABD1BD35BC81	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:ZTOvWqU+Rxwll7cRwOUsRqJC08M559292	rogid:CMVYYG4cMH7Z2Gmq21uNeDyFqqU559292	rigid:cgkzi05l/y5WCYjgaULTa6+b7JY	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54784	uniprotkb:P21691	intact:EBI-12568|uniprotkb:D6VZA8|ensemblfungi:YML065W	intact:EBI-17211|uniprotkb:D6VXG2|ensemblfungi:YKR101W	psi-mi:orc1_yeast(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:YML065W(locus name)|uniprotkb:Origin recognition complex 120 kDa subunit(gene name synonym)	psi-mi:sir1_yeast(display_long)|uniprotkb:SIR1(gene name)|psi-mi:SIR1(display_short)|uniprotkb:YKR101W(locus name)|uniprotkb:Silent information regulator 1(gene name synonym)|uniprotkb:Heterochromatin protein SIR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Triolo et al. (1996)	pubmed:8622770|doi:10.1038/381251a0|imex:IM-24890	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16211046|imex:IM-24890-4|dip:DIP-3056E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6WGG|rcsb pdb:6WGI|rcsb pdb:7MCA|reactome:R-SCE-68616|rcsb pdb:6WGC|reactome:R-SCE-68949|reactome:R-SCE-68962|ensemblfungi:YML065W(gene)|ensemblfungi:YML065W_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031491"(nucleosome binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:1M4Z|rcsb pdb:1ZBX|rcsb pdb:1ZHI|rcsb pdb:5V8F|rcsb pdb:5ZR1|rcsb pdb:6OM3|rcsb pdb:6RQC|refseq:NP_013646.1|sgd:S000004530|dip:DIP-2284N|mint:P54784	refseq:NP_013027.4|sgd:S000001809|ensemblfungi:YKR101W(gene)|ensemblfungi:YKR101W_mRNA(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031507"(heterochromatin assembly)|interpro:IPR021646|interpro:IPR037240|rcsb pdb:1Z1A|rcsb pdb:1ZBX|rcsb pdb:1ZHI|dip:DIP-2453N|mint:P21691	psi-mi:"MI:0465"(dip)	crc64:BDAA9D3E40B4B76A	crc64:00FEABD1BD35BC81	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:ZTOvWqU+Rxwll7cRwOUsRqJC08M559292	rogid:CMVYYG4cMH7Z2Gmq21uNeDyFqqU559292	rigid:cgkzi05l/y5WCYjgaULTa6+b7JY	false	sufficient binding region:5-228	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)